Pflugers Archiv : European journal of physiology最新文献

Intravascular volume expansion is prominently overestimated via hemoglobin concentration: a placebo-controlled and cross-over trial. 血红蛋白浓度显著高估了血管内体积扩张：一项安慰剂对照和交叉试验。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2025-10-03 DOI: 10.1007/s00424-025-03124-1

Meihan Guo, David Montero

{"title":"Intravascular volume expansion is prominently overestimated via hemoglobin concentration: a placebo-controlled and cross-over trial.","authors":"Meihan Guo, David Montero","doi":"10.1007/s00424-025-03124-1","DOIUrl":"https://doi.org/10.1007/s00424-025-03124-1","url":null,"abstract":"Blood volume (BV) expansion by means of intravenous infusion of colloids is an established procedure in clinical interventions. The essential questions of how much of the infused fluid stays in the circulation according to measured changes in hemoconcentration are uncertain. A placebo-controlled, single-blinded, and cross-over design was implemented to assess the effect of a definite increment in BV on hemodilution, as determined by hemoglobin concentration ([Hb]). Healthy women (n = 17) and men (n = 19) matched by sex, age (age = 26 ± 4 vs. 27 ± 3 yr, P = 0.522), and physical activity were subjected in a blind manner to the intravenous infusion of placebo-sham (PBO-sham) via saline infusion (10 mL; BD 0.9% NaCl) or albumin (volume equivalent to 10% of BV; Albumin CSL 20%). [Hb] was slightly reduced (-2.4%) after the PBO-sham infusion. For the albumin infusion, the amount of fluid infused ranged from 325 to 810 mL (547 ± 112 mL) in order to elicit a 10% increment in BV in each individual. [Hb] was markedly reduced (-17.2%) (13.8 ± 1.6 vs. 11.5 ± 1.4 g·dL-1, P < 0.001) after albumin infusion. The magnitude of hemodilution was well above the expected decrement (-9%) in all individuals. Sex differences were not detected. Cardiac chamber volumes were expanded by 7-10% by albumin infusion, without changes in LV filling pressure (P = 0.582). In conclusion, a colloid infusion eliciting a 10% BV expansion is markedly overestimated according to changes in [Hb] in healthy women and men. The overestimation of BV expansion ranges from 35 to 135% irrespective of sex.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145213407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Energy metabolism in different skeletal muscles and muscle fibers: implications for injury and dietary supplementation. 不同骨骼肌和肌纤维的能量代谢：对损伤和膳食补充的影响。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2025-10-01 Epub Date: 2025-09-27 DOI: 10.1007/s00424-025-03112-5

Andrey V Kuznetsov, Raimund Margreiter, Judith Hagenbuchner, Michael J Ausserlechner

{"title":"Energy metabolism in different skeletal muscles and muscle fibers: implications for injury and dietary supplementation.","authors":"Andrey V Kuznetsov, Raimund Margreiter, Judith Hagenbuchner, Michael J Ausserlechner","doi":"10.1007/s00424-025-03112-5","DOIUrl":"10.1007/s00424-025-03112-5","url":null,"abstract":"The necessary energy supply in skeletal muscles is based on either glycolysis or mitochondrial oxidative phosphorylation (OxPhos). These two bioenergetic pathways are in balanced complementation. Glycolysis is faster than OxPhos, whereas OxPhos is much more efficient. One common feature of both pathways is the compartmentation of high-energy phosphates and their metabolic channeling. The glycolytic muscles are wider, whereas oxidative muscles have significantly more mitochondria. Importantly, a striking difference in bioenergetic mechanisms in oxidative (slow-twitch) versus glycolytic (fast-twitch) muscles and muscle fibers has been clearly shown. The advantage is that the optimal fiber diversity can provide the best muscle function. Various creatine kinase isoforms and phosphocreatine play an important role in glycolytic and oxidative muscles energy metabolism, but their roles are very different, depending on the muscle type. In the glycolytic muscles, phosphocreatine, produced from creatine and ATP by cytosolic creatine kinase, is mostly considered a cellular energy store for fast ATP delivery, whereas in the oxidative muscles, phosphocreatine and mitochondrial creatine kinase are the main players in the intracellular energy transport.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"1231-1240"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145177527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased weight-bearing load reduces biological body weight while sodium and water balances are unaffected. 增加的负重会降低生物体重，而钠和水的平衡不受影响。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2025-10-01 Epub Date: 2025-09-02 DOI: 10.1007/s00424-025-03114-3

