Pain and Therapy最新文献

{"title":"Progressive Response of Repeated Treatment with High-Concentration (179 mg) Capsaicin Patch in Peripheral Neuropathic Pain After Surgical or Traumatic Nerve Injury: Findings from the 12-Month German CASPAR Registry Study.","authors":"Michael A Überall, Christian Simanski, Mike Zellnig, Mariëlle Eerdekens, Sylvia Engelen, Myriam Heine, Fabienne Percot, Rita Freitas, Lucia Garcia Guerra, Tamara Quandel","doi":"10.1007/s40122-025-00752-4","DOIUrl":"10.1007/s40122-025-00752-4","url":null,"abstract":"<p><strong>Introduction: </strong>Peripheral neuropathic pain after nerve injury (PNI) caused by surgery or trauma can severely impact daily life. The high-concentration capsaicin patch (HCCP, 179 mg) is a topical therapy approved for peripheral neuropathic pain, including PNI. This study utilizes data from the German Pain e-Registry (GPeR) to investigate the real-world effectiveness of HCCP in managing PNI across multiple treatments over 1 year.</p><p><strong>Methods: </strong>CASPAR is a retrospective, non-interventional cohort study investigating patients with peripheral neuropathic pain treated with HCCP. The present analysis included 499 patients with PNI who received ≥ 1 HCCP with ≥ 12 months of follow-up. Key measures included pain intensity, quality of life (QoL), affective distress, sleep disturbances, and overall functioning. Furthermore, analgesic use and adverse events associated with HCCP treatment were evaluated.</p><p><strong>Results: </strong>The mean average daily pain intensity (API) decreased from 52.5 mm on the visual analog scale (VAS) at baseline to 21.5 mm at month 12 in patients receiving four HCCPs. At month 12, a ≥ 30% reduction in API was observed in 25.8%, 44.9%, 85.3%, and 97.8% of patients receiving one, two, three, and four HCCP treatments, respectively. Significant improvements were also noted in physical and mental QoL, sleep, mood, and daily functioning. Patients receiving three or four HCCP treatments maintained pain relief and symptom improvements over the 12-month period, whereas those who discontinued treatment after one or two treatments experienced symptom rebound. In addition, repeated HCCP treatments were associated with a marked reduction in concomitant analgesic use and an increase in days of normal activities. Adverse events were mild-to-moderate application-site reactions, consistent with the well-established safety profile of HCCP.</p><p><strong>Conclusions: </strong>HCCP treatment is associated with reductions in pain intensity and improvements in sleep, mood, and overall QoL in patients with PNI. These benefits are amplified with continued treatment and are accompanied by reduced use of concomitant analgesics and more days of usual activities, although a direct causal relationship cannot be confirmed within the context of this observational study.</p><p><strong>Clinical trial registration: </strong>EU PAS number: EUPAS1000000106.</p>","PeriodicalId":19908,"journal":{"name":"Pain and Therapy","volume":" ","pages":"1399-1416"},"PeriodicalIF":4.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Posterior Quadratus Lumborum Block on Acute Pain Relief and Chronic Pain Prevention in Breast Cancer Surgery.","authors":"Min Wang, Shu-Jie Niu, Jin Wu, Yi-Wei Zhong, Zi-Yun Lu, Qun Fu, Bing-Bing Li","doi":"10.1007/s40122-025-00740-8","DOIUrl":"10.1007/s40122-025-00740-8","url":null,"abstract":"<p><strong>Introduction: </strong>Breast cancer surgery is a common surgical procedure often associated with acute and chronic postoperative pain. As part of multimodal analgesia, the erector spinae plane block (ESPB) has been shown to effectively alleviate pain after breast cancer surgery. This study is the first to apply the posterior quadratus lumborum block (posterior QLB) for perioperative analgesia in breast cancer surgery. The aim of this research was to evaluate whether ESPB and QLB2 can relieve acute and chronic pain following breast cancer surgery.