Pflugers Archiv : European journal of physiology最新文献_第8页

The impact of virtual reality and distractors on attentional processes: insights from EEG. 虚拟现实和干扰因素对注意过程的影响：脑电图的启示。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2024-11-01 Epub Date: 2024-08-19 DOI: 10.1007/s00424-024-03008-w

Chiara Pappalettera, Francesca Miraglia, Alessia Cacciotti, Lorenzo Nucci, Giulia Tufo, Paolo Maria Rossini, Fabrizio Vecchio

{"title":"The impact of virtual reality and distractors on attentional processes: insights from EEG.","authors":"Chiara Pappalettera, Francesca Miraglia, Alessia Cacciotti, Lorenzo Nucci, Giulia Tufo, Paolo Maria Rossini, Fabrizio Vecchio","doi":"10.1007/s00424-024-03008-w","DOIUrl":"10.1007/s00424-024-03008-w","url":null,"abstract":"Virtual reality (VR) allows to create controlled scenarios in which the quantity of stimuli can be modulated, as happen in real-life, where humans are subjected to various multisensory-often overlapping-stimuli. The present research aimed to study changes in attentional processes within an auditory oddball paradigm during a virtual exploration, while varying the amount of distractors. Twenty healthy volunteers underwent electroencephalography (EEG) during three different experimental conditions: an auditory oddball without VR (No-VR condition), an auditory oddball during VR exploration without distractors (VR-Empty condition), and an auditory oddball during VR exploration with a high level of distractors (VR-Full condition). Event-related potentials (ERPs) were computed averaging epochs of EEGs and analyzing peaks at 100 ms (N100) and 300 ms (P300) latencies. Results showed modulation of N100 amplitude in Fz and of P300 amplitude in Pz. Statistically significant differences in latency were observed only for P300 where the latency results delayed from the No-VR to VR-Full. The scalp topography revealed for P100 no significant differences between frequent and rare stimuli in either the No-VR and VR-Empty conditions. However, significant results were found in N100 in VR-Full condition. For P300, results showed differences between frequent and rare stimuli, in every condition. However, this difference is gradually less widespread from No-VR condition to the VR-Full. The emerging integration of VR with EEG may have important implications for studying brain attentional processing.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"1727-1742"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142000529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective actions of norepinephrine in neurological diseases. 去甲肾上腺素在神经系统疾病中的神经保护作用。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2024-11-01 Epub Date: 2024-08-13 DOI: 10.1007/s00424-024-02999-w

Maedeh Ghasemi, Nasrin Mehranfard

引用次数: 0

The role of GABA in modulation of taste signaling within the taste bud. GABA 在味蕾内味觉信号调节中的作用。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2024-11-01 Epub Date: 2024-08-29 DOI: 10.1007/s00424-024-03007-x

Ayaka Mikami, Hai Huang, Aiko Hyodo, Kengo Horie, Keiko Yasumatsu, Yuzo Ninomiya, Yoshihiro Mitoh, Seiji Iida, Ryusuke Yoshida

{"title":"The role of GABA in modulation of taste signaling within the taste bud.","authors":"Ayaka Mikami, Hai Huang, Aiko Hyodo, Kengo Horie, Keiko Yasumatsu, Yuzo Ninomiya, Yoshihiro Mitoh, Seiji Iida, Ryusuke Yoshida","doi":"10.1007/s00424-024-03007-x","DOIUrl":"10.1007/s00424-024-03007-x","url":null,"abstract":"Taste buds contain 2 types of GABA-producing cells: sour-responsive Type III cells and glial-like Type I cells. The physiological role of GABA, released by Type III cells is not fully understood. Here, we investigated the role of GABA released from Type III cells using transgenic mice lacking the expression of GAD67 in taste bud cells (Gad67-cKO mice). Immunohistochemical experiments confirmed the absence of GAD67 in Type III cells of Gad67-cKO mice. Furthermore, no difference was observed in the expression and localization of cell type markers, ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2), gustducin, and carbonic anhydrase 4 (CA4) in taste buds between wild-type (WT) and Gad67-cKO mice. Short-term lick tests demonstrated that both WT and Gad67-cKO mice exhibited normal licking behaviors to each of the five basic tastants. Gustatory nerve recordings from the chorda tympani nerve demonstrated that both WT and Gad67-cKO mice similarly responded to five basic tastants when they were applied individually. However, gustatory nerve responses to sweet-sour mixtures were significantly smaller than the sum of responses to each tastant in WT mice but not in Gad67-cKO mice. In summary, elimination of GABA signalling by sour-responsive Type III taste cells eliminates the inhibitory cell-cell interactions seen with application of sour-sweet mixtures.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"1761-1775"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Placental ischemia-upregulated angiotensin II type 1 receptor in hypothalamic paraventricular nucleus contributes to hypertension in rat. 胎盘缺血上调下丘脑室旁核血管紧张素 II 1 型受体导致大鼠高血压

