Pharmacogenomics最新文献

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Pharmacogenomics in Sri Lanka: a comprehensive systematic review of the research landscape and clinical implications. 斯里兰卡的药物基因组学:对研究现状和临床影响的全面系统回顾。
IF 1.9 4区 医学
Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2024-11-14 DOI: 10.1080/14622416.2024.2421743
Priyanga Ranasinghe, Hajanthy Jeyapragasam, Sandamini Liyanage, Nirmala Sirisena, Vajira Hw Dissanayake
{"title":"Pharmacogenomics in Sri Lanka: a comprehensive systematic review of the research landscape and clinical implications.","authors":"Priyanga Ranasinghe, Hajanthy Jeyapragasam, Sandamini Liyanage, Nirmala Sirisena, Vajira Hw Dissanayake","doi":"10.1080/14622416.2024.2421743","DOIUrl":"10.1080/14622416.2024.2421743","url":null,"abstract":"<p><p><b>Aim:</b> Pharmacogenomics is emerging in South Asia, including Sri Lanka, with potential to optimize drug therapy and reduce adverse effects. This review evaluates the state of pharmacogenomics research in Sri Lanka, emphasizing population-specific factors to guide future advancements.<b>Materials & methods:</b> A literature search was performed across PubMed/Web-of-Science/SciVerse-Scopus/Embase, and Sri Lanka Journals Online, along with searches for relevant theses in local health repositories/university databases. Studies were categorized into clinical correlational, descriptive or novel assay development studies.<b>Results:</b> Eleven published articles and eight theses were included. One study examined somatic variants (<i>KRAS</i> gene), while all others focused on germline variants. There were two clinical correlational studies: tamoxifen adverse effects and <i>CYP2D6</i> variants and <i>FTO</i> gene rs9939609 variants and weight gain caused by second-generation antipsychotics. Eight descriptive studies evaluated prevalence of <i>CYP2D6</i> variants, HLA-B*15:02 allele, <i>KRAS</i> gene mutations and variants related to statin, warfarin and anticancer drug metabolism. Additionally, nine studies developed, validated and tested novel assays for detecting key pharmacogenomically important variants.<b>Conclusion:</b> While pharmacogenomics research in Sri Lanka has made strides, more clinical studies and broader genomic research are needed. Overcoming challenges related to funding, public awareness and regional collaboration is essential to advance personalized medicine and improve therapeutic outcomes in Sri Lanka and South Asia.</p>","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"551-567"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between CYP3A4, CYP3A5 and ABCB1 genotype and tacrolimus treatment outcomes among allogeneic HSCT patients. 异基因造血干细胞移植患者的 CYP3A4、CYP3A5 和 ABCB1 基因型与他克莫司治疗效果之间的关系。
IF 2.1 4区 医学
Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2024-01-08 DOI: 10.2217/pgs-2023-0204
Teresa T Ho, Janelle B Perkins, Rebecca Gonzalez, James Kevin Hicks, Ronald Alvarez Martinez, Katie Duranceau, Brianna North, Jongphil Kim, Jamie K Teer, Jiqiang Yao, Sean J Yoder, Taiga Nishihori, Nelli Bejanyan, Joseph Pidala, Hany Elmariah
{"title":"Association between <i>CYP3A4</i>, <i>CYP3A5</i> and <i>ABCB1</i> genotype and tacrolimus treatment outcomes among allogeneic HSCT patients.","authors":"Teresa T Ho, Janelle B Perkins, Rebecca Gonzalez, James Kevin Hicks, Ronald Alvarez Martinez, Katie Duranceau, Brianna North, Jongphil Kim, Jamie K Teer, Jiqiang Yao, Sean J Yoder, Taiga Nishihori, Nelli Bejanyan, Joseph Pidala, Hany Elmariah","doi":"10.2217/pgs-2023-0204","DOIUrl":"10.2217/pgs-2023-0204","url":null,"abstract":"<p><p><b>Aim:</b> Successful treatment with tacrolimus to prevent graft versus host disease (GVHD) and minimize tacrolimus-related toxicities among allogeneic hematopoietic cell transplantation (alloHCT) recipients is contingent upon quickly achieving and maintaining concentrations within a narrow therapeutic range. The primary objective was to investigate associations between <i>CYP3A4, CYP3A5</i> or <i>ABCB1</i> genotype and the proportion of patients that attained an initial tacrolimus goal concentration following initiation of intravenous (iv.) and conversion to oral administration. <b>Materials & methods:</b> We retrospectively evaluated 86 patients who underwent HLA-matched (8/8) related donor alloHCT and were prescribed a tacrolimus-based regimen for GVHD prophylaxis. <b>Results & conclusion:</b> The findings of the present study suggests that <i>CYP3A5</i> genotype may impact attainment of initial therapeutic tacrolimus concentrations with oral administration in alloHCT recipients.</p>","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"29-40"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the utility of measurement methods applied in economic evaluations of pharmacogenomics applications. 评估药物基因组学应用经济评估中采用的测量方法的实用性。
