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Exercise-induced microRNAs: molecular pathways and adaptive remodeling of skeletal muscle. 运动诱导的microrna：骨骼肌的分子途径和适应性重塑。
IF 2.9 4区 医学
Pflugers Archiv : European journal of physiology Pub Date : 2026-05-09 DOI: 10.1007/s00424-026-03177-w
Kübra Özdemir, Yeliz Demir
{"title":"Exercise-induced microRNAs: molecular pathways and adaptive remodeling of skeletal muscle.","authors":"Kübra Özdemir, Yeliz Demir","doi":"10.1007/s00424-026-03177-w","DOIUrl":"https://doi.org/10.1007/s00424-026-03177-w","url":null,"abstract":"<p><p>Exercise is an effective physiological stimulus that promotes vast structural and functional changes in skeletal muscular tissue. Although transcriptional pathways that control exercise-based plasticity have been studied in depth, recent findings highlight the importance of microRNAs (miRNAs) as an essential post-transcriptional control platform mediating contractile stimuli and molecular and physiologic adaptations. This review provides a synthesis of existing evidence on exercise responsive miRNAs at the systems level, and especially on the topic of skeletal muscle remodeling. The review outlines the effects of different exercise regimens such as endurance, resistance, and high-intensity interval training to dynamic miRNA response to regulate major biological pathways such as mitochondrial biogenesis, protein turnover, angiogenesis, inflammatory signaling, and metabolic regulation. Acute exercise is also typified by temporary changes in miRNAs, which facilitate short-term stress signalling, and chronic training leads to more long-term miRNA re-programming, which facilitates long-term structural and functional remodeling. Also, circulating and exosome-bound miRNAs are also mentioned as potential agents of the muscle-to-organ interaction, thus supporting the idea of skeletal muscle that acts like an endocrine-like organ during exercise. Besides narrative synthesis, the review is based on an exploratory, data-driven re-analysis of publicly available skeletal muscle miRNA sequencing data to define convergent regulatory programs instead of data-specific differentiation. This is observed under integrative pathway and network-level analysis which identifies coordinated miRNA modules linked to mitochondrial regulation, cytoskeletal remodeling, and inflammatory control. Taken together, this framework brings together non-homogenous evidence throughout the literature and highlights the prospect of exercise-sensitive miRNAs as systems-level regulators of skeletal muscle adaptation.</p>","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":"478 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of IP3R and TRPC3 channels in vasoconstriction and hypertension. IP3R和TRPC3通道在血管收缩和高血压中的作用。
IF 2.9 4区 医学
Pflugers Archiv : European journal of physiology Pub Date : 2026-05-02 DOI: 10.1007/s00424-026-03175-y
Raiana Dos Anjos Moraes, Quiara Lovatti Alves, Liliane Barreto da Silva, Rafael Leonne Cruz de Jesus, Darízy Flávia Silva
{"title":"The role of IP<sub>3</sub>R and TRPC3 channels in vasoconstriction and hypertension.","authors":"Raiana Dos Anjos Moraes, Quiara Lovatti Alves, Liliane Barreto da Silva, Rafael Leonne Cruz de Jesus, Darízy Flávia Silva","doi":"10.1007/s00424-026-03175-y","DOIUrl":"10.1007/s00424-026-03175-y","url":null,"abstract":"<p><p>Hypertension is a major global health concern and a leading risk factor for cardiovascular diseases, including stroke, myocardial infarction, and heart failure. A hallmark of hypertension is elevated total peripheral vascular resistance, often driven by sustained and abnormal vasoconstriction. Calcium ions (Ca²⁺) play a central role in vascular smooth muscle cell (VSMC) contraction, and their intracellular concentration is tightly regulated by multiple signaling pathways. Among these, the inositol 1,4,5-trisphosphate receptor (IP<sub>3</sub>R) and the transient receptor potential canonical type 3 (TRPC3) channel are critical mediators of Ca²⁺ signaling. IP<sub>3</sub>R activation triggers Ca²⁺ release from the endoplasmic reticulum, while TRPC3 channels facilitate Ca²⁺ and Na⁺ influx across the plasma membrane. Several studies have shown that both IP<sub>3</sub>Rs and TRPC3 channels are upregulated in hypertensive animal models. Human studies have also demonstrated elevated