Pediatric Allergy and Immunology最新文献

{"title":"Egg allergen-specific T-cell and cytokine responses in healthy and egg-allergic children naturally tolerating baked egg.","authors":"Liselot De Vlieger, Lisa Nuyttens, Cheyenne Keppens, Toon Ieven, Charlotte Matton, Marianne Diels, Sophie Verelst, Marc Raes, Jasmine Leus, Katrien Coppens, Kate Sauer, Ellen Dilissen, Jonathan Cremer, Lieve Coorevits, Glynis Frans, Rik Schrijvers, Dominique M A Bullens","doi":"10.1111/pai.70018","DOIUrl":"https://doi.org/10.1111/pai.70018","url":null,"abstract":"<p><strong>Background: </strong>Type 1 regulatory T (Tr1) cells are critical players in maintaining peripheral tolerance, by producing high IL-10 levels in association with inducible T-cell co-stimulator (ICOS) expression. Whether these cells play a role in naturally acquired baked egg tolerance is unknown.</p><p><strong>Objectives: </strong>Evaluate frequencies of egg-responsive Tr1 and Th2 cells in egg-allergic children that naturally acquired baked egg tolerance (BET) versus non-egg-allergic (NEA) children.</p><p><strong>Methods: </strong>Peripheral blood mononuclear cells from 70 natural BET and 15 NEA children were stimulated for 7 days with ovalbumin and ovomucoid. By flowcytometry, egg-responsive Tr1 cells were identified by co-expression of CD49b and LAG3, and Th2 cells by expression of CD49b but absence of LAG3. Seven-day cultured supernatant was analyzed for Th1, Th2, Tr1, and Th17 cytokines by MSD.</p><p><strong>Results: </strong>Natural BET children had a higher percentage of egg-responsive Th2 cells vs. NEA children (6.75% vs. 10.35%, p = .006). No significant difference was found in frequencies of egg-responsive Tr1 cells between NEA and natural BET children (11.40% vs. 12.55%, p = .42), although Tr1-related IL-10 and IL-21 production was higher in BET children. Interestingly, egg-responsive Tr1 cells from NEA children expressed higher ICOS levels vs. natural BET children (97.90 vs. 88.20, p < .0001). Supernatant from natural BET children showed elevated levels of Th2 cytokines IL-5, IL-9 and IL-13 and Th17 cytokine IL-17A.</p><p><strong>Conclusion: </strong>Natural BET children maintain increased egg-specific Th2 responses, along with comparable proportions of egg-responsive Tr1 cells exhibiting higher IL-10 but lower ICOS expression in comparison with NEA children.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 1","pages":"e70018"},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal caffeine intake during pregnancy and the risk of childhood asthma by 10 years of age-Evidence from The Generation XXI birth cohort study.","authors":"Francisca de Castro Mendes, Milton Severo, Inês Paciência, Carla Lopes, Ana Cristina Santos, Henrique Barros, André Moreira, Pedro Moreira","doi":"10.1111/pai.70024","DOIUrl":"https://doi.org/10.1111/pai.70024","url":null,"abstract":"<p><strong>Background: </strong>We aimed to investigate the association between maternal caffeine intake during pregnancy and asthma in children by 10 years of age.</p><p><strong>Methods: </strong>We considered 5585 mother-child pairs enrolled in a population-based birth cohort. Consumption of regular and decaffeinated coffee, black and green tea, and cola beverages before and during pregnancy was obtained through face-to-face interviews within 72 h after giving birth, and total caffeine intake (mg/day) was estimated. Medical diagnosis of asthma was assessed and spirometry with bronchodilation was performed at 10 years of age. We used adjusted regression models to estimate the association between the caffeine intake/day during pregnancy with asthma by 10 years of age, and a quadratic relationship was verified between them. Consumption of caffeine before pregnancy, gestational age, maternal years of schooling, maternal self-reported medical diagnosis of asthma, smoking status before and during pregnancy, and children's sex were considered as confounders. We used nonlinear least squares models to estimate the knot point and its respective confidence interval (CI).</p><p><strong>Results: </strong>A higher intake of caffeine/day decreased the odds of having childhood asthma at 10 years of age (adjusted odds ratio [OR] = 0.60, 95% CI: 0.41; 0.88). The estimated knot point was 92.7 mg of caffeine/day (95% CI: 36.3, 163.3), where the risk was 7.2%, while for no intake (0 mg) the risk was 8.8%.</p><p><strong>Conclusion: </strong>Maternal caffeine intake up to an estimated intake of approximately 93 mg/day during pregnancy decreased childhood asthma risk by 10 years of age. Nonetheless, further studies are required to confirm our results.