Pflugers Archiv : European journal of physiology最新文献_第5页

Causality and scientific explanation of artificial intelligence systems in biomedicine. 生物医学中人工智能系统的因果关系和科学解释。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2025-04-01 Epub Date: 2024-10-29 DOI: 10.1007/s00424-024-03033-9

Florian Boge, Axel Mosig

{"title":"Causality and scientific explanation of artificial intelligence systems in biomedicine.","authors":"Florian Boge, Axel Mosig","doi":"10.1007/s00424-024-03033-9","DOIUrl":"10.1007/s00424-024-03033-9","url":null,"abstract":"With rapid advances of deep neural networks over the past decade, artificial intelligence (AI) systems are now commonplace in many applications in biomedicine. These systems often achieve high predictive accuracy in clinical studies, and increasingly in clinical practice. Yet, despite their commonly high predictive accuracy, the trustworthiness of AI systems needs to be questioned when it comes to decision-making that affects the well-being of patients or the fairness towards patients or other stakeholders affected by AI-based decisions. To address this, the field of explainable artificial intelligence, or XAI for short, has emerged, seeking to provide means by which AI-based decisions can be explained to experts, users, or other stakeholders. While it is commonly claimed that explanations of artificial intelligence (AI) establish the trustworthiness of AI-based decisions, it remains unclear what traits of explanations cause them to foster trustworthiness. Building on historical cases of scientific explanation in medicine, we here propagate our perspective that, in order to foster trustworthiness, explanations in biomedical AI should meet the criteria of being scientific explanations. To further undermine our approach, we discuss its relation to the concepts of causality and randomized intervention. In our perspective, we combine aspects from the three disciplines of biomedicine, machine learning, and philosophy. From this interdisciplinary angle, we shed light on how the explanation and trustworthiness of artificial intelligence relate to the concepts of causality and robustness. To connect our perspective with AI research practice, we review recent cases of AI-based studies in pathology and, finally, provide guidelines on how to connect AI in biomedicine with scientific explanation.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"543-554"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges and applications in generative AI for clinical tabular data in physiology. 生理学临床表格数据生成式人工智能的挑战与应用。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2025-04-01 Epub Date: 2024-10-17 DOI: 10.1007/s00424-024-03024-w

Chaithra Umesh, Manjunath Mahendra, Saptarshi Bej, Olaf Wolkenhauer, Markus Wolfien

引用次数: 0

The ethics of artificial intelligence systems in healthcare and medicine: from a local to a global perspective, and back. 人工智能系统在医疗保健领域的伦理问题：从地方视角到全球视角，再到全球视角。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2025-04-01 Epub Date: 2024-07-06 DOI: 10.1007/s00424-024-02984-3

Tijs Vandemeulebroucke

{"title":"The ethics of artificial intelligence systems in healthcare and medicine: from a local to a global perspective, and back.","authors":"Tijs Vandemeulebroucke","doi":"10.1007/s00424-024-02984-3","DOIUrl":"10.1007/s00424-024-02984-3","url":null,"abstract":"Artificial intelligence systems (ai-systems) (e.g. machine learning, generative artificial intelligence), in healthcare and medicine, have been received with hopes of better care quality, more efficiency, lower care costs, etc. Simultaneously, these systems have been met with reservations regarding their impacts on stakeholders' privacy, on changing power dynamics, on systemic biases, etc. Fortunately, healthcare and medicine have been guided by a multitude of ethical principles, frameworks, or approaches, which also guide the use of ai-systems in healthcare and medicine, in one form or another. Nevertheless, in this article, I argue that most of these approaches are inspired by a local isolationist view on ai-systems, here exemplified by the principlist approach. Despite positive contributions to laying out the ethical landscape of ai-systems in healthcare and medicine, such ethics approaches are too focused on a specific local healthcare and medical setting, be it a particular care relationship, a particular care organisation, or a particular society or region. By doing so, they lose sight of the global impacts ai-systems have, especially environmental impacts and related social impacts, such as increased health risks. To meet this gap, this article presents a global approach to the ethics of ai-systems in healthcare and medicine which consists of five levels of ethical impacts and analysis: individual-relational, organisational, societal, global, and historical. As such, this global approach incorporates the local isolationist view by integrating it in a wider landscape of ethical consideration so to ensure ai-systems meet the needs of everyone everywhere.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"591-601"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11958494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive overview of artificial intelligence in surgery: a systematic review and perspectives. 人工智能在外科手术中的综合综述：系统回顾与展望。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2025-04-01 Epub Date: 2025-03-15 DOI: 10.1007/s00424-025-03076-6

