Pain Research & Management最新文献

筛选
英文 中文
Clinical Application of Inferior Alveolar Nerve Block Device for Safe and Secure IANB by Any Operator. 下牙槽神经阻滞装置在任何操作者安全可靠IANB中的临床应用。
IF 2.9 3区 医学
Pain Research & Management Pub Date : 2023-09-08 eCollection Date: 2023-01-01 DOI: 10.1155/2023/1021918
Tomoyasu Noguchi, Kento Odaka, Ken-Ichi Fukuda
{"title":"Clinical Application of Inferior Alveolar Nerve Block Device for Safe and Secure IANB by Any Operator.","authors":"Tomoyasu Noguchi,&nbsp;Kento Odaka,&nbsp;Ken-Ichi Fukuda","doi":"10.1155/2023/1021918","DOIUrl":"10.1155/2023/1021918","url":null,"abstract":"<p><p>The inferior alveolar nerve block (IANB) is an established technique with a success rate of 60-80%; however, large errors have been reported among operators. Some dentists do not prefer to use IANB because of the risk of complications. Nevertheless, it is a useful technique for pain control, and a secure IANB offers significant benefits to operators and patients. This case series study aimed to investigate the efficacy of the \"IANB Device,\" a nerve block guide for IANB, and the adverse events associated with its use in clinical practice. IANB was performed using the device on five patients who had undergone detailed computed tomography examination for chronic orofacial pain in the third division of the trigeminal nerve. Lidocaine 1% (1 mL, no adrenaline added) was used as the local anesthetic. IANB was performed by three dentists with 2, 5, and 11 years of experience in orofacial pain treatment. Thus, the data were collected in triplicate for each patient. The primary endpoints were whether adjustment of the IANB device was required, changes in the sensation threshold of the lower lip, the time to disappearance of pain, the presence or absence of tongue sensation (\"Do you have numbness in your tongue?\": \"Yes/No\"), and discomfort (visual analog scale). The incidence of any other adverse events was recorded. The procedure was judged to be successful if the pain disappeared and an elevation in the sensation threshold of the lower lip was observed. Adjustment of the IANB device was not required in any patient. A significant elevation in the sensation threshold of the lower lip and the disappearance of pain were observed in all patients. Three of the five patients reported experiencing tongue numbness. Discomfort with the use of the IANB device was less than 30 mm on the visual analog scale. No notable complications were observed. The appropriate type, concentration, and dosage of the local anesthetic must be considered during general dental treatment and oral surgical procedures. Our findings suggest that the IANB device is useful for eliminating errors between operators, enhancing safety, and improving the success rate.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2023 ","pages":"1021918"},"PeriodicalIF":2.9,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10504047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10655407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional Alterations of the Basal Ganglia Are Associated with Voluntary Activation of the Core Stabilizing Muscles in Patients with Chronic Low Back Pain: A Cross-Sectional Study. 慢性腰痛患者基底节的功能改变与核心稳定肌的自主激活有关:一项横断面研究。
IF 2.9 3区 医学
Pain Research & Management Pub Date : 2023-08-31 eCollection Date: 2023-01-01 DOI: 10.1155/2023/2028379
Chanjuan Zhang, Xi Chen, Yi Yin, Dongfeng Xie, Jing Luo, Yinan Ai, Wenfeng Zhan, Hongjun Kan, Shuxian Zhang, Guihua Jiang, Xiquan Hu
{"title":"Functional Alterations of the Basal Ganglia Are Associated with Voluntary Activation of the Core Stabilizing Muscles in Patients with Chronic Low Back Pain: A Cross-Sectional Study.","authors":"Chanjuan Zhang,&nbsp;Xi Chen,&nbsp;Yi Yin,&nbsp;Dongfeng Xie,&nbsp;Jing Luo,&nbsp;Yinan Ai,&nbsp;Wenfeng Zhan,&nbsp;Hongjun Kan,&nbsp;Shuxian Zhang,&nbsp;Guihua Jiang,&nbsp;Xiquan Hu","doi":"10.1155/2023/2028379","DOIUrl":"10.1155/2023/2028379","url":null,"abstract":"<p><strong>Purpose: </strong>Deficits in voluntary activation of the core stabilizing muscles are consistently observed in patients with chronic low back pain (CLBP); however, the underlying neural mechanism remains unclear. This cross-sectional study aimed at testing the hypothesis that the impaired voluntary activation of core stabilizing muscles is associated with structural and functional alterations in the basal ganglia, thalamus, and cortex in patients with CLBP.