Pediatrics International最新文献_第4页

Behavioral problems in adolescents and young adults with neurodevelopmental disorders. 青少年和年轻成人神经发育障碍的行为问题。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70115

Yasumichi Kuwahara, Maina Yonezawa, Hiroaki Miya, Masaharu Moroto, Tomoko Iehara

{"title":"Behavioral problems in adolescents and young adults with neurodevelopmental disorders.","authors":"Yasumichi Kuwahara, Maina Yonezawa, Hiroaki Miya, Masaharu Moroto, Tomoko Iehara","doi":"10.1111/ped.70115","DOIUrl":"https://doi.org/10.1111/ped.70115","url":null,"abstract":"Background: The increasing prevalence of neurodevelopmental disorders (NDD), including autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), in children has led to concerns about waiting times for medical evaluation. Thus, Fukuchiyama City Hospital jointly established an ambulatory clinic for children with developmental disorders with the city government in 2010. This study aims to investigate behavioral challenges among patients aged 15 years and older attending the developmental outpatient clinic, particularly those diagnosed with ASD, to highlight challenges related to medical and social treatments.Methods: The study examined patients aged 15 years and older diagnosed with NDD who visited the outpatient clinic for developmental disorders at Fukuchiyama City Hospital from January to December 2023. It collected data on demographics, duration of outpatient visits, diagnoses, current communication skills, and behavioral problems from medical records.Results: Out of 68 patients, 45 were diagnosed with ASD. Communication difficulties were prevalent, with 31.1% lacking significant verbal communication skills. Behavioral problems included behavioral deviance, inattention, hyperactivity, impulsivity, harmful behavior toward others, and self-injury. Low levels of developmental quotient (DQ) were associated with maladaptive behaviors, but harmful behaviors were independent of IQ/DQ.Conclusions: The study highlights the behavioral problems in adolescents and young adult patients with ASD attending developmental clinics. Early and appropriate interventions, such as applied behavior analysis, are critical for addressing these challenging behaviors, especially harmful ones. The support of family and caregivers based on behavior analysis is necessary for enhancing the outcomes and quality of life of individuals with NDD.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70115"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in arteriovenous carboxyhemoglobin in neonates with noninflammatory pulmonary diseases. 新生儿非炎症性肺病动静脉碳氧血红蛋白的差异。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70117

Toshihiko Nakamura, Daisuke Hatanaka, Eisuke Fukama

{"title":"Differences in arteriovenous carboxyhemoglobin in neonates with noninflammatory pulmonary diseases.","authors":"Toshihiko Nakamura, Daisuke Hatanaka, Eisuke Fukama","doi":"10.1111/ped.70117","DOIUrl":"https://doi.org/10.1111/ped.70117","url":null,"abstract":"Background: To retrospectively examine whether differences in arteriovenous carboxyhemoglobin (a-vCOHb) can be used as a marker for evaluating the severity of neonatal lung disease that develops soon after birth.Methods: The subjects were 129 newborn neonates who were classified into three groups comprising 48 infants with severe respiratory disorder (group S), 46 with mild-to-moderate respiratory disorder (group M), and 35 in a control group without respiratory disorder (group C). Various parameters including COHb were measured using a blood gas analyzer/oximeter at the time of admission, with sampling of arteries and veins performed at short intervals (within 30 min).Results: The arterial COHb values were significantly higher in group C than in group S. The a-vCOHb values were significantly higher in groups C and M than in group S. This suggested that a loss of carbon monoxide excretion due to the generation of shunt blood with lung collapse at the alveolar level and a decrease in the total amount of carbon monoxide generated within the lungs resulted in the decrease of a-vCOHb values in group S. Receiver operating characteristic curve analysis of a-vCOHb for predicting the need for respiratory support identified an a-vCOHb cut-off value of 0.3% with a sensitivity of 75% and specificity of 74% (p < 0.001).Conclusion: An a-vCOHb cut-off value of 0.3% may be useful in determining the severity of lung disease in the early neonatal period.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e70117"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A high-throughput TREC- and KREC-based newborn screening for severe inborn errors of immunity. 基于TREC和krecs的新生儿严重先天性免疫错误的高通量筛查

