Pediatric Allergy and Immunology最新文献_第10页

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2024-08-01 DOI: 10.1111/pai.14225

Öner Özdemir

引用次数: 0

The contribution of milk substitutes to the nutritional status of children with cow's milk allergy. 牛奶替代品对牛奶过敏儿童营养状况的贡献。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2024-07-01 DOI: 10.1111/pai.14202

Zeynep Parlak-Hela, Umit Murat Sahiner, Bulent Enis Sekerel, Ozge Soyer

{"title":"The contribution of milk substitutes to the nutritional status of children with cow's milk allergy.","authors":"Zeynep Parlak-Hela, Umit Murat Sahiner, Bulent Enis Sekerel, Ozge Soyer","doi":"10.1111/pai.14202","DOIUrl":"https://doi.org/10.1111/pai.14202","url":null,"abstract":"Background: The impact of alternative milk substitutes on the nutritional status of children with cow's milk allergy (CMA), the prevailing cause of food allergies, is unresolved.Methods: A cross-sectional study was performed in children older than 2 years with IgE-mediated CMA. Patients' clinical characteristics, anthropometric measurements, dietary intake (by 3-day food diary), and biochemical markers of nutritional status were assessed.Results: One hundred two children with CMA (68.6% boys; median age, 3.7 years; 51% multiple food allergies) were evaluated. 44.1% of the children consumed plant-based beverages (PBB), 19.6% therapeutic formula and 36.3% did not consume any milk substitutes. In all age groups, dietary calcium, riboflavin, and vitamin D intake of those who did not use milk substitutes were lower than those who consumed formula or PBB (p < .01). Also in the 2-3 years old age group, dietary zinc (p = .011) and iron intake (p = .004) of the formula-fed group was higher. Formula-fed patients had higher levels of 25-OH vitamin D (μg/L) and serum vitamin B12 (ng/L) than PBB-fed patients (respectively; p < .001, p = .005) and those who did not consume any milk substitute (p < .001). Patients of all ages who did not utilize a milk substitute failed to obtain an adequate amount of dietary calcium.Conclusion: The use of milk substitutes positively affects dietary calcium, riboflavin, and vitamin D intake in CMA, but their contribution is variable. Those who do not use milk substitutes are at greater risk inadequate of dietary calcium intake. Personalized nutritional advice, given the clinical diversity and the impact of individual differences, is required.","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"35 7","pages":"e14202"},"PeriodicalIF":4.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141634177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Atypical familial hemophagocytic lymphohistiocytosis type 3 in children: A report of cases and literature review". 儿童非典型家族性嗜血细胞淋巴组织细胞增多症 3 型：病例报告和文献综述"。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2024-07-01 DOI: 10.1111/pai.14205

引用次数: 0

Efficacy and safety of sublingual immunotherapy using house dust mite tablet for 1-4 years old children with perennial allergic rhinitis. 使用屋尘螨片对 1-4 岁常年性过敏性鼻炎儿童进行舌下免疫疗法的有效性和安全性。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2024-07-01 DOI: 10.1111/pai.14203

Koki Sasamoto, Ken-Ichi Nagakura, Tomoyuki Asaumi, Naoko Fusayasu, Katsuyo Ohashi-Doi, Noriyuki Yanagida, Sakura Sato, Motohiro Ebisawa

