Pharmaceutical Development and Technology最新文献

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Drug Content Determination of Low-Dosed Hot-Melt Extruded Filaments using Raman Spectroscopy 利用拉曼光谱测定低剂量热熔挤出长丝的药物含量
IF 3.4 4区 医学
Pharmaceutical Development and Technology Pub Date : 2024-02-26 DOI: 10.1080/10837450.2024.2323622
Rebecca Chamberlain, Jörg Breitkreutz, Björn Fischer
{"title":"Drug Content Determination of Low-Dosed Hot-Melt Extruded Filaments using Raman Spectroscopy","authors":"Rebecca Chamberlain, Jörg Breitkreutz, Björn Fischer","doi":"10.1080/10837450.2024.2323622","DOIUrl":"https://doi.org/10.1080/10837450.2024.2323622","url":null,"abstract":"The aim of this study was to evaluate the suitability of a non-disruptive Raman spectroscopic method to quantify drug concentrations below 5 w% within a polymer matrix produced by hot-melt extrusio...","PeriodicalId":20004,"journal":{"name":"Pharmaceutical Development and Technology","volume":"2016 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139968968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoparticles as carriers of photosensitizers to improve photodynamic therapy in cancer 纳米颗粒作为光敏剂载体,改善癌症的光动力疗法
IF 3.4 4区 医学
Pharmaceutical Development and Technology Pub Date : 2024-02-26 DOI: 10.1080/10837450.2024.2322570
Duy Hieu Truong, Phuong Thi Thu Tran, Tuan Hiep Tran
{"title":"Nanoparticles as carriers of photosensitizers to improve photodynamic therapy in cancer","authors":"Duy Hieu Truong, Phuong Thi Thu Tran, Tuan Hiep Tran","doi":"10.1080/10837450.2024.2322570","DOIUrl":"https://doi.org/10.1080/10837450.2024.2322570","url":null,"abstract":"Photodynamic therapy (PDT) has emerged as a promising non-invasive therapeutic approach for cancer treatment, offering unique advantages over conventional treatments. The combination of light activ...","PeriodicalId":20004,"journal":{"name":"Pharmaceutical Development and Technology","volume":"79 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139968967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fabrication of controlled-release polymeric microneedles containing progesterone-loaded self-microemulsions for transdermal delivery. 制造含有黄体酮自微乳剂的控释聚合物微针,用于透皮给药。
IF 3.4 4区 医学
Pharmaceutical Development and Technology Pub Date : 2024-02-01 Epub Date: 2024-02-03 DOI: 10.1080/10837450.2024.2307996
Phuvamin Suriyaamporn, Porawan Aumklad, Theerasak Rojanarata, Prasopchai Patrojanasophon, Tanasait Ngawhirunpat, Boonnada Pamornpathomkul, Praneet Opanasopit
{"title":"Fabrication of controlled-release polymeric microneedles containing progesterone-loaded self-microemulsions for transdermal delivery.","authors":"Phuvamin Suriyaamporn, Porawan Aumklad, Theerasak Rojanarata, Prasopchai Patrojanasophon, Tanasait Ngawhirunpat, Boonnada Pamornpathomkul, Praneet Opanasopit","doi":"10.1080/10837450.2024.2307996","DOIUrl":"10.1080/10837450.2024.2307996","url":null,"abstract":"<p><p>Progesterone (PG) has been approved for hormone replacement therapy to mitigate the risk of endometrial carcinoma. However, there has been a lack of success in oral PG due to its rapid degradation. Transdermal PG has advantages but lacks efficacy due to its poor solubility (Log <i>p</i> = 3.9). Therefore, this study aimed to evaluate how combining self-microemulsifying drug delivery systems (SMEDDS) and polymeric microneedles (MNs) could improve the transdermal delivery of PG in a controlled-release manner. Among PG-SMEDDS, PG-SME5 was selected for its desirable properties and stability. The two-layer polymeric MNs formulation incorporating PG-SME5 (PG-SMEDDS-tMNs) was formulated from aqueous blends of polymers as a first layer and 20% PCL as a second layer. It successfully penetrated neonatal porcine skin with the dissolution of the first layer observed within 15 min after application. <i>In vitro</i> skin permeation revealed that the percentage of PG which permeated the skin over 82 h using PG-SMEDDS-tMNs was higher than a PG-suspension and PG-SMEDDS. The Higuchi kinetic showed controlled release over 15 days of PG from PG-SMEDDS-tMNs. These studies suggested that incorporating PG-SMEDDS into controlled-release two-layer polymeric MNs could be a promising approach for improving the transdermal delivery of PG.</p>","PeriodicalId":20004,"journal":{"name":"Pharmaceutical Development and Technology","volume":" ","pages":"98-111"},"PeriodicalIF":3.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139521609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and efficacy evaluation of a novel water-in-oil-in-water adjuvant for an inactivated foot-and-mouth disease vaccine. 用于口蹄疫灭活疫苗的新型水包油佐剂的开发与药效评估