</p><p><strong>Methods: </strong>We obtained structural and resting-state functional magnetic resonance imaging (rs-fMRI) data from 53 patients with CLBP and 67 healthy controls and estimated the alterations in grey matter volume (GMV) and functional and effective connectivity (EC) of regions with altered GMV via whole brain analysis. The voluntary activation of the multifidus (MF) and transversus abdominis (TrA) was evaluated by ultrasound imaging in these patients.</p><p><strong>Results: </strong>Compared with the HCs, they displayed a significant decrease in GMV in the bilateral thalamus and caudate nucleus, a significant increase in GMV in the left middle frontal gyrus, and increased resting-state functional connectivity between the right caudate nucleus and the bilateral precuneus (voxel-level <i>p</i> < 0.005, Gaussian random field-corrected <i>p</i> < 0.05). The patients also showed increased EC from the right caudate nucleus to the bilateral precuneus, which was significantly correlated with voluntary activation of the bilateral MF and TrA (all <i>p</i> < 0.050).</p><p><strong>Conclusions: </strong>Grey matter alterations may be confined to regions responsible for perception, motor control, and emotion regulation in patients with CLBP. The interrupted EC from the basal ganglia to the default mode network might be involved in the impairment of voluntary activation of the core stabilizing muscles.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2023 ","pages":"2028379"},"PeriodicalIF":2.9,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10484657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10213195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Personality in Chronic Headache: A Systematic Review with Meta-Analysis. 慢性头痛患者的人格特征:Meta分析系统综述。
IF 2.9 3区 医学
Pain Research & Management Pub Date : 2023-08-28 eCollection Date: 2023-01-01 DOI: 10.1155/2023/6685372
Sara Bottiroli, Alessia Renzi, Elena Ballante, Roberto De Icco, Grazia Sances, Annalisa Tanzilli, Tomaso Vecchi, Cristina Tassorelli, Federica Galli
{"title":"Personality in Chronic Headache: A Systematic Review with Meta-Analysis.","authors":"Sara Bottiroli,&nbsp;Alessia Renzi,&nbsp;Elena Ballante,&nbsp;Roberto De Icco,&nbsp;Grazia Sances,&nbsp;Annalisa Tanzilli,&nbsp;Tomaso Vecchi,&nbsp;Cristina Tassorelli,&nbsp;Federica Galli","doi":"10.1155/2023/6685372","DOIUrl":"10.1155/2023/6685372","url":null,"abstract":"<p><strong>Background: </strong>Chronic headache (CH) is a condition that includes different subtypes of headaches and that can impair different life domains. Personality traits can play a relevant role both in the development and in coping with this medical condition. The first aim of the present study is to realize a systematic review of the personality traits associated with CH compared to healthy controls; the second objective is to carry out a quantitative meta-analysis with the studies using the same instrument to assess personality traits.</p><p><strong>Method: </strong>The literature search encompassed articles published from 1988 until December 2022 on the major databases in the field of health and social sciences: PubMed, Scopus, PsychInfo, and Web of Science.</p><p><strong>Results: </strong>Thirteen studies were included in the systematic review, but only three studies were deeply explored in a meta-analysis since the only ones used a common instrument for personality assessment (Minnesota Multiphasic Personality Inventory). According to the meta-analysis, different subtypes of CH patients scored higher than healthy controls on Hypochondriasis and Hysteria Scales. The systematic review showed higher levels of depressive and anxious personality dimensions and pain catastrophizing in CH compared to healthy controls. Moreover, frequent-chronic forms and medication-overuse headache were the most symptomatic and frail categories showing higher levels of dysfunctional personality traits and psychopathological symptoms.