{"title":"Efficacy and safety of sublingual immunotherapy using house dust mite tablet for 1-4 years old children with perennial allergic rhinitis.","authors":"Koki Sasamoto, Ken-Ichi Nagakura, Tomoyuki Asaumi, Naoko Fusayasu, Katsuyo Ohashi-Doi, Noriyuki Yanagida, Sakura Sato, Motohiro Ebisawa","doi":"10.1111/pai.14203","DOIUrl":"https://doi.org/10.1111/pai.14203","url":null,"abstract":"Background: Sublingual immunotherapy (SLIT) for perennial allergic rhinitis (AR) has not been extensively studied in preschoolers. We investigated the efficacy and safety of house dust mite (HDM) SLIT-tablet for children aged 1-4 years.Methods: Children aged 1-4 years with AR were divided into SLIT (n = 22) and control (n = 12) groups based on their guardians' preferences. The SLIT group received a daily dose of 10,000 JAU of HDM SLIT-tablet for 12 months, whereas the control group received symptomatic treatment only.Results: The baseline median age was 41 and 34 months in the SLIT and control groups, respectively, and the median AR symptom score was 4 for both groups. Compared with baseline, the AR symptom score had decreased significantly in the SLIT group after 12 months (score: 3, p = .002), whereas it tended to increase in the control group (score: 6, p = .08). Adverse reactions to SLIT were mild and occurred in eight patients (36%). In the SLIT group, Dermatophagoides (D.) farinae-specific IgE (sIgE) levels increased during the first 6 months and decreased to baseline levels at 12 months. In the control group, D. farinae-sIgE levels had increased significantly at 12 months compared to baseline (p = .01). D. farinae-specific IgG4 and HDM IgE-blocking factor levels were significantly increased at 12 months compared to baseline in the SLIT group only (p < .001). A lower wheezing frequency was seen in the SLIT group (0.3%) compared to the control group (0.7%).Conclusion: This pilot study demonstrated the efficacy, safety, and immunomodulatory effects of HDM SLIT-tablet in preschoolers with AR.","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"35 7","pages":"e14203"},"PeriodicalIF":4.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141752353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anaphylaxis during OIT and its impact on treatment adherence: A retrospective study. OIT 期间的过敏性休克及其对治疗依从性的影响：回顾性研究。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2024-07-01 DOI: 10.1111/pai.14200

Francesca Galletta, Stefano Passanisi, Sara Manti, Giuseppe Crisafulli, Lucia Caminiti

引用次数: 0

Novel infantile presentations of chronic granulomatous disease. 慢性肉芽肿病的新型婴儿表现。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2024-07-01 DOI: 10.1111/pai.14190

Eric Lee, Isabelle Bosi, Ken Peacock, Christine Lau, Lara S Ford, Melanie Wong, Peter Hsu

引用次数: 0

A retrospective comparison of IgE-mediated cow's milk protein allergy management strategies in pediatric cohorts. 对儿科组群中 IgE 介导的牛奶蛋白过敏管理策略的回顾性比较。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2024-07-01 DOI: 10.1111/pai.14195

Juan Trujillo, Caoimhe Cronin, Tessa Ah Heng, Laura Flores, Anne Marie McGinley, Aoife Gallagher, Cristina Muñoz, Roberto Velasco, Jonathan Hourihane

{"title":"A retrospective comparison of IgE-mediated cow's milk protein allergy management strategies in pediatric cohorts.","authors":"Juan Trujillo, Caoimhe Cronin, Tessa Ah Heng, Laura Flores, Anne Marie McGinley, Aoife Gallagher, Cristina Muñoz, Roberto Velasco, Jonathan Hourihane","doi":"10.1111/pai.14195","DOIUrl":"https://doi.org/10.1111/pai.14195","url":null,"abstract":"Background: Complete avoidance of milk is the usual management for IgE-mediated cow's milk protein allergy (CMPA). A baked milk ladder is a method of dietary advancement therapy in IgE-mediated CMPA in Ireland, while in Spain, avoidance of milk awaiting natural tolerance acquisition through an oral food challenge (OFC) is employed. The aim of this study was to evaluate the use of dietary advancement therapy using a milk ladder compared with complete avoidance of milk for managing IgE-mediated CMPA.Methods: This is a retrospective chart review of 371 pediatric patients from the population who have been treated for IgE-mediated CMPA between 2011 and 2020, with the milk ladder (Ireland) or complete avoidance followed by an OFC (Spain). The main outcome was the introduction of cow's milk.Results: Milk ladder patients were 3.67 times more likely to succeed in comparison with milk avoidance (p < .001). Anaphylaxis during the treatment period occurred in 34 patients in the milk avoidance groups, while three patients in the milk ladder group experienced anaphylaxis due to accidental exposure to milk (p < .001). Failure to complete treatment was associated with a higher skin prick test in the milk avoidance group and a raised specific IgE in the milk ladder group.Conclusion: This is the first study that compares outcomes of dietary advancement therapy to complete avoidance for CMPA management, demonstrating that cow's milk can be successfully and safely reintroduced using dietary advancement therapy using a milk ladder.","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"35 7","pages":"e14195"},"PeriodicalIF":4.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiarray screening identifies plasma proteins associated with Th17 cell differentiation and viral defense in coincident asthma and obesity. 多阵列筛选确定了与哮喘和肥胖同时发生时 Th17 细胞分化和病毒防御相关的血浆蛋白。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2024-07-01 DOI: 10.1111/pai.14187