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2024-11-01 Epub Date: 2024-08-31 DOI: 10.1007/s00424-024-03010-2

Abdoulaye Issotina Zibrila, Jun Zhou, Xiaomin Wang, Ming Zeng, Md Ahasan Ali, Xiaoxu Liu, Asma A Alkuhali, Zhaoshu Zeng, Yuan Meng, Zheng Wang, Xuelan Li, Jinjun Liu

{"title":"Placental ischemia-upregulated angiotensin II type 1 receptor in hypothalamic paraventricular nucleus contributes to hypertension in rat.","authors":"Abdoulaye Issotina Zibrila, Jun Zhou, Xiaomin Wang, Ming Zeng, Md Ahasan Ali, Xiaoxu Liu, Asma A Alkuhali, Zhaoshu Zeng, Yuan Meng, Zheng Wang, Xuelan Li, Jinjun Liu","doi":"10.1007/s00424-024-03010-2","DOIUrl":"10.1007/s00424-024-03010-2","url":null,"abstract":"Preeclampsia (PE) is associated with increased angiotensin II sensitivity and poor neurological outcomes marked by temporal loss of neural control of blood pressure. Yet the role of centrally expressed angiotensin II type 1 receptor (AT1R) within the paraventricular nucleus of the hypothalamus (PVN) in the PE model is not understood. In a PE rat model with reduced placental perfusion pressure (RUPP) induced on gestational day 14 (GD14), the PVN expression and cellular localization of AT1R were assessed using immunofluorescence and western blotting. The sensitivity of RUPP to acute angiotensin II infusion was assessed. AT1R was antagonized by losartan (100 µg/kg/day) for 5 days intracerebroventricularly (ICV). Hemodynamic data and samples were collected on GD19 for further analysis. RUPP upregulated (p < 0.05) mRNA and protein of AT1R within the PVN and lowered (p < 0.05) circulating angiotensin II in rats. RUPP increased neural and microglial activation. Cellular localization assessment revealed that AT1R was primarily expressed in neurons and slightly in microglia and astrocytes. Infusion of 100 ng/kg as bolus increased the mean arterial pressure (MAP in mmHg) in both RUPP and Sham. ICV losartan infusion attenuated RUPP-increased MAP (113.6 ± 6.22 in RUPP vs. 92.16 ± 5.30 in RUPP + Los, p = 0.021) and the expression of nuclear transcription factor NF-κB, tyrosine hydroxylase (TH), NADPH oxidase 4 (NOX4) and reactive oxygen species (ROS) in the PVN. Our data suggest that centrally expressed AT1R, within the PVN, contributes to placental ischemia-induced hypertension in RUPP rats highlighting its therapeutic potential in PE.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"1677-1691"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune-mediated impairment of tonic immobility defensive behavior in an experimental model of colonic inflammation. 结肠炎实验模型中免疫介导的强直性固定防御行为损伤

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2024-11-01 Epub Date: 2024-09-02 DOI: 10.1007/s00424-024-03011-1