</p><p><strong>Conclusions: </strong>These results seem to confirm a \"neurotic profile\" in patients suffering from CH. The identification of the main personality traits involved in the onset and maintenance of headache disorders represents an important objective for developing psychological interventions.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2023 ","pages":"6685372"},"PeriodicalIF":2.9,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10477030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10522957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcomes of Pain Management Training for the Fourth- and Fifth-Year Medical Students. 四年级和五年级医学生疼痛管理培训的结果。
IF 2.9 3区 医学
Pain Research & Management Pub Date : 2023-08-25 eCollection Date: 2023-01-01 DOI: 10.1155/2023/6080769
Ayano Saeki, Yumiko Takao, Keiichiro Suzuki, Munetaka Hirose
{"title":"Outcomes of Pain Management Training for the Fourth- and Fifth-Year Medical Students.","authors":"Ayano Saeki,&nbsp;Yumiko Takao,&nbsp;Keiichiro Suzuki,&nbsp;Munetaka Hirose","doi":"10.1155/2023/6080769","DOIUrl":"10.1155/2023/6080769","url":null,"abstract":"<p><p>Pain management is a major medical issue. However, current medical education in Japan is inadequate with regard to training students to properly assess patients with acute and chronic pain and plan their treatment. Therefore, starting in 2019, Hyogo Medical University established a multidisciplinary educational system to better train medical students to provide pain care. The course, called clinical pain study, is offered to fourth- and fifth-year medical students. Fourth-year students learn the scientific aspects of pain through clinical practice. In this study, we assessed students' understanding of pain management based on the results of pretests and posttests performed before and after their practicum. These tests were administered from November 2019 to April 2022 to 263 fourth- and fifth-year medical students who took the clinical pain study class. The test results were compared in terms of the percentage of correct answers and the total score for each question using McNemar's chi-square test and paired <i>t</i>-tests, respectively. The results showed a significant improvement in the mean of the total score, confirming the improvement in medical students' knowledge (6.43 vs. 7.35 points; <i>p</i> < 0.001). Based on the results, overall, pain education at the university has had positive outcomes and will therefore be continued in the future.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2023 ","pages":"6080769"},"PeriodicalIF":2.9,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10155773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of Dry Needling in Improving Pain and Function in Comparison with Other Techniques in Patients with Chronic Neck Pain: A Systematic Review and Meta-Analysis. 与其他技术相比,干针在改善慢性颈部疼痛患者疼痛和功能方面的有效性:系统综述和荟萃分析。
IF 2.9 3区 医学
Pain Research & Management Pub Date : 2023-08-23 eCollection Date: 2023-01-01 DOI: 10.1155/2023/1523834
Mar Hernández-Secorún, Hugo Abenia-Benedí, Sergio Borrella-Andrés, Isabel Marqués-García, María Orosia Lucha-López, Pablo Herrero, Isabel Iguacel, José Miguel Tricás-Moreno, César Hidalgo-García
{"title":"Effectiveness of Dry Needling in Improving Pain and Function in Comparison with Other Techniques in Patients with Chronic Neck Pain: A Systematic Review and Meta-Analysis.","authors":"Mar Hernández-Secorún,&nbsp;Hugo Abenia-Benedí,&nbsp;Sergio Borrella-Andrés,&nbsp;Isabel Marqués-García,&nbsp;María Orosia Lucha-López,&nbsp;Pablo Herrero,&nbsp;Isabel Iguacel,&nbsp;José Miguel Tricás-Moreno,&nbsp;César Hidalgo-García","doi":"10.1155/2023/1523834","DOIUrl":"10.1155/2023/1523834","url":null,"abstract":"<p><p>The purpose of this systematic review and meta-analysis was to assess the short-, mid-, and long-term effectiveness of dry needling in improving pain and functional capacity of patients with chronic neck pain. Search strategy was performed on PubMed, Web of Science, Scopus, PEDro, and Cochrane Library Plus biomedical databases. The risk of bias was assessed using the RoB2 tool. Randomised controlled clinical trials in which at least 1 of the groups received dry needling were included. 