Pharmacogenomics最新文献_第5页

Meta-analysis revisiting the influence of UGT1A1*28 and UGT1A1*6 on irinotecan safety in colorectal cancer patients. 重新审视 UGT1A1*28 和 UGT1A1*6 对结直肠癌患者伊立替康安全性影响的 Meta 分析。

IF 1.9 4区医学

Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2024-08-22 DOI: 10.1080/14622416.2024.2385289

Cuc Thi Thu Nguyen, Thi Minh Thuy Nguyen, Thanh Huong Phung

{"title":"Meta-analysis revisiting the influence of UGT1A1*28 and UGT1A1*6 on irinotecan safety in colorectal cancer patients.","authors":"Cuc Thi Thu Nguyen, Thi Minh Thuy Nguyen, Thanh Huong Phung","doi":"10.1080/14622416.2024.2385289","DOIUrl":"10.1080/14622416.2024.2385289","url":null,"abstract":"Aim: To evaluate the association between irinotecan safety and the UGT1A1 gene polymorphism in colorectal cancer (CRC) patients.Materials & methods: The studies were systematically searched and identified from three databases (PubMed, Embase and The Cochrane Library) until 28 February 2023. The relationships were evaluated using pooled odds ratio (OR).Results: A total of 30 studies out of 600 were included, comprising 4471 patients. UGT1A1*28 was associated with a statistically significant increase in the OR for diarrhea (OR: 1.59, 95% CI = 1.24-2.06 in the additive model; OR = 3.24, 95% CI = 2.01-5.21 in the recessive model; and OR = 1.95, 95% CI = 1.42-2.69 in the dominant model) and neutropenia (OR = 1.70, 95% CI = 1.40-2.06 in the additive model; OR = 4.10, 95%CI = 2.69-6.23 in the recessive model; and OR = 1.93, 95% CI = 1.61-2.31 in the dominant model). Subgroup analysis indicated consistent associations in both Asian and non-Asian populations. UGT1A1*6 was associated with a statistically significant elevation in the OR for diarrhea (only in the recessive model, OR = 2.42; 95% CI = 1.14-5.11) and neutropenia (across all genetic models).Conclusion: The UGT1A1*28 and UGT1A1*6 alleles might be a crucial indicator for predicting irinotecan safety in CRC.","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"469-477"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Providers' use of pharmacogenetic testing to inform opioid prescribing among veterans. 医疗机构利用药物基因检测为退伍军人开具阿片类药物处方提供信息。

IF 1.9 4区医学

Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2024-10-09 DOI: 10.1080/14622416.2024.2409058

Rachele K Lipsky, Catherine Chanfreau-Coffinier, Deepak Voora, Jodie Trafton, Charlotte Williams, Susana B Martins, Sumitra Muralidhar, David W Oslin

{"title":"Providers' use of pharmacogenetic testing to inform opioid prescribing among veterans.","authors":"Rachele K Lipsky, Catherine Chanfreau-Coffinier, Deepak Voora, Jodie Trafton, Charlotte Williams, Susana B Martins, Sumitra Muralidhar, David W Oslin","doi":"10.1080/14622416.2024.2409058","DOIUrl":"10.1080/14622416.2024.2409058","url":null,"abstract":"Aim: To survey Veterans Health Administration providers who prescribed tramadol or codeine to patients with known genotyping for cytochrome 2D6 (CYP2D6) to ascertain awareness of their patient's pharmacogenetic (PGx) test status, whether these results influenced prescribing, perceived benefit of PGx testing, and resources needed to obtain and deliver PGx testing information.Materials & methods: A provider survey was conducted of those who prescribed tramadol or codeine in a patient genotyped for CYP2D6.Results: Of 876 eligible providers, 220 completed the survey. Ten percent were aware that their patient received a PGx test, 64% had not ordered any PGx test related to any medication in the prior year, 55% strongly agreed or agreed that PGx testing is or will be valuable to guide pain medication prescriptions, 29% felt that the evidence base for PGx testing is very strong or moderately strong, 22% responded likely or extremely likely to order a future PGx test, and 51% felt that it would be either very important or fairly important to have a local subject matter expert as a resource for PGx testing.Conclusion: There are modifiable factors that the Veterans Health Administration could address to optimize PGx testing for pain management.","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"495-501"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacogenetic markers and macrolide safety in influenza patients: insights from a prospective study. 流感患者的药物遗传标记和大环内酯安全性：来自一项前瞻性研究的见解。

