Pediatrics International最新文献

{"title":"Selective coronary arteriography via transradial access in young children.","authors":"Yasuto Maeda, Tadashi Inoue, Yoshiyuki Kagiyama, Ryuta Takase, Yusuke Koteda, Kenji Suda","doi":"10.1111/ped.15841","DOIUrl":"https://doi.org/10.1111/ped.15841","url":null,"abstract":"<p><strong>Background: </strong>Transradial access (TRA) is not a common vascular access in children. We have been performing TRA actively to reduce puncture complications, and the purpose of this study was to investigate the safety and efficacy of TRA in young children.</p><p><strong>Methods: </strong>The study included 29 patients aged 5-12 years who underwent diagnostic catheterization at Kurume University Hospital. Vascular access was placed through TRA in 11 of these patients and through transfemoral access (TFA) in 18 patients with comparable ages. We compared TRA with TFA using various demographic data.</p><p><strong>Results: </strong>The median age of TRA was 10 years (5-12 years) and that of TFA was 7 years (5-11 years). They were not significantly different. Transradial access showed an acceptably high success rate (91%), which was comparable with that of TFA (100%), although we had to switch to TFA in one patient in which the radial artery diameter was too small to puncture and due to failure of appropriate sedation and local anesthesia. A comparison between the two groups showed no significant differences in weight, puncture success rate, total time to completion of both arterial and venous puncture, or fluoroscopy time. However, none of the patients with TRA required post-catheter bed rest after removal of the arterial sheath, whereas patients with TFA required 6 h of bed rest. Although there were no puncture complications in group TRA, one patient with TFA had a subcutaneous hematoma.</p><p><strong>Conclusion: </strong>Transradial access can be performed safely in young children and may be more beneficial than TFA.</p>","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"66 1","pages":"e15841"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel scoring system for the prediction of disease severity in STEC-HUS.","authors":"Emi Ishibazawa, Tsunehisa Nagamori, Mio June Kurisawa, Masayuki Sato, Yoichiro Yoshida, Hironori Takahashi, Hiromi Manabe, Toru Ishioka, Yurika Miura, Hiroki Kajino, Yasuto Suzuki, Soichiro Wada, Shigetoshi Ogiwara, Yuji Tomii, Hayato Aoyagi, Kazushige Nagai, Hiroyuki Naito, Satoru Takahashi","doi":"10.1111/ped.15833","DOIUrl":"https://doi.org/10.1111/ped.15833","url":null,"abstract":"<p><strong>Background: </strong>Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS) is a life-threatening condition complicated by acute kidney injury, acute respiratory distress syndrome, and central nervous system disorders. The early identification of high-risk patients is required to facilitate timely and appropriate treatment.</p><p><strong>Methods: </strong>The medical records of patients with STEC-HUS treated at 11 hospitals in Hokkaido, Japan, were reviewed retrospectively. A multi-institutional retrospective analysis was performed in which patients were divided into two groups according to the presence or absence of severe complications requiring blood purification therapy or encephalopathy. We compared the laboratory values at diagnosis between the severe and mild groups. To identify patients at high risk of developing severe complications, a scoring system, referred to as the \"STEC-HUS severity (STEC-HUSS) score,\" was constructed based on the parameters showing significant differences.</p><p><strong>Results: </strong>Of the 41 patients with STEC-HUS, 11 were classified into the severe group and 30 into the mild group. Significant differences were observed between the groups in terms of white blood cell count, activated partial thromboplastin time, fibrinogen, D-dimer, total protein, aspartate transaminase, alanine transaminase, lactate dehydrogenase, creatinine, and C-reactive protein levels. The STEC-HUSS score was calculated on a scale of 0-10 by summing the number of test items that demonstrated abnormal values. The STEC-HUSS score, when the cut-off value was 4, showed a sensitivity of 100% and a specificity of 91% in the severe group.</p><p><strong>Conclusion: </strong>We developed a novel scoring system to identify patients at high risk of severe STEC-HUS.