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Challenges for the application of pharmacogenomics associated with the nomenclature of allelic variants. 与等位基因变体命名相关的药物基因组学应用的挑战。
IF 2.1 4区 医学
Pharmacogenomics Pub Date : 2023-10-01 Epub Date: 2023-10-17 DOI: 10.2217/pgs-2023-0160
Nadine de Godoy Torso, Paulo Caleb Jl Santos, Patricia Moriel
{"title":"Challenges for the application of pharmacogenomics associated with the nomenclature of allelic variants.","authors":"Nadine de Godoy Torso, Paulo Caleb Jl Santos, Patricia Moriel","doi":"10.2217/pgs-2023-0160","DOIUrl":"10.2217/pgs-2023-0160","url":null,"abstract":"","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"793-796"},"PeriodicalIF":2.1,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41237621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distribution of pharmacogene allele and phenotype frequencies in Brazilian psychiatric patients. 巴西精神病患者药物基因等位基因和表型频率的分布。
IF 2.1 4区 医学
Pharmacogenomics Pub Date : 2023-09-01 Epub Date: 2023-10-17 DOI: 10.2217/pgs-2023-0075
Guido Boabaid May, Bruna Raquel de Souza, Bárbara Yasmin Gueuvoghlanian-Silva, Esther Camilo Dos Reis, Sofia Rech Mostardeiro, Paula Pedrassani Boabaid May, Elvis Cueva Mateo, Giovanna Grunewald Vietta, Giovana Weber Hoss
{"title":"Distribution of pharmacogene allele and phenotype frequencies in Brazilian psychiatric patients.","authors":"Guido Boabaid May,&nbsp;Bruna Raquel de Souza,&nbsp;Bárbara Yasmin Gueuvoghlanian-Silva,&nbsp;Esther Camilo Dos Reis,&nbsp;Sofia Rech Mostardeiro,&nbsp;Paula Pedrassani Boabaid May,&nbsp;Elvis Cueva Mateo,&nbsp;Giovanna Grunewald Vietta,&nbsp;Giovana Weber Hoss","doi":"10.2217/pgs-2023-0075","DOIUrl":"10.2217/pgs-2023-0075","url":null,"abstract":"<p><p><b>Purpose:</b> This work was designed to identify the pharmacogenetic profile of Brazilian psychiatric patients receiving psychoactive drug treatment according to ethnicity. <b>Methods:</b> Based on the GnTech<sup>®</sup> database, this cross-sectional study analyzed data from self-reported sociodemographic and genetic results from the next-generation sequencing panel composed of 26 pharmacogenes from 359 psychotropic drug users. <b>Results:</b> Variant frequencies of multiple pharmacogenes presented differences between ethnicities (<i>CYP3A5</i>, <i>CYP2D6</i>, <i>CYP1A2</i>, <i>CYP2B6</i>, <i>CYP3A4</i>, <i>UGT1A4</i>, <i>UGT2B15</i>, <i>ABCB1 rs1045642</i>, <i>ADRA2A rs1800544</i>, <i>COMT rs4680</i>, <i>GRIK4 rs1954787</i>, <i>GSK3B rs334558</i>, <i>GSK3B rs6438552</i>, <i>HTR1A rs6295</i>, <i>HTR2A rs7997012</i>, <i>HTR2C rs1414334</i>, <i>MTHFR rs1801131</i>, <i>OPRM1 rs1799971</i> and <i>5-HTTLPR</i>), endorsing the necessity of individual-level analyses in drug treatment. <b>Conclusion:</b> A discussion of pharmacogenomic test implementation in psychiatric clinical practice is needed to improve treatment choices, especially in Brazil, a multiethnic country.</p>","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"747-760"},"PeriodicalIF":2.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41237622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HLA-B*57:01 typing in a Malaysian cohort: implications of abacavir hypersensitivity in people living with HIV. 马来西亚队列中的HLA-B*57:01分型：HIV感染者阿巴卡韦超敏反应的意义。
IF 2.1 4区 医学
Pharmacogenomics Pub Date : 2023-09-01 Epub Date: 2023-09-28 DOI: 10.2217/pgs-2023-0136
V Kalidasan, Iswarya Kunalan, Reena Rajasuriar, Vijay Kumar Subbiah, Kumitaa Theva Das
