Peritoneal Dialysis International最新文献_第2页

Early innovation to avoid late peritonitis-related complications. 及早创新，避免晚期腹膜炎相关并发症。

IF 2.7 3区医学

Peritoneal Dialysis International Pub Date : 2024-11-01 Epub Date: 2024-09-30 DOI: 10.1177/08968608241286470

Wed Mustafa, Jeffrey Perl, Muthana Al Sahlawi

引用次数: 0

Rapid point-of-care test for diagnosis of peritonitis in peritoneal dialysis patients. 用于诊断腹膜透析患者腹膜炎的快速护理点检测。

IF 2.7 3区医学

Peritoneal Dialysis International Pub Date : 2024-11-01 Epub Date: 2024-03-07 DOI: 10.1177/08968608241234728

Htay Htay, Jason Chon Jun Choo, Dorothy Hannah Huang, Mathini Jayaballa, David W Johnson, Riece Koniman, Elizabeth Ley Oei, Tan Chieh Suai, Sin Yan Wu, Marjorie Wai Yin Foo

{"title":"Rapid point-of-care test for diagnosis of peritonitis in peritoneal dialysis patients.","authors":"Htay Htay, Jason Chon Jun Choo, Dorothy Hannah Huang, Mathini Jayaballa, David W Johnson, Riece Koniman, Elizabeth Ley Oei, Tan Chieh Suai, Sin Yan Wu, Marjorie Wai Yin Foo","doi":"10.1177/08968608241234728","DOIUrl":"10.1177/08968608241234728","url":null,"abstract":"Background: Periplex® is a rapid point-of-care test based on the detection of interleukin-6 (IL-6) or matrix metalloproteinase-8 (MMP-8) to diagnose peritonitis in peritoneal dialysis (PD) patients.Methods: This single-centre study was conducted in Singapore General Hospital from 2019 to 2022. The study recruited PD patients suspected of having peritonitis. Periplex was performed at the presentation and recovery of peritonitis. Primary outcomes were sensitivity and specificity of Periplex at presentation. The positive and negative predictive values of tests were also performed.Results: A total of 120 patients were included in the study. The mean age was 60.9 ± 14.9 years, 53% were male, 79% were Chinese and 47.5% had diabetes mellitus. Periplex was positive in all patients with peritonitis (n = 114); sensitivity of 100%; 95% confidence interval (CI): 100-100%. Periplex was falsely positive in three patients with non-infective eosinophilic peritonitis, resulting in a low specificity of 50%; 95% CI: 41.1-59.0%. Periplex had a positive predictive value of 97.4% and a negative predictive value of 100%. During recovery from peritonitis, Periplex had high specificity (93.6%) and negative predictive value (98.7%) to indicate the resolution of infection. MMP-8 was more sensitive than IL-6 in detecting peritonitis. Periplex was positive in all patients with peritonitis regardless of the types of PD solutions used.Conclusions: Periplex had high sensitivity, and positive and negative predictive values in the diagnosis of peritonitis can be considered as a screening tool for peritonitis. Given its high specificity and negative predictive value, it may also be used to document the resolution of peritonitis.","PeriodicalId":19969,"journal":{"name":"Peritoneal Dialysis International","volume":" ","pages":"413-418"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140060171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sterility of antibiotic-admixed peritoneal dialysis solution over time. 抗生素混合腹膜透析液的长期无菌性。

IF 2.7 3区医学

Peritoneal Dialysis International Pub Date : 2024-11-01 Epub Date: 2023-12-19 DOI: 10.1177/08968608231213736

Ken-Soon Tan, Robyn Rogers, Deanna Shephard, Amanda Lewis, Narelle George, David W Johnson

{"title":"Sterility of antibiotic-admixed peritoneal dialysis solution over time.","authors":"Ken-Soon Tan, Robyn Rogers, Deanna Shephard, Amanda Lewis, Narelle George, David W Johnson","doi":"10.1177/08968608231213736","DOIUrl":"10.1177/08968608231213736","url":null,"abstract":"Background: Intraperitoneal antibiotics may be required daily for up to three weeks to treat peritoneal dialysis (PD)-related peritonitis. In some jurisdictions, antibiotic-admixed PD solutions are required to be used within 24 h due to concerns regarding microbial contamination and growth. This requires patients to attend the PD unit daily or alternatively for staff to perform home delivery with associated transport, staffing and cost implications.Objective: The aim of this study was to determine if significant microbial growth occurs in PD solutions following their injection with antibiotic or sterile water.Methods: Twelve PD solution bags were admixed with cefazolin sodium 1 g, diluted in 10 mL sterile water, while a further 12 PD solution bags were admixed with 10 mL sterile water using aseptic technique (AT) under supervision. All bags were stored at room temperature. Three bags from each experimental group were sampled for microbiologic culture at 0-, 24-, 48- and 72-h intervals.Results: One sterile water admixed bag sampled at 24 h yielded a Corynebacterium spp. after microbiologic culture. A repeat specimen from the same bag at day nine returned a negative culture result. All other sterile water and cefazolin admixed bags returned negative culture results at all time points.Conclusions: Antibiotic-admixed PD solutions prepared using AT and stored at room temperature remained sterile for up to 72 h. This suggests that patients can be safely issued with a supply of antibiotic-admixed PD bags for up to three days at a time.","PeriodicalId":19969,"journal":{"name":"Peritoneal Dialysis International","volume":" ","pages":"434-437"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138806932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving self-dependency in Pakistan: Correspondence. 提高巴基斯坦的自我依赖性：通信。

