Patient preference and adherence最新文献

{"title":"Use of Vitamins and Supplements During Pregnancy and Their Association with Maternal and Birth Outcomes: A Prospective Cohort Study.","authors":"Rahma Odeh Alshdaifat, Esra' O Taybeh, Zina Al-Alami, Abdallah Y Naser, Derar H Abdel-Qader, Alaa A Alsharif, Adnan Taybeh","doi":"10.2147/PPA.S609347","DOIUrl":"10.2147/PPA.S609347","url":null,"abstract":"<p><strong>Background: </strong>Previous research shows that sufficient maternal nutrition is essential for good maternal and fetal outcomes; however, maternal use of prenatal supplements might vary.</p><p><strong>Objective: </strong>The study tracks the type and the patterns of maternal supplement use in a Jordanian cohort, evaluating rates of adherence through pregnancy and exploring maternal and birth outcomes.</p><p><strong>Methodology: </strong>A prospective cohort study was conducted from February 2023 until March 2025 with 199 pregnant women enrolled through convenience sampling from the second trimester up to delivery, at Gynecologic and Pediatric Mafraq Government Hospital, Jordan. Assessment was done through structured interviews and medical record reviews at baseline, at monthly antenatal visits, and a clinical assessment at month seven of gestation. Information collected included sociodemographic data, medical and obstetric history, details of supplement use, maternal and neonatal outcomes.</p><p><strong>Results: </strong>Among the participants, the most used supplements were folic acid (82.9%) and iron (71.9%). Overall adherence to supplements was 63.8% with fluctuations across trimesters of pregnancy. Seven significant univariate associations were identified: low birth weight with multivitamin non-use, urinary tract infection (UTI) with calcium use, gestational hypertension with non-use of magnesium, iron, folic acid, and omega-3, and cesarean delivery with non-use of calcium and vitamin D (p<0.05). Only iron and magnesium were shown to be significantly associated with gestational hypertension (adjusted p=0.019) following Benjamini-Hochberg FDR adjustment for multiple comparisons; the other associations are considered exploratory. Following multivariable adjustment for covariates, calcium continued to be associated with increased odds of UTI (aOR=2.70) and decreased odds of cesarean birth (aOR=0.52), whereas iron and omega-3 continued to be associated with lower odds of gestational hypertension (aOR=0.13 and 0.09, respectively).</p><p><strong>Conclusion: </strong>Appropriate use of vitamins and supplements during pregnancy appears important, as insufficient intake of some supplements was associated with negative pregnancy and neonatal outcomes. Despite that the study findings do not establish causality; they support the importance of promoting proper supplement intake and adherence during pregnancy to prevent deficiency-related outcomes. Further studies are needed to confirm these associations.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"20 ","pages":"609347"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13546069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From \"Rational Agent\" to \"Bounded Rationality\": A Qualitative Study of Decision-Making Biases in Exercise Behavior Among Post-PCI Patients with Coronary Heart Disease.","authors":"Tiantian Xia, Hongyuan Li, Lei Liu, Runyang Jin, Yunqiao Xie, Guangying Zhang, Yutong Han, Haiyang Xing, Yingjie Wang, Jiayu Wang","doi":"10.2147/PPA.S631391","DOIUrl":"10.2147/PPA.S631391","url":null,"abstract":"<p><strong>Background: </strong>The participation rate of exercise training among post-PCI patients with CHD is low, and their exercise behavior decisions are often influenced by bounded rationality, leading to decision-making biases. However, existing studies lack in-depth exploration. Qualitative research can provide an in-depth understanding of patients' descriptions of their exercise behaviors and their actual experiences, thereby helping to systematically identify these decision-making biases.</p><p><strong>Objective: </strong>To explore the descriptions and related experiences of post-PCI patients with coronary heart disease regarding their own exercise behaviors, and to systematically identify the types of decision-making biases.</p><p><strong>Design: </strong>A qualitative descriptive study design.</p><p><strong>Methods: </strong>From December 2025 to February 2026, semi-structured face-to-face interviews were conducted with hospitalized post-PCI patients, and thematic analysis was used for coding and theme extraction.</p><p><strong>Results: </strong>This study enrolled 20 patients. Three major bias types (information perception bias, risk perception bias, and self-regulation bias) and eight specific manifestations. These included individual cognitive fixation, authoritative information transformation, autonomous information compensation, somatic state perception, negative reference constraint, exercise risk generalization, subjective will determination, and daily activity replacement.</p><p><strong>Conclusion: </strong>Decision-making biases have a considerable impact on exercise behaviour in post-PCI patients with CHD. This process is profoundly influenced by immediate somatic sensations, reference to others' experiences, vague concerns about exercise risk, and the replacement of structured exercise with daily activities, leading patients to prefer decisions that afford immediate psychological safety or convenience.