Pediatric Allergy and Immunology最新文献

筛选
英文 中文
Evaluation of the incidence of systemic symptoms in PR-10-related pollen-food allergy syndrome in Western Japan. 日本西部pr -10相关花粉食物过敏综合征全身性症状发生率的评估
IF 4.3 2区 医学
Pediatric Allergy and Immunology Pub Date : 2025-05-01 DOI: 10.1111/pai.70104
Masaaki Hamada, Makoto Kameda, Yuri Takaoka, Rumi Ueno, Shohei Akagawa, Tomoko Kawakami, Yoshina Yagi
{"title":"Evaluation of the incidence of systemic symptoms in PR-10-related pollen-food allergy syndrome in Western Japan.","authors":"Masaaki Hamada, Makoto Kameda, Yuri Takaoka, Rumi Ueno, Shohei Akagawa, Tomoko Kawakami, Yoshina Yagi","doi":"10.1111/pai.70104","DOIUrl":"https://doi.org/10.1111/pai.70104","url":null,"abstract":"<p><strong>Background: </strong>Pollen food allergy syndrome (PFAS) primarily presents as oral allergy syndrome (OAS) with occasional systemic symptoms. Few studies have examined the systemic symptoms of PR-10-related PFAS, which are common among pediatric patients in Japan.</p><p><strong>Methods: </strong>Two surveys were conducted to investigate the possibility of more severe patients in medical institutions and misdiagnoses among school children: one for patients diagnosed with PR-10-related PFAS at medical institutions and another for elementary and junior high school children whose parents completed an online questionnaire. We examined allergenic foods/symptoms, incidence of OAS, and systemic symptoms in PR-10-related PFAS patients allergic to Rosaceae fruits/soybeans.</p><p><strong>Results: </strong>Among 221 patients with PR-10-related PFAS at medical institutions, 205 and 86 developed allergic symptoms to Rosaceae fruits and soybeans, respectively. The incidence of systemic symptoms was significantly higher in the soybean group (43/86, 50.0%) than in the Rosaceae fruits group (43/205, 21.0%) (p < .001). Among the 29,906 school children, 3309 (11.1%) responded; 202 were children with PR-10-related PFAS, 194 and 29 developed allergic symptoms to Rosaceae fruits and soybeans, respectively. The incidence of systemic symptoms was higher in the soybean group (12/29, 41.4%) than in the Rosaceae fruits group (46/194, 23.7%), although not significantly (p = .067).</p><p><strong>Conclusion: </strong>Two surveys were conducted targeting patients with confirmed diagnoses and general students. The incidence of systemic symptoms associated with PR-10-related PFAS was similar at 20% for Rosaceae fruits and 40%-50% for soybeans in both surveys. Attention should be given to the potential for systemic symptoms in patients with PR-10-related PFAS.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 5","pages":"e70104"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on Nakiranda et al. 对Nakiranda等人的评论。
IF 4.3 2区 医学
Pediatric Allergy and Immunology Pub Date : 2025-05-01 DOI: 10.1111/pai.70098
Muhammad Zarrar
{"title":"Comment on Nakiranda et al.","authors":"Muhammad Zarrar","doi":"10.1111/pai.70098","DOIUrl":"https://doi.org/10.1111/pai.70098","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 5","pages":"e70098"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changing dietary intake to prevent allergy outcomes: A pilot study. 改变饮食摄入预防过敏:一项初步研究。
IF 4.3 2区 医学
Pediatric Allergy and Immunology Pub Date : 2025-05-01 DOI: 10.1111/pai.70097
Stina Bodén, Kaci Pickett-Nairne, Claudia Schaefer, McKayla Tsou, Gabby McBane, Courney Evans, Emily Bowhay, Wendy Moore, Deborah H Glueck, Carina Venter
{"title":"Changing dietary intake to prevent allergy outcomes: A pilot study.","authors":"Stina Bodén, Kaci Pickett-Nairne, Claudia Schaefer, McKayla Tsou, Gabby McBane, Courney Evans, Emily Bowhay, Wendy Moore, Deborah H Glueck, Carina Venter","doi":"10.1111/pai.70097","DOIUrl":"https://doi.org/10.1111/pai.70097","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 5","pages":"e70097"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond TREC: Pivotal role of tandem TREC/KREC assay in Czech SCID NBS pilot programme. 超越TREC:串联TREC/KREC测定在捷克SCID NBS试点项目中的关键作用。