TRPC3 expression in the context of pulmonary arterial hypertension (PAH). This review provides a comprehensive overview of the structural domains and membrane microdomains that facilitate IP<sub>3</sub>R-TRPC3 coupling and Ca²⁺ influx. IP₃ and endothelin-1 stimulate TRPC3 channels and promote their molecular coupling to IP<sub>3</sub>Rs, leading to activation of nonselective cation currents in artery myocytes. Increased expression and/or activity of IP<sub>3</sub>Rs and TRPC3 channels amplifies this signaling, contributing to the increased vascular tone characteristic of the hypertensive state. Understanding the molecular interplay between IP<sub>3</sub>Rs and TRPC3 channels offers new insight into the dysregulated Ca²⁺ signaling underlying hypertension. Targeting this coupling mechanism may represent a novel therapeutic strategy to restore vascular homeostasis and reduce blood pressure in affected individuals.</p>","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":"478 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Angiotensin converting enzyme-2 activation mitigates glucocorticoids-induced osteoporosis in rats by modulating oxidative stress, inflammation and the RANKL/OPG pathway. 血管紧张素转换酶-2激活通过调节氧化应激、炎症和RANKL/OPG通路减轻糖皮质激素诱导的大鼠骨质疏松症。
IF 2.9 4区 医学
Pflugers Archiv : European journal of physiology Pub Date : 2026-04-29 DOI: 10.1007/s00424-026-03167-y
Heba Fathy El-Domiaty, Mohamed Abdallah, Nesrin Abd Allah Salman, Walaa Abdellah Esa, Doaa Abdelsatar Madkour, Eman I Elgizawy
{"title":"Angiotensin converting enzyme-2 activation mitigates glucocorticoids-induced osteoporosis in rats by modulating oxidative stress, inflammation and the RANKL/OPG pathway.","authors":"Heba Fathy El-Domiaty, Mohamed Abdallah, Nesrin Abd Allah Salman, Walaa Abdellah Esa, Doaa Abdelsatar Madkour, Eman I Elgizawy","doi":"10.1007/s00424-026-03167-y","DOIUrl":"https://doi.org/10.1007/s00424-026-03167-y","url":null,"abstract":"","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":"478 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Guinea pig δβγ-ENaC is locked in an open state and uncoupled from regulation by proteases. 豚鼠δβγ-ENaC被锁定在开放状态，不受蛋白酶的调节。
IF 2.9 4区 医学
Pflugers Archiv : European journal of physiology Pub Date : 2026-04-25 DOI: 10.1007/s00424-026-03173-0
Rene Yufenyuy Lawong, Etang Collins Etang, Fabian May, Philipp Vorrat, Oliver Rauh, Mike Althaus
{"title":"Guinea pig δβγ-ENaC is locked in an open state and uncoupled from regulation by proteases.","authors":"Rene Yufenyuy Lawong, Etang Collins Etang, Fabian May, Philipp Vorrat, Oliver Rauh, Mike Althaus","doi":"10.1007/s00424-026-03173-0","DOIUrl":"https://doi.org/10.1007/s00424-026-03173-0","url":null,"abstract":"","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":"478 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of autonomic receptors in ethyl ferulate-induced cardiovascular effects in normotensive and hypertensive female rats. 自主神经受体在阿魏酸乙酯诱导的正常和高血压雌性大鼠心血管效应中的作用。
IF 2.9 4区 医学
Pflugers Archiv : European journal of physiology Pub Date : 2026-04-25 DOI: 10.1007/s00424-026-03170-3
Francisca Valdirene de S Nunes, Samuel S P Araujo, Juliana A da Silva, José Guilherme V de Assunção, Ariell A de Oliveira, Carlos E R Dourado, Vandercley de O Damasceno, Aldeídia P de Oliveira, Maria do Carmo C Martins, Mayara C de Morais, Damião P de Sousa, Thyago M de Queiroz, Renato N Soriano, Luiz G S Branco, Helio C Salgado, João Paulo J Sabino
{"title":"Role of autonomic receptors in ethyl ferulate-induced cardiovascular effects in normotensive and hypertensive female rats.","authors":"Francisca Valdirene de S Nunes, Samuel S P Araujo, Juliana A da Silva, José Guilherme V de Assunção, Ariell A de Oliveira, Carlos E R Dourado, Vandercley de O Damasceno, Aldeídia P de Oliveira, Maria do Carmo C Martins, Mayara C de Morais, Damião P de Sousa, Thyago M de Queiroz, Renato N Soriano, Luiz G S Branco, Helio C Salgado, João Paulo J Sabino","doi":"10.1007/s00424-026-03170-3","DOIUrl":"10.1007/s00424-026-03170-3","url":null,"abstract":"","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":"478 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proximal TGF-β Signaling in Chronic Injury: from a notorious fibrotic factor to a repair ally. 慢性损伤中的近端TGF-β信号：从臭名昭著的纤维化因子到修复盟友。
IF 2.9 4区 医学