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"20 ","pages":"631391"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13546058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negotiating Medication Adherence in Everyday Life with Inflammatory Bowel Disease: A Qualitative Study.","authors":"Emilie Ljungström, Henrik Hjortswang, Michael Eberhardson, Katarina Pihl Lesnovska","doi":"10.2147/PPA.S640901","DOIUrl":"10.2147/PPA.S640901","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory bowel disease (IBD), including Crohn's disease, ulcerative colitis, and IBD unclassified, is a chronic condition that can affect daily life. Maintenance therapy is essential, yet non-adherence remains common and may compromise treatment outcomes. This study aimed to explore how adults with IBD understand, negotiate, and enact medication adherence as part of everyday self-care.</p><p><strong>Methods: </strong>Inductive, qualitative, semi-structured interviews were conducted with adults diagnosed with IBD at a gastroenterology clinic in Sweden. Interviews were audio-recorded, transcribed verbatim, and analysed using content analysis.</p><p><strong>Results: </strong>Fifteen interviews were conducted (9 ulcerative colitis, 5 Crohn's disease, 1 IBD-U). Three main categories were identified: illness perceptions, healthcare perceptions, and treatment perceptions. Medication adherence was described as an ongoing process shaped by how participants interpreted symptoms, adapted to life with IBD, and evaluated the need for treatment. Participants weighed the perceived benefits of medication against concerns about adverse effects and often combined medical treatment with lifestyle-based strategies for symptom management. Trusting communication, continuity of care, and access to relevant information facilitate adherence, while practical treatment burdens and uncertainty regarding disease activity undermined adherence.</p><p><strong>Conclusion: </strong>Medication adherence in IBD is embedded within everyday self-care and influenced by illness perceptions, treatment beliefs, practical challenges, and healthcare encounters. Clinicians should acknowledge patients' concerns, dietary practices, and lifestyle strategies alongside medical treatment. Person-centred communication, clear treatment goals, and shared decision-making may support adherence and strengthen self-care.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"20 ","pages":"640901"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a Pre-Dialysis Breathing and Exercise Program on Quality of Life, Hemodynamic Parameters, and Dialysis Adequacy in Hemodialysis Patients.","authors":"Gizem Zorlu Görgülügil, Aysun Ünal, Gamze Nazik, Esra Kocabıyık, Alperen Burak Kocabıyık, Gökhan Köker, Üstün Yılmaz","doi":"10.2147/PPA.S607954","DOIUrl":"10.2147/PPA.S607954","url":null,"abstract":"<p><strong>Objective: </strong>Physical inactivity and reduced quality of life are common in patients undergoing maintenance hemodialysis. Although intradialytic exercise has been extensively investigated, the effects of structured pre-dialysis exercise combined with breathing techniques on mental well-being, hemodynamic parameters, and dialysis adequacy remain unclear. This study aimed to evaluate the impact of a pre-dialysis structured exercise program on quality of life, hemodynamic status, and dialysis adequacy in maintenance hemodialysis patients.</p><p><strong>Methodology: </strong>This prospective, controlled, non-randomized interventional study was conducted in a tertiary-care hemodialysis unit over 8 weeks. A total of 53 maintenance hemodialysis patients were included. The intervention group received a 20 minute structured exercise and breathing program before each dialysis session, three times weekly, while the control group received standard care. Outcomes included Physical and Mental Component Summary scores derived from SF-36, PSQI, FAS, hemodynamic parameters, Kt/V, and URR. Time × group interactions were analyzed using linear mixed-effects models.</p><p><strong>Results: </strong>A greater increase in MCS was observed in the intervention group; however, the time × group interaction did not reach statistical significance (p=0.081), indicating a trend toward improved mental well-being. Significant reductions were found in systolic blood pressure (p=0.049) and pulse rate (p=0.033). No significant interaction was observed for PCS, PSQI, FAS, diastolic blood pressure, respiratory rate, or oxygen saturation. Significant time - group interactions were detected for Kt/V (p=0.018) and URR (p=0.013); however, the observed changes were small and values remained within clinically acceptable ranges.</p><p><strong>Conclusion: </strong>Pre-dialysis structured exercise was associated with favorable hemodynamic effects and a trend toward improved mental well-being without compromising dialysis adequacy. These preliminary findings suggest that supervised pre-dialysis exercise may be a feasible supportive strategy in hemodialysis care.