662 studies were found; 14 clinical trials were selected for qualitative analysis and 13 for quantitative analysis. The quality of most of the studies included was \"high.\" All the studies reported improvements in cervical pain and/or disability, regardless of the protocol followed and the muscles targeted. No serious adverse effects were reported. Dry needling showed to be more effective when compared with other therapies in both women and men, without differences by sex. When the analysis was carried out by age, patients over 40 years old benefitted more than those below 40 years old. Our meta-analysis supports the use of dry needling to improve pain and functional capacity in patients with chronic neck pain at short- and mid-term intervals.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2023 ","pages":"1523834"},"PeriodicalIF":2.9,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10469395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10154240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of Temperament on the Acceptance of Two Conscious Sedation Techniques in Toddlers Undergoing Dental Treatment: A Randomised Cross Over Trial. 气质对接受牙科治疗的幼儿接受两种有意识镇静技术的影响:一项随机交叉试验。
IF 2.9 3区 医学
Pain Research & Management Pub Date : 2023-08-22 eCollection Date: 2023-01-01 DOI: 10.1155/2023/6655628
Palak Janiani, Deepa Gurunathan, Sivakumar Nuvvula
{"title":"Influence of Temperament on the Acceptance of Two Conscious Sedation Techniques in Toddlers Undergoing Dental Treatment: A Randomised Cross Over Trial.","authors":"Palak Janiani,&nbsp;Deepa Gurunathan,&nbsp;Sivakumar Nuvvula","doi":"10.1155/2023/6655628","DOIUrl":"10.1155/2023/6655628","url":null,"abstract":"<p><strong>Background: </strong>Pediatric dentists often find it challenging to handle pediatric patients due to their fear, unease, and anxiety toward dental procedures. To address this, sedation agents such as intranasal midazolam and nitrous oxide are commonly used as pharmacological behavior management methods. A child's temperament affects their behavior in unfamiliar settings.</p><p><strong>Aim: </strong>To study the effect of child temperament on the acceptance of the nasal mask and intranasal drug administration in children undergoing dental treatment.</p><p><strong>Methods: </strong>Thirty-two anxious children aged three to five were randomly assigned to two groups. During the first visit, one group received intranasal midazolam sedation, while the other group received nitrous oxide administered through a mask. On the subsequent visit, the groups crossed over. The parent assessed the child's temperament, and the acceptance of the sedation methods was recorded. The Ohio State University Behavioral Rating Scale (OSUBRS) was employed to assess behavior during the administration of local anesthesia. Statistical analysis was carried out using the chi-square test and Mann-Whitney <i>U</i> test (<i>p</i> value <0.05).</p><p><strong>Results: </strong>Children exhibited greater acceptance of the nasal mask compared to using the intranasal route for delivering midazolam during the induction process. A significant statistical influence of temperament was observed on the acceptance of the nasal mask and the intranasal atomisation device (<i>p</i> value <0.05). The mean OSUBRS scores did not show any statistically significant differences between the sedation groups (<i>p</i> = 0.14).</p><p><strong>Conclusion: </strong>Most children demonstrated a more favorable acceptance of the nasal mask during the induction process; however, intranasal midazolam can serve as an effective alternative for anxious patients who struggle to keep the nitrous oxide mask on during the dental procedure. The adoption of these methods is influenced directly by the child's temperament.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2023 ","pages":"6655628"},"PeriodicalIF":2.9,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10465248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10130946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of Ketamine in Pain Management and the Underlying Mechanism. 氯胺酮在疼痛管理中的应用及其潜在机制。