{"title":"<i>HLA-B*57:01</i> typing in a Malaysian cohort: implications of abacavir hypersensitivity in people living with HIV.","authors":"V Kalidasan,&nbsp;Iswarya Kunalan,&nbsp;Reena Rajasuriar,&nbsp;Vijay Kumar Subbiah,&nbsp;Kumitaa Theva Das","doi":"10.2217/pgs-2023-0136","DOIUrl":"10.2217/pgs-2023-0136","url":null,"abstract":"<p><p><b>Background:</b> Abacavir (ABC) in combination with other antiretroviral drugs, is used to treat people living with HIV (PLWH). However, it is linked to a fatal hypersensitivity reaction in susceptible individuals, and is strongly associated with the <i>HLA-B*57:01</i> allele. <b>Materials & methods:</b> A total of 152 patients, 50 PLWH and 102 HIV-1 negative patients, were assessed for the <i>HLA-B*57:01</i> allele through a sequence-specific primer PCR. <b>Results:</b> All PLWH tested negative for the <i>HLA-B*57:01</i> allele, but two HIV-negative patients were found to have <i>HLA-B*57</i>, with one of them expressing the <i>HLA-B*57:01</i> allele. <b>Conclusion:</b> Given the low prevalence of this risk allele in the population, testing for the presence of <i>HLA-B*57:01</i> in PLWH may not provide significant benefit for the reported population.</p>","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"761-769"},"PeriodicalIF":2.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41163341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe systemic adverse reactions to ophthalmic timolol in a CYP2D6 homozygous *4 allele carrier: a case report. CYP2D6纯合子*4等位基因携带者对噻吗洛尔的严重全身性不良反应：一例报告。
IF 2.1 4区 医学
Pharmacogenomics Pub Date : 2023-09-01 Epub Date: 2023-09-15 DOI: 10.2217/pgs-2023-0122
Anna Bollinger, Chiara Jeiziner, Henriette E Meyer Zu Schwabedissen, Kurt E Hersberger, Samuel S Allemann, Céline K Stäuble
{"title":"Severe systemic adverse reactions to ophthalmic timolol in a <i>CYP2D6</i> homozygous <i>*4</i> allele carrier: a case report.","authors":"Anna Bollinger,&nbsp;Chiara Jeiziner,&nbsp;Henriette E Meyer Zu Schwabedissen,&nbsp;Kurt E Hersberger,&nbsp;Samuel S Allemann,&nbsp;Céline K Stäuble","doi":"10.2217/pgs-2023-0122","DOIUrl":"10.2217/pgs-2023-0122","url":null,"abstract":"<p><p>A woman with ocular hypertension suffered from severe bradycardia, hypotension and syncope attacks in temporal relation with ophthalmic timolol application. Topically applied timolol is nasally absorbed and has been shown to reach potentially relevant systemic concentrations. Timolol is mainly metabolized by CYP2D6, which exhibits interindividual metabolic capacity due to genetic variations. A reactive pharmacogenetic panel test identified the patient as a <i>CYP2D6</i> homozygous <i>*4</i> allele carrier, which has been associated with a poor metabolizer phenotype and lacking enzyme activity. Thus, the adverse drug reactions possibly resulted from increased systemic timolol exposure. This case report highlights that pharmacogenetic panel testing can contribute to safe and effective pharmacotherapy, even for topically applied drugs.</p>","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"739-746"},"PeriodicalIF":2.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10243760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Donor-derived cell free DNA as a biomarker in kidney transplantation. 供体来源的无细胞DNA作为肾移植中的生物标志物。
IF 2.1 4区 医学
Pharmacogenomics Pub Date : 2023-09-01 Epub Date: 2023-09-21 DOI: 10.2217/pgs-2023-0138
Tarek Abdulhadi, Louai Alrata, Casey Dubrawka, Gwendolyn Amurao, Sri Mahathi Kalipatnapu, Che Isaac, Shelden Rodrigues, Karen Marie Flores, Dema Yaseen Alsabbagh, Omar Alomar, Tarek Alhamad
