Pediatric Allergy and Immunology最新文献_第3页

Short-lived neutralizing activity against SARS-CoV-2 in newborns of immunized mothers. 免疫母亲的新生儿对SARS-CoV-2的短暂中和活性。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2025-04-01 DOI: 10.1111/pai.70084

Marta Stracuzzi, Claudia Vanetti, Micaela Garziano, Maida Micheloni, Maria Luisa Murno, Gian Vincenzo Zuccotti, Mario Clerici, Vania Giacomet, Daria Trabattoni

{"title":"Short-lived neutralizing activity against SARS-CoV-2 in newborns of immunized mothers.","authors":"Marta Stracuzzi, Claudia Vanetti, Micaela Garziano, Maida Micheloni, Maria Luisa Murno, Gian Vincenzo Zuccotti, Mario Clerici, Vania Giacomet, Daria Trabattoni","doi":"10.1111/pai.70084","DOIUrl":"10.1111/pai.70084","url":null,"abstract":"Background: Newborns under 6 months of age are at high risk of hospitalization for acute respiratory failure following SARS-CoV-2 infection. Herein, we analyzed neonatal protection against SARS-CoV-2 passively acquired after mother vaccination and/or infection (hybrid immunity).Methods: We enrolled seventy-eight newborns of immunized mothers against SARS-CoV-2 before or during pregnancy, through vaccination and/or infection. Infants were stratified based on the anamnestic lack (SARS-CoV-2 Vaccinated - SV)/presence (SARS-CoV-2 Infected and Vaccinated - SIV) of COVID-19 maternal infection. SARS-CoV-2-specific Neutralizing Activity (NA) in plasma was assessed by virus neutralization assay (vNTA) against the SARS-CoV-2 Omicron strain at delivery (T0), 3 and 6 months after birth (T3 and T6). Cytokine and chemokine profiles in newborns were also analyzed.Results: At birth, significantly lower NA was observed in infants of SV compared to that of SIV mothers; NA declined equally in both groups 3 months after delivery. The presence of at least 4 immunizing events in the mother significantly enhances the NA against SARS-CoV-2 in newborns, regardless of the type of immunization (vaccination or hybrid immunity) and of the timing of the last maternal immunization. Finally, cytokines and chemokines plasma levels were high at birth in all newborns, followed by a decline over the subsequent month.Conclusion: Our findings suggest that, independently of a previous SARS-CoV-2 infection or vaccination, it is reasonable to upgrade the recommendation of a booster dose during pregnancy to a \"strongly recommended\" status, with a view to conferring protection to newborns in the first months after delivery.","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 4","pages":"e70084"},"PeriodicalIF":4.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low Th17 cells in patients with cystic fibrosis and allergic broncho-pulmonary aspergillosis. 囊性纤维化和过敏性支气管肺曲霉病患者Th17细胞水平低。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2025-04-01 DOI: 10.1111/pai.70090

Silviana Timpano, Irene Bellicini, Piercarlo Poli, Daniele Moratto, Manuela Cortesi, Marta Salvi, Marco Chiarini, Rita Padoan, Ramona Pezzotta, Simona Fiorentini, Arnaldo Caruso, Mauro Giacomelli, Raffaele Badolato

{"title":"Low Th17 cells in patients with cystic fibrosis and allergic broncho-pulmonary aspergillosis.","authors":"Silviana Timpano, Irene Bellicini, Piercarlo Poli, Daniele Moratto, Manuela Cortesi, Marta Salvi, Marco Chiarini, Rita Padoan, Ramona Pezzotta, Simona Fiorentini, Arnaldo Caruso, Mauro Giacomelli, Raffaele Badolato","doi":"10.1111/pai.70090","DOIUrl":"https://doi.org/10.1111/pai.70090","url":null,"abstract":"Background: Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity response to the allergens of Aspergillus fumigatus, which is the most frequently isolated fungus from the sputum of cystic fibrosis (CF) patients. Because a low number of Th17 lymphocytes is associated with the risk of fungal infections, we investigated inflammatory markers, Th17 cells, and T-cell polarization in CF patients with ABPA.Methods: We analyzed the levels of inflammatory markers, blood counts, chemokines, cytokines, and T cell subsets in blood and sputum of CF subjects to elucidate the immunological factors associated with CF patients with Aspergillus fumigatus (AF) positive sputum (AFS+) or with ABPA.Results: We observed that AFS+ patients have higher sputum and blood IL-6 levels than AF-negative sputum (AFS-) patients. Analysis of blood memory T-helper subsets associated with Th1, Th2, and Th17 polarization among circulating CD45RA-/CD4+ memory T-cell subsets showed higher numbers of CCR4+/CCR6+/CXCR3- and CCR4+/CCR6+/CXCR3+ memory CD4 cells in AFS+ compared to AFS- subjects. Further analysis of Th17-related subsets and IL-17 secreting T cells in subjects with AFS+ showed that those with ABPA have statistically significantly lower levels of Th17 cells as compared to those without ABPA.Conclusion: In CF, AF airway colonization is associated with increased blood counts of Th17-related subsets. However, CF patients with ABPA exhibit lower numbers of CCR4+/CCR6+/CXCR3+ memory CD4 cells and IL-17-secreting CD4 cells compared to control subjects and CF patients without AF sensitization.","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 4","pages":"e70090"},"PeriodicalIF":4.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12002360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IgE deficiency (<2.5 IU/mL) in children: Clinical insights from a population-based study of 123,393 subjects. 儿童IgE缺乏症（<2.5 IU/mL）：来自123,393名受试者的基于人群的研究的临床见解