IF 2.1 4区 医学
Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2024-01-30 DOI: 10.2217/pgs-2023-0221
Vasileios Fragoulakis, Margarita-Ioanna Koufaki, Korina Tzerefou, Konstantinos Koufou, George P Patrinos, Christina Mitropoulou
{"title":"Assessing the utility of measurement methods applied in economic evaluations of pharmacogenomics applications.","authors":"Vasileios Fragoulakis, Margarita-Ioanna Koufaki, Korina Tzerefou, Konstantinos Koufou, George P Patrinos, Christina Mitropoulou","doi":"10.2217/pgs-2023-0221","DOIUrl":"10.2217/pgs-2023-0221","url":null,"abstract":"<p><p>An increasing number of economic evaluations are published annually investigating the economic effectiveness of pharmacogenomic (PGx) testing. This work was designed to provide a comprehensive summary of the available utility methods used in cost-effectiveness/cost-utility analysis studies of PGx interventions. A comprehensive review was conducted to identify economic analysis studies using a utility valuation method for PGx testing. A total of 82 studies met the inclusion criteria. A majority of studies were from the USA and used the EuroQol-5D questionnaire, as the utility valuation method. Cardiovascular disorders was the most studied therapeutic area while discrete-choice studies mainly focused on patients' willingness to undergo PGx testing. Future research in applying other methodologies in PGx economic evaluation studies would improve the current research environment and provide better results.</p>","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"79-95"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139574561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A systematic review of single nucleotide polymorphisms affecting allopurinol pharmacokinetics and serum uric acid level. 影响别嘌醇药代动力学和血清尿酸水平的单核苷酸多态性系统综述。
IF 1.9 4区 医学
Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2024-09-30 DOI: 10.1080/14622416.2024.2403969
Farah Aida A Zairol Azwan, Yi Ying Teo, Nor Asyikin Mohd Tahir, Shamin Mohd Saffian, Mohd Makmor-Bakry, Mohd Shahrir Mohamed Said
{"title":"A systematic review of single nucleotide polymorphisms affecting allopurinol pharmacokinetics and serum uric acid level.","authors":"Farah Aida A Zairol Azwan, Yi Ying Teo, Nor Asyikin Mohd Tahir, Shamin Mohd Saffian, Mohd Makmor-Bakry, Mohd Shahrir Mohamed Said","doi":"10.1080/14622416.2024.2403969","DOIUrl":"10.1080/14622416.2024.2403969","url":null,"abstract":"<p><p><b>Aim:</b> To summarize the effects of single nucleotide polymorphisms (SNPs) on the pharmacokinetics of allopurinol to control uric acid levels.<b>Methods:</b> A comprehensive search was conducted in PubMed, Web of Science and Scopus databases from inception to January 2024, includes 17 articles focusing on SNPs and pharmacokinetics of allopurinol and oxypurinol.<b>Results:</b> A total of 11 SNPs showed a significant association with pharmacokinetics of allopurinol and oxypurinol, as well as their potential clinical implications.<b>Conclusion:</b> SNPs in ATP-binding cassette super-family G member 2 (<i>ABCG2</i>), solute carrier family 2 member 9 (<i>SLC2A9</i>), solute carrier family 17 member 1 (<i>SLC17A1</i>), solute carrier family 22 member 12 (<i>SLC22A12</i>), solute carrier family 22 member 13 (<i>SLC22A13</i>) and PDZ domain containing 1 (<i>PDZK1</i>) genes were associated with allopurinol clearance, while SNPs in aldehyde oxidase 1 (<i>AOX1</i>) genes involved in metabolism of allopurinol. SNPs in gremlin 2, DAN family BMP antagonist (<i>GREM2</i>) gene impacted uric acid control, but the specific mechanism governing the expression of <i>GREM2</i> remains unknown. Our study indicated that the identified SNPs show contradictory effects, reflecting inconsistencies and differences observed across various studies.</p>","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"479-494"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TPMT and NUDT15 genotyping, TPMT enzyme activity and metabolite determination for thiopurines therapy: a reference laboratory experience. 硫嘌呤治疗的TPMT和NUDT15基因分型,TPMT酶活性和代谢物测定:参考实验室经验。