IF 2.7 3区医学

Peritoneal Dialysis International Pub Date : 2024-11-01 Epub Date: 2024-09-24 DOI: 10.1177/08968608241285989

Hineptch Daungsupawong, Viroj Wiwanitkit

引用次数: 0

Comparative simulation of intraperitoneal aminoglycoside regimens for patients with peritonitis on automated peritoneal dialysis. 腹膜自动透析腹膜炎患者腹腔内氨基糖苷类药物治疗方案的比较模拟。

IF 2.7 3区医学

Peritoneal Dialysis International Pub Date : 2024-11-01 Epub Date: 2024-01-30 DOI: 10.1177/08968608231221062

Robert E Ariano, Sheryl A Zelenitsky, Christine Davis, Christie Sathianathan, William R Wolowich

{"title":"Comparative simulation of intraperitoneal aminoglycoside regimens for patients with peritonitis on automated peritoneal dialysis.","authors":"Robert E Ariano, Sheryl A Zelenitsky, Christine Davis, Christie Sathianathan, William R Wolowich","doi":"10.1177/08968608231221062","DOIUrl":"10.1177/08968608231221062","url":null,"abstract":"Background: Intraperitoneal (IP) aminoglycosides (AGs) continue to be the cornerstone of empiric management of peritonitis. AG dosing during automated peritoneal dialysis (APD), however, has not been well studied in patients with peritonitis. We sought to identify differences in AG exposure in the peritoneum and plasma for two different dosing regimens with little supporting evidence in patients on APD with peritonitis.Methods: A retrospective design that utilised the peritoneal and plasma concentration-time data from a prior study of 18 continuous ambulatory peritoneal dialysis (CAPD) patients with peritonitis to generate an in silico peritoneal and plasma PK model. This model was then used to compare via simulation using Phoenix© WinNonlin Software with IP AG dosing for a loading-dose regimen (1.5 mg/kg first dose) versus a fixed-dose regimen (0.6 mg/kg/d) in patients on APD with peritonitis.Results: Outcome measures were (1) percentage of time where peritoneal peak concentrations/minimal inhibitory concentration (MIC) ratio >10, (2) AUC/MIC > 74 and (3) plasma Cmin concentrations. Both regimens resulted in > 90% optimal peak/MIC ratio and AUC/MIC ratios on days 1 and 5 of the dose protocol. The loading-dose regimen resulted in IP exposures that were 2.5 times greater in the peritoneal compartment on day 1. By day 5, both protocols resulted in similar accumulation of AG plasma Cmin concentrations of 2.5-3.4 mg/L versus 2.4-3.3 mg/L, respectively, for the loading-dose regimen versus fixed-dose regimen.Conclusions: The current international guidelines for the treatment of peritoneal dialysis-associated peritonitis can continue to recommend the fixed-dose regimen for those on APD with the addition of plasma Cmin monitoring after 3 days to assess for drug accumulation.","PeriodicalId":19969,"journal":{"name":"Peritoneal Dialysis International","volume":" ","pages":"438-444"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139574468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance characteristics of a prototype dialysate turbidity monitoring system to detect peritonitis in patients receiving peritoneal dialysis. 用于检测腹膜透析患者腹膜炎的原型透析液浊度监测系统的性能特点。

IF 2.7 3区医学

Peritoneal Dialysis International Pub Date : 2024-11-01 Epub Date: 2023-09-18 DOI: 10.1177/08968608231195532

Benjamin Briggs, Guillermo Garcia-Garcia, Margarita Ibarra-Hernandez, Luz Alcantar-Vallin, Gary Walker, Eric Yu, Aly ElBadry, Brian Fisher, Don Williamson, Glenn M Chertow