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15872

Haruka Hiroki, Kunihiko Moriya, Toru Uchiyama, Fumi Hirose, Akifumi Endo, Iori Sato, Yasuhiro Tomaru, Kazumi Sawakami, Norio Shimizu, Hidenori Ohnishi, Tomohiro Morio, Kohsuke Imai

{"title":"A high-throughput TREC- and KREC-based newborn screening for severe inborn errors of immunity.","authors":"Haruka Hiroki, Kunihiko Moriya, Toru Uchiyama, Fumi Hirose, Akifumi Endo, Iori Sato, Yasuhiro Tomaru, Kazumi Sawakami, Norio Shimizu, Hidenori Ohnishi, Tomohiro Morio, Kohsuke Imai","doi":"10.1111/ped.15872","DOIUrl":"10.1111/ped.15872","url":null,"abstract":"Introduction: Severe combined immunodeficiency (SCID) due to T-cell deficiency is the most severe form of inborn error of immunity (IEI). It frequently leads to severe and recurrent infections and the first infection or live vaccines can sometimes be fatal. Patients with B-cell deficiency (BCD), such as X-linked agammaglobulinaemia (XLA), also suffer from severe or recurrent infections. Thus, early diagnosis via newborn screening (NBS) is suitable for these types of diseases. We developed a lyophylized TaqMan-based quantitative polymerase chain reaction (qPCR) kit with primers and probes for the simultaneous detection of T-cell receptor excision circles (TREC) and κ-deleting recombination excision circles (KREC). We also developed a fully automated DNA extraction and purification process using Magtration technology from dried blood spots (DBS), enabling high-throughput analysis METHODS: We examined 15,258 stored DBS collected from 2014 to 2015 by this method. Newborn screening samples from children with a known SCID, XLA or ataxia-telangiectasia (AT) were also examined as positive controls.Results: RPPH1 (internal control), TREC, and KREC all had near-normal distributions. One specimen was below the cut-off for TREC (0.00657%) after exclusion of 36 specimens due to the failure of DNA extraction (0.23%). The TREC levels in the patients with AT and SCID, and KREC levels in the patients with AT and XLA were all below cut-off or absent.Conclusions: This assay would allow the establishment of qPCR-based NBS in unfamiliar laboratories leading to the early diagnosis of SCID and BCD.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e15872"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistent candidemia and Candida endophthalmitis with relapsed acute lymphoblastic leukemia. 复发的急性淋巴细胞白血病伴有持续性念珠菌血症和念珠菌眼内炎。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15878

Yukihiro Matsukawa, Yuri Sawada, Yuhachi Ikeda, Takashi Taga

引用次数: 0

Immaturity of gut functions and induction of tolerance during early infancy. 婴儿期早期肠道功能不成熟和诱导耐受性。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15855

Yoshikazu Ohtsuka, Toshiaki Shimizu

引用次数: 0

A case of Wiedemann-Steiner syndrome caused by a novel KMT2A c.8862del variant. 一种新的KMT2A c.8862del变异引起的Wiedemann-Steiner综合征1例。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15873

Hikaru Nishida, Eri Imagawa, Toshiki Tsunogai, Naoya Saijo, Jin Ogata, Ken Sakurai, Kimihiko Oishi

引用次数: 0

A case of acute pancreatitis associated with food protein-induced enterocolitis syndrome. 急性胰腺炎合并食物蛋白性小肠结肠炎综合征1例。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70045

Tetsuro Fujino, Aki Hotta, Ayumi Nakata, Masumi Okuda, Yasuhiro Takeshima

引用次数: 0

Retrospective evaluation of mild encephalitis/encephalopathy with a reversible splenial lesion in children. 儿童轻度脑炎/脑病伴可逆性脾损害的回顾性评价。