{"title":"Donor-derived cell free DNA as a biomarker in kidney transplantation.","authors":"Tarek Abdulhadi,&nbsp;Louai Alrata,&nbsp;Casey Dubrawka,&nbsp;Gwendolyn Amurao,&nbsp;Sri Mahathi Kalipatnapu,&nbsp;Che Isaac,&nbsp;Shelden Rodrigues,&nbsp;Karen Marie Flores,&nbsp;Dema Yaseen Alsabbagh,&nbsp;Omar Alomar,&nbsp;Tarek Alhamad","doi":"10.2217/pgs-2023-0138","DOIUrl":"10.2217/pgs-2023-0138","url":null,"abstract":"<p><p>The early detection of acute rejection in the allograft is important as it provides an opportunity for timely therapeutic intervention in order to preserve graft function and achieve longer graft survival. Donor-derived cell-free DNA (dd-cfDNA) has emerged as a new biomarker in the field of kidney transplantation. In this review, we used data from various studies to examine the role of dd-cfDNA in comparison to creatinine and donor-specific antibodies in the early detection of transplant rejection. We also reviewed the use of dd-cfDNA in other organ transplants as well as the challenges and potential future direction for dd-cfDNA as a diagnostic tool.</p>","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"771-780"},"PeriodicalIF":2.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41143312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Review of pharmacogenomics of psychiatric comorbidities in autism spectrum disorder. 孤独症谱系障碍中精神合并症的药物基因组学研究进展。
IF 2.1 4区 医学
Pharmacogenomics Pub Date : 2023-09-01 Epub Date: 2023-09-28 DOI: 10.2217/pgs-2023-0134
Aida Alvarez, Valentin Bote, Cristina Lamborena, Raquel Medina, Alexandre Serra-LLovich, Amaia Hervas, Maria J Arranz
{"title":"Review of pharmacogenomics of psychiatric comorbidities in autism spectrum disorder.","authors":"Aida Alvarez,&nbsp;Valentin Bote,&nbsp;Cristina Lamborena,&nbsp;Raquel Medina,&nbsp;Alexandre Serra-LLovich,&nbsp;Amaia Hervas,&nbsp;Maria J Arranz","doi":"10.2217/pgs-2023-0134","DOIUrl":"10.2217/pgs-2023-0134","url":null,"abstract":"<p><p>Approximately 70% of individuals diagnosed with autism spectrum disorder (ASD) receive at least one psychotropic medication to treat comorbidities. However, the response to treatment with these drugs is far from satisfactory, with 30-50% of treated patients not responding adequately or developing severe and long-lasting side effects. There is strong evidence of the clinical utility of pharmacogenetics for the personalization of antipsychotic and antidepressant treatments in adult populations. However, the use of pharmacogenetic interventions for the personalization of treatment in ASD populations is minimal. The aim of this review is to summarize the findings of pharmacogenetic studies conducted in subjects with ASD and illustrate their utility in the personalization of treatment with psychoactive drugs in this population group.</p>","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"781-791"},"PeriodicalIF":2.1,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41145514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating pharmacogenomic testing into paired germline and somatic genomic testing in patients with cancer. 将药物基因组检测整合到癌症患者的配对种系和体细胞基因组检测中。
IF 2.1 4区 医学
Pharmacogenomics Pub Date : 2023-08-01 Epub Date: 2023-09-13 DOI: 10.2217/pgs-2023-0125
Nathan D Seligson, Jill M Kolesar, Benish Alam, Laura Baker, Jatinder K Lamba, Brooke L Fridley, Ameen A Salahudeen, Daniel L Hertz, J Kevin Hicks