IF 4.3 2区 医学
Pediatric Allergy and Immunology Pub Date : 2025-05-01 DOI: 10.1111/pai.70100
Markéta Bloomfield, Eva Hlaváčková, Helena Schneiderová, Marek Turnovec, Lukáš Tichý, Zbyněk Čech, Petr Chrastina, Lenka Dvořáková, Karolína Pešková, Renata Formánková, Petr Říha, Marcela Vlková, Petr Bejdák, Magdaléna Havlišová, Eva Froňková, Tomáš Kalina, Viktor Bíly, Dita Říčná, Hana Grombiříková, Petr Sedláček, Jiří Litzman, Tomáš Freiberger, Anna Šedivá, Adam Klocperk
{"title":"Beyond TREC: Pivotal role of tandem TREC/KREC assay in Czech SCID NBS pilot programme.","authors":"Markéta Bloomfield, Eva Hlaváčková, Helena Schneiderová, Marek Turnovec, Lukáš Tichý, Zbyněk Čech, Petr Chrastina, Lenka Dvořáková, Karolína Pešková, Renata Formánková, Petr Říha, Marcela Vlková, Petr Bejdák, Magdaléna Havlišová, Eva Froňková, Tomáš Kalina, Viktor Bíly, Dita Říčná, Hana Grombiříková, Petr Sedláček, Jiří Litzman, Tomáš Freiberger, Anna Šedivá, Adam Klocperk","doi":"10.1111/pai.70100","DOIUrl":"https://doi.org/10.1111/pai.70100","url":null,"abstract":"<p><strong>Background: </strong>Severe combined immunodeficiency (SCID) is a fatal but treatable inborn error of immunity (IEI). Newborn screening (NBS) using T-cell receptor excision circles (TREC) has been adopted globally, with very few countries incorporating kappa recombination excision circles (KREC) to also detect early B-cell development disorders, such as X-linked agammaglobulinemia (XLA).</p><p><strong>Objective: </strong>To evaluate the effectiveness of a 2-year pilot SCID NBS program in the Czech Republic, emphasising the utility of combined TREC/KREC screening.</p><p><strong>Methods: </strong>Between January 2022 and December 2023, a dual TREC/KREC NBS pilot was conducted across the Czech Republic, alongside spinal muscular atrophy (SMA) screening. Approximately 200,000 newborns were screened using quantitative real-time PCR on dried blood spots collected 48-72 h after birth.</p><p><strong>Results: </strong>The pilot referred 58 newborns, identifying 21 cases of IEI, including two SCID cases, with an overall incidence of TREC/KREC screenable IEI of 10.5/100,000 newborns. SCID incidence was 1/100,000. KREC screening proved invaluable, detecting 10 cases of congenital agammaglobulinemia including novel non-XLA forms, which increased the estimated incidence of agammaglobulinemia in the Czech Republic sixfold. Over one-third of low KREC results were linked to maternal immunosuppression.</p><p><strong>Conclusion: </strong>The Czech pilot demonstrated the effectiveness of integrated TREC/KREC NBS in detecting both T- and B-cell immunodeficiencies. As of 2024, SCID and SMA screening are included in the nationwide NBS, with KREC screening significantly improving early detection of B-cell disorders.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 5","pages":"e70100"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to "Systemic reactions to subcutaneous immunotherapy in children and adolescents". 更正“儿童和青少年皮下免疫治疗的全身反应”。
IF 4.3 2区 医学
Pediatric Allergy and Immunology Pub Date : 2025-05-01 DOI: 10.1111/pai.70101
{"title":"Correction to \"Systemic reactions to subcutaneous immunotherapy in children and adolescents\".","authors":"","doi":"10.1111/pai.70101","DOIUrl":"https://doi.org/10.1111/pai.70101","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 5","pages":"e70101"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on Tachdjian, R. et al. 评Tachdjian, R.等。
IF 4.3 2区 医学
Pediatric Allergy and Immunology Pub Date : 2025-05-01 DOI: 10.1111/pai.70099
Mengxin Zhang, Yun Zhao, Ye Xu, Fangfang Tao