IF 1.9 4区 医学
Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2025-02-16 DOI: 10.1080/14622416.2025.2463866
Sherin Shaaban, Brandon S Walker, Yuan Ji, Kamisha Johnson-Davis
{"title":"<i>TPMT</i> and <i>NUDT15</i> genotyping, TPMT enzyme activity and metabolite determination for thiopurines therapy: a reference laboratory experience.","authors":"Sherin Shaaban, Brandon S Walker, Yuan Ji, Kamisha Johnson-Davis","doi":"10.1080/14622416.2025.2463866","DOIUrl":"10.1080/14622416.2025.2463866","url":null,"abstract":"<p><strong>Aim: </strong>To share the experience of a US national reference laboratory, offering genotyping for <i>TPMT</i> and <i>NUDT15</i>, TPMT enzyme phenotyping and detection of thiopurine metabolites.</p><p><strong>Methods: </strong>Retrospective review of archived datasets related to thiopurines drug therapy including patients' data that underwent <i>TPMT</i> and <i>NUDT15</i> genotyping, and smaller data sets where genotyping was performed with TPMT enzyme levels (phenotyping) +/- therapeutic drug monitoring (TDM).</p><p><strong>Results: </strong>Thirteen percent of patients had variants in one or both genes tested. Testing for <i>NUDT15</i> revealed 3.9% additional patients requiring thiopurines dosing recommendations. A correlation between TPMT enzyme activity and <i>TPMT</i> polymorphisms (odds ratio OD = 71.41, <i>p</i>-value <0.001) and between older age and higher enzyme levels (OD = 0.98, <i>p</i>-value = 0.002) was identified. No correlation between sex and TPMT enzyme levels, nor between <i>TPMT</i> genotyping and the level of thiopurine metabolites was found.</p><p><strong>Conclusion: </strong>Adding <i>NUDT15</i> to <i>TPMT</i> genotyping, identified additional 3.9% patients to benefit from thiopurine dose modifications. A significant correlation between genetic variants in <i>TPMT</i> and TPMT enzyme levels and between age and enzyme levels was established, while no correlation was identified between sex and enzyme levels nor between <i>TPMT</i> variation and thiopurine metabolites. Providers rely more significantly on genotyping only approach, rather than genotyping and phenotyping.</p>","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"679-688"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing the clinical utility of pharmacogenomic genotyping and next generation sequencing in a military health system adult medicine clinic. 比较药物基因组基因分型和新一代测序在军事卫生系统成人医学诊所中的临床应用。
IF 1.9 4区 医学
Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2025-02-21 DOI: 10.1080/14622416.2025.2466413
David Saunders, Lydia D Hellwig, Austin Pagani, Mauricio De Castro, Mark Haigney, Lucas Poon, Nate Ehat, Andrew Heroy, Joya Libbus, Keiko Fox, Sachi Kalra, Thomas B Arnold, Clesson Turner, John Logan Black, Steven E Scherer, Ann M Moyer
{"title":"Comparing the clinical utility of pharmacogenomic genotyping and next generation sequencing in a military health system adult medicine clinic.","authors":"David Saunders, Lydia D Hellwig, Austin Pagani, Mauricio De Castro, Mark Haigney, Lucas Poon, Nate Ehat, Andrew Heroy, Joya Libbus, Keiko Fox, Sachi Kalra, Thomas B Arnold, Clesson Turner, John Logan Black, Steven E Scherer, Ann M Moyer","doi":"10.1080/14622416.2025.2466413","DOIUrl":"10.1080/14622416.2025.2466413","url":null,"abstract":"<p><strong>Introduction: </strong>Pharmacogenetic (PGx) screening is intended to optimize drug efficacy and reduce adverse drug reactions. Current screening options include genotyping assays for preselected PGx variants and broader next-generation sequencing panels (NGS). Few studies have directly compared preemptive PGx screening methods.