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Association of DNA methylation, polymorphism and mRNA level of ALAS1 with antituberculosis drug-induced liver injury. ALAS1的DNA甲基化、多态性和mRNA水平与抗结核药物引起的肝损伤的关系
IF 1.9 4区 医学
Pharmacogenomics Pub Date : 2024-09-12 DOI: 10.1080/14622416.2024.2392480
Zhuolu Hao, Bing Han, Xinyue Zhou, Hongkai Jian, Xiaomin He, Lihuan Lu, Meiling Zhang, Hongqiu Pan, Honggang Yi, Shaowen Tang
{"title":"Association of DNA methylation, polymorphism and mRNA level of ALAS1 with antituberculosis drug-induced liver injury.","authors":"Zhuolu Hao, Bing Han, Xinyue Zhou, Hongkai Jian, Xiaomin He, Lihuan Lu, Meiling Zhang, Hongqiu Pan, Honggang Yi, Shaowen Tang","doi":"10.1080/14622416.2024.2392480","DOIUrl":"https://doi.org/10.1080/14622416.2024.2392480","url":null,"abstract":"<p><p><b>Aim:</b> To investigate the association of DNA methylation, genetic polymorphisms and mRNA level of aminolevulinate synthase 1 (ALAS1) with antituberculosis drug-induced liver injury (AT-DILI) risk.<b>Methods:</b> Based on a 1:1 matched case-control study with 182 cases and 182 controls, one CpG island and three single nucleotide polymorphisms (SNPs) were detected. <i>ALAS1</i> mRNA level was detected in 34 samples.<b>Results:</b> Patients with methylation status were at high risk of AT-DILI (odds ratio: 1.567, 95% CI: 1.015-2.421, <i>p</i> = 0.043) and SNP rs352169 was associated with AT-DILI risk (GA vs. GG, odds ratio: 1.770, 95% CI: 1.101-2.847, <i>p</i> = 0.019). <i>ALAS1</i> mRNA level in the cases was significantly lower than that in the controls (0.75 ± 0.34 vs. 1.00 ± 0.42, <i>p</i> = 0.021).<b>Conclusion:</b> The methylation status and SNP rs352169 of <i>ALAS1</i> were associated with AT-DILI risk.</p>","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142293124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
It is time for educators to act: pharmacogenomics education and its implementation into clinical practice. 现在是教育工作者采取行动的时候了：药物基因组学教育及其在临床实践中的实施。
IF 1.9 4区 医学
Pharmacogenomics Pub Date : 2024-09-04 DOI: 10.1080/14622416.2024.2392482
Snezana Kusljic, Jasmine A Luzum
{"title":"It is time for educators to act: pharmacogenomics education and its implementation into clinical practice.","authors":"Snezana Kusljic, Jasmine A Luzum","doi":"10.1080/14622416.2024.2392482","DOIUrl":"https://doi.org/10.1080/14622416.2024.2392482","url":null,"abstract":"","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-analysis revisiting the influence of UGT1A1*28 and UGT1A1*6 on irinotecan safety in colorectal cancer patients. 重新审视 UGT1A1*28 和 UGT1A1*6 对结直肠癌患者伊立替康安全性影响的 Meta 分析。
IF 1.9 4区 医学
Pharmacogenomics Pub Date : 2024-08-22 DOI: 10.1080/14622416.2024.2385289
Cuc Thi Thu Nguyen, Nguyen Thi Minh Thuy, Phung Thanh Huong
{"title":"Meta-analysis revisiting the influence of <i>UGT1A1*28</i> and <i>UGT1A1*6</i> on irinotecan safety in colorectal cancer patients.","authors":"Cuc Thi Thu Nguyen, Nguyen Thi Minh Thuy, Phung Thanh Huong","doi":"10.1080/14622416.2024.2385289","DOIUrl":"https://doi.org/10.1080/14622416.2024.2385289","url":null,"abstract":"<p><p><b>Aim:</b> To evaluate the association between irinotecan safety and the <i>UGT1A1</i> gene polymorphism in colorectal cancer (CRC) patients.<b>Materials & methods:</b> The studies were systematically searched and identified from three databases (PubMed, Embase and The Cochrane Library) until 28 February 2023. The relationships were evaluated using pooled odds ratio (OR).