Pharmaceutical Development and Technology最新文献_第4页

Repurposing simvastatin with piperine through β-cyclodextrin inclusion complex: a dual-drug strategy to enhance solubility and antiproliferative activity in hepatic cancer cells. 辛伐他汀与胡椒碱通过β-环糊精包合物的再利用：提高肝癌细胞溶解度和抗增殖活性的双药策略。

IF 2.9 4区医学

Pharmaceutical Development and Technology Pub Date : 2026-07-01 Epub Date: 2026-07-24 DOI: 10.1080/10837450.2026.2706520

Riyad F Alzhrani, Syed Sarim Imam, Sultan Alshehri, Wael A Mahdi, Saad Alobid, Mohammed A Assiri, Gamaleldin I Harisa

{"title":"Repurposing simvastatin with piperine through β-cyclodextrin inclusion complex: a dual-drug strategy to enhance solubility and antiproliferative activity in hepatic cancer cells.","authors":"Riyad F Alzhrani, Syed Sarim Imam, Sultan Alshehri, Wael A Mahdi, Saad Alobid, Mohammed A Assiri, Gamaleldin I Harisa","doi":"10.1080/10837450.2026.2706520","DOIUrl":"10.1080/10837450.2026.2706520","url":null,"abstract":"The purpose of this feasibility study was to develop a co-delivery inclusion complex of Simvastatin (SIM) and Piperine (PIP) using different cyclodextrins to enhance solubility and evaluate its antiproliferative activity in hepatocellular carcinoma (HCC) cells. SIM has recently been repurposed as a potential anticancer agent; however, its low bioactivity is mainly driven by its poor aqueous solubility. SIM and PIP inclusion complexes were prepared using Beta-cyclodextrin (βCD), Methyl β-cyclodextrin (M βCD), and Hydroxypropyl β-cyclodextrin (HP βCD) via solvent evaporation (SE) and microwave irradiation (MI). Phase solubility studies revealed AL-type profiles, with a higher stability constant for M βCD. The optimized ternary complex PIP-SIM-M βCD (F6-SE) increased the solubility of PIP and SIM to 708.58 ± 19.1 and 127.1 ± 4.9 µg/mL, respectively. In vitro cytotoxicity studies demonstrated that the PIP-SIM-M βCD complex significantly inhibited HepG2 cell viability. Apoptosis data indicated a higher proportion of late apoptotic cells and suggested G1 phase arrest. Overall, these findings support the use of M βCD-based inclusion complexes as a promising formulation strategy for co-delivering SIM and PIP and enhancing their in vitro antiproliferative activity in liver cancer cells.","PeriodicalId":20004,"journal":{"name":"Pharmaceutical Development and Technology","volume":" ","pages":"1020-1032"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent progress in nanoparticulate lipid-based co-delivery systems containing gene-based cargoes for the treatment of oncological and non-oncological diseases. 含有基因载体的纳米颗粒脂质共递送系统用于治疗肿瘤和非肿瘤疾病的最新进展。

IF 2.9 4区医学

Pharmaceutical Development and Technology Pub Date : 2026-06-01 Epub Date: 2026-07-15 DOI: 10.1080/10837450.2026.2686958

Reza HosseinPour-Moghadam, Sima Sadrai, Tayebeh Toliyat

引用次数: 0

Strategies for inhibiting the burst release effect in peptide long-acting release delivery systems. 抑制肽长效释放系统中爆发释放效应的策略。

IF 2.9 4区医学

Pharmaceutical Development and Technology Pub Date : 2026-06-01 Epub Date: 2026-05-23 DOI: 10.1080/10837450.2026.2669967

Xianhua Zhang, Yuanlei Fu, Yuan Tan, Dongfang Cheng, Xiuzhi Wang, Baohua Niu, Ling Ni, Weijing Luan, Teng Liu