</p><p><strong>Materials and methods: </strong>The two PGx methods were compared in a cross-sectional study of adult Military Health System (MHS) clinic beneficiaries. Participants had initial targeted CYP2C19/CYP2D6 genotyping at a Military Health System Laboratory. Genotyping was followed by multi-gene NGS testing. Current prescriptions were recorded and potential drug-drug interactions screened to evaluate prescribing risk.</p><p><strong>Results: </strong>All participants (100%) had at least one clinically actionable NGS panel result compared to 81% with targeted CYP2C19/CYP2D6 genotyping. Participants (<i>n</i> = 162) had an average of 6.6 (range 0-22) prescriptions and 2.7 (range 0-24) drug-drug interactions. Among those with at least one clinically actionable NGS result, 42% were currently taking medication with actionable CPIC guidelines (Level A/B), compared with 24% with CYP2C19/CYP2D6 genotyping. Sixteen participants (10%) had uncertain NGS panel results, with none for CYP2C19/CYP2D6 genotyping.</p><p><strong>Conclusions: </strong>Preemptive multi-gene NGS detected more clinically actionable PGx results than targeted <i>CYP2C19/CYP2D6</i> genotyping. Effective PGx screening in the MHS may decrease preventable adverse effects and improve military readiness.</p>","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"637-645"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11901368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Providers' use of pharmacogenetic testing to inform opioid prescribing among veterans. 医疗机构利用药物基因检测为退伍军人开具阿片类药物处方提供信息。
IF 1.9 4区 医学
Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2024-10-09 DOI: 10.1080/14622416.2024.2409058
Rachele K Lipsky, Catherine Chanfreau-Coffinier, Deepak Voora, Jodie Trafton, Charlotte Williams, Susana B Martins, Sumitra Muralidhar, David W Oslin
{"title":"Providers' use of pharmacogenetic testing to inform opioid prescribing among veterans.","authors":"Rachele K Lipsky, Catherine Chanfreau-Coffinier, Deepak Voora, Jodie Trafton, Charlotte Williams, Susana B Martins, Sumitra Muralidhar, David W Oslin","doi":"10.1080/14622416.2024.2409058","DOIUrl":"10.1080/14622416.2024.2409058","url":null,"abstract":"<p><p><b>Aim:</b> To survey Veterans Health Administration providers who prescribed tramadol or codeine to patients with known genotyping for cytochrome 2D6 (<i>CYP2D6</i>) to ascertain awareness of their patient's pharmacogenetic (PGx) test status, whether these results influenced prescribing, perceived benefit of PGx testing, and resources needed to obtain and deliver PGx testing information.<b>Materials & methods:</b> A provider survey was conducted of those who prescribed tramadol or codeine in a patient genotyped for <i>CYP2D6</i>.<b>Results:</b> Of 876 eligible providers, 220 completed the survey. Ten percent were aware that their patient received a PGx test, 64% had not ordered any PGx test related to any medication in the prior year, 55% strongly agreed or agreed that PGx testing is or will be valuable to guide pain medication prescriptions, 29% felt that the evidence base for PGx testing is very strong or moderately strong, 22% responded likely or extremely likely to order a future PGx test, and 51% felt that it would be either very important or fairly important to have a local subject matter expert as a resource for PGx testing.<b>Conclusion:</b> There are modifiable factors that the Veterans Health Administration could address to optimize PGx testing for pain management.</p>","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"495-501"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of genetic and clinical factors on thiopurine drugs pharmacokinetics in Tunisian patients. 遗传和临床因素对突尼斯患者体内硫嘌呤药物药代动力学的影响。
IF 1.9 4区 医学
Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2024-10-09 DOI: 10.1080/14622416.2024.2406739
Zohra Chadli, Ibtissem Hannachi, Manel Ben Belgacem, Arwa Guediche, Haifa Ben Romdhane, Emna Kerkeni, Lamia Hamdi, Ahlem Slama, Amel Chaabane, Nadia Ben Fredj, Naceur A Boughattas, Leila Safer, Karim Aouam