</p><p><strong>Methods: </strong>A total of 120 female patients undergoing breast cancer surgery were randomly assigned to receive either ESPB, posterior QLB, or no intervention. All patients were administered sufentanil patient-controlled intravenous analgesia postoperatively. The primary outcome was the visual analog scale (VAS) pain scores recorded at 2, 6, 18, 24, and 48 h post-surgery under rest and motion conditions. Secondary outcomes included the incidence of moderate-to-severe pain within 24 and 48 h post-surgery, intraoperative fentanyl cumulative dosage, postoperative rescue analgesia, chronic pain incidence, recovery quality of life, and adverse events.</p><p><strong>Results: </strong>Compared to the group receiving conventional treatment (group C), the incidence of moderate-to-severe pain within 24 h post-surgery was significantly lower in both the group receiving ESPB (group E; 16.7% vs. 46.2%, P < 0.05) and the group receiving QLB (group Q; 20.5% vs. 46.2%, P < 0.05). Additionally, the proportion of patients requiring rescue analgesia was significantly reduced in both group E and group Q, compared to group C (group C vs. E vs. Q: 30.8% vs. 7.1% vs. 10.3%, P = 0.007; group C vs Q: 30.8% vs. 10.3%, P = 0.025; group C vs. E: 30.8% vs 7.1%, P = 0.006; group Q vs. E: 10.3% vs. 7.1%, P = 0.141). At 3 months post-surgery, group Q had a significantly lower incidence of chronic pain compared to both group C (19.5% vs. 71.8%, P < 0.05) and group E (19.5% vs. 57.1%, P < 0.05). No significant differences were observed between the groups in terms of VAS scores at 2, 6, 18, 24, or 48 h, intraoperative fentanyl consumption, postoperative nausea and vomiting, time to first mobilization, time to first oral intake, the length of hospital stay, or Quality of Recovery-15 Items (QoR-15) scores at 3 months post-surgery (all P > 0.05).</p><p><strong>Conclusion: </strong>Compared with conventional intravenous analgesia, the combination of ultrasound-guided ESPB and posterior QLB significantly reduces the incidence of moderate-to-severe pain and the need for rescue analgesia within 24 h post-surgery. Furthermore, a single posterior QLB significantly reduces the incidence of chronic pain at 3 months post-surgery in patients with breast cancer.</p><p><strong>Trial registration: </strong>Clinical trial number: ChiCTR2000041471.</p>","PeriodicalId":19908,"journal":{"name":"Pain and Therapy","volume":" ","pages":"1349-1362"},"PeriodicalIF":4.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of Mirogabalin in Lumbar Spinal Stenosis Patients with Peripheral Neuropathic Pain on NSAIDs: Post Hoc Analysis of the MiroTAS Study.","authors":"Takuya Nikaido, Shunsuke Tabata, Kazuhito Shiosakai, Taichi Nakatani, Hiroshi Sakoda","doi":"10.1007/s40122-025-00732-8","DOIUrl":"10.1007/s40122-025-00732-8","url":null,"abstract":"<p><strong>Introduction: </strong>The primary analysis of the MiroTAS study in patients with lumbar spinal stenosis (LSS) taking non-steroidal anti-inflammatory drugs showed that mirogabalin add-on therapy further improved pain and quality of life (QOL) without new safety concerns.</p><p><strong>Methods: </strong>This post hoc analysis of the MiroTAS study examined the timing of onset of mirogabalin-related adverse drug reactions (mrADRs) (composite of somnolence, dizziness, edema, and peripheral edema), factors affecting safety and efficacy, and the relationships between baseline numbness severity (by spine painDETECT questionnaire [SPDQ] score), EQ-5D-5L scores, leg pain improvement (by visual analogue scale [VAS]), and patient satisfaction (by Patient Global Impression of Change [PGIC] scores).</p><p><strong>Results: </strong>Among 110 patients, there were no significant differences in the incidence rates of mrADRs by patient characteristics. The mrADRs occurred mainly after the first administration and uptitration period of mirogabalin. EQ-5D-5L scores significantly improved from baseline to week 12 in patients with mrADRs vs those without (difference 0.0767; p = 0.0304 by t test). The proportion of patients with PGIC scores ≤ 3 at week 12 was numerically higher in patients with mrADRs vs those without. There were no differences in the percentage of patients with reduced leg pain by VAS score (improvement ≥ 20 mm) at week 12 by patient characteristics except for spondylolysis/spondylolisthesis as a complication. Baseline SPDQ numbness scores were positively correlated with improvement in EQ-5D-5L at week 12 (Spearman's rank correlation coefficient 0.2811, p = 0.0092).