IF 3.4 4区 医学
Pharmaceutical Development and Technology Pub Date : 2024-02-01 Epub Date: 2024-01-17 DOI: 10.1080/10837450.2024.2305107
Rong Zhang, Yanming Wei, Xuerong Liu, Yongshu Wu
{"title":"Development and efficacy evaluation of a novel water-in-oil-in-water adjuvant for an inactivated foot-and-mouth disease vaccine.","authors":"Rong Zhang, Yanming Wei, Xuerong Liu, Yongshu Wu","doi":"10.1080/10837450.2024.2305107","DOIUrl":"10.1080/10837450.2024.2305107","url":null,"abstract":"<p><p>To develop a novel water-in-oil-in-water (W/O/W) adjuvant and evaluate the effect on foot-and-mouth disease (FMD) inactivated vaccine, in this study, we prepared the novel nano-emulsion adjuvant based on QS-21 (BEA) which is composed of the mixture of mineral oil Marcol52, surfactant Tween80, oleate polyoxyethylene ether ester, polyoxyethylene palmitic acid ester and span80, cosurfactant polyethylene glycol and QS-21. The two-step emulsification method formed the W/O/W nano-emulsion with two films and three-phase structures. The effective particle diameter of the BEA was about 184 nm, and it has good thermal stability. Then, BEA was emulsified as an adjuvant to prepare for the inactivated FMDV vaccine, and BALB/c mice and pigs were immunized to evaluate its safety and immunization effect. The results showed that the inactivated BEA-FMDV vaccine significantly increased BALB/c mice and pigs' antibodies and cytokine IFN-γ in serum. Meanwhile, the pig-neutralizing antibodies were higher than control group. Safety tests found no symptoms of FMD or significant toxic reactions. After 28 days of immunization, the protection rate can reach 93.3%. The BEA vaccine had good stability at 4 °C, no stratification after 180 days, and the content of 146S in the vaccine did not decrease. In conclusion, the BEA prepared in this study is suitable for FMDV inactivated vaccine and is an effective adjuvant.</p>","PeriodicalId":20004,"journal":{"name":"Pharmaceutical Development and Technology","volume":" ","pages":"75-85"},"PeriodicalIF":3.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139467020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oridonin loaded peptide nanovesicles alleviate nonalcoholic fatty liver disease in mice. 装载奥利多宁的肽纳米粒子能缓解小鼠的非酒精性脂肪肝。
IF 3.4 4区 医学
Pharmaceutical Development and Technology Pub Date : 2024-02-01 Epub Date: 2024-02-19 DOI: 10.1080/10837450.2024.2315460
Lifen Zhang, Yao Yu, Qi Wang, Xi Huang, Zheng Feng, Zhi Li
{"title":"Oridonin loaded peptide nanovesicles alleviate nonalcoholic fatty liver disease in mice.","authors":"Lifen Zhang, Yao Yu, Qi Wang, Xi Huang, Zheng Feng, Zhi Li","doi":"10.1080/10837450.2024.2315460","DOIUrl":"10.1080/10837450.2024.2315460","url":null,"abstract":"<p><p>This study was to construct a nanovesicle delivery system to improve the loading efficiency and stability of ORI for the treatment of nonalcoholic fatty liver disease (NAFLD). This nanovesicles (NVs) exerted a narrow size distribution (195.6 ± 11.49 nm) and high entrapment efficiency (84.46 ± 1.34%). <i>In vitro</i> cell studies demonstrated that the NVs treatment enhanced the cellular uptake of ORI and reduced lipid over-accumulation and total cholesterol levels in NAFLD cell model. At the same time, <i>in vivo</i> study proved that, compared with the normal group, the model group mice showed a decrease in body weight, a significant increase in liver index (6.71 ± 0.62, <i>p</i> < 0.01), and symptoms of liver lipid accumulation, lipid vesicles, and liver tissue fibrosis. Compared with the model group, after high-dose ORI NVs intervention, mice gained weight, decreased liver index (4.69 ± 0.55, <i>p</i> < 0.01), reduced hepatic lipid droplet vacuoles, reduced lipid accumulation (reduced oil red area, <i>p</i> < 0.001), and alleviated the degree of liver fibrosis (reduced blue collagen area, <i>p</i> < 0.001). In conclusion, ORI/HP-β-CD/H9-HePC NVs showed specific liver accumulation and improved therapeutic effects, the nano drug loading system provides a promising strategy for the encapsulation of ORI to effectively alleviate the process of NAFLD.