Pflugers Archiv : European journal of physiology Pub Date : 2026-04-23 DOI: 10.1007/s00424-026-03168-x
Stellor Nlandu Khodo
{"title":"Proximal TGF-β Signaling in Chronic Injury: from a notorious fibrotic factor to a repair ally.","authors":"Stellor Nlandu Khodo","doi":"10.1007/s00424-026-03168-x","DOIUrl":"https://doi.org/10.1007/s00424-026-03168-x","url":null,"abstract":"","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":"478 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13102887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective effects of vitamin E and quercetin against MDMA-induced cardiac and hematological dysfunction in male wistar rats. 维生素E和槲皮素对mdma诱导的雄性wistar大鼠心脏和血液功能障碍的保护作用。
IF 2.9 4区 医学
Pflugers Archiv : European journal of physiology Pub Date : 2026-04-23 DOI: 10.1007/s00424-026-03169-w
Ayodeji Folorunsho Ajayi, David Tolulope Oluwole, Moses Agbomhere Hamed, Ayomide Jonathan Jegede, Florence Bukola Adisa, Lateef Olabisi Okeleji, Toluwalope Oluwafisayo Iyiola, Oyedayo Phillips Akano
{"title":"Protective effects of vitamin E and quercetin against MDMA-induced cardiac and hematological dysfunction in male wistar rats.","authors":"Ayodeji Folorunsho Ajayi, David Tolulope Oluwole, Moses Agbomhere Hamed, Ayomide Jonathan Jegede, Florence Bukola Adisa, Lateef Olabisi Okeleji, Toluwalope Oluwafisayo Iyiola, Oyedayo Phillips Akano","doi":"10.1007/s00424-026-03169-w","DOIUrl":"https://doi.org/10.1007/s00424-026-03169-w","url":null,"abstract":"","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":"478 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mask slipped: wakeable nociceptors express OSMR/SST. 面罩滑落：可唤醒的伤害感受器表达OSMR/SST。
IF 2.9 4区 医学
Pflugers Archiv : European journal of physiology Pub Date : 2026-04-21 DOI: 10.1007/s00424-026-03172-1
Michael J M Fischer, Peter W Reeh
{"title":"The mask slipped: wakeable nociceptors express OSMR/SST.","authors":"Michael J M Fischer, Peter W Reeh","doi":"10.1007/s00424-026-03172-1","DOIUrl":"https://doi.org/10.1007/s00424-026-03172-1","url":null,"abstract":"","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":"478 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Active bile acid metabolism could contribute to muscle preservation in hibernating bears via the TGR5 pathway. 活跃的胆汁酸代谢可能通过TGR5途径促进冬眠熊的肌肉保存。
IF 2.9 4区 医学
Pflugers Archiv : European journal of physiology Pub Date : 2026-04-20 DOI: 10.1007/s00424-026-03171-2
Reiko Nakao, Lydie Humbert, Isabelle Chery, Guillemette Gauquelin-Koch, Jonas Kindberg, Andrea L Miller, Alexandra Thiel, Etienne Lefai, Stéphane Blanc, Dominique Rainteau, Fabrice Bertile
{"title":"Active bile acid metabolism could contribute to muscle preservation in hibernating bears via the TGR5 pathway.","authors":"Reiko Nakao, Lydie Humbert, Isabelle Chery, Guillemette Gauquelin-Koch, Jonas Kindberg, Andrea L Miller, Alexandra Thiel, Etienne Lefai, Stéphane Blanc, Dominique Rainteau, Fabrice Bertile","doi":"10.1007/s00424-026-03171-2","DOIUrl":"https://doi.org/10.1007/s00424-026-03171-2","url":null,"abstract":"","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":"478 5","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex-sensitive and insensitive endocrine responses and infradian changes while trekking in the Himalayas. 在喜马拉雅山徒步旅行时，性别敏感和性别不敏感的内分泌反应和红外变化。
IF 2.9 4区 医学
Pflugers Archiv : European journal of physiology Pub Date : 2026-04-08 DOI: 10.1007/s00424-026-03166-z
Danilo Bondi, Sofia Bonan, Simone Cantarelli, Francesca Ietta, Ilenia Casini, Alberto Taverna, Riccardo Rua, Maria Teresa Guagnano, Arcangelo Barbonetti, Suwas Bhandari, Ashish Shrestha, Anna Maria Aloisi, Vittore Verratti
{"title":"Sex-sensitive and insensitive endocrine responses and infradian changes while trekking in the Himalayas.","authors":"Danilo Bondi, Sofia Bonan, Simone Cantarelli, Francesca Ietta, Ilenia Casini, Alberto Taverna, Riccardo Rua, Maria Teresa Guagnano, Arcangelo Barbonetti, Suwas Bhandari, Ashish Shrestha, Anna Maria Aloisi, Vittore Verratti","doi":"10.1007/s00424-026-03166-z","DOIUrl":"10.1007/s00424-026-03166-z","url":null,"abstract":"","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":"478 4","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13061754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147634280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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