Pediatric Allergy and Immunology最新文献

{"title":"Evaluation of the incidence of systemic symptoms in PR-10-related pollen-food allergy syndrome in Western Japan.","authors":"Masaaki Hamada, Makoto Kameda, Yuri Takaoka, Rumi Ueno, Shohei Akagawa, Tomoko Kawakami, Yoshina Yagi","doi":"10.1111/pai.70104","DOIUrl":"https://doi.org/10.1111/pai.70104","url":null,"abstract":"<p><strong>Background: </strong>Pollen food allergy syndrome (PFAS) primarily presents as oral allergy syndrome (OAS) with occasional systemic symptoms. Few studies have examined the systemic symptoms of PR-10-related PFAS, which are common among pediatric patients in Japan.</p><p><strong>Methods: </strong>Two surveys were conducted to investigate the possibility of more severe patients in medical institutions and misdiagnoses among school children: one for patients diagnosed with PR-10-related PFAS at medical institutions and another for elementary and junior high school children whose parents completed an online questionnaire. We examined allergenic foods/symptoms, incidence of OAS, and systemic symptoms in PR-10-related PFAS patients allergic to Rosaceae fruits/soybeans.</p><p><strong>Results: </strong>Among 221 patients with PR-10-related PFAS at medical institutions, 205 and 86 developed allergic symptoms to Rosaceae fruits and soybeans, respectively. The incidence of systemic symptoms was significantly higher in the soybean group (43/86, 50.0%) than in the Rosaceae fruits group (43/205, 21.0%) (p < .001). Among the 29,906 school children, 3309 (11.1%) responded; 202 were children with PR-10-related PFAS, 194 and 29 developed allergic symptoms to Rosaceae fruits and soybeans, respectively. The incidence of systemic symptoms was higher in the soybean group (12/29, 41.4%) than in the Rosaceae fruits group (46/194, 23.7%), although not significantly (p = .067).</p><p><strong>Conclusion: </strong>Two surveys were conducted targeting patients with confirmed diagnoses and general students. The incidence of systemic symptoms associated with PR-10-related PFAS was similar at 20% for Rosaceae fruits and 40%-50% for soybeans in both surveys. Attention should be given to the potential for systemic symptoms in patients with PR-10-related PFAS.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 5","pages":"e70104"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on Nakiranda et al.","authors":"Muhammad Zarrar","doi":"10.1111/pai.70098","DOIUrl":"https://doi.org/10.1111/pai.70098","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 5","pages":"e70098"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changing dietary intake to prevent allergy outcomes: A pilot study.","authors":"Stina Bodén, Kaci Pickett-Nairne, Claudia Schaefer, McKayla Tsou, Gabby McBane, Courney Evans, Emily Bowhay, Wendy Moore, Deborah H Glueck, Carina Venter","doi":"10.1111/pai.70097","DOIUrl":"https://doi.org/10.1111/pai.70097","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 5","pages":"e70097"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Systemic reactions to subcutaneous immunotherapy in children and adolescents\".","authors":"","doi":"10.1111/pai.70101","DOIUrl":"https://doi.org/10.1111/pai.70101","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 5","pages":"e70101"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond TREC: Pivotal role of tandem TREC/KREC assay in Czech SCID NBS pilot programme.","authors":"Markéta Bloomfield, Eva Hlaváčková, Helena Schneiderová, Marek Turnovec, Lukáš Tichý, Zbyněk Čech, Petr Chrastina, Lenka Dvořáková, Karolína Pešková, Renata Formánková, Petr Říha, Marcela Vlková, Petr Bejdák, Magdaléna Havlišová, Eva Froňková, Tomáš Kalina, Viktor Bíly, Dita Říčná, Hana Grombiříková, Petr Sedláček, Jiří Litzman, Tomáš Freiberger, Anna Šedivá, Adam Klocperk","doi":"10.1111/pai.70100","DOIUrl":"https://doi.org/10.1111/pai.70100","url":null,"abstract":"<p><strong>Background: </strong>Severe combined immunodeficiency (SCID) is a fatal but treatable inborn error of immunity (IEI). Newborn screening (NBS) using T-cell receptor excision circles (TREC) has been adopted globally, with very few countries incorporating kappa recombination excision circles (KREC) to also detect early B-cell development disorders, such as X-linked agammaglobulinemia (XLA).</p><p><strong>Objective: </strong>To evaluate the effectiveness of a 2-year pilot SCID NBS program in the Czech Republic, emphasising the utility of combined TREC/KREC screening.</p><p><strong>Methods: </strong>Between January 2022 and December 2023, a dual TREC/KREC NBS pilot was conducted across the Czech Republic, alongside spinal muscular atrophy (SMA) screening. Approximately 200,000 newborns were screened using quantitative real-time PCR on dried blood spots collected 48-72 h after birth.</p><p><strong>Results: </strong>The pilot referred 58 newborns, identifying 21 cases of IEI, including two SCID cases, with an overall incidence of TREC/KREC screenable IEI of 10.5/100,000 newborns. SCID incidence was 1/100,000. KREC screening proved invaluable, detecting 10 cases of congenital agammaglobulinemia including novel non-XLA forms, which increased the estimated incidence of agammaglobulinemia in the Czech Republic sixfold. Over one-third of low KREC results were linked to maternal immunosuppression.</p><p><strong>Conclusion: </strong>The Czech pilot demonstrated the effectiveness of integrated TREC/KREC NBS in detecting both T- and B-cell immunodeficiencies. As of 2024, SCID and SMA screening are included in the nationwide NBS, with KREC screening significantly improving early detection of B-cell disorders.