Leda Menescal-de-Oliveira, Mariulza Rocha Brentegani, Fernanda Pincelli Teixeira, Humberto Giusti, Rafael Simone Saia

{"title":"Immune-mediated impairment of tonic immobility defensive behavior in an experimental model of colonic inflammation.","authors":"Leda Menescal-de-Oliveira, Mariulza Rocha Brentegani, Fernanda Pincelli Teixeira, Humberto Giusti, Rafael Simone Saia","doi":"10.1007/s00424-024-03011-1","DOIUrl":"10.1007/s00424-024-03011-1","url":null,"abstract":"Ulcerative colitis has been associated with psychological distress and an aberrant immune response. The immunomodulatory role of systemic cytokines produced during experimental intestinal inflammation in tonic immobility (TI) defensive behavior remains unknown. The present study characterized the TI defensive behavior of guinea pigs subjected to colitis induction at the acute stage and after recovery from intestinal mucosa injury. Moreover, we investigated whether inflammatory mediators (tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-8, IL-10, and prostaglandins) act on the mesencephalic nucleus, periaqueductal gray matter (PAG). Colitis was induced in guinea pigs by intrarectal administration of acetic acid. The TI defensive behavior, histology, cytokine production, and expression of c-FOS, IBA-1, and cyclooxygenase (COX)-2 in PAG were evaluated. Colitis reduced the duration of TI episodes from the first day, persisting throughout the 7-day experimental period. Neuronal c-FOS immunoreactivity was augmented in both columns of the PAG (ventrolateral (vlPAG) and dorsal), but there were no changes in IBA-1 expression. Dexamethasone, infliximab, and parecoxib treatments increased the duration of TI episodes, suggesting a modulatory role of peripheral inflammatory mediators in this behavior. Immunoneutralization of TNF-α, IL-1β, and IL-8 in the vlPAG reversed all effects produced by colitis. In contrast, IL-10 neutralization further reduced the duration of TI episodes. Our results reveal that peripherally produced inflammatory mediators during colitis may modulate neuronal functioning in mesencephalic structures such as vlPAG.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"1743-1760"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central and peripheral mechanisms underlying respiratory deficits in a mouse model of accelerated senescence. 加速衰老小鼠模型呼吸功能障碍的中枢和外周机制。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2024-11-01 Epub Date: 2024-08-16 DOI: 10.1007/s00424-024-03006-y

Alembert Lino-Alvarado, Octavio A C Maia, Maria Aparecida Oliveira, Ana C Takakura, Wothan Tavares-Lima, Henrique T Moriya, Thiago S Moreira

{"title":"Central and peripheral mechanisms underlying respiratory deficits in a mouse model of accelerated senescence.","authors":"Alembert Lino-Alvarado, Octavio A C Maia, Maria Aparecida Oliveira, Ana C Takakura, Wothan Tavares-Lima, Henrique T Moriya, Thiago S Moreira","doi":"10.1007/s00424-024-03006-y","DOIUrl":"10.1007/s00424-024-03006-y","url":null,"abstract":"Aging invariably decreases sensory and motor stimuli and affects several neuronal systems and their connectivity to key brain regions, including those involved in breathing. Nevertheless, further investigation is needed to fully comprehend the link between senescence and respiratory function. Here, we investigate whether a mouse model of accelerated senescence could develop central and peripheral respiratory abnormalities. Adult male Senescence Accelerated Mouse Prone 8 (SAMP8) and the control SAMR1 mice (10 months old) were used. Ventilatory parameters were assessed by whole-body plethysmography, and measurements of respiratory input impedance were performed. SAMP8 mice exhibited a reduction in the density of neurokinin-1 receptor immunoreactivity in the entire ventral respiratory column. Physiological experiments showed that SAMP8 mice exhibited a decreased tachypneic response to hypoxia (FiO2 = 0.08; 10 min) or hypercapnia (FiCO2 = 0.07; 10 min). Additionally, the ventilatory response to hypercapnia increased further due to higher tidal volume. Measurements of respiratory mechanics in SAMP8 mice showed decreased static compliance (Cstat), inspiratory capacity (IC), resistance (Rn), and elastance (H) at different ages (3, 6, and 10 months old). SAMP8 mice also have a decrease in contractile response to methacholine compared to SAMR1. In conclusion, our findings indicate that SAMP8 mice display a loss of the NK1-expressing neurons in the respiratory brainstem centers, along with impairments in both central and peripheral respiratory mechanisms. These observations suggest a potential impact on breathing in a senescence animal model.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"1665-1676"},"PeriodicalIF":2.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Persistent sodium currents in neurons: potential mechanisms and pharmacological blockers. 更正：神经元中的持续钠电流：潜在机制和药理阻断剂。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2024-10-01 DOI: 10.1007/s00424-024-02995-0