</p><p><strong>Conclusions: </strong>Mirogabalin was not related to specific patient characteristics regarding the onset of mrADRs and was effective for LSS regardless of patient characteristics. Caution is needed regarding the onset of mrADRs after first administration and uptitration of mirogabalin, but these may not reduce QOL or patient satisfaction. Patients with high numbness scores may be more likely to benefit from treatment with mirogabalin in terms of QOL.</p><p><strong>Trial registration: </strong>Japan Registry of Clinical Trials (jRCTs021200007).</p>","PeriodicalId":19908,"journal":{"name":"Pain and Therapy","volume":" ","pages":"1293-1310"},"PeriodicalIF":4.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrode Placement Affects Clinical Outcome in Transcutaneous Electrical Nerve Stimulation for Knee Osteoarthritis: A Combined Cadaver Study and Randomized Controlled Trial.","authors":"Yu Xu, Yanfu Bai, Meimin Deng, Xuyi Hu, Manqin Lian, Zhisheng Huang, Lingling Su","doi":"10.1007/s40122-025-00750-6","DOIUrl":"10.1007/s40122-025-00750-6","url":null,"abstract":"<p><strong>Introduction: </strong>Transcutaneous electrical nerve stimulation (TENS) is a widely used physical therapy for knee osteoarthritis (OA) pain management. However, the optimal electrode placement for TENS in knee OA remains unclear. Given that TENS delivers stimulation via electrodes to cutaneous nerves, placing electrodes in areas with high nerve density should be the precondition to exert its therapeutic effects. However, high-density nerve areas around the knee and corresponding electrode placement strategies have yet to be investigated.</p><p><strong>Methods: </strong>An anatomic study was conducted on 20 adult formalin-fixed cadavers to identify the high-density nerve areas around the knee. Then, to standardize electrode placement, the patellar width was used as a reference to determine distances from the patellar borders. Subsequently, 80 patients with Kellgren-Lawrence grade 2 or 3 knee OA were enrolled in a randomized, double-blinded trial. Participants received TENS therapy with electrodes placed either on the identified high-density nerve areas (study cohort, n = 40) or on traditional pain areas (control cohort, n = 40).</p><p><strong>Results: </strong>Four high-density nerve areas were identified: the quadriceps tendon, patellar ligament, medial joint line area, and superior medial area of the knee. Over the follow-up period, patients in the study cohort showed significantly greater improvements in VAS score and WOMAC index total score, as well as in pain, stiffness, and function subscales compared with those in the control cohort (all P < 0.05).</p><p><strong>Conclusions: </strong>These findings suggest that positioning electrodes over high-density nerve areas allows TENS more effectively activate sensory afferents, thereby enhancing pain relief.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registry identifier, ChiCTR2500098200, 4 March 2025, retrospectively registered.</p>","PeriodicalId":19908,"journal":{"name":"Pain and Therapy","volume":" ","pages":"1363-1377"},"PeriodicalIF":4.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the Anatomy of Posterior Cervical Interfascial Space: Implications for Regional Blocks and Pain Management. A Narrative Review.","authors":"Yufeng Zhang, Huili Li, Songchao Xu, Ruijuan Guo, Danxu Ma, Yun Wang","doi":"10.1007/s40122-025-00754-2","DOIUrl":"10.1007/s40122-025-00754-2","url":null,"abstract":"<p><p>The posterior cervical area exhibits a complex anatomy comprising fascia, nerves, and muscles. With the widespread adoption of ultrasound in regional anesthesia, numerous posterior cervical interfascial plane block techniques have been developed in recent years. The injectate spreads along the fascial plane, blocking nerves that traverse the interfascial space after being injected into the target plane. The posterior cervical interfascial blocks have been manifesting the great potential for perioperative analgesia and chronic pain management in the head, neck, and shoulder regions. However, a