<b>Results:</b> A total of 30 studies out of 600 were included, comprising 4471 patients. <i>UGT1A1*28</i> was associated with a statistically significant increase in the OR for diarrhea (OR: 1.59, 95% CI = 1.24-2.06 in the additive model; OR = 3.24, 95% CI = 2.01-5.21 in the recessive model; and OR = 1.95, 95% CI = 1.42-2.69 in the dominant model) and neutropenia (OR = 1.70, 95% CI = 1.40-2.06 in the additive model; OR = 4.10, 95%CI = 2.69-6.23 in the recessive model; and OR = 1.93, 95% CI = 1.61-2.31 in the dominant model). Subgroup analysis indicated consistent associations in both Asian and non-Asian populations. <i>UGT1A1*6</i> was associated with a statistically significant elevation in the OR for diarrhea (only in the recessive model, OR = 2.42; 95% CI = 1.14-5.11) and neutropenia (across all genetic models).<b>Conclusion:</b> The <i>UGT1A1*28</i> and <i>UGT1A1*6</i> alleles might be a crucial indicator for predicting irinotecan safety in CRC.</p>","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142018282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A critical review of RAF inhibitors in BRAF-mutated glioma treatment RAF 抑制剂在 BRAF 突变胶质瘤治疗中的重要作用综述
IF 2.1 4区 医学
Pharmacogenomics Pub Date : 2024-06-03 DOI: 10.1080/14622416.2024.2355859
John-Victor El Khoury, Sophie Wehbe, Fouad Attieh, Marc Boutros, C. Kesrouani, H. Kourie
{"title":"A critical review of RAF inhibitors in BRAF-mutated glioma treatment","authors":"John-Victor El Khoury, Sophie Wehbe, Fouad Attieh, Marc Boutros, C. Kesrouani, H. Kourie","doi":"10.1080/14622416.2024.2355859","DOIUrl":"https://doi.org/10.1080/14622416.2024.2355859","url":null,"abstract":"","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141268881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of CYP2D6 and ADRB1 polymorphisms on heart rate of post-PCI patients treated with metoprolol. CYP2D6和ADRB1多态性对接受美托洛尔治疗的PCI术后患者心率的影响
IF 2.1 4区 医学
Pharmacogenomics Pub Date : 2024-05-31 DOI: 10.2217/pgs-2017-0203
Xiaofeng Gao, Huan Wang, Hui Chen
{"title":"Impact of <i>CYP2D6</i> and <i>ADRB1</i> polymorphisms on heart rate of post-PCI patients treated with metoprolol.","authors":"Xiaofeng Gao, Huan Wang, Hui Chen","doi":"10.2217/pgs-2017-0203","DOIUrl":"10.2217/pgs-2017-0203","url":null,"abstract":"<p><p><b>Aim:</b> To explore the effect of <i>CYP2D6*10</i> (100C > T) and <i>ADRB1</i> 1165 G > C polymorphisms on heart rate of post-PCI (percutaneous coronary intervention) patients treated with metoprolol succinate sustained-release tablets. <b>Methods:</b> A total of 756 inpatients with metoprolol succinate sustained-release tablets were selected and the genotypes of <i>CYP2D6*10</i> and <i>ADRB1</i> 1165G > C were detected in 319 patients using gene chip detection. The target heart rate was defined as a resting heart rate < 70 beats/min. Clinical data were collected. <b>Results:</b> A total of 319 inpatients were enrolled in the study. The mutant allele frequencies of <i>CYP2D6</i> and <i>ADRB1</i> were 57.21 and 69.44%, respectively. Whatever the dose of metoprolol, the heart rates were lower in patients with homozygous mutation of <i>CYP2D6</i> than those with heterozygous mutation and wild-type (p < 0.05). Nevertheless, this effect was not seen between different genotypes of <i>ADRB1</i>. Logistic regression analysis showed that the dose of metoprolol and the genotypes of <i>CYP2D6</i> were predictors of heart rate <70 beats/min in these patients. Further multivariate analysis indicated that patients with homozygous mutation had better control of heart rates compared with those with wild-type and heterozygous mutation of <i>CYP2D6*10</i> genotypes (all: p < 0.001). <b>Conclusion:</b><i>CYP2D6*10</i> polymorphisms were associated with the heart rate of post-PCI patients treated with metoprolol succinate sustained-release tablets.</p>","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35515184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SALL4 upregulates brain-derived neurotrophic factor to mediate Hedgehog signaling to inhibit carboplatin sensitivity in colon adenocarcinoma SALL4 上调脑源性神经营养因子，介导刺猬信号转导，抑制结肠腺癌对卡铂的敏感性
