Pharmaciana最新文献_第10页

Prevalence of diabetes distress and associated factors among patients with diabetes using antihypertensive medications in community health centres in Bandung City, Indonesia 印度尼西亚万隆市社区卫生中心使用抗高血压药物的糖尿病患者糖尿病痛苦患病率及相关因素

Pharmaciana Pub Date : 2021-07-30 DOI: 10.12928/pharmaciana.v11i2.20094

S. Alfian, I. Wicaksono, N. A. Putri, R. Abdulah

{"title":"Prevalence of diabetes distress and associated factors among patients with diabetes using antihypertensive medications in community health centres in Bandung City, Indonesia","authors":"S. Alfian, I. Wicaksono, N. A. Putri, R. Abdulah","doi":"10.12928/pharmaciana.v11i2.20094","DOIUrl":"https://doi.org/10.12928/pharmaciana.v11i2.20094","url":null,"abstract":"Diabetes distress is common among patients with type 2 diabetes mellitus (T2DM), which remains unrecognized in primary care settings. A higher level of diabetes distress was found among T2DM patients with comorbidities. The objectives of this study are to assess the prevalence rate of diabetes distress and its association with sociodemographic factors among T2DM patients using antihypertensive medication in Bandung City, Indonesia. An observational cross-sectional survey was performed in six community health centres in Bandung City, Indonesia, among T2DM patients aged at least 18 years who were using antihypertensive medications. Diabetes distress subscales (emotional, regimen, interpersonal, and physician-related distress) were evaluated using the validated Diabetes Distress Scale. Pearson χ2 and Mann–Whitney tests were performed to assess the associations of patients’ sociodemographic factors (age, gender, insurance type, education, and duration since diagnosed with diabetes and hypertension) with diabetes distress. Of 105 patients who participated and completed the survey (response rate 93.8%), most of them were female and were aged 60-69 years. A total of 38 patients (36.2%) had moderate-high diabetes distress with emotional (56.2%) and regimen (53.3%) distress as the most commonly reported distress. Moderate-high emotional and regimen diabetes distress were significantly higher among the elderly (p 0.014) and patients who could not afford to pay the health insurance premium (p 0.012). Emotional and regimen distress as dominant forms of diabetes distress was observed among T2DM patients using antihypertensive medications. A routine diabetes distress assessment is needed in T2DM patients with comorbidity in primary care settings.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47176840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Nanoemulsifying Drug Delivery System (SNEDDS) of piroxicam 吡罗西康自纳米乳化给药系统的研究

Pharmaciana Pub Date : 2021-07-30 DOI: 10.12928/pharmaciana.v11i2.20973

Yudha Rizky Nuari, Iis Wahyuningsih, Sekar Prabawati

{"title":"Self-Nanoemulsifying Drug Delivery System (SNEDDS) of piroxicam","authors":"Yudha Rizky Nuari, Iis Wahyuningsih, Sekar Prabawati","doi":"10.12928/pharmaciana.v11i2.20973","DOIUrl":"https://doi.org/10.12928/pharmaciana.v11i2.20973","url":null,"abstract":"Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that is commonly used for arthritis, gout, and other musculoskeletal disorders. Piroxicam is poorly soluble in water and according to the biopharmaceutical drug classification system (BCS) is classified as a Class II drug with good permeability but poor dissolution. The self-nanoemulsifying drug delivery system (SNEDDS) has been extensively employed to improve the dissolution and absorption of water-insoluble drugs within the gastrointestinal tract, leading to enhanced oral bioavailability and increased therapeutic effect of the loaded drugs. Therefore, the present study aims to evaluate the anti-inflammatory activity of piroxicam-loaded SNEDDS as compared to conventional piroxicam suspension that was observed in male Wistar strain rats. The SNEDDS was tailored from a mixture of oleic acid, tween 80, and propylene glycol. Twenty male Wistar strain rats (aged 2-3 months, weighed 150-250g) were selected and were divided equally into 4 different groups receiving 1% PVP, SNEDDS carrier, piroxicam suspension (1.8 mg/Kg BW), and SNEDDS piroxicam (1.8 mg/Kg BW). Acute inflammation was induced by a carrageenan-induced paw edema model where the carrageenan was injected sub plantar in the hind paw of the rats to induce edema. Several parameters including paw edema volume, AUC 0-6 , and percent anti-inflammatory effect, were measured to evaluate the anti-inflammatory activity experienced in each group. At the end of this study, the piroxicam SNEDDS group significantly demonstrated better protection from paw edema compared to the piroxicam suspension group (ρ<0.05), suggesting that SNEDDS may enhance the anti-inflammatory activity of piroxicam.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42507121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of glycemic index determination method 评价血糖指数测定方法