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"20 ","pages":"607954"},"PeriodicalIF":2.6,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13546035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of the Medication Adherence Scale for Iraqi Patients with Rheumatoid Arthritis (MASIPRA): A Cross-Sectional Study.","authors":"Lamyaa Abdullah Habeeb, Ehab Mudher Mikhael, Mohammed Hadi Alosami","doi":"10.2147/PPA.S624651","DOIUrl":"10.2147/PPA.S624651","url":null,"abstract":"<p><strong>Background: </strong>Adherence to disease-modifying anti-rheumatic drugs (DMARDs) is essential to ensure optimum benefit for rheumatoid arthritis (RA) patients. However, adherence to DMARDs was suboptimal worldwide, especially in developing countries like Iraq. Many adherence scales are available to help healthcare providers assess RA patients' adherence to their prescribed therapies; however, such tools are often generic, lengthy, unavailable in Arabic, or not freely accessible.</p><p><strong>Objective: </strong>To develop and validate the Medication Adherence Scale for Iraqi Patients with Rheumatoid Arthritis (MASIPRA) and examine its psychometric properties.</p><p><strong>Methods: </strong>The Medication Adherence Scale for Iraqi Patients with Rheumatoid Arthritis was developed based on previously validated scales with cultural adaptation. It consists of ten items rated on a 5-point Likert scale. Content validity of MASIPRA was done by a panel of seven experts. Clarity of the scale items was established through testing on ten RA patients. Reliability of MASIPRA was confirmed through testing internal consistency (Cronbach's alpha) and test-retest reliability. Convergent validity was established by correlating the total MASIPRA score with an already validated scale, the Morisky Medication Adherence Scale-4 (MMAS-4). Concurrent validity was confirmed by correlating the MASIPRA score with the RA clinical disease activity index (CDAI).</p><p><strong>Results: </strong>MASIPRA showed good internal consistency (Cronbach's alpha=0.804) and test-retest reliability (r=0.804, p< 0.001). It was strongly and significantly correlated with MMAS-4 (r=0.863, p< 0.001) and significantly but inversely correlated with CDAI (r = -0.278, p=0.005). Compared with the MMAS-4, the MASIPRA showed higher sensitivity and specificity in discriminating RA patients according to their disease activity.</p><p><strong>Conclusion: </strong>The MASIPRA is a brief, reliable, and valid instrument for assessing adherence to DMARDs among Iraqi patients with RA.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"20 ","pages":"624651"},"PeriodicalIF":2.6,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing Attributes and Levels for a Discrete Choice Experiment on Internet Hospital Service Preferences Among Chinese Patients with Chronic Diseases: A Mixed-Methods Study.","authors":"Yichun Gu, Dan Qin, Xin Yang, Wenxing Dong, Botao Tian, Siyu Ding, Ruixiang Li, Yan Bai, Da He","doi":"10.2147/PPA.S607771","DOIUrl":"10.2147/PPA.S607771","url":null,"abstract":"<p><strong>Background: </strong>Internet hospitals are increasingly used to support chronic disease care in China. Although previous research has examined online healthcare preferences, evidence on the systematic development of context-specific attributes and levels for Chinese patients with chronic diseases remains limited.</p><p><strong>Objective: </strong>This study aimed to develop candidate attributes and levels for a future discrete choice experiment (DCE) on Internet hospital preferences among Chinese patients with chronic diseases.</p><p><strong>Methods: </strong>A mixed-methods approach was applied to systematically develop the relevant attributes and levels. Potential attributes were first identified through a systematic literature review. Next, qualitative interviews with 24 patients with chronic diseases were conducted to elicit contextual attributes. These attributes were then evaluated by 12 experts, and the expert ranking method was applied to prioritize the most relevant ones. Finally, the attributes and levels were determined in accordance with the established principles for developing DCE attributes and levels.</p><p><strong>Results: </strong>The literature review included 11 studies and generated 34 potential attributes. Patient interviews identified 29 candidate attributes across four dimensions: platform and institutional characteristics, physician service quality, specific services, and drug delivery and related costs. After expert consultation and ranking, seven candidate attributes with 18 levels were retained for a future DCE: out-of-pocket cost, ease of use, physician's professional title, mode of consultation, upload of self-monitoring data and automatic alerts for abnormal readings, access to electronic medical records and test results, and patient ratings.</p><p><strong>Conclusion: </strong>This study developed a preliminary attribute-level framework for a future DCE. The framework provides a structured basis for pilot testing and subsequent preference elicitation, and may inform patient-centered Internet hospital service design after further validation.