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2025-04-01 DOI: 10.1111/pai.70092

Shay Nemet, Daniel Elbirt, Ramon Cohen, Keren Mahlab-Guri, Shira Bezalel-Rosenberg, Ilan Asher, Limor Rubin, Aviv Talmon, Yaarit Ribak, Ruslan Sergienko, Yuval Tal, Oded Shamriz

{"title":"IgE deficiency (<2.5 IU/mL) in children: Clinical insights from a population-based study of 123,393 subjects.","authors":"Shay Nemet, Daniel Elbirt, Ramon Cohen, Keren Mahlab-Guri, Shira Bezalel-Rosenberg, Ilan Asher, Limor Rubin, Aviv Talmon, Yaarit Ribak, Ruslan Sergienko, Yuval Tal, Oded Shamriz","doi":"10.1111/pai.70092","DOIUrl":"https://doi.org/10.1111/pai.70092","url":null,"abstract":"Background: Immunoglobulin (Ig)E deficiency (<2.5 IU/mL) in adults is linked to higher risks of cancer and autoimmunity, but its significance in children remains unclear. This study evaluates the clinical importance of IgE deficiency in a nationwide pediatric cohort.Methods: A retrospective, population-based study included 123,393 Israeli children tested for IgE levels between 2002 and 2022. Participants were categorized into four groups: deficient (<2.5 IU/mL), normal (2.5-100 IU/mL), high (100-1000 IU/mL), and very high (≥1000 IU/mL). Outcomes included cancer, inborn errors of immunity (IEI), and autoimmune disorders, with up to 5 years of follow-up. The data were analyzed using univariable methods and multivariable Cox regression.Results: Among the cohort, 2114 children (1.71%) had IgE deficiency, with a mean age of 3.73 years. Most (95.60%) were tested only once. IgE deficiency was associated with increased risks of solid tumors (HR = 2.721; 95% CI: 1.313-5.638), IEI (HR = 1.646; 95% CI: 1.095-2.474), and autoimmune disorders (HR = 1.266; 95% CI: 1.099-1.458) compared to normal IgE levels. No link was found between IgE deficiency and hematological malignancies. Selective IgM deficiency was the most common IEI associated with IgE deficiency (40%). Asthma prevalence was highest in children with very high IgE (N = 5574; 57.01%) and lowest in the normal IgE group (N = 24,171; 38.91%). The IgE-deficient group fell in the middle range (N = 903; 42.72%). In IgE-deficient children, allergic rhinitis was less common (11.26% vs. 14.09%).Conclusion: IgE deficiency in children is associated with higher risks of solid tumors, autoimmune disorders, and IEI, suggesting potential immune dysregulation. Close monitoring of IgE-deficient children should be considered.","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 4","pages":"e70092"},"PeriodicalIF":4.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The 5-10-15 plan: An approach to managing atopic dermatitis flares in pediatric patients. 5-10-15计划：一种处理儿科患者特应性皮炎发作的方法。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2025-04-01 DOI: 10.1111/pai.70082

Nicole Edmonds, Patricia Zhao, Aaron D Smith, Monica Lawrence, Barrett J Zlotoff

引用次数: 0

Reply to Shaharyar et al. 对 Shaharyar 等人的答复

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2025-04-01 DOI: 10.1111/pai.70083

Meg O Sullivan, Margaret Curtin, Rachel Flynn, Juan Trujillo, James O Mahony

引用次数: 0

Editorial comment on "When I became older, I started having to manage that more myself"-Experiences of adolescents with food allergies: A qualitative study. 对“当我长大了，我开始更多地自己管理”的评论-青少年食物过敏的经历：一项定性研究。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2025-04-01 DOI: 10.1111/pai.70091

Ashna Asim, Carmen Riggioni, Philippe Eigenmann

引用次数: 0

Reply to Prof. Tiejuan Shao et al. 回复邵铁娟教授等。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2025-04-01 DOI: 10.1111/pai.70093