{"title":"Strategies for inhibiting the burst release effect in peptide long-acting release delivery systems.","authors":"Xianhua Zhang, Yuanlei Fu, Yuan Tan, Dongfang Cheng, Xiuzhi Wang, Baohua Niu, Ling Ni, Weijing Luan, Teng Liu","doi":"10.1080/10837450.2026.2669967","DOIUrl":"10.1080/10837450.2026.2669967","url":null,"abstract":"Peptide medications are essential for the treatment of numerous illnesses and offer several benefits, including minimal toxicity and excellent specificity. Nevertheless, issues including peptide medicines' short in vivo half-life and poor oral bioavailability have significantly restricted the clinical use of many peptide medications with lengthy therapy cycles. Extended single injection cycles and fewer injections are possible with long-acting formulations. In situ gel and microsphere formulations are among the most promising for the long-acting administration of peptide drugs; however, the burst release effect that occurs during the initial stage of administration of these two formulations may raise the risk of adverse drug reactions, making this a critical problem that requires immediate attention. With the goal of providing a thorough theoretical foundation and useful advice for the optimization of the performance of these two types of long-acting injections, as well as encouraging the advancement of the technology of long-acting administration of peptide drugs, this paper examines the causes of the burst release effect of in situ gel and microsphere formulations from the physicochemical properties of peptide drugs, polymer matrix, solvent, and preparation process, among other aspects. Additionally, it seeks to increase patient drug compliance and the effectiveness of peptide medications.","PeriodicalId":20004,"journal":{"name":"Pharmaceutical Development and Technology","volume":" ","pages":"711-728"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147988654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rutin-loaded film-forming spray for accelerated wound repair: a QbD-guided translational approach. “芦丁负载成膜喷雾加速伤口修复：qbd引导的翻译方法”。

IF 2.9 4区医学

Pharmaceutical Development and Technology Pub Date : 2026-06-01 Epub Date: 2026-06-23 DOI: 10.1080/10837450.2026.2682783

Preeti Karwa, Ayesha Syed, Sohal Mallick, Mohd Osama Nabi

{"title":"Rutin-loaded film-forming spray for accelerated wound repair: a QbD-guided translational approach.","authors":"Preeti Karwa, Ayesha Syed, Sohal Mallick, Mohd Osama Nabi","doi":"10.1080/10837450.2026.2682783","DOIUrl":"10.1080/10837450.2026.2682783","url":null,"abstract":"Wound healing remains a major clinical challenge, necessitating advanced topical systems that accelerate repair while minimizing complications. Rutin, a flavonoid with potent antioxidant, anti-inflammatory and angiogenic properties, suffers from poor solubility and instability, limiting therapeutic application. To overcome these drawbacks, a rutin-loaded film-forming spray (FFS) was developed using a Quality by Design (QbD) framework and optimized via a Box-Behnken design. Eudragit® RLPO and Eudragit® E100 were employed as film-forming polymers, propylene glycol as a plasticizer, and menthol as a permeation enhancer. The optimized formulation, CO-RUT (F1), exhibited favorable physicochemical characteristics, including rapid drying (56 ± 2 s), suitable viscosity (3.8 ± 0.076 cPs), and uniform drug content (95.3% ± 2%). In vitro release demonstrated sustained delivery over 8 h (86.7% ± 1.6%), following Korsmeyer-Peppas kinetics indicative of anomalous diffusion. Ex vivo permeation achieved 97.8% cumulative permeation, attributed to the synergistic effects of menthol and propylene glycol. Most critically, in vivo wound healing studies in rats showed complete wound closure by day 16, significantly outperforming marketed formulations and controls. Histopathological examination confirmed superior epithelialization, collagen deposition, and angiogenesis. The CO-RUT (F1) formulation which integrates QbD principles with robust experimental design demonstrates strong translational potential as a novel wound-healing platform and provides a methodological framework for developing next-generation film-forming sprays.","PeriodicalId":20004,"journal":{"name":"Pharmaceutical Development and Technology","volume":" ","pages":"794-819"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bortezomib/SBE-β-cyclodextrin inclusion complex for improved anticancer performance: formulation, characterization, and biological evaluation. 硼替佐米/SBE-β-环糊精包合物用于提高抗癌性能：配方、表征和生物学评价。

IF 2.9 4区医学

Pharmaceutical Development and Technology Pub Date : 2026-06-01 Epub Date: 2026-06-02 DOI: 10.1080/10837450.2026.2673573

Saber Hakiminasab, Mohammad Mashreghi, Bizhan Malaekeh-Nikouei, Seyedeh Hoda Alavizadeh, Shiva Golmohammadzadeh, Leila Arabi, Fatemeh Akbarzadeh-Ebrahimi, Mahmoud Reza Jaafari