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 5","pages":"e70100"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12050992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144034967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on Tachdjian, R. et al.","authors":"Mengxin Zhang, Yun Zhao, Ye Xu, Fangfang Tao","doi":"10.1111/pai.70099","DOIUrl":"https://doi.org/10.1111/pai.70099","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 5","pages":"e70099"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air pollution and hospitalization risk in infants with bronchiolitis: A systematic review and meta-analysis.","authors":"Anna Comotti, Ilaria Alberti, Giulia Carla Immacolata Spolidoro, Emilia Vassilopoulou, Carlo Agostoni, Matteo Bonzini, Michele Carugno, Gregorio Paolo Milani","doi":"10.1111/pai.70102","DOIUrl":"10.1111/pai.70102","url":null,"abstract":"<p><p>Bronchiolitis is one of the leading causes of hospitalization among infants. Established risk factors include young age, prematurity, and exposure to tobacco smoke. Emerging evidence suggests that air pollution may also contribute to the burden of respiratory diseases. However, its link with bronchiolitis hospitalizations remains debated. To address this, we conducted a systematic review and meta-analysis to assess whether exposure to air pollutants is associated with an increased risk of hospitalization for bronchiolitis in infants. A systematic review and meta-analysis were conducted following the PRISMA guidelines. PubMed, Embase, and Web of Science were searched up to May 2024. Eligible studies examined the relationship between air pollutants and bronchiolitis hospitalizations in infants up to 2 years of age. Meta-analyses were performed to estimate the association between pollutant levels and hospitalization risk. Out of 788 identified studies, 23 met the inclusion criteria. Studies were heterogeneous regarding design, adjustment for confounders, and statistical approaches. Particulate matter with diameter ≤2.5 μm (PM_2.5) or ≤10 μm (PM₁₀) and nitrogen dioxide (NO₂) were the most studied pollutants, with positive associations found between short-, medium-, and long-term exposure and increased hospitalization risk. Meta-analyses showed a 2%-9% increase in hospitalization risk for exposure to PM_2.5, PM₁₀, and NO₂; however, statistical significance was reached only for short-term exposure to PM₁₀. In contrast, data on sulfur dioxide, carbon monoxide, ozone, and black carbon were sparse and inconsistent. PM_2.5, PM₁₀, and NO₂ are likely relevant risk factors for an increased risk of hospitalization for bronchiolitis in infants. Further research using a standardized approach is needed to clarify the role of other pollutants in bronchiolitis.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 5","pages":"e70102"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant food-dependent exercise-induced allergic reactions to prawn in four junior-high-school students.","authors":"Kazuki Iio, Naoki Kajita, Yusuke Hagiwara, Koichi Yoshida","doi":"10.1111/pai.70106","DOIUrl":"https://doi.org/10.1111/pai.70106","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 5","pages":"e70106"},"PeriodicalIF":4.3,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Dr. Yingli Lin et al.","authors":"Xiaolan Zhang, Yujie Han, Qiaohuan Tian, Linjun Du, Lifang Chen, Yue Zhang, Xuening Guo, Xiaoying Li","doi":"10.1111/pai.70070","DOIUrl":"https://doi.org/10.1111/pai.70070","url":null,"abstract":"","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 4","pages":"e70070"},"PeriodicalIF":4.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emulsion containing a chitosan derivative in children with mild atopic dermatitis: A randomized controlled trial.","authors":"Nagatoshi Sagara, Kenichi Akashi, Miori Sato, Mizuho Nagao, Toshio Katsunuma","doi":"10.1111/pai.70076","DOIUrl":"10.1111/pai.70076","url":null,"abstract":"<p><strong>Background: </strong>Recently, partially myristoylated carboxymethyl chitosan (PMCMC) was developed in Japan. To compare the efficacy and safety of PMCMC-containing emulsion and petrolatum, we conducted a randomized controlled trial.</p><p><strong>Methods: </strong>Eligible patients were children aged 1-<6 years who had mild atopic dermatitis (with Eczema Area and Severity Index [EASI] ≤7.0). Participants were randomly assigned (1:1) to receive PMCMC-containing emulsion or petrolatum. Study treatments were applied to the body twice daily for 8 weeks. The co-primary endpoints were the changes in EASI and total score of Quality of life in Primary Caregivers of children with Atopic Dermatitis (QP-CAD) from baseline to the end of the treatment.</p><p><strong>Results: </strong>Between February 2020 and August 2022, 80 participants (39, emulsion group; 41, petrolatum group) were enrolled and included in the analysis. The decrease in EASI at the end of the treatment was greater in the emulsion group than in the petrolatum group with the LS mean (SE) change of -0.74 (0.31) in the emulsion group and 0.29 (0.31) in the petrolatum group (difference -1.02, 95% CI -1.90 to -0.15; p = .022). The decrease in total QP-CAD was also greater in the emulsion group than in the petrolatum group with the LS mean (SE) change of -1.63 (1.08) and 1.55 (1.01), respectively (difference -3.18, 95% CI -6.13 to -0.22; p = .035). All adverse events in the emulsion group were mild.</p><p><strong>Conclusion: </strong>PMCMC-containing emulsion significantly improved disease severity of children and quality of life of caregivers compared with petrolatum.</p><p><strong>Trial registration: </strong>https://jrct.mhlw.go.jp/-number: jRCTs031190201.</p>","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 4","pages":"e70076"},"PeriodicalIF":4.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}