</p>","PeriodicalId":20004,"journal":{"name":"Pharmaceutical Development and Technology","volume":" ","pages":"123-130"},"PeriodicalIF":3.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139703129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solid self-microemulsifying drug delivery system (S-SMEDDS) prepared by spray drying to improve the oral bioavailability of cinnamaldehyde (CA). 通过喷雾干燥法制备固体自微乳化给药系统(S-SMEDDS),以提高肉桂醛(CA)的口服生物利用度。
IF 3.4 4区 医学
Pharmaceutical Development and Technology Pub Date : 2024-02-01 Epub Date: 2024-02-09 DOI: 10.1080/10837450.2024.2312851
Yun Meng, Ye Cai, Mengyao Cui, Yuhang Xu, Long Wu, Xiang Li, Xiaoqin Chu
{"title":"Solid self-microemulsifying drug delivery system (S-SMEDDS) prepared by spray drying to improve the oral bioavailability of cinnamaldehyde (CA).","authors":"Yun Meng, Ye Cai, Mengyao Cui, Yuhang Xu, Long Wu, Xiang Li, Xiaoqin Chu","doi":"10.1080/10837450.2024.2312851","DOIUrl":"10.1080/10837450.2024.2312851","url":null,"abstract":"<p><p>The aim of this study was to prepare a solid self-microemulsifying drug delivery system (S-SMEDDS) of cinnamaldehyde (CA) by spray drying technique to improve the oral bioavailability of CA. The preparation of CA S-SMEDDS with maltodextrin as the solid carrier, a core-wall material mass ratio of 1:1, a solid content of 20% (w/v), an inlet air temperature of 150 °C, an injection speed of 5.2 mL/min, and an atomization pressure of 0.1 MPa was determined by using the encapsulation rate as the index of investigation. Differential scanning calorimetry (DSC) revealed the possibility of CA being encapsulated in S-SMEDDS in an amorphous form. The <i>in-vitro</i> release showed that the total amount of CA released by S-SMEDDS was approximately 1.3 times higher than that of the CA suspension. Pharmacokinetic results showed that the relative oral bioavailability of CA S-SMEDDS was also increased to 1.6-fold compared to CA suspension. Additionally, we explored the mechanism of CA uptake and transport of lipid-soluble drugs CA by S-SMEDDS in a Caco-2/HT29 cell co-culture system for the first time. The results showed that CA S-SMEDDS uptake on the co-culture model was mainly an energy-dependent endocytosis mechanism, including lattice protein-mediated endocytosis and vesicle-mediated endocytosis. Transport experiments showed that CA S-SMEDDS significantly increased the permeability of CA in this model. These findings suggested that CA S-SMEDDS is an effective oral solid dosage form for increasing the oral bioavailability of lipid-soluble drug CA.</p>","PeriodicalId":20004,"journal":{"name":"Pharmaceutical Development and Technology","volume":" ","pages":"112-122"},"PeriodicalIF":3.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139672402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation and evaluation of vaginal suppo-sponges loaded with benzydamine, in-vitro/in-vivo study. 制备和评估装有苄达明的阴道海绵,体外/体内研究
IF 3.4 4区 医学
Pharmaceutical Development and Technology Pub Date : 2024-02-01 DOI: 10.1080/10837450.2024.2306803
Noha S El-Salamouni, Marwa A Yakout, Gihan S Labib, Ragwa M Farid
{"title":"Preparation and evaluation of vaginal suppo-sponges loaded with benzydamine, <i>in-vitro/in-vivo study</i>.","authors":"Noha S El-Salamouni, Marwa A Yakout, Gihan S Labib, Ragwa M Farid","doi":"10.1080/10837450.2024.2306803","DOIUrl":"10.1080/10837450.2024.2306803","url":null,"abstract":"<p><p>This study aimed to design a new Benzydamine HCl (BNZ) suppo-sponge for controlled, mucoadhesive dosage form for vaginal candidiasis treatment, offering advantages over traditional creams, ointments, or gels. BNZ-loaded suppo-sponges were fabricated by simple casting / freeze-drying technique utilizing the cross-linking of chitosan (Cs) with vanillin (V). Vaginal suppo-sponges were prepared based on different vanillin cross-linking ratios (V).