IF 2.9 3区 医学
Pain Research & Management Pub Date : 2023-08-16 eCollection Date: 2023-01-01 DOI: 10.1155/2023/1928969
Xiaofan Ma, Jia Yan, Hong Jiang
{"title":"Application of Ketamine in Pain Management and the Underlying Mechanism.","authors":"Xiaofan Ma,&nbsp;Jia Yan,&nbsp;Hong Jiang","doi":"10.1155/2023/1928969","DOIUrl":"10.1155/2023/1928969","url":null,"abstract":"<p><p>Since ketamine was approved by the FDA as an intravenous anesthetic, it has been in clinical use for more than 50 years. Apart from its anesthetic effects, ketamine is one of the few intravenous anesthetics with potent analgesic properties. As part of the effort to develop pain management, renewed interest has focused on the use of ketamine for the treatment of acute and chronic pain. Ketamine is commonly used to treat various kinds of chronic pain syndromes and is also applied to control perioperative pain and reduce the consumption of postoperative analgesics. However, its precise mechanisms of action remain mysterious for a large part. Despite extensive research in the field, the mechanism of ketamine is still unclear. Its analgesic effect appears to be largely mediated by blockade of NMDARs, but opioid, GABA, and monoaminergic system seem to partly participate in the pain transmission procedure. Its metabolites also have an analgesic effect, which may prolong pain relief. More recently, the antidepressant effect of ketamine has been considered to reduce pain-related aversion to relieve chronic pain. Overall, the analgesic mechanism of ketamine seems to be a complex combination of multiple factors. Due to its potent analgesic properties, ketamine is an analgesic with great clinical application prospects. Exploring the precise mechanism of action of ketamine will help guide clinical medication and confirm indications for ketamine analgesia. This review aims to list the application of ketamine in pain management and discuss its analgesic mechanism.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2023 ","pages":"1928969"},"PeriodicalIF":2.9,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10447145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10077935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Efficacy of Manual Therapy and Pressure Biofeedback-Guided Deep Cervical Flexor Muscle Strength Training on Pain and Functional Limitations in Individuals with Cervicogenic Headaches: A Randomized Comparative Study. 手动治疗和压力生物反馈引导的颈深屈肌力量训练对颈源性头痛患者疼痛和功能限制的疗效:一项随机比较研究。
IF 2.9 3区 医学
Pain Research & Management Pub Date : 2023-08-14 eCollection Date: 2023-01-01 DOI: 10.1155/2023/1799005
Shahnaz Hasan, Nasrin Bharti, Ahmad H Alghadir, Amir Iqbal, Naiyer Shahzad, Abeer R Ibrahim
{"title":"The Efficacy of Manual Therapy and Pressure Biofeedback-Guided Deep Cervical Flexor Muscle Strength Training on Pain and Functional Limitations in Individuals with Cervicogenic Headaches: A Randomized Comparative Study.","authors":"Shahnaz Hasan,&nbsp;Nasrin Bharti,&nbsp;Ahmad H Alghadir,&nbsp;Amir Iqbal,&nbsp;Naiyer Shahzad,&nbsp;Abeer R Ibrahim","doi":"10.1155/2023/1799005","DOIUrl":"10.1155/2023/1799005","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to compare the efficacy of manual therapy and pressure biofeedback-guided DCFM strength training on pain intensity and functional limitations in individuals with CGH. <i>Trial Design</i>. A double-blinded, two-arm parallel group randomized comparative design.</p><p><strong>Methods: </strong>After applying the eligibility criteria, sixty out of eighty-nine CGH patients were recruited from King Saud University Medical Center in Riyadh and randomly allocated to intervention groups using simple random sampling. Group 1 underwent pressure biofeedback-guided DCFM strength training and conventional treatment, while Group 2 received manual therapy and conventional treatment for three consecutive weeks. The main outcome measures were scores on the visual analog scale (VAS) and the headache disability index (HDI). One assessor and two physical therapists were blinded to group allocation.