{"title":"Integrating pharmacogenomic testing into paired germline and somatic genomic testing in patients with cancer.","authors":"Nathan D Seligson,&nbsp;Jill M Kolesar,&nbsp;Benish Alam,&nbsp;Laura Baker,&nbsp;Jatinder K Lamba,&nbsp;Brooke L Fridley,&nbsp;Ameen A Salahudeen,&nbsp;Daniel L Hertz,&nbsp;J Kevin Hicks","doi":"10.2217/pgs-2023-0125","DOIUrl":"10.2217/pgs-2023-0125","url":null,"abstract":"<p><p>Precision medicine has revolutionized clinical care for patients with cancer through the development of targeted therapy, identification of inherited cancer predisposition syndromes and the use of pharmacogenetics to optimize pharmacotherapy for anticancer drugs and supportive care medications. While germline (patient) and somatic (tumor) genomic testing have evolved separately, recent interest in paired germline/somatic testing has led to an increase in integrated genomic testing workflows. However, paired germline/somatic testing has generally lacked the incorporation of germline pharmacogenomics. Integrating pharmacogenomics into paired germline/somatic genomic testing would be an efficient method for increasing access to pharmacogenomic testing. In this perspective, the authors argue for the benefits of implementing a comprehensive approach integrating somatic and germline testing that is inclusive of pharmacogenomics in clinical practice.</p>","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"731-738"},"PeriodicalIF":2.1,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10225242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effects of CYP3A4 and CYP2C9 genotype on systemic anastrozole and fulvestrant concentrations in SWOG S0226. CYP3A4和CYP2C9基因型对SWOG S0226中系统阿那曲唑和富维司琼浓度的影响。
IF 1.9 4区 医学
Pharmacogenomics Pub Date : 2023-08-01 Epub Date: 2023-08-24 DOI: 10.2217/pgs-2023-0097
Delaney V Rutherford, Sarah Medley, Nicholas C Henderson, Christina L Gersch, Ted A Vandenberg, Kathy S Albain, Shaker R Dakhil, Nagendra R Tirumali, Julie R Gralow, Gabriel N Hortobagyi, Lajos Pusztai, Rita S Mehta, Daniel F Hayes, Kelley M Kidwell, N Lynn Henry, William E Barlow, James M Rae, Daniel L Hertz
{"title":"Effects of <i>CYP3A4</i> and <i>CYP2C9</i> genotype on systemic anastrozole and fulvestrant concentrations in SWOG S0226.","authors":"Delaney V Rutherford, Sarah Medley, Nicholas C Henderson, Christina L Gersch, Ted A Vandenberg, Kathy S Albain, Shaker R Dakhil, Nagendra R Tirumali, Julie R Gralow, Gabriel N Hortobagyi, Lajos Pusztai, Rita S Mehta, Daniel F Hayes, Kelley M Kidwell, N Lynn Henry, William E Barlow, James M Rae, Daniel L Hertz","doi":"10.2217/pgs-2023-0097","DOIUrl":"10.2217/pgs-2023-0097","url":null,"abstract":"<p><p><b>Objective & methods:</b> This study tested associations of genotype-predicted activity of CYP3A4, other pharmacogenes, <i>SLC28A7</i> (rs11648166) and <i>ALPPL2</i> (rs28845026) with systemic concentrations of the endocrine therapies anastrozole and fulvestrant in SWOG S0226 trial participants. <b>Results:</b> Participants in the anastrozole-only arm with low CYP3A4 activity (i.e. <i>CYP3A4*22</i> carriers) had higher systemic anastrozole concentrations than patients with high CYP3A4 activity (β-coefficient = 10.03; 95% CI: 1.42, 18.6; p = 0.025). In an exploratory analysis, participants with low CYP2C9 activity had lower anastrozole concentrations and higher fulvestrant concentrations than participants with high CYP2C9 activity. <b>Conclusion:</b> Inherited genetic variation in <i>CYP3A4</i> and <i>CYP2C9</i> may affect concentrations of endocrine therapy and may be useful to personalize dosing and improve treatment outcomes.</p>","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"665-673"},"PeriodicalIF":1.9,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10565537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10303343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of OPRM1/COMT gene polymorphisms on sufentanil labor analgesia: a cohort study based on propensity score matching. OPRM1/COMT基因多态性对舒芬太尼分娩镇痛的影响：一项基于倾向评分匹配的队列研究。