comprehensive review of these methods as well as their indications, contraindications, and complications remain lacking. This article summarizes the anatomy of the posterior cervical musculofascial layers, highlighting the characteristics of interfascial plane block techniques and their potential limitations. By using the fascial anatomy as an entry point for studying interfascial plane blocks, it enhances our understanding of the mechanisms underlying the efficacy and complications of these block techniques. It not only reviews well-studied blocks such as trapezius plane (TP), multifidus cervicis plane (MCP), inter-semispinal plane (ISP), and erector spinae plane (ESP) block but also includes recently developed techniques from the past 5 years, such as the retrolaminar cervical block, serratus posterior superior intercostal plane (SPSIP) block, and C2 dorsal root ganglion (DRG) \"three-in-one\" block. The available evidence suggests that while posterior cervical interfascial plane blocks effectively target the dorsal rami of cervical nerves, non-posterior cervical block techniques also exhibit analgesic potential for the posterior cervical region. This review aims to provide insights for further exploration of novel approaches in this emerging field. In conclusion, posterior cervical interfascial plane blocks demonstrate significant clinical value and warrant further development and optimization.</p>","PeriodicalId":19908,"journal":{"name":"Pain and Therapy","volume":" ","pages":"1203-1222"},"PeriodicalIF":4.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-Hospital Pain and Opioid Consumption After Primary Total Knee Arthroplasty Compared to Primary Total Hip Arthroplasty: Results from 7330 Patients Treated in a Fast-Track Setting.","authors":"Janne Kristin Hofstad, Tina Strømdal Wik, Pål Klepstad, Kari Hanne Gjeilo, Siri Bjørgen Winther, Olav A Foss","doi":"10.1007/s40122-025-00716-8","DOIUrl":"10.1007/s40122-025-00716-8","url":null,"abstract":"<p><strong>Introduction: </strong>Differences in in-hospital pain and consumption of opioids after primary total hip arthroplasty (THA) and knee arthroplasty (TKA) have been rarely studied in a setting where the patient course is otherwise similar. The aim of this study was to compare early pain intensity and opioid usage between patients who have undergone THA and TKA to identify potential implications for outpatient surgery.</p><p><strong>Methods: </strong>This institutional register study included 4655 patients receiving THA and 2675 patients receiving TKA. Pain at rest and during mobilization were collected once preoperatively, and postoperatively at five time-points, twice on the Day of surgery, once each on day 1 and day 2 after surgery, and at discharge, on a numeric rating scale (NRS) 0-10. Rescue opioids in oral morphine-equivalent doses (MME) were consecutively registered. Postoperative mobilization was registered twice daily.</p><p><strong>Results: </strong>Overall mean pain were 2.0 (Cl 2.0-2.0) after THA and 2.3 (Cl 2.3-2.4) after TKA at rest, and 3.3 (Cl 3.3-3.3) and 3.7 (Cl 3.7-3.8) during mobilization, respectively. Patients undergoing TKA had a transient increase in pain intensity the day after surgery, whereas patients undergoing THA had improved pain levels. Outpatient criteria for pain (NRS < 5 during mobilization) were feasible for 37% of THA and 35% of TKA. Total median MME was 30.0 (0-573) after THA and 52.5 (0-390) after TKA. Patients undergoing TKA were less mobilized during hospitalization.</p><p><strong>Conclusion: </strong>A comparable number of THA and TKA cases were eligible for same-day discharge based on outpatient discharge criteria for pain. Patients receiving TKA can expect an increase in pain intensity and opioid needs on the day after surgery.