Olivia Chevalier, Gérard Dubey, Amine Benkabbou, Mohammed Anass Majbar, Amine Souadka

{"title":"Comprehensive overview of artificial intelligence in surgery: a systematic review and perspectives.","authors":"Olivia Chevalier, Gérard Dubey, Amine Benkabbou, Mohammed Anass Majbar, Amine Souadka","doi":"10.1007/s00424-025-03076-6","DOIUrl":"10.1007/s00424-025-03076-6","url":null,"abstract":"The rapid integration of artificial intelligence (AI) into surgical practice necessitates a comprehensive evaluation of its applications, challenges, and physiological impact. This systematic review synthesizes current AI applications in surgery, with a particular focus on machine learning (ML) and its role in optimizing preoperative planning, intraoperative decision-making, and postoperative patient management. Using PRISMA guidelines and PICO criteria, we analyzed key studies addressing AI's contributions to surgical precision, outcome prediction, and real-time physiological monitoring. While AI has demonstrated significant promise-from enhancing diagnostics to improving intraoperative safety-many surgeons remain skeptical due to concerns over algorithmic unpredictability, surgeon autonomy, and ethical transparency. This review explores AI's physiological integration into surgery, discussing its role in real-time hemodynamic assessments, AI-guided tissue characterization, and intraoperative physiological modeling. Ethical concerns, including algorithmic opacity and liability in high-stakes scenarios, are critically examined alongside AI's potential to augment surgical expertise. We conclude that longitudinal validation, improved AI explainability, and adaptive regulatory frameworks are essential to ensure safe, effective, and ethically sound integration of AI into surgical decision-making. Future research should focus on bridging AI-driven analytics with real-time physiological feedback to refine precision surgery and patient safety strategies.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"617-626"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Competing effects of activation history on force and cytosolic Ca²⁺ in intact single mice myofibers. 激活历史对完整的单个小鼠肌纤维的力和胞浆Ca2+的竞争影响。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2025-03-01 Epub Date: 2024-12-30 DOI: 10.1007/s00424-024-03061-5

Alexander M Zero, Charles L Rice, Leonardo Nogueira

{"title":"Competing effects of activation history on force and cytosolic Ca2+ in intact single mice myofibers.","authors":"Alexander M Zero, Charles L Rice, Leonardo Nogueira","doi":"10.1007/s00424-024-03061-5","DOIUrl":"10.1007/s00424-024-03061-5","url":null,"abstract":"The purpose was to investigate the changes in cytosolic Ca2+ and force output during post-tetanic potentiation (PTP) during pre-fatigue and during prolonged low-frequency force depression (PLFFD) following fatigue. Intact single myofibers from the flexor digitorum brevis of mice were electrically stimulated to record force (n = 8) and free cytosolic Ca2+ concentration ([Ca2+]c) with FURA-2 (n = 6) at 32 °C. Initially, force and [Ca2+]c were measured during brief (350 ms) trains of stimuli at 30, 50, 70, and 200 Hz at ~ 2 s intervals (Force-frequency protocol, FFP). Then, a conditioning stimulus (CS) of six 120 Hz stimuli, separated by ~ 3 s, was used to induce PTP, immediately followed by an FFP. Myofiber fatigue was produced by 150 Hz trains every 3 s until peak force decayed 70% of the initial. Thirty minutes after the fatigue, the CS was repeated to assess the effect of PTP on force and [Ca2+]c during PLFFD. The CS in unfatigued myofibers induced PTP as the submaximal force was enhanced and accompanied by increased peak [Ca2+]c with no change in myofilament Ca2+ sensitivity. After fatigue, PLFFD was due to lowered peak [Ca2+]c. Inducing PTP during PLFFD enhanced submaximal force primarily through greater peak [Ca2+]c, mitigating the submaximal force deficits. Despite the impaired force during PLFFD, myofibers remained sensitive to PTP, and this mitigated the submaximal force deficits through increased peak [Ca2+]c without a change in myofilament Ca2+ sensitivity. Therefore, force adjustments of intact single myofibers due to activation history are principally accomplished by opposing adjustments in [Ca2+]c.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"407-419"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperosmolality activates polycystin-2 and TRPM4 in renal primary cilium. 高渗透压激活肾原纤毛中的多囊素-2和TRPM4。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2025-03-01 Epub Date: 2024-12-17 DOI: 10.1007/s00424-024-03050-8