IF 2.1 4区 医学
Pharmacogenomics Pub Date : 2023-08-01 Epub Date: 2023-08-23 DOI: 10.2217/pgs-2023-0103
Yao Chen, Quanyao Chen, Can Cai, Xiuxian Lin, Weiwei Yu, Huiqiong Huang, Wenmin Xie, Min Lin, Weida Chen, Hui Wu, Tingting Su, Lingsong Wang
{"title":"Effect of <i>OPRM1/COMT</i> gene polymorphisms on sufentanil labor analgesia: a cohort study based on propensity score matching.","authors":"Yao Chen, Quanyao Chen, Can Cai, Xiuxian Lin, Weiwei Yu, Huiqiong Huang, Wenmin Xie, Min Lin, Weida Chen, Hui Wu, Tingting Su, Lingsong Wang","doi":"10.2217/pgs-2023-0103","DOIUrl":"10.2217/pgs-2023-0103","url":null,"abstract":"<p><p><b>Background:</b> This study investigated the use of <i>COMT</i> G1947A and <i>OPRM1</i> A118G polymorphisms as predictive markers for sufentanil epidural analgesia. <b>Methods:</b> The visual analogue scale (VAS) score, and sufentanil consumption of 136 pairs of parturients using sufentanil with lidocaine and ropivacaine for epidural analgesia were used for analysis. <b>Results:</b> <i>OPRM1</i> AG/GG had lower VAS score difference between fifth and 0 min (1.55 vs 1.87; p = 0.012) and higher consumption (19.65 μg vs 17.11 μg; p = 0.049) than AA carriers. <i>COMT</i> GA/AA had higher VAS score difference than GG carriers (1.86 vs 1.55; p = 0.021). <b>Conclusion:</b> Sufentanil may provide better epidural labor analgesia in <i>OPRM1</i> AA and <i>COMT</i> GA/AA carriers compared with <i>OPRM1</i> AG/GG and <i>COMT</i> GG carriers. <b>Clinical Trial Registration</b>: ChiCTR1900026897 (Chinese Clinical Trial Center Registry).</p>","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"675-684"},"PeriodicalIF":2.1,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10115360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interethnic differences in drug response: projected impact of genetic variations in the Saudi population. 药物反应的种族间差异：沙特人口基因变异的预测影响。
IF 2.1 4区 医学
Pharmacogenomics Pub Date : 2023-08-01 Epub Date: 2023-08-23 DOI: 10.2217/pgs-2023-0105
Abdullah Alsultan, Abdullah A Alalwan, Bashayer Alshehri, Majed Al Jeraisy, Jahad Alghamdi, Saeed Alqahtani, Ahmed A Albassam
{"title":"Interethnic differences in drug response: projected impact of genetic variations in the Saudi population.","authors":"Abdullah Alsultan,&nbsp;Abdullah A Alalwan,&nbsp;Bashayer Alshehri,&nbsp;Majed Al Jeraisy,&nbsp;Jahad Alghamdi,&nbsp;Saeed Alqahtani,&nbsp;Ahmed A Albassam","doi":"10.2217/pgs-2023-0105","DOIUrl":"10.2217/pgs-2023-0105","url":null,"abstract":"Ethnicity is known to have an impact on drug responses. This is particularly important for drugs that have a narrow therapeutic window, nonlinearity in pharmacokinetics and are metabolized by enzymes that demonstrate genetic polymorphisms. However, most clinical trials are conducted among Caucasians, which might limit the usefulness of the findings of such studies for other ethnicities. The representation of participants from Saudi Arabia in global clinical trials is low. Therefore, there is a paucity of evidence to assess the impact of ethnic variability in the Saudi population on drug response. In this article, the authors assess the projected impact of genetic polymorphisms in drug-metabolizing enzymes and drug targets on drug response in the Saudi population.","PeriodicalId":20018,"journal":{"name":"Pharmacogenomics","volume":" ","pages":"685-696"},"PeriodicalIF":2.1,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10059854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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