{"title":"Bortezomib/SBE-β-cyclodextrin inclusion complex for improved anticancer performance: formulation, characterization, and biological evaluation.","authors":"Saber Hakiminasab, Mohammad Mashreghi, Bizhan Malaekeh-Nikouei, Seyedeh Hoda Alavizadeh, Shiva Golmohammadzadeh, Leila Arabi, Fatemeh Akbarzadeh-Ebrahimi, Mahmoud Reza Jaafari","doi":"10.1080/10837450.2026.2673573","DOIUrl":"10.1080/10837450.2026.2673573","url":null,"abstract":"Bortezomib (BTZ) is a potent anticancer agent whose clinical application is limited by poor aqueous solubility. We engineered a sulfobutylether-β-cyclodextrin (SBE-β-CD) inclusion complex via aqueous complexation and freeze-drying to enhance BTZ solubility and therapeutic performance. Phase solubility analysis demonstrated a 25.7-fold increase in BTZ solubility at a 1:20 molar ratio (F1), in 25 °C. Complex formation was confirmed by differential scanning calorimetry (DSC) and Fourier-transform infrared (FTIR) spectroscopy. The F1 formulation exhibited sustained drug release at physiological pH of 7.4. Although F1 showed slightly reduced in vitro cytotoxicity compared with conventional BTZ (cBTZ) in C26 and U266 cell lines, it significantly improved in vivo antitumor efficacy in C26 tumor-bearing mice, achieving a tumor growth delay (TGD) of 52.14% versus 29.34% for cBTZ. Furthermore, a calcein/SBE-β-CD complex (F1', 1:20 molar ratio, as a fluorescent model drug) demonstrated enhanced cellular uptake and tumor accumulation in C26 tumor-bearing mice. These findings highlight SBE-β-CD as a promising platform for BTZ encapsulation, enabling improved drug delivery and anticancer efficacy and merits further investigation.","PeriodicalId":20004,"journal":{"name":"Pharmaceutical Development and Technology","volume":" ","pages":"764-777"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intranasal mucoadhesive biomaterials for nose-to-brain neuroactive delivery: platform design and model-informed translation for time-bounded CNS exposure. 鼻-脑神经传递的鼻内黏附生物材料：平台设计和有时间限制的中枢神经系统暴露的模型信息翻译。

IF 2.9 4区医学

Pharmaceutical Development and Technology Pub Date : 2026-06-01 Epub Date: 2026-07-03 DOI: 10.1080/10837450.2026.2689058

Tae-Yoon Kim, Jung-Hyun Kim

{"title":"Intranasal mucoadhesive biomaterials for nose-to-brain neuroactive delivery: platform design and model-informed translation for time-bounded CNS exposure.","authors":"Tae-Yoon Kim, Jung-Hyun Kim","doi":"10.1080/10837450.2026.2689058","DOIUrl":"10.1080/10837450.2026.2689058","url":null,"abstract":"Intranasal nose-to-brain delivery remains difficult to translate because regional deposition, mucociliary clearance, epithelial transport, local instability, tolerability feedback, and systemic absorption jointly determine central nervous system (CNS) exposure. This evidence-mapping review evaluates mucoadhesive biomaterial platforms as formulation-development tools for improving residence, release control, deposition reproducibility, and exposure interpretability in neuroactive intranasal delivery, using insomnia-relevant timing requirements as a stringent case for controlled onset and offset. PubMed/MEDLINE, Embase, Web of Science Core Collection, and Scopus were searched from 1 January 2008 to 30 April 2026. Seventeen primary intranasal platform studies were included; route-attribution credibility was high in five studies, moderate in five, low in six, and not assessable in one. Platform classes included in situ gelling depots, pre-formed gels, polymeric nanoparticles, lipid or vesicular carriers, hybrid nanoparticle-in-gel systems, and device-coupled dry powders. Key formulation variables were translated into development endpoints, including rheology, gelation, mucoadhesion, release kinetics, deposition, permeability, systemic leakage, and nasal tolerability. The proposed model-informed strategies are conceptual; no new physiologically based pharmacokinetic simulations were performed. Successful platforms should be judged by reproducible onset, controlled offset, bounded systemic exposure, and recovery-phase safety rather than by peak brain concentrations or targeting ratios alone.","PeriodicalId":20004,"journal":{"name":"Pharmaceutical Development and Technology","volume":" ","pages":"862-876"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Capryol-ethyl oleate self-microemulsifying system for improved intestinal absorption and hypoglycemic activity of empagliflozin. 改善恩格列净肠道吸收和降血糖活性的油酸辛醇-乙酯自微乳化系统。

IF 2.9 4区医学

Pharmaceutical Development and Technology Pub Date : 2026-06-01 Epub Date: 2026-05-20 DOI: 10.1080/10837450.2026.2674731