</p><p><strong>Key message: </strong>Maternal caffeine intake during pregnancy up to an estimated intake of approximately 93 mg/day decreased the risk of asthma in children by 10 years of age, but considering caffeine's potential adverse effects on other health outcomes, further studies are needed to explore its link to childhood asthma.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 1","pages":"e70024"},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perilipin-1 autoantibodies are a robust marker of acquired lipodystrophy and may precede clinical detection.","authors":"Clément Triaille, Fernando Corvillo, Ann Mertens, Ilse Hoffman, Tania Roskams, Margarita López-Trascasa, Lien De Somer, Kristina Casteels","doi":"10.1111/pai.70026","DOIUrl":"10.1111/pai.70026","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 1","pages":"e70026"},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11715144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial comment on \"Association between nasopharyngeal airway lipidome signatures of infants with severe bronchiolitis and risk of recurrent wheeze: A prospective multicenter cohort study\".","authors":"Fabio S Ryser, Ömer Kalayci, Philippe Eigenmann","doi":"10.1111/pai.70020","DOIUrl":"https://doi.org/10.1111/pai.70020","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 1","pages":"e70020"},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on G. N. Vallianatou et al.","authors":"Quanjie Hu, Zhuoxuan Lv, Hongxia Niu","doi":"10.1111/pai.70023","DOIUrl":"https://doi.org/10.1111/pai.70023","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 1","pages":"e70023"},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of parental age at delivery with childhood allergic disease and the modified effect of breastfeeding.","authors":"Ye Zhang, Ruoyu Lu, Yiting Chen, Jiajun Lyu, Rong Li, Wenhui Kang, Anda Zhao, Zidi Ning, Yabin Hu, Yong Yin, Shilu Tong, Jiajun Yuan, Shenghui Li","doi":"10.1111/pai.70025","DOIUrl":"https://doi.org/10.1111/pai.70025","url":null,"abstract":"<p><strong>Background: </strong>Childhood allergic diseases are a global concern; quite limited studies have examined the impacts of parental age at delivery. This study aimed to explore the association between separate and combined parental age at delivery and childhood allergic diseases and whether adequate breastfeeding could modify this association.</p><p><strong>Methods: </strong>This cross-sectional study sampled 15,976 children from Shanghai, China. The International Study of Asthma and Allergies in Childhood questionnaire was adopted to evaluate allergic diseases. Multivariate logistic regression models were used to examine the association of parental age and exclusive breastfeeding with allergic diseases.</p><p><strong>Results: </strong>The prevalence of allergic rhinitis, asthma, food allergy, drug allergy, urticaria, and eczema was 21.2%, 14.2%, 8.7%, 3.9%, 15.6%, and 35.5%, respectively. Either of parental age at delivery ≥25 years could increase the risk of allergic diseases in most cases, where paternal age showed a stronger effect. The risk was further elevated when parental age were both ≥25 years (OR ranged from 1.266 to 1.541, all p < .05 except for drug allergy). Breastfeeding >6 months was inversely associated with all types of allergic diseases and involved in attenuating the risk caused by parental age ≥25 years. These findings were generally validated by sensitivity examination as well as stratified analyses.</p><p><strong>Conclusions: </strong>Parental age at delivery ≥25 years was a risk factor for most childhood allergic diseases. Breastfeeding >6 months applied to modifying the risk chalked up to parental age. These findings are significant given the rising age of parents and increasing prevalence of childhood allergic diseases.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 1","pages":"e70025"},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term outcomes of low-dose followed by conventional oral immunotherapy for egg allergy.","authors":"Kento Takahashi, Ken-Ichi Nagakura, Yoko Miura, Sakura Sato, Motohiro Ebisawa, Noriyuki Yanagida","doi":"10.1111/pai.70027","DOIUrl":"https://doi.org/10.1111/pai.70027","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 1","pages":"e70027"},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diversity of complementary diet and early food allergy risk.","authors":"Stina Bodén, Anna Lindam, Carina Venter, Richard Lundberg Ulfsdotter, Magnus Domellöf, Christina E West","doi":"10.1111/pai.70035","DOIUrl":"10.1111/pai.70035","url":null,"abstract":"<p><strong>Introduction: </strong>Diet diversity (DD) in infancy may be protective for early food allergy (FA) but there is limited knowledge about how DD incorporating consumption frequency influences FA risk.