Pharmaciana Pub Date : 2021-07-30 DOI: 10.12928/pharmaciana.v11i2.20666

R. Listyaningrum

{"title":"Evaluation of glycemic index determination method","authors":"R. Listyaningrum","doi":"10.12928/pharmaciana.v11i2.20666","DOIUrl":"https://doi.org/10.12928/pharmaciana.v11i2.20666","url":null,"abstract":"In Indonesia, determination of glycemic index (GI) was performed according to approved protocols prescribed by FAO (1998) and BPOM (2011); but, remarkable differences among these methods exist, primarily regarding the points of recommendation. This present work aimed to evaluate the technical steps of the protocol for determining GI between two protocols recommended by BPOM (2011) and FAO (1998). Ten healthy subjects (age 21-36 years old and body mass index (BMI) 18.5-24.9 kg/m 2 ) were recruited for the study. The blood glucose was measured with repeated glucose trials, while the number of sampling points for the blood glucose test was also investigated. The range of GI for rice, wheat cookies, NS-cookies, HMT-cookies were 68–77; 55– 60; 35 – 43; 35– 41, respectively, using the combination of three different aspects between FAO and BPOM protocol. Noticeably, the difference in glucose trials did not cause significant variations to GI (n=10, p>0.05). Regarding statistical performance between methods, the Coefficient of Variance (CV) resulted from BPOM protocol (10 subjects, 5 sampling points) ranged 37 to 49%, being slightly higher compared to CV obtained from FAO protocol (7 subjects with triplicate glucose trials, 7 sampling points), i.e., 33% and 35%. The conclusive remark was noticed, that the most satisfying protocol for determination of GI was achieved using no less than two reference food trials, seven subjects, and seven blood sampling points.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41471958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Homology modeling and mutation prediction of ACE2 from COVID-19 新冠病毒ACE2同源性建模及突变预测

Pharmaciana Pub Date : 2021-07-30 DOI: 10.12928/pharmaciana.v11i2.19089

Purnawan Pontana Putra, A. Fauzana, Khairunnisa Assyifa Salva, M. Sofiana, Intan Permata Sari, H. Lucida

引用次数: 0

The development of Moringa leaves effervescent granules with effervescent agent of citric acid and sodium bicarbonate 用柠檬酸和碳酸氢钠泡腾剂制备辣木叶泡腾剂颗粒

Pharmaciana Pub Date : 2021-07-30 DOI: 10.12928/pharmaciana.v11i2.20873

K. C. Rani, N. Parfati, N. I. Ekajayani, I. Kurniawan, Ni Putu Wangi Kristiani

{"title":"The development of Moringa leaves effervescent granules with effervescent agent of citric acid and sodium bicarbonate","authors":"K. C. Rani, N. Parfati, N. I. Ekajayani, I. Kurniawan, Ni Putu Wangi Kristiani","doi":"10.12928/pharmaciana.v11i2.20873","DOIUrl":"https://doi.org/10.12928/pharmaciana.v11i2.20873","url":null,"abstract":"Moringa leaves are part of Moringa Oleifera, which have a high antioxidant content, therefore, it is beneficial for overcoming free radicals in the body. Furthermore, the leaves contents have the potential to be developed into a functional drink in the form of effervescent granules. The important aspects influencing the physical characteristics, stability, and acceptability of granule is the type and ratio of the effervescent agent. In this study, citric acid and sodium bicarbonate were used as effervescent agents because they both provide acceptable texture and mouthfeel. This study aimed to develop an effervescent granule formula of Moringa leaves and to optimize the molar ratio of citric acid and sodium bicarbonate as the effervescent agent. Three molar ratios of citric acid and sodium bicarbonate were optimized, namely 1:3.11 (Formulation 1), 1:3 (Formulation 2), and 1:2.93 (Formulation 3). These formulations were developed using the wet granulation method. The results showed effervescent granules of the three formulations exhibited good flowability and uniform particle size distribution. Furthermore, formulation 3 showed better granule flow characteristics than the others. The results after reconstitution showed the granules were quickly dispersed within 207-234 secs, the pH of the preparation ranged between 5.74-5.92 (neutral pH), the viscosity was between 326-333 cps, and exhibited dilatant flow characteristics. Also, the organoleptic and sensory evaluation results showed formulation 3 was the most acceptable in terms of color, taste, aroma, and texture. Based on these findings, it was concluded that formulation 3 which used (citric acid ratio, sodium bicarbonate 1:2.93) was the optimal formulation.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43676485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