Jovana Zlatkovic, Jakob Bellman, Daniel Hägg, Mathilda Magnusson, Claes Ohlsson, Gerald DiBona, Fredrik Anesten, John-Olov Jansson

{"title":"Increased weight-bearing load reduces biological body weight while sodium and water balances are unaffected.","authors":"Jovana Zlatkovic, Jakob Bellman, Daniel Hägg, Mathilda Magnusson, Claes Ohlsson, Gerald DiBona, Fredrik Anesten, John-Olov Jansson","doi":"10.1007/s00424-025-03114-3","DOIUrl":"10.1007/s00424-025-03114-3","url":null,"abstract":"Increased weight-bearing load has previously been shown to reduce body weight in obese rodents, primarily by lowering food intake. However, it remains unclear whether increased loading also affects body weight through acute changes in extracellular water. This study aimed to determine whether increased weight-bearing load acutely produces negative sodium and water balances, as indicators of changes in whole-body extracellular sodium and water content. Diet-induced obese (DIO) rats were housed in metabolic cages with free access to hypotonic 0.5% NaCl solution and a low-sodium, high-fat diet. A novel, less traumatic loading method was used, where intra-abdominal capsules implanted two weeks earlier were either filled in vivo with wolfram granulate (Load group) or sham-filled (Control group), resulting in 15% and 2% increases in body weight, respectively. Compared to controls, increased weight-bearing load decreased body weight by 4.2% (95% CI -6.3, -2.0; P = 0.001) and reduced food intake by 1.6 percentage points (95% CI -2.6, -0.6; P = 0.003). No significant differences in sodium or water balance were observed. These findings suggest that load-induced reductions in body weight are not mediated by changes in whole-body extracellular sodium or water content, indicating that fluid homeostasis does not contribute to the homeostatic regulation of body weight.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"1287-1294"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-invasive motor unit analysis reveals specific responses during maximal muscle contraction under normobaric hypoxia. 无创运动单元分析揭示了在常压缺氧下最大肌肉收缩时的特定反应。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2025-10-01 Epub Date: 2025-09-10 DOI: 10.1007/s00424-025-03119-y

Danilo Bondi, Giacomo Valli, Carmen Santangelo, Salvatore Annarumma, Tiziana Pietrangelo, Stefania Fulle, Vittore Verratti

{"title":"Non-invasive motor unit analysis reveals specific responses during maximal muscle contraction under normobaric hypoxia.","authors":"Danilo Bondi, Giacomo Valli, Carmen Santangelo, Salvatore Annarumma, Tiziana Pietrangelo, Stefania Fulle, Vittore Verratti","doi":"10.1007/s00424-025-03119-y","DOIUrl":"10.1007/s00424-025-03119-y","url":null,"abstract":"Hypoxia has been extensively studied as a stressor which pushes human bodily systems to responses and adaptations. Nevertheless, a few evidence exist onto constituent trains of motor unit action potential, despite recent advancements which allow to decompose surface electromyographic signals. This study aimed to investigate motor unit properties from noninvasive approaches during maximal isometric exercise in normobaric hypoxia. Applying a cross-over design, 18 participants (gender-matched, on average age 22.6 y, BMI 23.6 kg/m2, and bioimpedance phase angle 6.4) were exposed twice to hypoxia (FiO2 ≊ 15.0% and FiO2 ≊ 13.4%, separately, by using a tent connected with a hypoxic generator) and once to normobaric normoxia. After ≊ 30 min inside the tent, participants performed a series of 9 unilateral isometric contractions of the right knee extensors at maximum intensity for 5 s, interspersed with 15 s of passive recovery, while acquiring high-density surface EMG signals through a 64-electrodes grid and cardiorespiratory variables, and registering symptoms; then, a post-processing motor unit decomposition technique was applied. We found an increase in MU discharge rate as a response to acute normobaric hypoxia, although to a little extent and differently across sexes. Moreover, males experienced a more prominent increase of MU conduction velocity due to hypoxia. MUs responses to normobaric hypoxia were only slightly and non-homogeneously associated with hypoxic cardiorespiratory responses. Normobaric hypoxia affects the neuromuscular system with a relatively greater effect on peripheral rather than central features.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"1295-1308"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488839/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the use of the myocardial performance index as a parameter of cardiac function in two experimental models of heart disease: myocardial infarction and pulmonary hypertension. 心肌性能指标作为心功能参数在心肌梗死和肺动脉高压两种心脏病实验模型中的应用评价