Steven J Kleene

{"title":"Hyperosmolality activates polycystin-2 and TRPM4 in renal primary cilium.","authors":"Steven J Kleene","doi":"10.1007/s00424-024-03050-8","DOIUrl":"10.1007/s00424-024-03050-8","url":null,"abstract":"Autosomal dominant polycystic kidney disease (ADPKD) is a debilitating disease characterized by renal cysts. It arises from mutations in proteins expressed in part in the primary cilia of renal epithelial cells. One of these, polycystin-2 (PC2), is an ion-conducting channel. To date, ion channels in the cilium have only been characterized in standard normosmolar external solutions, but the osmolality of the renal filtrate bathing the cilia varies widely. Here I report that urine, which better represents the filtrate, activates a large cation-conducting current in the cilia. With defined external solutions, hyperosmolality through addition of urea, NaCl, or D-mannitol activates a similar current. Most but not all of this current is conducted through TRPM4 channels. It is greatly reduced by internal MgATP or 9-phenanthrol, which inhibit TRPM4, or by shRNA knockdown of TRPM4. However, part of the current activated by urea conducts Ca2+ through channels that remain to be identified. External hyperosmolality also greatly increases the activity of ciliary PC2 channels; this is the first physiological stimulus identified for these channels. Possibilities are discussed for the mechanisms of channel activation and the roles for these activities in regulatory volume increase and cystogenesis.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"479-494"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142837744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined exercise-induced modulation of Notch pathway and muscle quality in senescence-accelerated mice. 运动诱导的Notch通路与衰老加速小鼠肌肉质量的联合调节。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2025-03-01 Epub Date: 2025-01-13 DOI: 10.1007/s00424-024-03048-2

Ana P Pinto, Ângelo Augusto J Sarni, Maria Eduarda A Tavares, Alisson L da Rocha, Ruither O Gomes Carolino, Ivo V de Sousa Neto, Driele C Da Silva Ferreira, Vitor R Munoz, Giovana R Teixeira, Fernando M Simabuco, José R Pauli, Dennys E Cintra, Eduardo R Ropelle, Ellen C de Freitas, Adelino S R da Silva