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15869

Xin Li, Suzhen Sun, Huifeng Zhang

{"title":"Retrospective evaluation of mild encephalitis/encephalopathy with a reversible splenial lesion in children.","authors":"Xin Li, Suzhen Sun, Huifeng Zhang","doi":"10.1111/ped.15869","DOIUrl":"10.1111/ped.15869","url":null,"abstract":"Background: Comprehensive documentation on consecutive years of mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) in children is lacking. This study aims to provide an in-depth analysis of the clinical profiles of MERS in children across different age groups, focusing on pathogens and recovery time.Methods: In this retrospective study, 43 patients diagnosed with MERS were enrolled between December 2017 and November 2021. Due to different clinical manifestations at different ages, we categorized them into two age groups: the 6-year-old or younger group and the over 6-year-old group. Clinical data were described and compared for these age cohorts.Results: Sixty percent of the cases occurred during winter, with two distinct peaks in onset age, at 1-3 years of age and 7-8 years of age. Intestinal infections were prevalent among children aged below 6 years, mainly caused by rotavirus; convulsion was the most common symptom (92.6% vs. 50%, p = 0.005). Conversely, respiratory tract infections were often observed in children older than 6 years of age, which were mainly attributed to mycoplasma pneumonia; headache and dizziness were characteristic symptoms (62.5% vs. 18.5%, p = 0.003). No significant differences were found in treatment outcomes between the two age groups. Nonetheless, MERS type II exhibited a notably longer clinical recovery time than type I (4.8 ± 1.7 vs. 8.2 ± 5.5).Conclusion: Mild encephalitis/encephalopathy with a reversible splenial lesion exhibits a distinct seasonal pattern with varied clinical manifestations across different age groups. Although the prognosis was favorable, discernible differences in clinical symptoms and pathogens were observed between the two age cohorts. It was noted that the clinical recovery time for MERS type II was comparatively protracted in comparison with type I.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e15869"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver function trends in children with suspected drug-induced hepatocellular injury: A survey using an electronic medical records database. 疑似药物性肝细胞损伤儿童的肝功能趋势：一项使用电子病历数据库的调查

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.15847

Masayoshi Nakakuni, Kosuke Nakano, Ayano Inui, Shinji Kobayashi, Naoko Deguchi, Seiji Mitsui, Takeshi Kuriyama, Seiko Miyazaki

{"title":"Liver function trends in children with suspected drug-induced hepatocellular injury: A survey using an electronic medical records database.","authors":"Masayoshi Nakakuni, Kosuke Nakano, Ayano Inui, Shinji Kobayashi, Naoko Deguchi, Seiji Mitsui, Takeshi Kuriyama, Seiko Miyazaki","doi":"10.1111/ped.15847","DOIUrl":"10.1111/ped.15847","url":null,"abstract":"Background: Drug-induced liver injury (DILI) is a common adverse drug event with limited pediatric data in the literature. This study aimed to use pediatric electronic medical records to assess hepatocellular DILI in pediatric patients who were prescribed liver-injury-inducing drugs.Methods: The Pediatric Medical Information Collection System (P-MICS) is a centralized database integrating electronic medical records from over 40 medical pediatric centers. Pediatric patients in the P-MICS with serum alanine aminotransferase (ALT) levels five or more times the upper limit of normal and who were below 15 years of age were selected. Those with liver diseases unrelated to drug-induced causes were excluded. We identified drugs prescribed 2 to 90 days before the first elevated ALT reading. High-risk liver-injury-causing drugs were determined based on the LiverTox score. We analyzed post-event ALT and total bilirubin levels (TB) and DILI management.Results: Of the 817 patients with suspected DILI, 251 were prescribed four drugs identified as high-risk drugs for hepatocellular DILI: methotrexate (n = 129), aspirin (n = 82), vancomycin (n = 58), and cyclophosphamide (n = 51). The median ALT level at the first event was 245 U/L. Approximately 35% of methotrexate users and cyclophosphamide users experienced recurrent ALT elevation. Some methotrexate users also showed TB elevation. Discontinuation of high-risk drugs resulted in fewer relapses and TB elevations than pharmacotherapy.Conclusions: The P-MICS effectively identifies pediatric patients with potential liver injury and tracks liver function in those prescribed liver-injury-causing drugs. This study underscores liver injury risks in pediatric anticancer drug users, highlighting the utility of the P-MICS in monitoring off-label drug safety in children.","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"67 1","pages":"e15847"},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ACVRL1 and MTHFR double variants in an adolescent with paradoxical cerebral embolism. ACVRL1和MTHFR双变异体在青少年脑栓塞中的应用

IF 1 4区医学

Pediatrics International Pub Date : 2025-01-01 DOI: 10.1111/ped.70025

Takeshi Sato, Yosuke Ichihashi, Hikaru Tsuruta, Po-Sung Chu, Takenori Akiyama, Tomoyuki Hishida, Tomonobu Hasegawa

引用次数: 0