</p>","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"66 1","pages":"e15833"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative visualization of the Adamkiewicz artery in infant neuroblastoma.","authors":"Eiichiro Watanabe, Akihiro Yoneda, Teizaburo Mori, Masaaki Nishimoto, Yoshiyuki Tsutsumi","doi":"10.1111/ped.15844","DOIUrl":"https://doi.org/10.1111/ped.15844","url":null,"abstract":"","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"66 1","pages":"e15844"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Child with refractory thrombocytopenia born to a mother with immune thrombocytopenia.","authors":"Yui Asatsuma, Takeo Mukai, Kyosuke Ibi, Satsuki Kakiuchi, Shota Kato, Naoto Takahashi, Motohiro Kato","doi":"10.1111/ped.15747","DOIUrl":"10.1111/ped.15747","url":null,"abstract":"","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"66 1","pages":"e15747"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139973002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of parent-child interaction therapy for children born premature.","authors":"Miyuki Matano, Koyuru Kurane, Kei Wakabayashi, Yukari Yada, Yumi Kono, Toshihiro Tajima, Hitoshi Osaka, Yukifumi Monden","doi":"10.1111/ped.15742","DOIUrl":"10.1111/ped.15742","url":null,"abstract":"<p><strong>Background: </strong>Premature children are known to be at a high risk of developing behavioral problems. This study examined the effectiveness of parent-child interaction therapy (PCIT) in reducing behavioral problems in young children born premature.</p><p><strong>Methods: </strong>The study included 18 child-parent pairs with children born at less than 35 weeks of gestation (range: 23-34 weeks, median: 31.0 weeks) and aged 27-52 months (median: 38.0 months). They were assigned to either the PCIT group (n = 7) or the non-PCIT group (n = 11) based on maternal desire for treatment. The study was designed to examine the effects of PCIT. Specifically, the Eyberg Child Behavior Inventory (ECBI) intensity score, ECBI problem score, and Parenting Stress Index Short Form (PSI-SF) scores were compared before treatment and after 6 months.</p><p><strong>Results: </strong>In the PCIT group, the mean ECBI intensity score was 135.7 (SD = 13.5; T-score = 64) at baseline and 90.1 (SD = 15.5; T-score = 46) at post-assessment, the mean ECBI problem score was 9.8 (SD = 1.9; T-score = 54) at baseline and 4.4 (SD = 3.1; T-score = 44) at post-assessment, the mean PSI-SF total score was 60.1 (SD = 4.8; 95%tile) at baseline and 49.6 (SD = 5.6; 85%tile) at post-assessment, showing a significant improvement (ECBI intensity scores: p < 0.001, d = 2.03; ECBI problem scores: p < 0.001, d = 1.94; PSI-SF total scores: p = 0.004, d = 0.86). On the other hand, none of the scores showed significant change in the non-PCIT group.</p><p><strong>Conclusions: </strong>The PCIT can be considered as a potential treatment option for behavioral problems in young children born premature.</p>","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"66 1","pages":"e15742"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139973092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-hoc safety/efficacy analyses from pediatric delgocitinib atopic dermatitis trials.","authors":"Tatsuki Fukuie, Hiroyuki Toyama, Mai Tanaka, Katsuyo Ohashi-Doi, Kenji Kabashima","doi":"10.1111/ped.15798","DOIUrl":"10.1111/ped.15798","url":null,"abstract":"<p><strong>Background: </strong>Delgocitinib ointment is usually recommended for use in children at a concentration of 0.25%. However, there are no clear criteria for dosing, except that a 0.5% formulation may also be used, depending on symptom severity. Treatment of atopic dermatitis is based on combinations of topical corticosteroids, tacrolimus ointment, and delgocitinib ointment, but there are no reports on the safety of delgocitinib ointment when used in combination with other drugs.</p><p><strong>Methods: </strong>This is a post-hoc analysis of data from two delgocitinib ointment trials with pediatric atopic dermatitis patients. The efficacy and safety of the 0.25% and 0.5% formulations were compared. Efficacy and safety were evaluated after up to 4 and 56 weeks of treatment, respectively. The safety of delgocitinib ointment when used in combination with topical corticosteroids and/or tacrolimus ointment was investigated.