Peter Müller, Andreas Draguhn, Alexei V Egorov

引用次数: 0

Stability of N-type inactivation and the coupling between N-type and C-type inactivation in the Aplysia Kv1 channel. plysia Kv1 通道中 N 型失活的稳定性以及 N 型和 C 型失活之间的耦合。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2024-10-01 Epub Date: 2024-07-15 DOI: 10.1007/s00424-024-02982-5

Tokunari Iwamuro, Kazuki Itohara, Yasuo Furukawa

{"title":"Stability of N-type inactivation and the coupling between N-type and C-type inactivation in the Aplysia Kv1 channel.","authors":"Tokunari Iwamuro, Kazuki Itohara, Yasuo Furukawa","doi":"10.1007/s00424-024-02982-5","DOIUrl":"10.1007/s00424-024-02982-5","url":null,"abstract":"The voltage-dependent potassium channels (Kv channels) show several different types of inactivation. N-type inactivation is a fast inactivating mechanism, which is essentially an open pore blockade by the amino-terminal structure of the channel itself or the auxiliary subunit. There are several functionally discriminatable slow inactivation (C-type, P-type, U-type), the mechanism of which is supposed to include rearrangement of the pore region. In some Kv1 channels, the actual inactivation is brought about by coupling of N-type and C-type inactivation (N-C coupling). In the present study, we focused on the N-C coupling of the Aplysia Kv1 channel (AKv1). AKv1 shows a robust N-type inactivation, but its recovery is almost thoroughly from C-type inactivated state owing to the efficient N-C coupling. In the I8Q mutant of AKv1, we found that the inactivation as well as its recovery showed two kinetic components apparently correspond to N-type and C-type inactivation. Also, the cumulative inactivation which depends on N-type mechanism in AKv1 was hindered in I8Q, suggesting that N-type inactivation of I8Q is less stable. We also found that Zn <math><msup><mrow></mrow> <mrow><mn>2</mn> <mo>+</mo></mrow> </msup> </math> specifically accelerates C-type inactivation of AKv1 and that H382 in the pore turret is involved in the Zn <math><msup><mrow></mrow> <mrow><mn>2</mn> <mo>+</mo></mrow> </msup> </math> binding. Because the region around Ile <math><msup><mrow></mrow> <mn>8</mn></msup> </math> (I8) in AKv1 has been suggested to be involved in the pre-block binding of the amino-terminal structure, our results strengthen a hypothesis that the stability of the pre-block state is important for stable N-type inactivation as well as the N-C coupling in the Kv1 channel inactivation.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"1493-1516"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141617021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Absence of claudin-3 does not alter intestinal absorption of phosphate in mice. 缺少 claudin-3 不会改变小鼠肠道对磷酸盐的吸收。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2024-10-01 Epub Date: 2024-08-08 DOI: 10.1007/s00424-024-02998-x

Zsuzsa Radványi, Udo Schnitzbauer, Eva Maria Pastor-Arroyo, Simone Hölker, Nina Himmerkus, Markus Bleich, Dominik Müller, Tilman Breiderhoff, Nati Hernando, Carsten A Wagner