<sub>n</sub>), from 0 to 2%w/w. To best of our knowledge, this is the first study that uses Schiff's base between chitosan and vanillin as a drug delivery system to treat fungal vaginal infections. Schiff's base formation was confirmed by FT-IR. <i>In-vitro</i> appraisal showed acceptable physical and mechanical characteristics. Formulations based on cross-linking of Cs with V showed a more pronounced <i>in-vitro</i> antifungal activity. <i>In-vitro</i> drug release revealed a prolonged release pattern, becoming more noticeable with the higher cross-linked suppo-sponges (22.34% after 8 h). In-vivo testing of CsV<sub>2</sub> suppo-sponge indicated a more pronounced reduction in fungal count than both CsV<sub>0</sub> and Tantum<sup>®</sup> Rosa in the first week, with a peak reduction on day 7 and the 10<sup>th</sup> and 11<sup>th</sup> days of the second week. Conclusively, Chitosan/vanillin suppo-sponges represent a promising delivery system for drugs intended for local treatment of vaginal candidiasis. than both CsV<sub>0</sub> and Tantum<sup>®</sup> Rosa in the first week, with a peak reduction on day 7 and the 10<sup>th</sup> and 11<sup>th</sup> days of the second week. Conclusively, Chitosan/vanillin suppo-sponges represent a promising delivery system for drugs intended for local treatment of vaginal candidiasis.</p>","PeriodicalId":20004,"journal":{"name":"Pharmaceutical Development and Technology","volume":" ","pages":"86-97"},"PeriodicalIF":3.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139501893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An innovative carrier for the formulation of amorphous solid dispersion by hot-melt extrusion with no further downstream processes: a case study with indomethacin. 通过热熔挤出法配制无定形固体分散体的创新载体,无需进一步的下游工艺:吲哚美辛案例研究。
IF 3.4 4区 医学
Pharmaceutical Development and Technology Pub Date : 2024-02-01 Epub Date: 2024-01-25 DOI: 10.1080/10837450.2024.2306802
S P Lacerda, S Del Confetto, L Haurie, M Bernard, S Faget, M I Ré
{"title":"An innovative carrier for the formulation of amorphous solid dispersion by hot-melt extrusion with no further downstream processes: a case study with indomethacin.","authors":"S P Lacerda, S Del Confetto, L Haurie, M Bernard, S Faget, M I Ré","doi":"10.1080/10837450.2024.2306802","DOIUrl":"10.1080/10837450.2024.2306802","url":null,"abstract":"<p><p>The aim of this work was to study the possibility to use Sepitrap<sup>TM</sup> as a carrier for the formulation of amorphous solid dispersions by HME (hot melt extrusion) processing aiming solubility enhancement of poorly water<b>-</b>soluble drugs. Sepitrap<sup>TM</sup> is a microencapsulated powder solubilizer designed to simplify the manufacture of drugs in oral solid forms, not yet tested for this purpose. The performance of Sepitrap<sup>TM</sup> was evaluated in HME processing for amorphous solid dispersions of poorly-water soluble drugs with indomethacin as a model drug. The study was conducted using a twin-screw extruder, two compositions of Sepitrap<sup>TM</sup> and different loads of indomethacin, demonstrating that Sepitrap<sup>TM</sup> could represent a new range of carriers for amorphous solid dispersions for HME processing, reducing necessary downstream steps such as grinding.</p>","PeriodicalId":20004,"journal":{"name":"Pharmaceutical Development and Technology","volume":" ","pages":"131-142"},"PeriodicalIF":3.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139485660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel bioequivalent oral disintegrating tablet of aripiprazole prepared by direct compression technique with shortened disintegration time. 采用直接压片技术制备的新型生物等效阿立哌唑口腔崩解片,缩短了崩解时间。
IF 3.4 4区 医学
Pharmaceutical Development and Technology Pub Date : 2024-01-01 Epub Date: 2024-01-12 DOI: 10.1080/10837450.2024.2301780
Do Hwan Kim, Jun Soo Park, Min Young Jeong, In Gyu Yang, Wookyung Kim, Seung Bo Shim, Hye Seon Kim, Hyun Yang Park, Myoung Jin Ho, Myung Joo Kang