In-vitro studies on antioxidant and antidiabetic potential of Sesoot (Garcinia picrorrhiza Miq.) fruit ethanolic extract from Indonesia 印尼芝麻果乙醇提取物抗氧化和抗糖尿病作用的体外研究

Pharmaciana Pub Date : 2021-07-30 DOI: 10.12928/pharmaciana.v11i2.20110

S. Utami, Sonny Pamuji Laksono, Qomariyah Sachrowardi, D. N. Mustaqimah, S. Endrini, Ndaru Andri Damayanti, Said Nafik, Betharie Cendera Arrahmani, H. Kusuma, W. Widowati

{"title":"In-vitro studies on antioxidant and antidiabetic potential of Sesoot (Garcinia picrorrhiza Miq.) fruit ethanolic extract from Indonesia","authors":"S. Utami, Sonny Pamuji Laksono, Qomariyah Sachrowardi, D. N. Mustaqimah, S. Endrini, Ndaru Andri Damayanti, Said Nafik, Betharie Cendera Arrahmani, H. Kusuma, W. Widowati","doi":"10.12928/pharmaciana.v11i2.20110","DOIUrl":"https://doi.org/10.12928/pharmaciana.v11i2.20110","url":null,"abstract":"Diabetes mellitus (DM) is a disease that can be identified by high levels of blood glucose. Garcinia plants have been widely used for many traditional medicines as antioxidant, anticancer, antidiabetics, and antiinflammation. The antioxidant and antidiabetic activities of ( Garcinia picrorrhiza Miq.) or sesoot fruit extract were evaluated in this study and compared with xanthone. The antioxidant and antidiabetic of ethanolic ripe sesoot ( G. picrorrhiza Miq.) fruit extract (GpKar) was evaluated by (ABTS) reducing activity, α-glucosidase, β-glucosidase, and α-amylase inhibitor activity. GpKar showed higher ABTS-reducing activity (IC 50 = 49.30 µg/mL) than xanthone (IC 50 = 404.30 µg/mL). GpKar showed IC 50 = 109.32 µg/mL for α-glucosidase inhibitory activity, while xanthones had a better activity (IC 50 = 33.97 µg/mL). GpKar also showed lower α-amylase inhibitory activity and β-glucosidase (IC 50 = 126.01 and 9432.09 µg/mL) compared to xanthone (IC 50 = 44.32 and 405.03 µg/mL, respectively). The compounds of GpKar are proven to have antioxidant and antidiabetic activities. Therefore, it will be industrially relevant to develop a natural medicine for decreasing DM risk, thus evaluating the antioxidant and antidiabetic effect of G. picrorrhiza by a pre-clinic study is needed.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42173393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibitory activity of several extract of Piper betle Leaf against S. aureus 椒叶几种提取物对金黄色葡萄球菌的抑制活性研究