</p><p><strong>Results: </strong>Sixty out of eighty participants aged 29-40 years were randomized into intervention groups (<i>n</i> = 30/group; age (mean ± standard deviation): group 1 = 35.0 ± 2.82; group 2 = 34.87 ± 2.60), and their data were analyzed. A significant improvement (95% CI, <i>p</i> < 0.05) was observed within each group when comparing the VAS and HDI scores between baseline and postintervention. In contrast, between-group comparisons for the outcome score of VAS and HDI revealed nonsignificant differences in the first, second, and third weeks after intervention, except for the VAS score, which showed a significant difference in weeks 2 and 3 after intervention. Cohen's <i>d</i>-value indicated that the intervention effect size for reducing pain was larger in group 1 than in group 2 at weeks 2 and 3.</p><p><strong>Conclusion: </strong>Compared with manual therapy, pressure biofeedback-guided DCFM strength training showed a greater reduction in pain intensity (assessed using the VAS) at weeks two and three. However, both treatments were equally effective in lowering headache-related functional limitations in patients with CGH. This trial is registered with ClinicalTrial.gov PRS (Identifier ID: NCT05692232).</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2023 ","pages":"1799005"},"PeriodicalIF":2.9,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10442171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10433384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial Intelligence for Automatic Pain Assessment: Research Methods and Perspectives. 用于自动疼痛评估的人工智能:研究方法与展望
IF 2.5 3区 医学
Pain Research & Management Pub Date : 2023-06-28 eCollection Date: 2023-01-01 DOI: 10.1155/2023/6018736
Marco Cascella, Daniela Schiavo, Arturo Cuomo, Alessandro Ottaiano, Francesco Perri, Renato Patrone, Sara Migliarelli, Elena Giovanna Bignami, Alessandro Vittori, Francesco Cutugno
{"title":"Artificial Intelligence for Automatic Pain Assessment: Research Methods and Perspectives.","authors":"Marco Cascella, Daniela Schiavo, Arturo Cuomo, Alessandro Ottaiano, Francesco Perri, Renato Patrone, Sara Migliarelli, Elena Giovanna Bignami, Alessandro Vittori, Francesco Cutugno","doi":"10.1155/2023/6018736","DOIUrl":"10.1155/2023/6018736","url":null,"abstract":"<p><p>Although proper pain evaluation is mandatory for establishing the appropriate therapy, self-reported pain level assessment has several limitations. Data-driven artificial intelligence (AI) methods can be employed for research on automatic pain assessment (APA). The goal is the development of objective, standardized, and generalizable instruments useful for pain assessment in different clinical contexts. The purpose of this article is to discuss the state of the art of research and perspectives on APA applications in both research and clinical scenarios. Principles of AI functioning will be addressed. For narrative purposes, AI-based methods are grouped into behavioral-based approaches and neurophysiology-based pain detection methods. Since pain is generally accompanied by spontaneous facial behaviors, several approaches for APA are based on image classification and feature extraction. Language features through natural language strategies, body postures, and respiratory-derived elements are other investigated behavioral-based approaches. Neurophysiology-based pain detection is obtained through electroencephalography, electromyography, electrodermal activity, and other biosignals. Recent approaches involve multimode strategies by combining behaviors with neurophysiological findings. Concerning methods, early studies were conducted by machine learning algorithms such as support vector machine, decision tree, and random forest classifiers. More recently, artificial neural networks such as convolutional and recurrent neural network algorithms are implemented, even in combination. Collaboration programs involving clinicians and computer scientists must be aimed at structuring and processing robust datasets that can be used in various settings, from acute to different chronic pain conditions. Finally, it is crucial to apply the concepts of explainability and ethics when examining AI applications for pain research and management.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2023 ","pages":"6018736"},"PeriodicalIF":2.5,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10322534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9862200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scraping Therapy Improved Muscle Regeneration through Regulating GLUT4/Glycolytic and AMPK/mTOR/4EBP1 Pathways in Rats with Lumbar Multifidus Injury. 刮痧疗法通过调节GLUT4/糖酵解和AMPK/mTOR/4EBP1通路促进腰椎多裂肌损伤大鼠肌肉再生。
