Peritoneal Dialysis International最新文献

{"title":"Rationale and design of the CORDIAL first-in-human clinical trial: A system for sorbent-assisted continuous flow peritoneal dialysis.","authors":"Joost Christiaan de Vries, Maaike K van Gelder, Dian P Bolhuis, Frank Simonis, Marianne C Verhaar, María Auxiliadora Bajo Rubio, Gloria Del Peso, Rafael Selgas, Gabriele Donati, Giulia Ligabue, Gianni Cappelli, Karin Gf Gerritsen","doi":"10.1177/08968608251381933","DOIUrl":"10.1177/08968608251381933","url":null,"abstract":"<p><p>Peritoneal dialysis (PD) has important disadvantages compared to hemodialysis, including low plasma clearance and limited technique survival. A new device for sorbent-assisted (continuous flow) peritoneal dialysis (SAPD) has been designed that is based on continuous recirculation of peritoneal dialysate <i>via</i> a single-lumen peritoneal catheter with regeneration of spent dialysate by sorbents. SAPD treatment may enhance plasma clearance of uremic solutes by increasing the mass transfer area coefficient and maintenance of a high plasma-to-dialysate concentration gradient. In addition, SAPD treatment may preserve integrity of the peritoneal membrane for a longer period of time by avoiding the need for high initial glucose concentrations and by reducing the number of exchanges and (dis)connections of the peritoneal catheter, which may lower the risk of peritonitis. The primary aim of this first-in-human clinical trial is to evaluate the (short-term) clinical safety and performance of SAPD treatment in a small group (<i>n</i> = 12) of stable adult PD patients in a clinical setting (proof of concept). Key secondary objectives include an evaluation of efficacy in terms of plasma clearance, ultrafiltration, and patient tolerance.</p>","PeriodicalId":19969,"journal":{"name":"Peritoneal Dialysis International","volume":" ","pages":"528-534"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145150313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond modified creatinine index: Practical assessment of Sarcopenia in peritoneal dialysis.","authors":"Wanhaier Abudoureheman, Fan Zhang, Qiuzi Sun","doi":"10.1177/08968608261476564","DOIUrl":"10.1177/08968608261476564","url":null,"abstract":"","PeriodicalId":19969,"journal":{"name":"Peritoneal Dialysis International","volume":" ","pages":"598"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reversing the decline in peritoneal dialysis prevalence: The 2023 peritoneal dialysis reimbursement initiative in Taiwan.","authors":"Yen-Hsuan Tai, Yang Ho, Mu-Chi Chung, Ben-Chung Cheng, Chih-Yu Yang, Chih-Ching Lin, Yung-Ho Hsu, Mai-Szu Wu, Kuan-Yu Hung, Der-Cherng Tarng","doi":"10.1177/08968608251355424","DOIUrl":"10.1177/08968608251355424","url":null,"abstract":"<p><p>BackgroundDespite the exceptional quality of peritoneal dialysis (PD) care in Taiwan and the country's globally high PD patient survival rates, PD utilization has declined. This trend is likely due to limited patient awareness and disparities in financial incentives between hemodialysis (HD) and PD. To address this issue, a new initiative has been launched to rebalance these incentives and promote PD adoption, with the goal of reversing the declining trend.MethodsEnforcing a policy to encourage PD therapy among specific patient populations is crucial, given its benefits for proactive patients and fewer hospital visits. To address these trends, Taiwan's National Health Insurance Administration launched a reimbursement initiative in July 2023, guided by the expertise of the Peritoneal Dialysis Working Committee of the Taiwan Society of Nephrology. This initiative encourages the setup of new PD units, education for new staff, and an integrative care approach provided by medical centers and their collaborative community clinics. Additionally, this initiative encourages comprehensive SDM on KRT modality choice and reimburses telemedicine video consultations.ResultsIn this reimbursement initiative, our primary focus is on improving PD quality rather than solely increasing the quantity of new PD patients. As of the end of 2023, the short-term outcomes of this initiative are promising, including the reopening of six previously closed PD units, the establishment of 68 new units, and an increase in the crude PD prevalence rates from 7.5% to 7.9% (<i>p</i> = 0.006). Since the implementation began, the adherence rate at medical centers, as measured by a scoring system evaluating the high standard of PD care quality, has reached 100%, while regional hospitals have reached nearly 90%.ConclusionsThe short-term outcomes of this initiative are promising, and it is still ongoing, with plans to continue for at least three years. We look forward to sharing the long-term outcomes and insights gained from this initiative in the near future. While healthcare systems differ across countries, Taiwan's model may offer valuable insights for other nations by showing how such initiatives can mobilize healthcare teams, empower patients, and ultimately support long-term expansion of PD.