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"20 ","pages":"607771"},"PeriodicalIF":2.6,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13544151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148897651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediating Role of Family Resilience and Avoidance Between Financial Toxicity and Quality of Life in Cancer Patients: A Cross-Sectional Study.","authors":"Yafang Liu, Lifen Wu, Kaiyang Nie, Xinlian Yang, Yongli Lyu","doi":"10.2147/PPA.S616987","DOIUrl":"10.2147/PPA.S616987","url":null,"abstract":"<p><strong>Background: </strong>Financial toxicity has become a critical issue in cancer treatment. The substantial financial burden associated with cancer care may negatively affect patients' physical and psychological well-being and reduce their quality of life. However, the mechanisms underlying the relationship between financial toxicity and quality of life remain underexplored in the Chinese context. This study examined the roles of family resilience and avoidance coping in this relationship among patients with cancer in China.</p><p><strong>Methods: </strong>A total of 722 patients with cancer were recruited through convenience sampling from seven tertiary hospitals in Henan, Shaanxi, Sichuan, Heilongjiang, Jilin, and Hubei Provinces. Data were collected using four standardized scales. Statistical analyses were performed using SPSS and AMOS, including descriptive analyses and mediation analysis.</p><p><strong>Results: </strong>Family resilience and avoidance coping independently mediated the association between financial toxicity and quality of life (<i>β</i> family resilience = -0.061, 95% CI: -0.109, -0.019; <i>β</i> avoidance coping = -0.049, 95% <i>CI</i>: -0.091, -0.021), accounting for 21.03% and 16.90% of the total effect, respectively. The serial indirect effect through family resilience and avoidance coping was also significant.</p><p><strong>Conclusion: </strong>Higher financial toxicity was associated with poorer quality of life among patients with cancer. Family resilience and avoidance coping may play important mediating roles in this association, both independently and sequentially. These findings provide a basis for developing patient- and family-centered interventions aimed at mitigating the adverse effects of financial toxicity.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"20 ","pages":"616987"},"PeriodicalIF":2.6,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13540585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of a Novel Dietary Knowledge and Needs Questionnaire: The Postoperative Colorectal Cancer TCM Diet Questionnaire (PCRC-TDQ).","authors":"Lanxia Pan, Ankang Liu, Jie Zhang, Xia Li, Xiaodong Li","doi":"10.2147/PPA.S634018","DOIUrl":"10.2147/PPA.S634018","url":null,"abstract":"<p><strong>Background: </strong>Postoperative colorectal cancer (CRC) patients may benefit from both conventional nutritional support and culturally specific Traditional Chinese Medicine (TCM) dietary guidance, yet no validated instrument specifically assesses their TCM dietary knowledge and educational needs. This study aimed to develop and preliminarily validate the Postoperative Colorectal Cancer TCM Diet Questionnaire (PCRC-TDQ) for assessing postoperative CRC patients' TCM dietary knowledge and educational needs.</p><p><strong>Methods: </strong>An initial 40-item pool was generated through literature review, multidisciplinary discussion, qualitative interviews, two rounds of Delphi expert consultation with 20 experts, and pilot testing, resulting in a 30-item preliminary questionnaire. The questionnaire was administered to 252 postoperative CRC patients, and 250 valid questionnaires were included in the psychometric analysis. Item analysis, content-validity assessment, exploratory factor analysis (EFA), and reliability testing were conducted.</p><p><strong>Results: </strong>Three items (K6, N7, and N9) were removed after exploratory factor analysis (EFA), resulting in the final 27-item PCRC-TDQ comprising 19 knowledge items and eight needs items. The PCRC-TDQ contained two conceptual domains (TCM dietary knowledge and dietary needs), with four underlying factors identified within these domains, explaining 51.43% of the total variance. Item-level content validity indices ranged from 0.88 to 1.00, and the scale-level content validity index/average was 0.990. Cronbach's alpha was 0.899 for the total instrument, 0.913 for the knowledge domain, and 0.849 for the needs domain.</p><p><strong>Conclusion: </strong>The 27-item PCRC-TDQ demonstrated satisfactory preliminary content validity, structural validity, internal consistency, and test-retest reliability in the study sample. It may serve as a preliminary assessment tool during initial postoperative dietary consultations to identify TCM dietary knowledge gaps and educational needs. Independent structural validation, including confirmatory factor analysis in separate cohorts, and multicenter validation are required before routine clinical implementation.