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2025-10-01 Epub Date: 2025-08-30 DOI: 10.1007/s00424-025-03117-0

Alexandre Luz de Castro, Patrick Turck, Angela Maria Vicente Tavares, Custódio José Gaspar, Alan Bahr, Alexsandra Zimmer, Tânia Regina G Fernandes, Rafael Oliveira Fernandes, Vanessa Duarte Ortiz, Sílvio Tasca, Elissa Fernandes, Daniela Drosdowski, Cristina Campos Carraro, Adriane Belló-Klein, Alex Sander da Rosa Araujo

{"title":"Evaluation of the use of the myocardial performance index as a parameter of cardiac function in two experimental models of heart disease: myocardial infarction and pulmonary hypertension.","authors":"Alexandre Luz de Castro, Patrick Turck, Angela Maria Vicente Tavares, Custódio José Gaspar, Alan Bahr, Alexsandra Zimmer, Tânia Regina G Fernandes, Rafael Oliveira Fernandes, Vanessa Duarte Ortiz, Sílvio Tasca, Elissa Fernandes, Daniela Drosdowski, Cristina Campos Carraro, Adriane Belló-Klein, Alex Sander da Rosa Araujo","doi":"10.1007/s00424-025-03117-0","DOIUrl":"10.1007/s00424-025-03117-0","url":null,"abstract":"Myocardial performance index (MPI) has been used in the estimation of ventricular function in a non-invasive way through echocardiography. This index has presented relevant results in clinical and experimental studies. However, there are no studies evaluating whether this index correlates with other cardiac parameters in experimental models of heart disease, such as monocrotaline-induced pulmonary artery hypertension (PAH) and acute myocardial infarction (AMI). In view of that, the present study evaluated rats submitted to PAH and perform a broad analysis of echocardiographic, hemodynamic and morphometric parameters of the right ventricle (RV) and pulmonary artery (PA). Besides that, the present study also evaluated rats submitted to experimental AMI and performed a broad echocardiographic evaluation of left ventricle (LV). Subsequently, it was analyzed whether the parameters collected presented correlation with the MPI. In PAH model, monocrotaline was administrated and the animals were divided into the following groups: control and PAH. In AMI model, infarction was induced by coronary artery ligation and the groups were as follows: SHAM and AMI. In PAH model, MPI presented correlation with RV functional parameters, as well as with parameters that evaluate flow and resistance in the PA. In addition, this index also presented correlation with LV parameters in infarcted rats. To our knowledge, this is the first study that evaluates the correlation of MPI with parameters of the RV in rats with PAH induce by monocrotaline. Besides that, this is the first study that compares the use of this index in two different experimental models of cardiac diseases.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"1273-1285"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AT₁ receptors play a role in sepsis-induced vasoplegia by increasing iNOS expression in the perivascular adipose tissue. AT1受体通过增加血管周围脂肪组织中iNOS的表达，在脓毒症诱导的血管截瘫中发挥作用。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2025-10-01 Epub Date: 2025-08-30 DOI: 10.1007/s00424-025-03113-4

Wanessa M C Awata, Gustavo F Pimenta, Thales M H Dourado, Kathleen A Paulino, Marcela M Blascke de Mello, Lucas C Pinheiro, Michele M Castro, Carlos R Tirapelli