</p>","PeriodicalId":19969,"journal":{"name":"Peritoneal Dialysis International","volume":" ","pages":"559-568"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144576100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reimagining peritoneal dialysis through technology-driven innovation.","authors":"Foo Marjorie, Htay Htay","doi":"10.1177/08968608261484215","DOIUrl":"10.1177/08968608261484215","url":null,"abstract":"","PeriodicalId":19969,"journal":{"name":"Peritoneal Dialysis International","volume":" ","pages":"428-430"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein-energy-wasting and patient survival in maintenance peritoneal dialysis: Anthropometry or bioimpedance spectroscopy for the diagnosis? Results of a prospective multicenter study.","authors":"Natália K Scatone, Cristina Techy Roth-Stefanski, Naiane Rodrigues de Almeida, Viviane Calice-Silva, Gilson Biagini, Fabiana B Nerbass, Thyago Proença de Moraes","doi":"10.1177/08968608251396334","DOIUrl":"10.1177/08968608251396334","url":null,"abstract":"<p><p>BackgroundProtein-energy-wasting (PEW) is a prevalent condition in patients undergoing peritoneal dialysis (PD) associated with poor outcomes and anthropometry assessment is necessary for its diagnosis. The aim of this study was to compare whether anthropometry or bioimpedance spectroscopy (BIS) in the diagnosis of PEW differ in predicting all-cause mortality in PD patients.MethodsProspective, multicenter and observational study. The diagnosis of PEW was performed using the criteria of the International Society of Renal Nutrition and Metabolism (ISRNM). The measurement of muscle and fat mass was done using both anthropometry and BIS. Patients were followed for up to two years for adverse events. The survival rates of the patients identified with PEW according to both methods were compared. Patient survival was analyzed using a competing risk approach as proposed by Fine and Gray.ResultsWe included 121 patients with mean age of 58.9 ± 14.2 years, almost half of them with diabetes as the primary kidney disease (48.4%) and 52.5% were males. We identified 16 (13.2%) patients with PEW using anthropometry and 25 (20.7%) using BIS. In 92 (76%) patients there was no diagnosis of PEW independent of the method used to measure muscle mass and fat. PEW was a strong predictor of death. After adjustments for confounders the diagnosis of PEW using anthropometry was a better predictor of patient survival comparing to BIS.ConclusionPEW was associate with all-cause mortality either using anthropometry or BIS. Both assessment tools have clinical utility; however, in this study, anthropometry demonstrated greater effectiveness in identifying patients at increased risk of mortality.</p>","PeriodicalId":19969,"journal":{"name":"Peritoneal Dialysis International","volume":" ","pages":"551-558"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145605571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Beyond modified creatinine index: Practical assessment of sarcopenia in peritoneal dialysis.","authors":"Cheuk-Chun Szeto","doi":"10.1177/08968608261476562","DOIUrl":"10.1177/08968608261476562","url":null,"abstract":"","PeriodicalId":19969,"journal":{"name":"Peritoneal Dialysis International","volume":" ","pages":"599"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Predictive value of body roundness index (BRI) for clinical outcomes in peritoneal dialysis patients remains to be determined.","authors":"Cheuk-Chun Szeto","doi":"10.1177/08968608261476558","DOIUrl":"10.1177/08968608261476558","url":null,"abstract":"","PeriodicalId":19969,"journal":{"name":"Peritoneal Dialysis International","volume":" ","pages":"597"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148679532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences and perspectives of patients and their caregivers on gastrointestinal symptoms in peritoneal dialysis: Workshop report.","authors":"Ashik Hayat, David W Johnson, Karine Manera, Andrea K Viecelli, Martin Wilkie, Jenny Shen, Angela Yee-Moon Wang, Htay Htay, Allison Jaure, Yeoungjee Cho, Rachael Walker","doi":"10.1177/08968608251361298","DOIUrl":"10.1177/08968608251361298","url":null,"abstract":"<p><p>IntroductionGastrointestinal (GI) symptoms are common and can be debilitating for patients receiving peritoneal dialysis (PD). However, they are rarely reported and there is no widely accepted or validated tool for measuring GI health in these patients to facilitate shared decision making.MethodsAn online consensus workshop was conducted to describe the experiences and perspectives about the impacts of GI symptoms in patients receiving PD and their caregivers and suggestions for measuring GI symptoms in clinical practice and research. A diverse range of patients currently receiving PD or who received PD within the past 5 years and their caregivers from different regions were recruited. After the initial presentation, small-group facilitated discussions were conducted similarly to focus groups, followed by a large-group summarisation of the workshop findings. Transcripts were thematically analysed using an inductive approach informed by grounded theory.Summary of the workshopThirty-five participants attended the online workshop, including 32 patients and 3 caregivers from 7 countries. Four themes were identified: restricting the ability to live freely <i>(inability to predict and prepare,</i> s<i>uffering from severe and disruptive symptoms)</i>, persistent anguish and struggle <i>(living in fear, isolated by burden)</i>, uncertainty about healthcare management <i>(inadequate education and information, lack of individualised care, experimenting to find solution</i>s), measuring GI health in a relevant and robust manner (<i>enabling comprehensive symptom monitoring</i>, <i>individualising frequency of symptom recording</i>, r<i>ecommending user-friendly and innovative tools).