{"title":"Novel bioequivalent oral disintegrating tablet of aripiprazole prepared by direct compression technique with shortened disintegration time.","authors":"Do Hwan Kim, Jun Soo Park, Min Young Jeong, In Gyu Yang, Wookyung Kim, Seung Bo Shim, Hye Seon Kim, Hyun Yang Park, Myoung Jin Ho, Myung Joo Kang","doi":"10.1080/10837450.2024.2301780","DOIUrl":"10.1080/10837450.2024.2301780","url":null,"abstract":"<p><p>Herein, we aimed to formulate a novel oral disintegrating tablet (ODT) of aripiprazole (ARP) capable of rapid disintegration using a direct compression technique. Different ODTs were fabricated with directly compressible excipients, and their disintegration time, wettability (water absorption ratio and wetting time), and mechanical properties (hardness and friability) were evaluated. The optimized ODT comprised F-Melt® type C, Prosolv® SMCC HD90, and Na croscarmellose (10 mg of ARP in a 130 mg tablet). The ODT with 3.1-5.2 kp hardness exhibited rapid disintegration (14.1-17.2 sec), along with appropriate mechanical strength (friability < 0.24%). In a bioequivalent study in Korean healthy subjects (randomized, single-dose, two-period crossover design, <i>n</i> = 37), the novel ODT offered the equivalent pharmacokinetic profile to that of a conventional immediate release tablet (Otsuka, Abilify®, Japan), despite different disintegration and dissolution profiles. The 90% confidence intervals of the geometric mean test to reference ratios considering the area-under-the-curve and maximum plasma drug concentrations were 1.0306-11051 and 0.9448-1.1063, respectively, satisfying FDA regulatory criteria for bioequivalence. The novel ART ODT was physicochemically stable under the accelerated storage condition (40 °C, RH75%) for 24 weeks. Therefore, the novel ARP-loaded ODT is expected to be an alternative to oral ARP therapy, providing improved patient adherence.</p>","PeriodicalId":20004,"journal":{"name":"Pharmaceutical Development and Technology","volume":" ","pages":"62-73"},"PeriodicalIF":3.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139378170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficient treatment of colon cancer with codelivery of TRAIL and imatinib by liposomes. 用脂质体联合递送 TRAIL 和伊马替尼有效治疗结肠癌。
IF 3.4 4区 医学
Pharmaceutical Development and Technology Pub Date : 2024-01-01 Epub Date: 2024-01-30 DOI: 10.1080/10837450.2024.2301763
Rongrong Fu, Rui Chang, Andong Peng, Changshun Feng, Weifan Zhu, Yi Chen, Xue Tian, Rui Wang, Hui Yan, Dianlong Jia, Jun Li
{"title":"Efficient treatment of colon cancer with codelivery of TRAIL and imatinib by liposomes.","authors":"Rongrong Fu, Rui Chang, Andong Peng, Changshun Feng, Weifan Zhu, Yi Chen, Xue Tian, Rui Wang, Hui Yan, Dianlong Jia, Jun Li","doi":"10.1080/10837450.2024.2301763","DOIUrl":"10.1080/10837450.2024.2301763","url":null,"abstract":"<p><p>To solve the problem of resistance of tumor cells to TRAIL and the inevitable side effects of imatinib during treatment, we successfully prepared a kind of multifunctional liposome that encapsulated imatinib in its internal water phase and inserted TRAIL on its membrane in this study, which named ITLPs. The liposomes appeared uniform spherical and the particle size was approximately 150 nm. ITLPs showed high accumulation in TRAIL-resistance cells and HT-29 tumor-bearing mice model. In vitro cytotoxicity assay results showed that the killing activity of HT-29 cells treated with ITLPs increased by 50% and confirmed that this killing activity was mediated by the apoptosis pathway. Through mechanism studies, it was found that ITLPs arrested up to 32.3% of cells in phase M to exert anti-tumor effects. In vivo anti-tumor study showed that ITLPs achieved 61.8% tumor suppression and little toxicity in the HT-29 tumor-bearing mice model. Overall results demonstrated that codelivery of imatinib and TRAIL via liposomes may be a prospective method in the treatment of the TRAIL-resistance tumor.</p>","PeriodicalId":20004,"journal":{"name":"Pharmaceutical Development and Technology","volume":" ","pages":"52-61"},"PeriodicalIF":3.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139478774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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