{"title":"AT1 receptors play a role in sepsis-induced vasoplegia by increasing iNOS expression in the perivascular adipose tissue.","authors":"Wanessa M C Awata, Gustavo F Pimenta, Thales M H Dourado, Kathleen A Paulino, Marcela M Blascke de Mello, Lucas C Pinheiro, Michele M Castro, Carlos R Tirapelli","doi":"10.1007/s00424-025-03113-4","DOIUrl":"10.1007/s00424-025-03113-4","url":null,"abstract":"Sepsis enhances the anticontractile effect of perivascular adipose tissue (PVAT), which contributes to a reduced response to vasoconstrictor agents. In the early stages of sepsis, the renin-angiotensin-aldosterone system (RAAS) is activated, and this response can lead to poorer clinical outcomes. We hypothesized that AT1 receptors (AT1R) contribute to vascular hyporesponsiveness during sepsis by increasing the expression of inducible nitric oxide synthase (iNOS) in the periaortic PVAT, resulting in elevated nitric oxide (NO) production. In our study, male Wistar Hannover rats underwent lethal sepsis via a cecal ligation and puncture (CLP) model. We evaluated the role of AT1R in sepsis-induced PVAT dysfunction by administering a single dose of losartan (a selective AT1R antagonist; 10 mg/kg, gavage) to the rats 1 h prior to the CLP surgery. We observed increased levels of circulating angiotensin II in septic rats. Functional analyses revealed that AT1R blockade prevented the enhanced anticontractile effect of PVAT and the resulting vascular hyporesponsiveness to phenylephrine during sepsis. Additionally, losartan inhibited sepsis-induced iNOS expression and the overproduction of NO in both the PVAT and the aorta. Experiments using 1400W, a selective iNOS inhibitor, indicated that iNOS plays a crucial role in the sepsis-induced increase in the anticontractile effect of PVAT. In summary, AT1R mediate iNOS expression in PVAT, leading to the overproduction of NO, which ultimately contributes to sepsis-induced vasoplegia. Furthermore, AT1R-mediated iNOS expression is an important mechanism related to vasoplegia in the vasculature. The present results implicate AT1R as active players in sepsis-induced PVAT and vascular dysfunction.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"1259-1271"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144964611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breaking the link between sarcoplasmic reticulum calcium leakage and mitochondria to counteract unloading-induced muscle atrophy. 打破肌浆网钙渗漏与线粒体之间的联系，以抵消卸荷引起的肌肉萎缩。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2025-10-01 Epub Date: 2025-09-20 DOI: 10.1007/s00424-025-03120-5

Carlo Reggiani, Lorenzo Marcucci

引用次数: 0

Ryanodine receptor stabilizer S-107 rescues slow-type rat soleus muscle function after 7-day hindlimb unloading. Ryanodine受体稳定剂S-107在7天后恢复慢型大鼠比目鱼肌功能。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1007/s00424-025-03108-1

Daria A Sidorenko, Roman O Bokov, Gleb V Galkin, Natalia A Vilchinskaya, Sergey A Tyganov, Irina D Lvova, Boris S Shenkman, Timur M Mirzoev, Kristina A Sharlo