Francisca de Castro Mendes, Milton Severo, Inês Paciência, Carla Lopes, Ana Cristina Santos, Henrique Barros, André Moreira, Pedro Moreira

引用次数: 0

Bedding materials and early infant wheezing: A randomised controlled trial. 床上用品与婴儿早期喘息：一项随机对照试验。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2025-04-01 DOI: 10.1111/pai.70073

Caroline Halley, Janice Kang, Phillipa Barnes, Michael Keall, Robert Siebers, Cheryl Davies, Philippa Howden-Chapman, Julian Crane

{"title":"Bedding materials and early infant wheezing: A randomised controlled trial.","authors":"Caroline Halley, Janice Kang, Phillipa Barnes, Michael Keall, Robert Siebers, Cheryl Davies, Philippa Howden-Chapman, Julian Crane","doi":"10.1111/pai.70073","DOIUrl":"10.1111/pai.70073","url":null,"abstract":"Background: Various observational studies have suggested that infants and young children who regularly sleep in synthetic bedding materials are more likely to experience wheezing and asthma, while children who use feather duvets and/or feather pillows are less likely to wheeze.Methods: In Wellington, New Zealand, we conducted a three-armed, parallel, randomised trial of 460 infants who were assigned to use different bedding materials: synthetic, wool or feather bedding in the form of sleepsacks from 3 months of age to 2 years of age to test the hypothesis that children exposed to feather materials are less likely to develop wheezing. Pregnant women were recruited before birth. Parents were unaware of the primary research hypothesis and were told this was a study of child warmth and wheezing. We have reported wheezing (parental and GP), a variety of respiratory health parameters and atopic status at 2 years.Results: One hundred and forty-seven infants received a synthetic sleepsack, 150 wool and 144 feather. We have found no significant differences in reported or doctor-diagnosed wheezing or other respiratory health measures by bedding material used. For frequency of wheezing presentation at GP surgery, there was a significant increased rate for children using feather materials compared to synthetic, relative rate 2.00 (95% CI: 1.14, 3.52).Conclusion: This study does not support earlier observational studies that suggest higher rates of wheezing for children using synthetic bedding or lower rates for feather materials, at least for early childhood wheezing. Our study suggests that the explanation for the observational study findings may lie in selection bias, where the parents of at-risk children avoid feather bedding materials.","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 4","pages":"e70073"},"PeriodicalIF":4.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11960039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolomic studies of respiratory infections in early life: A narrative review. 生命早期呼吸道感染的代谢组学研究：叙述性回顾。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2025-04-01 DOI: 10.1111/pai.70086

Nicole Prince, Jessica A Lasky-Su, Rachel S Kelly

{"title":"Metabolomic studies of respiratory infections in early life: A narrative review.","authors":"Nicole Prince, Jessica A Lasky-Su, Rachel S Kelly","doi":"10.1111/pai.70086","DOIUrl":"https://doi.org/10.1111/pai.70086","url":null,"abstract":"Respiratory infections are a leading cause of morbidity and mortality during the early life period, and experiencing recurrent infections may increase the risk of developing chronic respiratory diseases, such as asthma. Over the last several decades, metabolomics methods have been applied to inform upon the underlying biochemistry of pediatric respiratory infection response, to discriminate between respiratory infection types, and to identify biomarkers of severity and susceptibility. While these studies have demonstrated the power of applying metabolomics to the study of pediatric respiratory infection and contributed to an understanding of respiratory infections during the unique period of immune development, key differences in study design, infection type(s) of interest, biosamples, metabolomics measurement methods, and lack of external validation have limited the translation of these findings into the clinic. The purpose of this review is to summarize overlaps across existing studies of commonly reported metabolomics findings and emphasize areas of opportunity for future study. We highlight several metabolomics pathways-such as the citric acid cycle and sphingolipid metabolism-that have been reported consistently in respiratory infection response. We then discuss putatively identified metabolomic markers to discriminate between respiratory infection types and possible markers of infection severity and proneness. Finally, we close with a summary and perspective of future directions of the field.","PeriodicalId":19929,"journal":{"name":"Pediatric Allergy and Immunology","volume":"36 4","pages":"e70086"},"PeriodicalIF":4.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial comment on "The Naples pediatric food allergy score: A multivariable model for the prediction of food allergy in children". 社论评论“那不勒斯儿童食物过敏评分：预测儿童食物过敏的多变量模型”。

IF 4.3 2区医学

Pediatric Allergy and Immunology Pub Date : 2025-04-01 DOI: 10.1111/pai.70094

Martina Votto, Rachel L Peters, Philippe Eigenmann

引用次数: 0