{"title":"Absence of claudin-3 does not alter intestinal absorption of phosphate in mice.","authors":"Zsuzsa Radványi, Udo Schnitzbauer, Eva Maria Pastor-Arroyo, Simone Hölker, Nina Himmerkus, Markus Bleich, Dominik Müller, Tilman Breiderhoff, Nati Hernando, Carsten A Wagner","doi":"10.1007/s00424-024-02998-x","DOIUrl":"10.1007/s00424-024-02998-x","url":null,"abstract":"Intestinal absorption of phosphate is bimodal, consisting of a transcellular pathway and a poorly characterized paracellular mode, even though the latter one contributes to the bulk of absorption under normal dietary conditions. Claudin-3 (Cldn3), a tight junction protein present along the whole intestine in mice, has been proposed to tighten the paracellular pathway for phosphate. The aim of this work was to characterize the phosphate-related phenotype of Cldn3-deficient mice. Cldn3-deficient mice and wildtype littermates were fed standard diet or challenged for 3 days with high dietary phosphate. Feces, urine, blood, intestinal segments and kidneys were collected. Measurements included fecal, urinary, and plasma concentrations of phosphate and calcium, plasma levels of phosphate-regulating hormones, evaluation of trans- and paracellular phosphate transport across jejunum and ileum, and analysis of intestinal phosphate and calcium permeabilities. Fecal and urinary excretion of phosphate as well as its plasma concentration was similar in both genotypes, under standard and high-phosphate diet. However, Cldn3-deficient mice challenged with high dietary phosphate had a reduced urinary calcium excretion and increased plasma levels of calcitriol. Intact FGF23 concentration was also similar in both groups, regardless of the dietary conditions. We found no differences either in intestinal phosphate transport (trans- or paracellular) and phosphate and calcium permeabilities between genotypes. The intestinal expression of claudin-7 remained unaltered in Cldn3-deficient mice. Our data do not provide evidence for a decisive role of Cldn3 for intestinal phosphate absorption and phosphate homeostasis. In addition, our data suggest a novel role of Cldn3 in regulating calcitriol levels.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"1597-1612"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11381482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mild hyperbaric oxygen exposure protects heart during ischemia/reperfusion and affects vascular relaxation. 轻度高压氧暴露可在缺血/再灌注期间保护心脏，并影响血管松弛。

IF 4.6 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2024-10-01 Epub Date: 2024-07-25 DOI: 10.1007/s00424-024-02992-3

Christopher Gutierrez, Magdalena Peirone, Andrea Carranza, Guillermo Di Girolamo, Patricia Bonazzola, Rocío Castilla

{"title":"Mild hyperbaric oxygen exposure protects heart during ischemia/reperfusion and affects vascular relaxation.","authors":"Christopher Gutierrez, Magdalena Peirone, Andrea Carranza, Guillermo Di Girolamo, Patricia Bonazzola, Rocío Castilla","doi":"10.1007/s00424-024-02992-3","DOIUrl":"10.1007/s00424-024-02992-3","url":null,"abstract":"Mild hyperbaric oxygen therapy (mHBOT) is an adjuvant therapy used in conditions where tissue oxygenation is reduced and is implemented using pressures less than 1.5 ATA and 100% O2 (instead of the classical HBOT at 1.9-3 ATA) which results in cheaper, easier to implement, and equally effective. mHBOT is offered for wellness and beauty and as an anti-aging strategy, in spite of the absence of studies on the cardiovascular system. Consequently, we investigated the impact of mHBOT on the cardiovascular system. Mechanical and energetic parameters of isolated heart submitted to ischemia/reperfusion injury and arterial contractile response from mHBOT-exposed rats were evaluated. In the heart, mHBOT increased pre-ischemic velocity of contraction and ischemic end-diastolic pressure and developed pressure and contractile economy during reperfusion. mHBOT decreased infarct size and increased the plasma nitrite levels. In the artery, mHBOT increased acetylcholine sensitivity. mHBOT protects the heart during ischemia/reperfusion and affects vascular relaxation.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"1587-1595"},"PeriodicalIF":4.6,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0