</p><p><strong>Results: </strong>The dose-response relationship was examined according to baseline disease severity. The proportions of subjects with mild disease who achieved cumulative investigator's global assessment of 0 (clear) or 1 (almost clear) were 46.2% (0.25% ointment), 71.4% (0.5% ointment), and 7.7% (vehicle). For subjects with moderate to severe disease, the corresponding proportions were 19.0%, 20.0%, and 0.0%, respectively. No overall differences were seen in the safety profiles of the 0.25% and 0.5% delgocitinib ointment doses, or in the safety profiles of the two doses relating to disease severity or to concomitant use of topical corticosteroids and/or tacrolimus ointment.</p><p><strong>Conclusions: </strong>These analyses indicate that after up to 4 weeks of treatment, delgocitinib 0.5% ointment may be more effective than the 0.25% dose for mild atopic dermatitis, and that after up to 56 weeks of treatment, delgocitinib is well tolerated in a pediatric trial population when used as prescribed in combination with topical corticosteroids and/or tacrolimus ointment.</p>","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"66 1","pages":"e15798"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid hormone may predict treatment failure in Kawasaki disease.","authors":"Yuichiro Hashida, Yoichi Mino, Keisuke Okuno, Hitoshi Uemasu, Shinji Sakata, Masanobu Fujimoto, Noriyuki Namba","doi":"10.1111/ped.15723","DOIUrl":"10.1111/ped.15723","url":null,"abstract":"<p><strong>Background: </strong>In systemic inflammatory conditions, inflammatory cytokines can cause low thyroid hormone levels. There are no reports discussing the relation between thyroid hormone levels and response to treatment for Kawasaki disease.</p><p><strong>Methods: </strong>We investigated 67 patients who underwent treatment in the acute phase of Kawasaki disease. We divided patients into two groups based on their response to initial intravenous immunoglobulin (IVIG) treatment: the responder group (n = 40), and the non-responder group (n = 27). The serum levels of the thyroid hormones free triiodothyronine (FT3), free thyroxine (FT4), and thyroid-stimulating hormone (TSH) were compared before and after treatment in all patients, and between responder and non-responder groups.</p><p><strong>Results: </strong>The FT3, FT4, and TSH levels were low before the initial treatment and increased significantly after treatment (p < 0.05). The FT3, FT4, and TSH levels before treatment were significantly lower in the non-responder group than in the responder group (p < 0.05). Logistic regression analysis suggested that the addition of pre-treatment FT4 values to Gunma score was useful in predicting treatment failure.</p><p><strong>Conclusions: </strong>Thyroid hormone and TSH levels were lower in the non-responder group than in the responder group in the initial IVIG treatment for Kawasaki disease. This study suggests that Kawasaki disease in the acute phase is associated with low thyroid hormone levels and TSH. It is possible that these hormone levels predict response to the initial IVIG.</p>","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"66 1","pages":"e15723"},"PeriodicalIF":1.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139703144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safe extraction technique of a metallic blade after heated tobacco ingestion.","authors":"Keiichi Uchida, Honoka Yokoyama, Akira Yamamoto, Kiyoshi Hashimoto, Yuhki Koike, Yasuhiko Mohri","doi":"10.1111/ped.15763","DOIUrl":"10.1111/ped.15763","url":null,"abstract":"","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"66 1","pages":"e15763"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140922743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric hereditary angioedema attack triggered by COVID-19: A case report.","authors":"Jintaro Ishikawa, Eisuke Inage, Yuko Tanaka, Asuka Honjo, Takahiro Kudo, Yoshikazu Ohtsuka, Toshiaki Shimizu","doi":"10.1111/ped.15752","DOIUrl":"10.1111/ped.15752","url":null,"abstract":"","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"66 1","pages":"e15752"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140922789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obturator internus muscle abscess in a case of X-linked agammaglobulinemia.","authors":"Yusuke Shimaoka, Takashi Ishikawa, Rinshu Shimabukuro, Mitsuru Kubota, Akira Ishiguro, Toshinao Kawai","doi":"10.1111/ped.15775","DOIUrl":"10.1111/ped.15775","url":null,"abstract":"","PeriodicalId":20039,"journal":{"name":"Pediatrics International","volume":"66 1","pages":"e15775"},"PeriodicalIF":1.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141082043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}