Eglal M Hathout, Suleiman S Eltokhy, Dalia H Abdelkader, Gamal M El Maghraby

{"title":"Capryol-ethyl oleate self-microemulsifying system for improved intestinal absorption and hypoglycemic activity of empagliflozin.","authors":"Eglal M Hathout, Suleiman S Eltokhy, Dalia H Abdelkader, Gamal M El Maghraby","doi":"10.1080/10837450.2026.2674731","DOIUrl":"10.1080/10837450.2026.2674731","url":null,"abstract":"Empagliflozin (EMPA) is a poorly permeable oral hypoglycemic agent. It is potential substrate for P-glycoprotein (P-gp). This work assessed the impact of anatomical sites on EMPA intestinal absorption and assessed self-microemulsifying drug delivery systems (SMEDDS) as a novel strategy for augmented intestinal permeability and oral hypoglycemia of EMPA. A pseudo-ternary phase diagram was used to select a nano-formulation encompassing 60% tween 60: 30% transcutol: 5% capryol: 5% ethyl oleate. This was characterized for droplet size which was 31.2 nm, PDI was 0.292, and zeta potential which was -1.2 mV. EMPA absorption was assessed using in situ intestinal absorption, and the system was evaluated in vivo using diabetic rats. In situ intestinal absorption studies from aqueous solutions demonstrated poor permeability of EMPA from all tested segments relating to the regional distribution of P-gp efflux transporters. Perfusion of EMPA as microemulsion resulting from reconstitution of SMEDDS enhanced ileal and colonic absorption by 1.9 and 1.85-fold, respectively. Furthermore, in vivo studies demonstrated significant augmentation in oral hypoglycemic activity of EMPA, revealed as 1.45-fold elevation in area under blood glucose reduction curve after administration of SMEDDS compared to EMPA aqueous dispersion. SMEDDS formulation successfully improved intestinal absorption, hypoglycemic efficacy and hence oral bioavailability of EMPA.","PeriodicalId":20004,"journal":{"name":"Pharmaceutical Development and Technology","volume":" ","pages":"778-793"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147960203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mixture design-modelling and optimization of ketoprofen solid lipid nanoparticles for augmented anti-inflammatory activity following pharmacodynamic evaluation in rats. 酮洛芬固体脂质纳米颗粒增强大鼠抗炎活性的混合物设计建模和优化。

IF 2.9 4区医学

Pharmaceutical Development and Technology Pub Date : 2026-06-01 Epub Date: 2026-05-31 DOI: 10.1080/10837450.2026.2673037

Amal Abdullah Alrashidi, Mostafa M Bahaa, Esmat E Zain Eldein, Ahmed M Abdelhaleem Ali, Mohamed A Etman, Heba A Yassin

{"title":"Mixture design-modelling and optimization of ketoprofen solid lipid nanoparticles for augmented anti-inflammatory activity following pharmacodynamic evaluation in rats.","authors":"Amal Abdullah Alrashidi, Mostafa M Bahaa, Esmat E Zain Eldein, Ahmed M Abdelhaleem Ali, Mohamed A Etman, Heba A Yassin","doi":"10.1080/10837450.2026.2673037","DOIUrl":"10.1080/10837450.2026.2673037","url":null,"abstract":"Topical administration of non-steroidal anti-inflammatory drugs (NSAIDs) is often limited by poor skin permeability and short duration of action. Solid lipid nanoparticles (SLNs) offer a promising carrier system to enhance dermal delivery and sustain local therapeutic effects. This study aimed to formulate and optimize ketoprofen (KP)-loaded SLNs to improve its efficacy in topical inflammatory conditions. A mixture design was applied for modeling and optimization of formulation variables. SLNs were prepared using hot melting and solvent evaporation techniques and characterized for particle size, polydispersity index (PDI), zeta potential, entrapment efficiency, and drug release. Pharmacodynamic evaluation was conducted using a carrageenan-induced paw edema model in rats, compared with a marketed formulation (FASTUM gel 2.5%). The optimized SLNs showed a particle size of 51.9±4.55 nm, PDI of 0.398±0.02, and zeta potential of -14.2±0.61 mV, indicating acceptable stability. The optimized formulation significantly reduced paw edema by 57.65% and decreased PGE2 and TNF-α levels by 55.6% and 58.4%, respectively (P < 0.05). Additionally, the SLN gel exhibited enhanced bioadhesion (+81%) and doubled permeation flux compared to the pure drug gel. These findings support SLNs as an effective platform for topical NSAID delivery.","PeriodicalId":20004,"journal":{"name":"Pharmaceutical Development and Technology","volume":" ","pages":"744-763"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147942358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coreopsis tinctoria-loaded gels for dermal delivery: development, optimization, retention capacity, and skin photoaging repair. 用于皮肤递送的药用胶：开发、优化、保留能力和皮肤光老化修复。