</i>ConclusionThis study demonstrated a high burden of GI symptoms in patients receiving PD. These symptoms were unpredictable in their onset, threatening patients' wellbeing and quality of life. A feasible measure of GI symptoms needs to be developed and implemented to inform treatment decisions and aid in consistent reporting in PD trials.</p>","PeriodicalId":19969,"journal":{"name":"Peritoneal Dialysis International","volume":" ","pages":"518-527"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144732713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PD catheter malfunction due to incisional hernia entrapment.","authors":"Jean Bertrand, Inès Dufour, Assma Ballout, Tom Darius, Eric Goffin","doi":"10.1177/08968608251404124","DOIUrl":"10.1177/08968608251404124","url":null,"abstract":"<p><p>A 69-year-old male with end-stage kidney disease secondary to ischemic cardiomyopathy and peripheral arterial disease presented with early peritoneal dialysis (PD) catheter dysfunction, 14 weeks after laparoscopic insertion of a Di Paolo catheter. The patient experienced slow and incomplete effluent drainage (800 mL out of 1000 mL instilled). Clinical examination revealed a reducible, non-painful right incisional hernia at the site of a prior aortofemoral vascular bypass. Abdominal imaging, including X-ray and CT scan, identified catheter malposition in the right iliac fossa, with the catheter tip trapped in the right incisional hernia sac containing small bowel. Laparoscopic exploration confirmed adhesions and catheter entrapment. After adhesiolysis and repositioning of the catheter into the pouch of Douglas, a functional peroperative test confirmed excellent catheter function. Hernia repair was performed on both sides, with prosthetic mesh on the right and Lichtenstein repair on the left to prevent contralateral hernia development. Postoperative recovery was uneventful, and PD resumed after 3 weeks. This case illustrates a rare cause of PD catheter malfunction due to hernia entrapment. The weight of the catheter may have contributed to its migration into the pre-existing hernia. Systematic screening for abdominal wall hernias in patients with prior vascular or abdominal surgery should be part of pre-PD evaluation to avoid such complications.</p>","PeriodicalId":19969,"journal":{"name":"Peritoneal Dialysis International","volume":" ","pages":"593-595"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of a continuous glucose monitoring system in people with diabetes on peritoneal dialysis.","authors":"Jennifer K Williams, Mark Gilchrist, Angela C Shore","doi":"10.1177/08968608251406514","DOIUrl":"10.1177/08968608251406514","url":null,"abstract":"<p><p>BackgroundLack of data on the accuracy of continuous glucose monitoring systems currently limits their usage in people with diabetes on peritoneal dialysis (PD).AimWe aimed to assess the analytical and clinical accuracy of the FreeStyle Libre (FSL) continuous glucose monitoring system in people with diabetes on PD.Methods12 participants using Icodextrin in their PD regime were recruited to a single-centre observational study. They wore a blinded research model of the FSL for 10 days. Results from the FSL were compared with venous glucose measured on a Yellow Springs Instrument (YSI) and self-monitored capillary blood glucose (SMBG) recorded five times per day over the 10-day study.ResultsThe mean absolute relative difference from 84 FSL-YSI matched pairs was 9.8% (95% CI 8.6-11.1) and from 416 FSL-SMBG matched pairs, it was 17.3% (95% CI 16.24-18.43). The systematic error for the FSL as determined by Bland-Altman analysis was -0.6 ± 1.0 mmol/l compared with YSI and -1.4 ± 1.9 mmol/l compared with SMBG. With regard clinical accuracy, compared with YSI and SMBG, respectively, 100% and 99.9% of sensor values were in clinically acceptable zones A and B of Parkes consensus error grid.ConclusionWe demonstrated satisfactory performance of the FSL monitoring system by both analytical and clinical metrics in this cohort of PD patients using treatment prescriptions including Icodextrin-based fluids. Larger studies are now needed to provide clinicians with appropriate reassurance if this technology is to be used with confidence in people on PD.</p>","PeriodicalId":19969,"journal":{"name":"Peritoneal Dialysis International","volume":" ","pages":"535-543"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145810833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}