{"title":"Ryanodine receptor stabilizer S-107 rescues slow-type rat soleus muscle function after 7-day hindlimb unloading.","authors":"Daria A Sidorenko, Roman O Bokov, Gleb V Galkin, Natalia A Vilchinskaya, Sergey A Tyganov, Irina D Lvova, Boris S Shenkman, Timur M Mirzoev, Kristina A Sharlo","doi":"10.1007/s00424-025-03108-1","DOIUrl":"10.1007/s00424-025-03108-1","url":null,"abstract":"During periods of muscle disuse, calcium accumulates in the myoplasm of slow-tonic muscle fibers, leading to multiple negative consequences for muscle function. Leaky ryanodine receptors (RyRs) could contribute to this excessive accumulation of calcium. We hypothesized that the administration of S-107, a stabilizer of RyRs, would reduce the accumulation of calcium in the myoplasm/mitochondria and improve rat soleus muscle function during disuse. Male Wistar rats underwent 7 days of hindlimb suspension (HS), receiving S-107 in their food daily throughout the experiment. Seven days of HS led to cytosolic and mitochondrial calcium accumulation, enhanced mitochondrial respiration, and reduced mitochondrial biogenesis in the soleus muscle. This was accompanied by reductions in the proportion of slow-type myofibres, maximal isometric force, and fatigue resistance. Administering S-107 during HS prevented the accumulation of calcium in the mitochondria and the overactivation of mitochondrial respiration. It also attenuated the decline in markers of mitochondrial biogenesis and the decrease in fatigue resistance. S-107 treatment also partially prevented the decline in the soleus muscle force production but had only a minor effect on myoplasmic calcium accumulation. Our findings suggest that the destabilization of RyRs during muscle disuse leads to an accumulation of calcium in both the mitochondria and the myoplasm, which in turn causes a decline in muscle strength and resistance to fatigue.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"1245-1258"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial ATP synthase 8 single-nucleotide polymorphism affects oxidative stress and survival of mice. 线粒体ATP合酶8单核苷酸多态性影响小鼠氧化应激和存活。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2025-09-20 DOI: 10.1007/s00424-025-03123-2

Gesine Reichart, Johannes Mayer, Tursonjan Tokay, Timo Kirschstein, Falko Lange, Rüdiger Köhling

{"title":"Mitochondrial ATP synthase 8 single-nucleotide polymorphism affects oxidative stress and survival of mice.","authors":"Gesine Reichart, Johannes Mayer, Tursonjan Tokay, Timo Kirschstein, Falko Lange, Rüdiger Köhling","doi":"10.1007/s00424-025-03123-2","DOIUrl":"https://doi.org/10.1007/s00424-025-03123-2","url":null,"abstract":"Single-nucleotide polymorphisms in mitochondrial DNA (mtDNA) encoded genes of respiratory chain complexes are known to be associated with severe diseases and life-threatening syndromes. In the assembly of the ATP synthase, the enzyme that in the final steps of oxidative phosphorylation generates ATP from ADP and inorganic phosphate, two subunits (ATP6 and ATP8) are mtDNA-encoded. In our study, we investigated the impact of a single-nucleotide polymorphism in MT-ATP8 with respect to memory function in a preclinical model. Here, we have employed two conplastic mouse strains. The mouse strain C57BL/6 J-mtAKR/J served as a control with wild-type sequence in MT-ATP8, while C57BL/6 J-mtFVB/NJ exhibited an m.7778G > T transversion. Using two age groups (3 months and 24 months), levels of reactive oxygen species (ROS), spatial learning in the Morris-Water-Maze, and long-term potentiation were assessed. Immunohistologically, the expressions of NeuN and GFAP were quantified. Additionally, the lifespan of both strains was registered. In comparison to young C57BL/6 J-mtFVB/NJ mice, aged animals had higher ROS levels in the hippocampus. A decreased NeuN/GFAP level was found in C57BL/6 J-mtFVB/NJ mice as well as in old animals of the control strain. Aged animals performed worse in the swimming trials, but no significant differences between both strains were detected. The long-term potentiation recordings revealed reduced synaptic plasticity in young C57BL/6 J-mtFVB/NJ mice. Interestingly, C57BL/6 J-mtFVB/NJ mice presented an extended lifespan compared to animals of the control strain. Together, our data suggest a minor impact of a single-nucleotide polymorphism in MT-ATP8 on spatial learning and oxidative stress depending on the neuronal tissue. In line with the concept of mitohormesis, our findings may be linked to the longevity of mice harbouring single-nucleotide polymorphisms.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Professor Helmut Acker (1939-2025) : A Pioneer in Oxygen Sensing and Molecular Physiology. 赫尔穆特·阿克教授（1939-2025）：氧传感和分子生理学的先驱。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2025-09-19 DOI: 10.1007/s00424-025-03122-3

Till Acker, Joachim Fandrey, Jörgen Carlsson

引用次数: 0