IF 1.9 4区医学

Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2025-01-19 DOI: 10.1080/14622416.2025.2454217

A A Skryabina, V V Nikiforov, M Z Shakhmardanov, M S Zastrozhin, D A Sychev

{"title":"Pharmacogenetic markers and macrolide safety in influenza patients: insights from a prospective study.","authors":"A A Skryabina, V V Nikiforov, M Z Shakhmardanov, M S Zastrozhin, D A Sychev","doi":"10.1080/14622416.2025.2454217","DOIUrl":"10.1080/14622416.2025.2454217","url":null,"abstract":"Background: Macrolides are widely used antibiotics, but adverse drug reactions (ADRs), particularly in genetically predisposed individuals, can compromise their safety. This study examines the impact of pharmacogenetic markers on macrolide safety in participants with bacterial complications of influenza.Objective: To evaluate how polymorphisms in genes encoding transporter proteins (ABCB1) and enzymes (CYP3A4, CYP3A5) influence ADR risk during macrolide therapy.Methods: A prospective study included 100 participants with lower respiratory tract bacterial complications of influenza treated with azithromycin or erythromycin for five days. Genotyping targeted ABCB1 (3435C>T), CYP3A4 (C>T intron 6), and CYP3A5 (6986A>G) polymorphisms. ADRs were monitored daily and correlated with genetic markers.Results: The ABCB1 (3435C>T) polymorphism was associated with higher rates of abdominal pain and diarrhea in CT and TT genotypes (OR = 2.12, p = 0.043). The CYP3A4 (C>T intron 6) polymorphism increased ADR risk in erythromycin-treated participants (OR = 24.0, p = 0.0339). No significant effects were observed for CYP3A5 (6986A>G).Conclusion: Genetic polymorphisms in ABCB1 and CYP3A4 genes predict macrolide-related ADRs. Pharmacogenetic screening could improve macrolide safety, particularly for genetically susceptible individuals.","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"661-665"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of immunorelated gene polymorphisms on trastuzumab targeting breast cancer cell in vitro. 免疫相关基因多态性对曲妥珠单抗体外靶向乳腺癌细胞的影响

IF 1.9 4区医学

Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2024-10-11 DOI: 10.1080/14622416.2024.2404819

Linyu Yu, Congmin Zhang, Liangyu Liu, Xiaoping Chen

引用次数: 0

Effect of UGT1A6 and UGT2B7 polymorphisms on the valproic acid serum concentration and drug-induced liver injury. UGT1A6 和 UGT2B7 多态性对丙戊酸血清浓度和药物性肝损伤的影响

IF 1.9 4区医学

Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2024-11-20 DOI: 10.1080/14622416.2024.2409061

Mengchen Yu, Yan Zhao, Fan Zhou, Weiliang Li, Jing Liu, Linlin Zhao, Zhirui Song, Ling Tong, Ying Zhang, Yajuan Wang, Shenglan Shang, Airong Yu

{"title":"Effect of UGT1A6 and UGT2B7 polymorphisms on the valproic acid serum concentration and drug-induced liver injury.","authors":"Mengchen Yu, Yan Zhao, Fan Zhou, Weiliang Li, Jing Liu, Linlin Zhao, Zhirui Song, Ling Tong, Ying Zhang, Yajuan Wang, Shenglan Shang, Airong Yu","doi":"10.1080/14622416.2024.2409061","DOIUrl":"10.1080/14622416.2024.2409061","url":null,"abstract":"Aim: Valproic acid (VPA) is a classic broad-spectrum antiepileptic drug, with significant pharmacokinetic variability. Genetic polymorphisms contribute to this variability, influencing both VPA trough serum concentration (VPA concentration) and VPA-induced liver injury. Our study aims to investigate the association between polymorphisms of uridine diphosphate glucuronyl transferase (UGT) 1A6, UGT2B7 and VPA concentration and screen for potential genetic loci affecting VPA-induced liver injury.Methods: This study included epilepsy patients treated with VPA. PCR-RFLP method was used to determine the genotypes of UGT1A6 and UGT2B7. Chemiluminescent microparticle immunoassay was used to measure VPA concentration. Multiple linear regression and logistic regression were employed to analyze factors influencing VPA concentration and VPA-induced liver injury, respectively.Results: The correlation between UGT polymorphism and VPA concentration was analyzed in 133 samples. For VPA-induced liver injury, 105 patients were analyzed, with 29 in the liver injury group and 76 in the control group. Our finding showed patients with the UGT1A6-T19G variant had significantly lower VPA concentrations compared with wild-type patients and UGT1A6-T19G, A541G, A552C and UGT2B7-C802T, G211T, A268G polymorphisms showed no impact on VPA-induced liver injury.Conclusion: This study demonstrated UGT1A6-T19G polymorphisms affected the VPA concentration, providing a theoretical basis for the individualized clinical use of VPA.","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"527-538"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid point of care testing: the next frontier in pharmacogenomics. 快速护理点检测：药物基因组学的下一个前沿。