{"title":"Comment on Tachdjian, R. et al.","authors":"Mengxin Zhang, Yun Zhao, Ye Xu, Fangfang Tao","doi":"10.1111/pai.70099","DOIUrl":"https://doi.org/10.1111/pai.70099","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 5","pages":"e70099"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Air pollution and hospitalization risk in infants with bronchiolitis: A systematic review and meta-analysis. 空气污染与毛细支气管炎婴儿住院风险:一项系统综述和荟萃分析
IF 4.3 2区 医学
Pediatric Allergy and Immunology Pub Date : 2025-05-01 DOI: 10.1111/pai.70102
Anna Comotti, Ilaria Alberti, Giulia Carla Immacolata Spolidoro, Emilia Vassilopoulou, Carlo Agostoni, Matteo Bonzini, Michele Carugno, Gregorio Paolo Milani
{"title":"Air pollution and hospitalization risk in infants with bronchiolitis: A systematic review and meta-analysis.","authors":"Anna Comotti, Ilaria Alberti, Giulia Carla Immacolata Spolidoro, Emilia Vassilopoulou, Carlo Agostoni, Matteo Bonzini, Michele Carugno, Gregorio Paolo Milani","doi":"10.1111/pai.70102","DOIUrl":"10.1111/pai.70102","url":null,"abstract":"<p><p>Bronchiolitis is one of the leading causes of hospitalization among infants. Established risk factors include young age, prematurity, and exposure to tobacco smoke. Emerging evidence suggests that air pollution may also contribute to the burden of respiratory diseases. However, its link with bronchiolitis hospitalizations remains debated. To address this, we conducted a systematic review and meta-analysis to assess whether exposure to air pollutants is associated with an increased risk of hospitalization for bronchiolitis in infants. A systematic review and meta-analysis were conducted following the PRISMA guidelines. PubMed, Embase, and Web of Science were searched up to May 2024. Eligible studies examined the relationship between air pollutants and bronchiolitis hospitalizations in infants up to 2 years of age. Meta-analyses were performed to estimate the association between pollutant levels and hospitalization risk. Out of 788 identified studies, 23 met the inclusion criteria. Studies were heterogeneous regarding design, adjustment for confounders, and statistical approaches. Particulate matter with diameter ≤2.5 μm (PM<sub>2.5</sub>) or ≤10 μm (PM<sub>10</sub>) and nitrogen dioxide (NO<sub>2</sub>) were the most studied pollutants, with positive associations found between short-, medium-, and long-term exposure and increased hospitalization risk. Meta-analyses showed a 2%-9% increase in hospitalization risk for exposure to PM<sub>2.5</sub>, PM<sub>10</sub>, and NO<sub>2</sub>; however, statistical significance was reached only for short-term exposure to PM<sub>10</sub>. In contrast, data on sulfur dioxide, carbon monoxide, ozone, and black carbon were sparse and inconsistent. PM<sub>2.5</sub>, PM<sub>10</sub>, and NO<sub>2</sub> are likely relevant risk factors for an increased risk of hospitalization for bronchiolitis in infants. Further research using a standardized approach is needed to clarify the role of other pollutants in bronchiolitis.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 5","pages":"e70102"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concomitant food-dependent exercise-induced allergic reactions to prawn in four junior-high-school students. 四名初中生对虾伴随食物依赖运动引起的过敏反应。
IF 4.3 2区 医学
Pediatric Allergy and Immunology Pub Date : 2025-05-01 DOI: 10.1111/pai.70106
Kazuki Iio, Naoki Kajita, Yusuke Hagiwara, Koichi Yoshida
{"title":"Concomitant food-dependent exercise-induced allergic reactions to prawn in four junior-high-school students.","authors":"Kazuki Iio, Naoki Kajita, Yusuke Hagiwara, Koichi Yoshida","doi":"10.1111/pai.70106","DOIUrl":"https://doi.org/10.1111/pai.70106","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 5","pages":"e70106"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New insights into the mechanisms of childhood food allergies. 对儿童食物过敏机制的新见解。
IF 4.3 2区 医学
Pediatric Allergy and Immunology Pub Date : 2025-04-01 DOI: 10.1111/pai.70069
Liam Gubbels, Richard Saffery, Melanie R Neeland