{"title":"Effects of genetic and clinical factors on thiopurine drugs pharmacokinetics in Tunisian patients.","authors":"Zohra Chadli, Ibtissem Hannachi, Manel Ben Belgacem, Arwa Guediche, Haifa Ben Romdhane, Emna Kerkeni, Lamia Hamdi, Ahlem Slama, Amel Chaabane, Nadia Ben Fredj, Naceur A Boughattas, Leila Safer, Karim Aouam","doi":"10.1080/14622416.2024.2406739","DOIUrl":"10.1080/14622416.2024.2406739","url":null,"abstract":"<p><p><b>Aim:</b> Thiopurine drugs are used in the treatment of various diseases including inflammatory bowel disease. Thiopurine-S-methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) are the crucial enzymes involved in thiopurines metabolism. The present study aims to investigate in Tunisian patients, the influence of genetic and nongenetic factors on thiopurine drugs pharmacokinetics.<b>Experimental approach:</b> We have included patients having received thiopurine drugs and have undergone 6-thioguanine nucleotides (6-TGN) concentration monitoring. The identification of TPMT and ITPA polymorphisms was performed using the polymerase chain reaction-restriction fragment length polymorphism method. The impact of both genetic and nongenetic factors on the variability of the 6-TGN C/D ratio was analyzed through a stepwise multiple regression model.<b>Key results:</b> One hundred and twenty-three patients were included in the study. For TPMT, the most frequent variant allele was TPMT*3B (3.3%). For ITPA, the predominant polymorphism was the c.IVS2 + 21A> C (7%). We have demonstrated that only gender, the <i>TPMT*3A</i> and <i>TPMT*3C</i> alleles are significantly involved on the variability of thiopurines pharmacokinetics.<b>Conclusion:</b> Our study is the first to evaluate, in African patients, the impact of both genetic and nongenetic factors on the thiopurine drugs pharmacokinetics. Considering the narrow therapeutic range of these drugs, TPMT genotyping combined with 6-TGN blood concentration monitoring may enhance their efficacy and safety.</p>","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"441-450"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-analysis revisiting the influence of UGT1A1*28 and UGT1A1*6 on irinotecan safety in colorectal cancer patients. 重新审视 UGT1A1*28 和 UGT1A1*6 对结直肠癌患者伊立替康安全性影响的 Meta 分析。
IF 1.9 4区 医学
Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2024-08-22 DOI: 10.1080/14622416.2024.2385289
Cuc Thi Thu Nguyen, Thi Minh Thuy Nguyen, Thanh Huong Phung
{"title":"Meta-analysis revisiting the influence of <i>UGT1A1*28</i> and <i>UGT1A1*6</i> on irinotecan safety in colorectal cancer patients.","authors":"Cuc Thi Thu Nguyen, Thi Minh Thuy Nguyen, Thanh Huong Phung","doi":"10.1080/14622416.2024.2385289","DOIUrl":"10.1080/14622416.2024.2385289","url":null,"abstract":"<p><p><b>Aim:</b> To evaluate the association between irinotecan safety and the <i>UGT1A1</i> gene polymorphism in colorectal cancer (CRC) patients.<b>Materials & methods:</b> The studies were systematically searched and identified from three databases (PubMed, Embase and The Cochrane Library) until 28 February 2023. The relationships were evaluated using pooled odds ratio (OR).<b>Results:</b> A total of 30 studies out of 600 were included, comprising 4471 patients. <i>UGT1A1*28</i> was associated with a statistically significant increase in the OR for diarrhea (OR: 1.59, 95% CI = 1.24-2.06 in the additive model; OR = 3.24, 95% CI = 2.01-5.21 in the recessive model; and OR = 1.95, 95% CI = 1.42-2.69 in the dominant model) and neutropenia (OR = 1.70, 95% CI = 1.40-2.06 in the additive model; OR = 4.10, 95%CI = 2.69-6.23 in the recessive model; and OR = 1.93, 95% CI = 1.61-2.31 in the dominant model). Subgroup analysis indicated consistent associations in both Asian and non-Asian populations. <i>UGT1A1*6</i> was associated with a statistically significant elevation in the OR for diarrhea (only in the recessive model, OR = 2.42; 95% CI = 1.14-5.11) and neutropenia (across all genetic models).<b>Conclusion:</b> The <i>UGT1A1*28</i> and <i>UGT1A1*6</i> alleles might be a crucial indicator for predicting irinotecan safety in CRC.</p>","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"469-477"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacogenetic markers and macrolide safety in influenza patients: insights from a prospective study. 流感患者的药物遗传标记和大环内酯安全性:来自一项前瞻性研究的见解。
IF 1.9 4区 医学
Pharmacogenomics Pub Date : 2024-01-01 Epub Date: 2025-01-19 DOI: 10.1080/14622416.2025.2454217
A A Skryabina, V V Nikiforov, M Z Shakhmardanov, M S Zastrozhin, D A Sychev
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