{"title":"Combined exercise-induced modulation of Notch pathway and muscle quality in senescence-accelerated mice.","authors":"Ana P Pinto, Ângelo Augusto J Sarni, Maria Eduarda A Tavares, Alisson L da Rocha, Ruither O Gomes Carolino, Ivo V de Sousa Neto, Driele C Da Silva Ferreira, Vitor R Munoz, Giovana R Teixeira, Fernando M Simabuco, José R Pauli, Dennys E Cintra, Eduardo R Ropelle, Ellen C de Freitas, Adelino S R da Silva","doi":"10.1007/s00424-024-03048-2","DOIUrl":"10.1007/s00424-024-03048-2","url":null,"abstract":"The Notch signaling pathway is crucial for skeletal muscle development, regeneration, inflammation, and aging. This study investigated the association between interleukin-10 (IL-10) and the Notch pathway in C2C12 cells, as well as explored the effects of combined endurance and resistance exercise on the Notch and autophagy pathways in the skeletal muscle of senescence-accelerated mouse-resistant 1 Sedentary (SAMR1 CT), SAMR1 exercised (SAMR1 EX), senescence-accelerated prone mouse 8 Sedentary (SAMP8 CT), and SAMP8 exercised (SAMP8 EX). C2C12 myoblasts were transfected with siIL-10. Histological analysis, reverse transcription-quantitative polymerase chain reaction, and immunoblotting were performed on the quadriceps and tibialis anterior muscles. A publicly available dataset was analyzed to assess the Notch pathway in older men. In summary, IL-10 knockdown in myoblasts reduced the Notch pathway gene and protein expression. In SAMP8 mice, combined exercise improved muscle fiber organization, enhanced balance and coordination, and increased Notch2 and Hes1 mRNA levels. NOTCH2 mRNA levels were also higher in older men compared to young subjects with similar physical activity levels. These findings suggest that combined physical exercise enhances muscle regeneration via the Notch pathway in aged muscle.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"393-405"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of the estrous cycle on brain monoamines and behavioral and respiratory responses to CO₂ in mice. 发情周期对小鼠大脑单胺类物质以及对二氧化碳的行为和呼吸反应的影响。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2025-03-01 Epub Date: 2024-11-27 DOI: 10.1007/s00424-024-03040-w

Beatriz Dominiquini-Moraes, Mariana Bernardes-Ribeiro, Luis Gustavo A Patrone, Elisa M Fonseca, Alana T Frias, Kaoma S Costa Silva, Roberta Araujo-Lopes, Raphael E Szawka, Kênia C Bícego, Hélio Zangrossi, Luciane H Gargaglioni

{"title":"Impact of the estrous cycle on brain monoamines and behavioral and respiratory responses to CO2 in mice.","authors":"Beatriz Dominiquini-Moraes, Mariana Bernardes-Ribeiro, Luis Gustavo A Patrone, Elisa M Fonseca, Alana T Frias, Kaoma S Costa Silva, Roberta Araujo-Lopes, Raphael E Szawka, Kênia C Bícego, Hélio Zangrossi, Luciane H Gargaglioni","doi":"10.1007/s00424-024-03040-w","DOIUrl":"10.1007/s00424-024-03040-w","url":null,"abstract":"The prevalence of panic disorder is two to four times higher in women compared to that in men, and hormonal changes during the menstrual cycle play a role in the occurrence of panic attacks. Here, we investigated the effect of the estrous cycle on the ventilatory and behavioral responses to CO2 in mice. Female mice in proestrus, estrus, metestrus, or diestrus were exposed to 20% CO2, and their escape behaviors, brain monoamines, and plasma levels of 17β-estradiol (E2) and progesterone (P4) were measured. Pulmonary ventilation (V̇E), oxygen consumption (V̇O2), and body core temperature (TB) were also measured during normocapnia followed by CO2. Females exposed to 20% CO2 exhibited an escape behavior, but the estrous cycle did not affect this response. Females in all phases of the estrous cycle showed higher V̇E and lower TB during hypercapnia. In diestrus, there was an attenuation of CO2-induced hyperventilation with no change in V̇O2, whereas in estrus, this response was accompanied by a reduction in V̇O2. Hypercapnia also increased the concentration of plasma P4 and central DOPAC, the main dopamine metabolite, in all females. There was an estrous cycle effect on brainstem serotonin, with females in estrus showing a higher concentration than females in the metestrus and diestrus phases. Therefore, our data suggest that hypercapnia induces panic-related behaviors and ventilatory changes that lead to an increase in P4 secretion in female mice, likely originating from the adrenals. The estrous cycle does not affect the behavioral response but interferes in the ventilatory and metabolic responses to CO2 in mice.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"349-369"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142731789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatially dependent tissue distribution of thyroid hormones by plasma thyroid hormone binding proteins. 血浆甲状腺激素结合蛋白对甲状腺激素空间依赖性组织分布的影响。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2025-03-01 Epub Date: 2025-01-03 DOI: 10.1007/s00424-024-03060-6