IF 1.9 4区医学

Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2024-07-23 DOI: 10.1080/14622416.2024.2366691

Marc Leach, William G Newman, John H McDermott

引用次数: 0

It is time for educators to act: pharmacogenomics education and its implementation into clinical practice. 现在是教育工作者采取行动的时候了：药物基因组学教育及其在临床实践中的实施。

IF 1.9 4区医学

Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2024-09-04 DOI: 10.1080/14622416.2024.2392482

Snezana Kusljic, Jasmine A Luzum

引用次数: 0

Genetic variation on dolutegravir pharmacokinetics and relation to safety and efficacy outcomes: a systematic review. 多替格拉韦药代动力学的遗传变异及其与安全性和有效性结果的关系：系统综述。

IF 1.9 4区医学

Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2024-12-19 DOI: 10.1080/14622416.2024.2441104

Lisanne A H Bevers, Rebecca L Jensen, Andrew Owen, Angela Colbers, Daniel F Carr, David M Burger

{"title":"Genetic variation on dolutegravir pharmacokinetics and relation to safety and efficacy outcomes: a systematic review.","authors":"Lisanne A H Bevers, Rebecca L Jensen, Andrew Owen, Angela Colbers, Daniel F Carr, David M Burger","doi":"10.1080/14622416.2024.2441104","DOIUrl":"10.1080/14622416.2024.2441104","url":null,"abstract":"Background: Dolutegravir (DTG) is an antiviral agent used for the treatment of HIV, however, there is uncertainty over the influence of genetic variation on DTG exposure, and whether it has clinical implications for the efficacy or toxicity in different populations. This systematic review aims to create an overview of the impact of pharmacogenomics (PGx) on DTG exposure, efficacy, and toxicity.Methods: Publications up to 14 November 2023 were searched and articles were selected on the following criteria: original research articles providing data on people with HIV, data on PGx and either PK or PD or both PD and PGx.Results: 711 records were identified, and after screening 10 articles were included. Commonly analyzed genes across the articles were UGT1A1, ABCB1, ABCG2, and NR1I2. The most reported variant associated with PD variability was in SLC22A2, with carriers at higher risk of neuropsychiatric adverse events.Conclusions: This review concludes that while PGx testing may help explain some variability in DTG pharmacokinetics when combined with therapeutic drug monitoring (TDM), current evidence is insufficient to support its routine clinical use. The role of PGx research for DTG remains relevant, especially in specific patient populations where interindividual PK variations are still unexplained.","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"623-635"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MIR27A rs895819 TC genotype increases risk of fluoropyrimidine-induced severe toxicity independently of DPYD variations. MIR27A rs895819 TC 基因型会增加氟嘧啶诱发严重毒性的风险，与 DPYD 变异无关。

IF 2.1 4区医学

Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2024-02-14 DOI: 10.2217/pgs-2023-0223

Georgia Ragia, Eirini Biziota, Triantafyllia Koukaki, Kyriakos Amarantidis, Vangelis G Manolopoulos

引用次数: 0

Screening and analysis of single nucleotide polymorphism in the 3'-UTR microRNA target regions and its implications for lung tumorigenesis. 3'-UTR微RNA靶区单核苷酸多态性的筛选和分析及其对肺肿瘤发生的影响

IF 1.9 4区医学

Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2024-05-30 DOI: 10.1080/14622416.2024.2355864

Anmol Bhatia, Atul Kumar Upadhyay, Siddharth Sharma

引用次数: 0