IF 2.9 4区医学

Pharmaceutical Development and Technology Pub Date : 2026-06-01 Epub Date: 2026-05-11 DOI: 10.1080/10837450.2026.2669970

Juan Du, Keke Tao, Xinmei Chen

{"title":"Coreopsis tinctoria-loaded gels for dermal delivery: development, optimization, retention capacity, and skin photoaging repair.","authors":"Juan Du, Keke Tao, Xinmei Chen","doi":"10.1080/10837450.2026.2669970","DOIUrl":"10.1080/10837450.2026.2669970","url":null,"abstract":"This study aimed to develop dermal gels loaded with Coreopsis tinctoria (CTGs) and evaluate its therapeutic effect against skin photoaging. The formulation was optimized using viscosity, water loss rate and moisture retention rate as evaluation indexes, and CTGs were prepared and characterized. Dermal release was investigated, and skin retention was evaluated using fluorescence imaging. Finally, a mouse skin photoaging model was established using ultraviolet B (UVB) to evaluate the effects of CTGs on improving skin condition and repairing photoaging damage. CTGs with uniform appearance, appropriate viscosity and good stability were successfully prepared. In vitro drug release from CTGs followed the Korsmeyer-Peppas model. Compared with the liquid formulation, CTGs significantly prolonged skin retention time and improved skin adhesion within 8 h. CTGs attenuated UVB-induced dermal damage, increased SOD activity and hydroxyproline (Hyp) content, and reduced MDA content and tyrosinase (Tyr) activity, indicating strong antioxidant and tyrosinase inhibitory activity. CTGs represent a promising dermal delivery strategy for ameliorating skin photoaging and abnormal pigmentation.","PeriodicalId":20004,"journal":{"name":"Pharmaceutical Development and Technology","volume":" ","pages":"729-743"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface engineering of nanocarriers with polymer coatings: materials, strategies, functional outcomes, and clinical translation. 高分子涂层纳米载体的表面工程：材料、策略、功能结果和临床转化。

IF 2.9 4区医学

Pharmaceutical Development and Technology Pub Date : 2026-06-01 Epub Date: 2026-06-29 DOI: 10.1080/10837450.2026.2693861

Hassan Gamal Mostafa, Nermin M Sheta, Michael M Farag, Rania Moataz El-Dahmy, Sally A Abdel Halim

{"title":"Surface engineering of nanocarriers with polymer coatings: materials, strategies, functional outcomes, and clinical translation.","authors":"Hassan Gamal Mostafa, Nermin M Sheta, Michael M Farag, Rania Moataz El-Dahmy, Sally A Abdel Halim","doi":"10.1080/10837450.2026.2693861","DOIUrl":"10.1080/10837450.2026.2693861","url":null,"abstract":"Polymer coating of nanocarriers has emerged as a powerful strategy to improve the performance of advanced drug delivery systems by enhancing stability, bioavailability, targeting capability, and therapeutic efficiency. Surface functionalization with biocompatible polymers can significantly modify the physicochemical and biological behavior of nanoparticles, enabling improved interaction with biological barriers and controlled drug release profiles. This review provides a comprehensive overview of the most widely used polymers for nanocarrier surface modification, including chitosan, alginate, hyaluronic acid, polyethylene glycol (PEG), methacrylate copolymers, pectin, dextran, and poly-L-lysine. The mechanisms by which these polymers enhance nanocarrier functionality are discussed in detail. In addition, the review summarizes commonly employed coating techniques such as adsorption, covalent conjugation, layer-by-layer assembly, and polymer grafting, highlighting their influence on nanoparticle characteristics and therapeutic performance. Particular emphasis is placed on the pharmaceutical outcomes associated with polymer-coated nanocarriers, including improved drug stability, enhanced bioavailability, site-specific targeting, and prolonged circulation time. Finally, the major scientific, manufacturing, safety, and regulatory challenges that limit the clinical translation of polymer-coated nanocarrier systems are critically discussed. Overall, polymer surface engineering represents a promising approach for the development of next-generation nanomedicines, although further advances in large-scale manufacturing, standardized characterization, and regulatory frameworks are required to facilitate their successful clinical and commercial implementation.","PeriodicalId":20004,"journal":{"name":"Pharmaceutical Development and Technology","volume":" ","pages":"877-905"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148302569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0