{"title":"New insights into the mechanisms of childhood food allergies.","authors":"Liam Gubbels, Richard Saffery, Melanie R Neeland","doi":"10.1111/pai.70069","DOIUrl":"10.1111/pai.70069","url":null,"abstract":"<p><p>IgE-mediated food allergies are common and can be life-threatening, especially for children. With increasingly rapid advances in immunological technologies, including the ability to profile highly complex immune features from small sample volumes, our understanding of the immune mechanisms that underpin the development of food allergies continues to grow. This also extends to the immune mechanisms associated with the outcomes of oral immunotherapy (OIT). This review focuses on studies within the past 5 years related to immune signatures associated with food allergy in childhood, immune responses that determine reaction severities to offending allergens, immune alterations that occur during OIT in children, and immune effects of adjunct therapies including omalizumab, dupilumab, and abrocitinib. We conclude by providing a perspective on current evidence and directions for future research that will enable new prediction and screening tools and facilitate the development of effective curative strategies.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 4","pages":"e70069"},"PeriodicalIF":4.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of diagnostic tests for immediate-type allergic reactions to amide group local anesthetics in children. 儿童对酰胺类局麻药立即型过敏反应诊断试验的评价。
IF 4.3 2区 医学
Pediatric Allergy and Immunology Pub Date : 2025-04-01 DOI: 10.1111/pai.70085
Sinem Aslan, Hülya Anıl, Muhammet Kaya, Koray Harmancı
{"title":"Evaluation of diagnostic tests for immediate-type allergic reactions to amide group local anesthetics in children.","authors":"Sinem Aslan, Hülya Anıl, Muhammet Kaya, Koray Harmancı","doi":"10.1111/pai.70085","DOIUrl":"10.1111/pai.70085","url":null,"abstract":"<p><strong>Background: </strong>Local anesthetics (LAs) are widely utilized to provide analgesia in minor surgical interventions. Although patients are frequently referred for suspected LA allergies in clinical practice, confirmed cases of immediate-type hypersensitivity remain rare. This study aims to establish an optimal diagnostic protocol for immediate-type LA allergy in children and to assess the practicality and reliability of an alternative diagnostic approach for hypersensitivity testing of amide-type local anesthetics.</p><p><strong>Methods: </strong>The medical records of patients diagnosed with suspected immediate-type reactions to LAs administered by pediatric dentists between January 2019 and August 2024 were retrospectively reviewed. All children underwent a skin prick test (SPT), followed if negative by an intradermal test (IDT) at a 1:10 dilution. If intradermal testing was also negative, a subcutaneous provocation test was subsequently performed.</p><p><strong>Results: </strong>A total of 88 patients (47 boys, 41 girls), with a mean age of 8.5 ± 3.5 years, were included. In most cases (n = 59, 67%), the suspected LA was unidentified. Among the known agents, articaine (n = 18, 20.5%) and lidocaine (n = 11, 12.5%) were the most frequently reported. IDT results were positive in 11 patients (12.5%), with articaine in 8 cases (61.5%), prilocaine in 3 cases (23%), and lidocaine in 2 cases (15.5%). Intradermal testing at a 1:10 dilution demonstrated a high negative predictive value (99%) for immediate-type reactions.</p><p><strong>Conclusion: </strong>For the diagnosis of immediate-type LA allergy, including cases with a history of anaphylaxis, an IDT at a 1:10 dilution following a negative SPT, followed by subcutaneous provocation, may serve as a time-efficient and reliable diagnostic strategy.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 4","pages":"e70085"},"PeriodicalIF":4.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信