IF 2.1 4区 医学
Pharmacogenomics Pub Date : 2024-05-22 DOI: 10.1080/14622416.2024.2344429
Minhan Chen, Ying Liu, Weihua Xing
{"title":"SALL4 upregulates brain-derived neurotrophic factor to mediate Hedgehog signaling to inhibit carboplatin sensitivity in colon adenocarcinoma","authors":"Minhan Chen, Ying Liu, Weihua Xing","doi":"10.1080/14622416.2024.2344429","DOIUrl":"https://doi.org/10.1080/14622416.2024.2344429","url":null,"abstract":"","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141108931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of genetic polymorphisms on pharmacokinetics and treatment response of mycophenolic acid: a scoping review 基因多态性对霉酚酸药代动力学和治疗反应的影响：范围综述
IF 2.1 4区 医学
Pharmacogenomics Pub Date : 2024-05-17 DOI: 10.1080/14622416.2024.2344430
H. Yow, Muthi’ Ikawati, Soni Siswanto, Adam Hermawan, Alim Khodimul Rahmat, Janet Sui-Ling Tan, Y. Tee, Kok-Peng Ng, Z. Ikawati
{"title":"Influence of genetic polymorphisms on pharmacokinetics and treatment response of mycophenolic acid: a scoping review","authors":"H. Yow, Muthi’ Ikawati, Soni Siswanto, Adam Hermawan, Alim Khodimul Rahmat, Janet Sui-Ling Tan, Y. Tee, Kok-Peng Ng, Z. Ikawati","doi":"10.1080/14622416.2024.2344430","DOIUrl":"https://doi.org/10.1080/14622416.2024.2344430","url":null,"abstract":"","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141126729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic diversity of cytochrome P450 in patients receiving psychiatric care in Greece: a step towards clinical implementation 希腊接受精神病治疗的患者细胞色素 P450 的遗传多样性：向临床实施迈出的一步
IF 2.1 4区 医学
Pharmacogenomics Pub Date : 2024-05-15 DOI: 10.1080/14622416.2024.2346072
G. Ragia, Myria Pallikarou, Yiota Manolopoulou, T. Vorvolakos, V. Manolopoulos
{"title":"Genetic diversity of cytochrome P450 in patients receiving psychiatric care in Greece: a step towards clinical implementation","authors":"G. Ragia, Myria Pallikarou, Yiota Manolopoulou, T. Vorvolakos, V. Manolopoulos","doi":"10.1080/14622416.2024.2346072","DOIUrl":"https://doi.org/10.1080/14622416.2024.2346072","url":null,"abstract":"","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140974308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The cost–effectiveness of zolbetuximab in CLDN18.2-positive gastric or gastroesophageal junction adenocarcinoma 唑贝妥昔单抗治疗CLDN18.2阳性胃癌或胃食管交界腺癌的成本效益
IF 2.1 4区 医学
Pharmacogenomics Pub Date : 2024-05-13 DOI: 10.1080/14622416.2024.2344438
Shufei Lai, Shaohong Luo, Qingwen Huang, Shen Lin, Xiaoting Huang, Honglin Xue, Yijun Cai, Xiongwei Xu, X. Weng
{"title":"The cost–effectiveness of zolbetuximab in CLDN18.2-positive gastric or gastroesophageal junction adenocarcinoma","authors":"Shufei Lai, Shaohong Luo, Qingwen Huang, Shen Lin, Xiaoting Huang, Honglin Xue, Yijun Cai, Xiongwei Xu, X. Weng","doi":"10.1080/14622416.2024.2344438","DOIUrl":"https://doi.org/10.1080/14622416.2024.2344438","url":null,"abstract":"","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140983016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polymorphism of CYP3A4*18 is associated with anti-tuberculosis drug-induced hepatotoxicity CYP3A4*18 的多态性与抗结核药物引起的肝毒性有关
IF 2.1 4区 医学
Pharmacogenomics Pub Date : 2024-05-13 DOI: 10.1080/14622416.2024.2346069
Shih-Wei Lee, Pei-Tzu Chen, Chi-Wei Liu, Yuan-Hsu Li, Lawrence Shih-Hsin Wu
{"title":"Polymorphism of\u0000 CYP3A4*18\u0000 is associated with anti-tuberculosis drug-induced hepatotoxicity","authors":"Shih-Wei Lee, Pei-Tzu Chen, Chi-Wei Liu, Yuan-Hsu Li, Lawrence Shih-Hsin Wu","doi":"10.1080/14622416.2024.2346069","DOIUrl":"https://doi.org/10.1080/14622416.2024.2346069","url":null,"abstract":"","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140985323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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