</p><p><strong>Methods: </strong>Three measures of DD were investigated in 2060 infants at 6 and/or at 9 months of age within the NorthPop Birth Cohort Study: a weighted DD score based on intake frequency, the number of introduced foods, and the number of introduced allergenic foods. In multivariable logistic regression models based on directed acyclic graphs, associations to parentally reported physician-diagnosed FA at age 9 and 18 months were estimated, including sensitivity and stratified analyses.</p><p><strong>Results: </strong>High weighted DD scores (24-31p) at age 9 months were associated with 61% decreased odds of FA at age 18 months [OR (95% CI) = 0.39 0.18-0.88] compared with infants with the lowest DD scores (0-17p). The association remained significant after exclusion of early FA cases. Having introduced 13-14 foods at age 9 months, independent of consumption frequency, was associated with 45% decreased odds of FA [OR (95% CI) = 0.55 (0.31-0.98)] compared to having introduced 0-10 foods. When stratifying, significantly reduced odds for FA were seen for children with eczema and for children with no FA history in the family. No association was seen between DD at age 6 months and FA at age 18 months.</p><p><strong>Conclusion: </strong>A diverse diet at age 9 months may prevent FA at age 18 months. Our results underscore the need for additional investigations on the impact of consumption frequency in infancy.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 1","pages":"e70035"},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between maternal fish intake and polyunsaturated fatty acid status with childhood asthma in a high fish-eating population.","authors":"Cealan O Henry, Philip J Allsopp, Alison J Yeates, Toni Spence, Marie C Conway, Maria S Mulhern, Emelyn Shroff, Conrad F Shamlaye, Juliette Henderson, Edwin van Wijngaarden, Gary J Myers, J J Strain, Emeir M McSorley","doi":"10.1111/pai.70019","DOIUrl":"10.1111/pai.70019","url":null,"abstract":"<p><strong>Background: </strong>Studies investigating associations between prenatal polyunsaturated fatty acid status (PUFAs), in particular the anti-inflammatory n-3 PUFAs, and the development of childhood asthma have yielded conflicting results.</p><p><strong>Objective: </strong>To determine the associations between maternal fish intake (a rich source of the n-3 PUFAs), maternal or cord PUFAs with the prevalence of childhood asthma in a high fish-eating population.</p><p><strong>Methods: </strong>We examined these associations between fish intake and PUFA concentrations with childhood asthma prevalence in the Seychelles Child Development Study Nutrition Cohort 2, a large observational study in a high fish-eating population. Maternal fish intake during pregnancy and child's fish intake at 7 years were assessed by questionnaire, with frequency reported as meals/week. Serum concentrations of PUFAs were quantified in maternal blood collected at 28 weeks' gestation (n = 1448) and in cord blood (n = 1088). Asthma in children at 7 years was assessed using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire (n = 1098).</p><p><strong>Results: </strong>A total of 97 children (10.5%) were reported to have asthma. In regression analysis, the odds of childhood asthma were not associated with maternal fish intake or maternal PUFA status. Cord DHA concentrations were associated with increased asthma prevalence when the highest quartile (≥0.123 mg/mL) was compared with the lowest (<0.061 mg/mL).</p><p><strong>Conclusion: </strong>The results from this current study add to the growing body of evidence that fish consumption during pregnancy is not associated with asthma development in offspring. The associations between cord blood DHA and asthma prevalence are unexpected and warrant further investigation.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 1","pages":"e70019"},"PeriodicalIF":4.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Anaphylaxis during OIT and its impact on treatment adherence: A retrospective study\".","authors":"","doi":"10.1111/pai.70006","DOIUrl":"https://doi.org/10.1111/pai.70006","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"35 12","pages":"e70006"},"PeriodicalIF":4.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}