Pharmaciana Pub Date : 2021-07-30 DOI: 10.12928/pharmaciana.v11i2.16999

A. Jamil, Siti Rofida, Dinda Farida, Dwi Retno Nur Syahida, Trimianti Hidahyatun Nazah

{"title":"Inhibitory activity of several extract of Piper betle Leaf against S. aureus","authors":"A. Jamil, Siti Rofida, Dinda Farida, Dwi Retno Nur Syahida, Trimianti Hidahyatun Nazah","doi":"10.12928/pharmaciana.v11i2.16999","DOIUrl":"https://doi.org/10.12928/pharmaciana.v11i2.16999","url":null,"abstract":"A high number of infections from year to year require infectious diseases to get serious attention. The antimicrobial compound exploration must be continued to anticipate the development of infectious diseases. The purpose of this study was to find out in vitro antimicrobial activity of n-hexane, ethyl acetate, and ethanol fractions of Piper betle green leaves against S. aureus , and profiles of secondary metabolite compounds contained in these three extracts. The antimicrobial activity test was carried out by disk diffusion test of the fraction of n-hexane, ethyl acetate, and ethanol at a concentration of 6,25, 12,5, and 18,75 µg/disk. Detection of secondary metabolite content was done by the Thin Layer Chromatography method with stain-view reagents. The highest antimicrobial activity was found in the ethyl acetate fraction and was significantly different from the activity in the ethanol and n-hexane fractions. However, the antibacterial activity of all fractions was lower compared to the positive control of amoxiclav 30µg/disk. The phytochemical screening results of secondary metabolites of each fraction were shown that the n-hexane fraction contained alkaloids, terpenoids, flavonoids, polyphenols, and anthraquinone; the ethyl acetate fraction contained terpenoids, polyphenols, and anthraquinone; while the ethanol fraction contained alkaloids, terpenoids, polyphenols, and anthraquinone. Based on the test results, it is concluded that all fractions of Piper betle leaf extract had high antimicrobial activity; meanwhile, the ethyl acetate fraction had the highest activities among others. Each fraction was proven to have a different composition of secondary metabolites.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48184510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced skin localization of doxycycline using microparticles and hydrogel: Effect of oleic acid as penetration enhancer 使用微粒和水凝胶增强多西环素的皮肤定位：油酸作为渗透促进剂的作用

Pharmaciana Pub Date : 2021-07-30 DOI: 10.12928/pharmaciana.v11i2.21044

Aliyah Aliyah, Windy Winalda Oktaviana, Kadek Saka Dwipayanti, Arini Putri Erdiana, Rifka Nurul Utami, A. Permana

{"title":"Enhanced skin localization of doxycycline using microparticles and hydrogel: Effect of oleic acid as penetration enhancer","authors":"Aliyah Aliyah, Windy Winalda Oktaviana, Kadek Saka Dwipayanti, Arini Putri Erdiana, Rifka Nurul Utami, A. Permana","doi":"10.12928/pharmaciana.v11i2.21044","DOIUrl":"https://doi.org/10.12928/pharmaciana.v11i2.21044","url":null,"abstract":"One of the disadvantages of gel preparations is the poor ability to penetrate the skin. Herein we developed a sodium carboxymethylcellulose (NaCMC)-based gel containing microparticle of doxycycline hyclate (DOX). Oleic acid (OA) was added into the gel formulation specifically to increase the penetrability of DOX microparticles. The objective of this work was to determine the effect of varying concentration of OA on the physical characteristics, penetration and retention abilities of DOX. DOX microparticles were initially prepared using PLGA as a matrix and then incorporated into a NaCMC-based gel with various OA concentrations: 0%, 2.5%, 5%, 7.5%, and 10% for F1, F2, F3, F4, and F5, respectively. The gel preparations were evaluated for their organoleptic test, homogeneity, pH measurement, viscosity, spreadability, as well as ex vivo penetration and retention abilities. The physical characteristics tests revealed a homogeneous yellow gel with a distinctive odor and pH values compatible with the pH requirements of human skin. The retention test showed the formulation retained 1236.46 µg of DOX in the skin. Finally, the skin retention of DOX from microparticles loaded gel was significantly higher compared to the free DOX loaded gel, indicating the microparticles can be extremely effective in retaining the DOX in the infected area.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46784969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

In-vitro diffusion study of ibuprofen--cyclodextrin inclusion complex nanogel 布洛芬--环糊精包合纳米凝胶的体外扩散研究