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"20 ","pages":"634018"},"PeriodicalIF":2.6,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Canadian Insights into Pediatric Growth Hormone Deficiency: Perspectives on Daily and Long-Acting Growth Hormone from Patients, Caregivers, and Healthcare Providers.","authors":"David Nguyen, Ufuk Coşkun, Chantal Cadieux, Jamie Harvey, Olga Moshkovich, Neha Durgam, M Alex Bellenger, Vicky Turner, Duygu Alpan, Triza Brion","doi":"10.2147/PPA.S562128","DOIUrl":"10.2147/PPA.S562128","url":null,"abstract":"<p><strong>Purpose: </strong>Many patients with growth hormone deficiency (GHD) do not reach their target height in adulthood which is largely linked to treatment non-adherence. Patients report preferring a less frequent treatment regimen. Research is needed to explore reasons for non-adherence and treatment regimen preferences in patients with GHD. The purpose of this study was to explore GHD treatment preferences in health care practitioners (HCPs), patients with GHD aged 12-17 years, and caregivers of patients with GHD aged 3-17 years living in Canada.</p><p><strong>Patients and methods: </strong>This qualitative interview study comprised of 60-minute interviews with Canadian HCPs, adolescents with GHD, and caregivers of pediatric patients. Interviews explored treatment decisions, adherence, access barriers, and preferences between daily and once-weekly growth hormone treatment regimens. Thematic analysis of interview transcripts was conducted.</p><p><strong>Results: </strong>12 HCPs and 25 patient/caregiver interviews were completed. Limited awareness of once-weekly treatments and equity issues were observed across all participant groups. Most caregivers and patients preferred once-weekly injections for convenience and reduced burden. Emotional and logistical challenges were noted, especially for daily regimens. HCPs reported positive transitions to once-weekly regimens, though concerns remain about long-term data and coverage. Preferences leaned toward less invasive formats (e.g, pills) and medications that do not require refrigeration.</p><p><strong>Conclusion: </strong>This study explored experiences of Canadian GHD patients, caregivers, and HCPs, revealing strong preferences for once-weekly GH treatment due to convenience and reduced burden. Findings also highlighted gaps in treatment awareness, support, and education, emphasizing the need for targeted information and expanded patient resources.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"20 ","pages":"562128"},"PeriodicalIF":2.6,"publicationDate":"2026-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13540350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148888376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family Function and Medication Safety Behaviors in Older Adults with Cancer: A Serial Mediation Analysis.","authors":"Yuchen Jiao, Maomao Zhang, Liuliu Zhang, Bing Wu","doi":"10.2147/PPA.S632685","DOIUrl":"10.2147/PPA.S632685","url":null,"abstract":"<p><strong>Purpose: </strong>Medication safety behaviors are critical for preventing medication-related harm in older adults with cancer, given polypharmacy, complex antitumor regimens, and age-related physiological changes. Guided by the Capability-Opportunity-Motivation-Behavior (COM-B) model, the primary objective of this study was to examine the association between family function and medication safety behaviors among older adults with cancer. The secondary objective was to explore the potential individual and serial mediating roles of medication beliefs and medication literacy in this association.</p><p><strong>Patients and methods: </strong>A cross-sectional survey was conducted in two tertiary cancer hospitals in Jiangsu Province, China, from June 2024 to April 2025. Of 260 hospitalized patients aged 60 years or older recruited by convenience sampling, 251 provided valid questionnaires. Participants completed measures of family function, medication beliefs, medication literacy, and medication safety behaviors. Pearson correlation analysis examined bivariate associations. The serial mediation model was tested using PROCESS version 4.0 Model 6 with 5000 bootstrap samples.</p><p><strong>Results: </strong>The mean (SD) medication safety behavior score was 31.85 (5.75). Family function, medication beliefs, medication literacy, and medication safety behaviors were positively correlated (all P < 0.01). In the serial mediation model, the coefficient for the direct pathway between family function and medication safety behaviors was 1.084 (95% CI: 0.778-1.389). The combined indirect estimate was 0.525 (95% CI: 0.348-0.733), accounting for 32.63% of the total association. Statistically significant indirect associations were observed through medication beliefs alone, medication literacy alone, and the hypothesized serial pathway involving medication beliefs and medication literacy.</p><p><strong>Conclusion: </strong>In this cross-sectional study, better family function was associated with safer medication behaviors, with model-based indirect associations through medication beliefs, medication literacy, and their hypothesized serial pathway. These findings highlight the potential value of considering family function, medication beliefs, and medication literacy together when developing and testing medication-safety support for older adults with cancer.</p>","PeriodicalId":19972,"journal":{"name":"Patient preference and adherence","volume":"20 ","pages":"632685"},"PeriodicalIF":2.6,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13532878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}