IF 2.9 3区 医学
Pain Research & Management Pub Date : 2023-06-22 eCollection Date: 2023-01-01 DOI: 10.1155/2023/8870256
Bin Zou, Juan Du, Qiwen Xuan, Yajing Wang, Zixiao Wang, Wen Zhang, Lianghua Wang, Wei Gu
{"title":"Scraping Therapy Improved Muscle Regeneration through Regulating GLUT4/Glycolytic and AMPK/mTOR/4EBP1 Pathways in Rats with Lumbar Multifidus Injury.","authors":"Bin Zou,&nbsp;Juan Du,&nbsp;Qiwen Xuan,&nbsp;Yajing Wang,&nbsp;Zixiao Wang,&nbsp;Wen Zhang,&nbsp;Lianghua Wang,&nbsp;Wei Gu","doi":"10.1155/2023/8870256","DOIUrl":"10.1155/2023/8870256","url":null,"abstract":"<p><strong>Background: </strong>High morbidity of nonspecific low back pain (NLBP) and large consumption of medical resources caused by it have become a heavy social burden. There are many factors inducing NLBP, among which the damage and atrophy of multifidus (MF) are most closely related to NLBP. Scraping therapy can have significant treatment effects on NLBP with fewer adverse reactions and less medical fund input than other modalities or medications. However, the mechanism of scraping therapy treating NLBP remains unclarified. Here, we wanted to investigate the effects of scraping therapy on promoting MF regeneration and the underlying mechanisms.</p><p><strong>Methods: </strong>A total of 54 male rats (SD, 6-7 weeks old) were randomly divided into nine groups, namely, K, M6h, M1d, M2d, M3d, G6h, G1d, G2d, and G3d, with six rats in each group. They were injected with bupivacaine (BPVC) to intentionally induce MF injury. We then performed scraping therapy on the rats that had been randomly chosen and compared treatment effects at different time points. <i>In vitro</i> data including skin temperature and tactile allodynia threshold were collected and histological sections were analyzed. mRNA sequencing was applied to distinguish the genes or signaling pathways that had been altered due to scraping therapy, and the results were further verified through reverse transcription polymerase chain reaction and Western blot analysis.</p><p><strong>Results: </strong>Transitory petechiae and ecchymosis both on and beneath the rats' skin raised by scraping therapy gradually faded in about 3 d. Cross-sectional area (CSA) of MF was significantly smaller 30 h, 2 d, and 4 d after modeling (<i>P</i>=0.007, <i>P</i>=0.001, and <i>P</i>=0.015, respectively, vs. the blank group) and was significantly larger in the scraping group 1 d after treatment (<i>P</i>=0.002 vs. the model 1d group). Skin temperature significantly increased immediately after scraping (<i>P</i> < 0.001) and hindlimb pain threshold increased on the 2nd day after scraping (<i>P</i>=0.046 and <i>P</i>=0.028, respectively). 391 differentially expressed genes and 8 signaling pathways were characterized 6 h after scraping; only 3 differentially expressed genes and 3 signaling pathways were screened out 2 d after treatment. The amounts of mRNAs or proteins for GLUT4, HK2, PFKM, PKM, LDHA (which belong to the GLUT4/glycolytic pathway), p-mTOR, p-4EBP1 (which belong to the AMPK/mTOR/4EBP1 pathway), and BDH1 were enhanced, and p-AMPK<i>α</i> was decreased after scraping therapy.</p><p><strong>Conclusions: </strong>Scraping therapy has therapeutic effects on rats with multifidus injury by promoting muscle regeneration via regulating GLUT4/glycolytic and AMPK/mTOR/4EBP1 signaling pathways.</p>","PeriodicalId":19913,"journal":{"name":"Pain Research & Management","volume":"2023 ","pages":"8870256"},"PeriodicalIF":2.9,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10310458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9747911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信