Pharmaciana Pub Date : 2021-07-30 DOI: 10.12928/pharmaciana.v11i2.20024

F. Darusman, Debby Prihasti Ayustine, Saadiya Noerman, Sani Ega Priani, Widad Aghnia Shalannandia

{"title":"In-vitro diffusion study of ibuprofen--cyclodextrin inclusion complex nanogel","authors":"F. Darusman, Debby Prihasti Ayustine, Saadiya Noerman, Sani Ega Priani, Widad Aghnia Shalannandia","doi":"10.12928/pharmaciana.v11i2.20024","DOIUrl":"https://doi.org/10.12928/pharmaciana.v11i2.20024","url":null,"abstract":"The inclusion complex is one way to enhance active substance solubility, affecting medicine dissolution and penetration. The inclusion complex is formed by utilizing b-cyclodextrin as the host of the active compounds. The Ibuprofen (2-(4-isobutyl-phenyl)propionate) is a propionate acid derivative and classified in class II of the Biopharmaceutic Classification System, which has low dissolutions and high permeability. This study aims to develop a nanogel containing ibuprofen-β-cyclodextrin inclusion complex with the ratio of 1:1, 1:2 and 2:1; and to compare the in-vitro diffusion profile with pure ibuprofen gel. The inclusion complex of ibuprofen-β-cyclodextrin was prepared using the coprecipitation method with the three molar comparison ratio of 1:1, 1:2, and 2:1. The in-vitro study was performed using the gel-based viscolam, comparing the three formulas of ibuprofen-β-cyclodextrin with pure ibuprofen gel. The ibuprofen concentration of each gel tested in the experiment was 1%. The particle size characterization of ibuprofen-β-cyclodextrin inclusion complex gel resulted in having nanoparticle size (510 nm). This characteristic indicates that the inclusion complex gel could enhance the cumulative release amount of ibuprofen compared with pure ibuprofen gel with a relatively smaller particle size (156 nm). Pure ibuprofen and inclusion complex powder size measured to be 763 nm and 957 nm, respectively. The ibuprofen-b-cyclodextrin inclusion complex gel with a molar ratio of 2:1 demonstrated an increase in in-vitro diffusion profile of ibuprofen with a cumulative release amount of 740.3 µg.cm -2 . Meanwhile, pure ibuprofen gel had the cumulative release amount of 294.74 µg.cm -2 . The gel containing ibuprofen-β-cyclodextrin inclusion complex could enhance the cumulative release amount of ibuprofen compared to pure ibuprofen gel. The ibuprofen-β-cyclodextrin inclusion complex gel at a ratio of 2:1 exhibited an increase in the diffusion of ibuprofen in-vitro .","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45624019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Comparison between clinic and home measurements of blood pressure, total cholesterol, blood sugar to identify 10-year atherosclerotic cardiovascular disease risk score 比较临床和家庭测量血压、总胆固醇、血糖来确定10年动脉粥样硬化性心血管疾病的风险评分

Pharmaciana Pub Date : 2021-03-31 DOI: 10.12928/PHARMACIANA.V11I1.13731

Putri Ani Sunjaya, Agatha Nensida Venary, Ruth Estika Ave Haryono, Rita Suhadi

{"title":"Comparison between clinic and home measurements of blood pressure, total cholesterol, blood sugar to identify 10-year atherosclerotic cardiovascular disease risk score","authors":"Putri Ani Sunjaya, Agatha Nensida Venary, Ruth Estika Ave Haryono, Rita Suhadi","doi":"10.12928/PHARMACIANA.V11I1.13731","DOIUrl":"https://doi.org/10.12928/PHARMACIANA.V11I1.13731","url":null,"abstract":"The clinical guideline recommends home monitoring for hypertension, diabetes, and hyperlipidemia maintenance therapy. The study aimed to compare the 10-year atherosclerotic cardiovascular disease (ASCVD) risk calculated using systolic blood pressure, fasting total-cholesterol, and fasting blood sugar measured at the clinic and home. This analytical cross-sectional study was done in population from villages in Sleman District, Yogyakarta. The subjects were selected purposively with the criteria of 40-79 years old and signing the informed consent. The home-measured systolic blood pressure was monitored with a digital sphygmomanometer and peripheral finger-stick methods for cholesterol and blood sugar. On the same occasion, the clinic measurements were monitored with a mercury sphygmomanometer for systolic blood pressure, and with venous plasma analyzed in the laboratory for cholesterol and blood glucose. Measurements between methods were compared with paired T-tests. The subjects (n=171) had a mean age of 52.6 (8.1) years; 21.6% were male. The systolic blood pressure, total cholesterol, and blood glucose from clinic and home measurement were 130.0 (21.1) mmHg and 137.6 (22.4) mmHg (p<0.001); 202.8 (32.8) mg/dl and 205.2 (44.8) mg/dl (p= 0.44); and 98.5 (42.9) mg/dl and 91.9 (34.6) mg/dl (p<0.001) respectively. The average ASCVD risks of the clinic and home measurements were 6.4 (6.2)% and 7.1 (6.9)% (p<0.001); however, both methods had the same ASCVD risk category at borderline risk (5-<7.5%). Conclusion: The ASCVD risk scores calculated using clinic and home measurements were statistically different.","PeriodicalId":20051,"journal":{"name":"Pharmaciana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45592920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0