Hannes Manell, Nikolaos Tsolakis, Christer Janson, Andrei Malinovschi, Kjell Alving

{"title":"Multiarray screening identifies plasma proteins associated with Th17 cell differentiation and viral defense in coincident asthma and obesity.","authors":"Hannes Manell, Nikolaos Tsolakis, Christer Janson, Andrei Malinovschi, Kjell Alving","doi":"10.1111/pai.14187","DOIUrl":"https://doi.org/10.1111/pai.14187","url":null,"abstract":"Background: The immunological mechanisms behind the clinical association between asthma and obesity in adolescence are not fully understood. This study aimed to find new plasma protein biomarkers associated specifically with coincident asthma and obesity in adolescents.Methods: This was a cross-sectional study in children and adolescents 10-19 years old (N = 390). Relative plasma concentrations of 113 protein biomarkers related to inflammation and immune response were determined by proximity extension assay (Target 96; Olink, Uppsala, Sweden). Differences in protein concentrations between healthy controls (n = 84), subjects with asthma (n = 138), subjects with obesity (n = 107), and subjects with both asthma and obesity (AO; n = 58) were analyzed by ANCOVA, adjusting for age and sex, and in a separate model adjusting also for the sum of specific IgE antibody concentrations to a mix of food allergens (fx5) and aeroallergens (Phadiatop). Proteins elevated in the AO group but not in the obesity or asthma groups were considered specifically elevated in asthma and obesity.Results: Five proteins were elevated specifically in the AO group compared to controls (here sorted from largest to smallest effect of asthma and obesity combined): CCL8, IL-33, IL-17C, FGF-23, and CLEC7A. The effects of adjusting also for specific IgE were small but IL-33, IL-17C, and FGF-23 were no longer statistically significant.Conclusion: We identified several new potential plasma biomarkers specifically elevated in coincident asthma and obesity in adolescents. Four of the proteins, CCL8, IL-33, IL-17C, and CLEC7A, have previously been associated with viral mucosal host defense and Th17 cell differentiation.","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"35 7","pages":"e14187"},"PeriodicalIF":4.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141535045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inborn errors of immunity and protozoa. 先天性免疫错误与原生动物。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2024-07-01 DOI: 10.1111/pai.14194

Mariana de Gouveia-Pereira Pimentel, Carolina Sanchez Aranda, Pedro Fiorini Puccini, Celso José Mendanha da Silva, Leticia Helena Caldas Lopes, Evaristo Villalba-Alemán, Ricardo Gava, Thiago Kury Moreno de Souza, Lara Novaes Teixeira, Luiza Schimd Salvador, Dirceu Solé, José Eduardo Tolezano, Marta Maria Geraldes Teixeira

引用次数: 0

Comment on: van der Rijst LP et al. 评论：van der Rijst LP et al.

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2024-07-01 DOI: 10.1111/pai.14201

Sujoy Khan

引用次数: 0