{"title":"Performance characteristics of a prototype dialysate turbidity monitoring system to detect peritonitis in patients receiving peritoneal dialysis.","authors":"Benjamin Briggs, Guillermo Garcia-Garcia, Margarita Ibarra-Hernandez, Luz Alcantar-Vallin, Gary Walker, Eric Yu, Aly ElBadry, Brian Fisher, Don Williamson, Glenn M Chertow","doi":"10.1177/08968608231195532","DOIUrl":"10.1177/08968608231195532","url":null,"abstract":"Background: The risk of peritonitis has limited wider adoption of peritoneal dialysis (PD) in the United States. We developed a prototype bedside dialysate turbidity monitoring system, aiming to improve diagnostic accuracy relative to conventional approaches which depend on visual inspection and reporting of insensitive and non-specific symptoms.Methods: The prototype system was tested in a single-centre, proof-of-principle clinical study in patients receiving intermittent PD. We obtained multiple effluent dialysate samples from each consenting participant. We compared turbidity measurements with diagnostic criteria endorsed by the International Society of Peritoneal Dialysis (ISPD).Results: Overall, we analysed 983 specimens from 65 patients, including 105 samples from patients with peritonitis and 878 samples from patients without peritonitis. An operating point derived from a previous in vitro study yielded an unadjusted sensitivity and specificity of 95.2% and 91.5%, respectively. The majority of samples that did not meet ISPD diagnostic criteria were either cases detected before criteria were met or were related to active peritonitis treatment and resolution.Conclusion: This proof-of-principle study demonstrates the feasibility and diagnostic accuracy of a prototype dialysate turbidity monitoring system for peritonitis surveillance.","PeriodicalId":19969,"journal":{"name":"Peritoneal Dialysis International","volume":" ","pages":"419-425"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10363173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PD peritonitis in patients undergoing capsule endoscopy: A descriptive study. 接受胶囊内镜检查的患者发生 PD 性腹膜炎：描述性研究

IF 2.7 3区医学

Peritoneal Dialysis International Pub Date : 2024-11-01 Epub Date: 2024-01-30 DOI: 10.1177/08968608231221063

Mina Khair, Dharmenaan Palamuthusingam, Carmel M Hawley, Elaine M Pascoe, David Wayne Johnson, Saw Yu Mon, Magid Fahim

{"title":"PD peritonitis in patients undergoing capsule endoscopy: A descriptive study.","authors":"Mina Khair, Dharmenaan Palamuthusingam, Carmel M Hawley, Elaine M Pascoe, David Wayne Johnson, Saw Yu Mon, Magid Fahim","doi":"10.1177/08968608231221063","DOIUrl":"10.1177/08968608231221063","url":null,"abstract":"Peritoneal dialysis (PD) patients who undergo gastroendoscopy and colonoscopy are at increased risk of peritoneal dialysis-associated peritonitis (PD peritonitis) following the procedure (defined as occurring within 7 days of intervention). As per current International Society for PD (ISPD) guidelines, antibiotic prophylaxis is currently recommended pre-colonoscopy in PD patients given the risk of post-colonoscopy PD peritonitis. The risk of PD peritonitis in patients undergoing capsule endoscopy (CE) is unknown. This binational data-linkage study between the Australia and New Zealand Dialysis and Transplant Registry and all hospital admission data sets in Australia and New Zealand evaluated all patients with PD who underwent CE between 2006 and 2015. The objective of the study was to assess the risk of PD peritonitis in patients undergoing CE. Descriptive statistics were used to describe patient characteristics and clinical outcomes. Overall, 23 patients with PD underwent CE. Twelve patients underwent CE alone (i.e. no other concomitant procedures) and none of these patients experienced an episode of PD peritonitis. The remaining 11 patients underwent CE and other invasive endoscopic/abdominal surgical procedures, of whom 2 suffered PD peritonitis. CE is likely a relatively safe procedure in PD patients. PD patients undergoing CE may not require prior antibiotic prophylaxis. Given their relative safety, CE may be an appealing diagnostic tool in a select group of PD patients for the investigation of gastrointestinal disease.","PeriodicalId":19969,"journal":{"name":"Peritoneal Dialysis International","volume":" ","pages":"455-458"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139574399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peritoneal dialysis-related peritonitis due to Pasteurella multocida in Australia. 澳大利亚由多杀性巴氏杆菌引起的腹膜透析相关腹膜炎。

IF 2.7 3区医学

Peritoneal Dialysis International Pub Date : 2024-10-29 DOI: 10.1177/08968608241292477

Isabelle Ingham, Erin Jose, James Burgess, Laura Cuthbertson, Matthew D Jose

引用次数: 0

Impact of home-based exercise on residual kidney function in patients initiating peritoneal dialysis: A feasibility multicenter randomized controlled trial. 居家锻炼对腹膜透析患者残余肾功能的影响：可行性多中心随机对照试验。