Anish D Bagga, Brian P Johnson, Qiang Zhang

{"title":"Spatially dependent tissue distribution of thyroid hormones by plasma thyroid hormone binding proteins.","authors":"Anish D Bagga, Brian P Johnson, Qiang Zhang","doi":"10.1007/s00424-024-03060-6","DOIUrl":"10.1007/s00424-024-03060-6","url":null,"abstract":"Plasma thyroid hormone (TH) binding proteins (THBPs), including thyroxine-binding globulin (TBG), transthyretin (TTR), and albumin (ALB), carry THs to extrathyroidal sites, where THs are unloaded locally and then taken up via membrane transporters into the tissue proper. The respective roles of THBPs in supplying THs for tissue uptake are not completely understood. To investigate this, we developed a spatial human physiologically based kinetic (PBK) model of THs, which produces several novel findings. (1) Contrary to postulations that TTR and/or ALB are the major local T4 contributors, the three THBPs may unload comparable amounts of T4 in Liver, a rapidly perfused organ; however, their contributions in slowly perfused tissues follow the order of abundances of T4TBG, T4TTR, and T4ALB. The T3 amounts unloaded from or loaded onto THBPs in a tissue acting as a T3 sink or source respectively follow the order of abundance of T3TBG, T3ALB, and T3TTR regardless of perfusion rate. (2) Any THBP alone is sufficient to maintain spatially uniform TH tissue distributions. (3) The TH amounts unloaded by each THBP species are spatially dependent and nonlinear in a tissue, with ALB being the dominant contributor near the arterial end but conceding to TBG near the venous end. (4) Spatial gradients of TH transporters and metabolic enzymes may modulate these contributions, producing spatially invariant or heterogeneous TH tissue concentrations depending on whether the blood-tissue TH exchange operates in near-equilibrium mode. In summary, our modeling provides novel insights into the differential roles of THBPs in local TH tissue distribution.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"453-478"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142922508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Personalising dietary advice for disease prevention: concepts and experiences. 预防疾病的个性化饮食建议：概念和经验。

IF 2.9 4区医学

Pflugers Archiv : European journal of physiology Pub Date : 2025-03-01 Epub Date: 2025-01-25 DOI: 10.1007/s00424-025-03064-w

Hannelore Daniel

{"title":"Personalising dietary advice for disease prevention: concepts and experiences.","authors":"Hannelore Daniel","doi":"10.1007/s00424-025-03064-w","DOIUrl":"10.1007/s00424-025-03064-w","url":null,"abstract":"Personalised nutrition (PN) as a new endeavour emerged in the background of the human genome project with the ease to analyse genetic heterogeneity. First commercial offers with recommendations for diet and lifestyle changes, usually based on a few polymorphisms, entered markets soon after the presentation of the human genome blueprint. Although PN has seen many attempts, meanwhile, with the inclusion of other biomedical measures such as microbiome and/or continuous glucose monitoring, scientific assessments of such approaches in various settings revealed limited success. Although personalisation improved general compliance over generic advice, particular benefits in referring to biomedical measures and individual risks did, in most cases, not provide any significant advantage. Moreover, scholars criticised such approaches as of limited impact from a public health perspective by attracting mainly technology-open individuals of high social status and proper financial capabilities. Based on these experiences, new avenues for personalising dietary advice are developed, and those are going beyond pure biomedical data by assessing the entire food environment of the individual with its capabilities and constraints in the given life setting. Embedded into digital environments for data collection but also for bidirectional communication, new possibilities emerge. Artificial intelligence methods allow for the multitude of input data and highly complex decision trees to be derived to customize advice. And that can be delivered on the spot and in time in any language whenever decisions are made on what to buy or what to eat. But systems can also be employed to increase physical activity levels and for the adoption of a more healthy lifestyle in general.","PeriodicalId":19954,"journal":{"name":"Pflugers Archiv : European journal of physiology","volume":" ","pages":"335-339"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0