IF 2.7 3区医学

Peritoneal Dialysis International Pub Date : 2024-10-17 DOI: 10.1177/08968608241290362

Kiyotaka Uchiyama, Seiki Yamada, Noriyuki Ofuji, Shohei Fukagawa, Shin Sato, Naoki Chigusa, Takahide Kimura, Takahiro Kasai, Koji Hosoya, Jun Ito, Wataru Kakuda, Naoki Washida

{"title":"Impact of home-based exercise on residual kidney function in patients initiating peritoneal dialysis: A feasibility multicenter randomized controlled trial.","authors":"Kiyotaka Uchiyama, Seiki Yamada, Noriyuki Ofuji, Shohei Fukagawa, Shin Sato, Naoki Chigusa, Takahide Kimura, Takahiro Kasai, Koji Hosoya, Jun Ito, Wataru Kakuda, Naoki Washida","doi":"10.1177/08968608241290362","DOIUrl":"https://doi.org/10.1177/08968608241290362","url":null,"abstract":"Background: Although the impact of aerobic exercise (AE) and resistance training (RT) on peritoneal dialysis (PD) patients is well established, the impact of exercise programs on residual kidney function (RKF) has not been elucidated.Methods: Patients were randomly assigned to either the exercise (n = 25) or control groups (n = 30). Patients in the exercise group performed AE three times a week and RT twice a week at home for 24 weeks. The control group did not receive any specific intervention. The primary outcome was RKF, assessed by residual glomerular filtration rate (rGFR). Secondary outcomes included urinary protein levels, distance covered in the incremental shuttle walking test (ISWT), and glycated hemoglobin (HbA1c) percentages.Results: Linear mixed-effects models showed no significant changes in mean rGFR between the exercise and control groups at 12 weeks (-0.40; 95% confidence interval (CI): -2.17, 1.36; p = 0.65) and at 24 weeks (0.65; 95% CI: -1.15, 2.45; p = 0.48). There was a trend toward improvement in mean urinary protein level and ISWT results, and a significant decrease in mean HbA1c percentage at 24 weeks in the exercise group (-1.07, 95% CI: -2.29, 0.15, p = 0.09; 37.7, 95% CI: -10.1, 85.5, p = 0.12; -0.57, 95% CI: -0.97, -0.18, p = 0.005, respectively) compared to the control group.Conclusion: The 24-week home-based exercise program did not demonstrate beneficial effects on RKF in incident PD patients. Nonetheless, it may have an impact on reducing urinary protein levels and HbA1c percentages.","PeriodicalId":19969,"journal":{"name":"Peritoneal Dialysis International","volume":" ","pages":"8968608241290362"},"PeriodicalIF":2.7,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between fill volume and transport in peritoneal dialysis-from bench to bedside. 腹膜透析中充盈量与转运之间的关系--从工作台到床边。

IF 2.7 3区医学

Peritoneal Dialysis International Pub Date : 2024-10-15 DOI: 10.1177/08968608241290019

Carl M Öberg

{"title":"Relationship between fill volume and transport in peritoneal dialysis-from bench to bedside.","authors":"Carl M Öberg","doi":"10.1177/08968608241290019","DOIUrl":"https://doi.org/10.1177/08968608241290019","url":null,"abstract":"Introduction: Larger fill volumes in peritoneal dialysis (PD) typically improve small solute clearance and water removal, and vice versa-but the relationship between intraperitoneal volume and the capacities for solute and water transport in PD has been little studied. Here, it is proposed that this relative relationship is described by a simple ratio (Volumenew/Volumeold)2/3 up to a critical break-point volume, beyond which further volume increase is less beneficial in terms of solute and water removal.Method: To scrutinize this hypothesis, experiments were conducted in a rat model of PD alongside a retrospective analysis of data from a prior clinical study. Rats underwent PD with either three consecutive fills of 8 + 8 + 8 mL (n = 10) or 12 + 12 + 12 mL (n = 10), with 45-minute dwell time intervals. This approach yielded 60 estimations of water and solute transport, characterized by osmotic conductance to glucose and solute diffusion capacities, respectively.Results: Comparative analysis of the predictive efficacy of the two models-the simple ratio versus the break-point model-was performed using Monte Carlo cross-validation. The break-point model emerged as a superior predictor for both water and solute transfer, demonstrating its capability to characterize both experimental data from rats and clinical data from patients.Conclusion: The present analysis indicates that relatively simple calculations can be used to approximate clinical effects on solute and water removal when prescribing a lower or higher fill volume to patients with PD.","PeriodicalId":19969,"journal":{"name":"Peritoneal Dialysis International","volume":" ","pages":"8968608241290019"},"PeriodicalIF":2.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0