</p>","PeriodicalId":19908,"journal":{"name":"Pain and Therapy","volume":" ","pages":"971-983"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Importance of Image Guidance in Common Spine Interventional Procedures for Pain Management: A Comprehensive Narrative Review.","authors":"Martina Rekatsina, Philip W H Peng","doi":"10.1007/s40122-025-00731-9","DOIUrl":"10.1007/s40122-025-00731-9","url":null,"abstract":"<p><strong>Introduction: </strong>Image-guided spinal injections are commonly performed by pain physicians and supported by literature. A recent survey showed that half of the Canadian providers still perform landmark-guided injections. This comprehensive review aims to describe the evidence supporting imaging modalities (fluoroscopy, computed tomography (CT) and ultrasound) in improving the accuracy and safety in several commonly performed spine injections. Relevant anatomy and pitfalls of landmark-guided injections are also discussed.</p><p><strong>Methods: </strong>An extensive literature search was conducted in PubMed, Medline and Embase databases, complemented by a manual search. Search terms included all spine interventions and imaging modalities.</p><p><strong>Results: </strong>Literature shows that incorrect needle placement without imaging guidance can reach 50% in caudal, 30.4% in lumbar interlaminar and 53% in cervical interlaminar epidural steroid injections. Lumbar and cervical transforaminal steroid injections require imaging to identify intravascular or intradiscal needle placement; misplacement rates can be as high as 20% at cervical, 8% at thoracic, 6-15% at lumbar and 16.5-21% at sacral levels. Imaging techniques for sacroiliac joint steroid injections are superior to non-imaging techniques, while medial branch blocks and facet joint injections require image guidance.</p><p><strong>Conclusion: </strong>Image guidance is a mandatory requirement when performing spinal procedures for pain management. Fluoroscopy enhances the safety and accuracy of spinal injections, with stored images benefiting patient records. Ultrasound also has an increasingly important role either alone or with fluoroscopy. CT is also effective but with limited accessibility.</p>","PeriodicalId":19908,"journal":{"name":"Pain and Therapy","volume":" ","pages":"841-863"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating an early Interdisciplinary Multimodal Assessment for Patients at Risk of Developing Chronic Pain: Results of a Multicentre RCT in Germany.","authors":"Daniel Szczotkowski, Sandra Meyer-Moock, Thomas Kohlmann, Karin Deppe, Anne Gärtner, Greta Hoffmann, Thomas Isenberg, Gabriele Lindena, Ursula Marschall, Carolin Martin, Beatrice Metz-Oster, Lena Milch, André Möller, Bernd Nagel, Frank Petzke, Anke Preissler, Julia Pritzke-Michael, Leonie Schouten, Katja Schwenk, Catharina Schumacher, Anja Waidner, Ulrike Kaiser","doi":"10.1007/s40122-025-00729-3","DOIUrl":"10.1007/s40122-025-00729-3","url":null,"abstract":"<p><strong>Introduction: </strong>Patients at risk of developing chronic pain are often significantly impaired in their daily, social and work activities. An early interdisciplinary multimodal assessment (IMA) includes a systematically integrated view of medical, psychosocial and functional factors to direct patients to need-based treatment services. This multicentre, randomised, controlled trial examined the effects of an IMA on preventing chronic pain and improving care for adult patients.</p><p><strong>Methods: </strong>The intervention group (IG) received an IMA in accordance with standardised guidelines. The control group (CG) was offered a unimodal medical pain assessment (MPA). Data from the Characteristic Pain Intensity (PI) and Disability Score (DS), as primary outcomes, were collected at assessment and 3 and 6 months later together with secondary outcomes (e.g. depression, anxiety, stress, catastrophizing, health-related quality of life).</p><p><strong>Results: </strong>A total of 620 (68.4%) valid questionnaires were available at the 6-month follow-up. The mean reduction (numerical rating scale, 0-10) in terms of improvement within both groups (IG/CG) was 1.6/1.7 points for PI and 1.9/1.8 points for DS. Most secondary outcomes improved as well. However, the differences between the two groups did not reach statistical significance, although there was a tendency for the IG to have a greater effect on some psychological outcomes. Regarding the recommended treatment approaches, the focus in the IG was more on physical activity and psychological and psychosomatic interventions, whereas in the CG there was also a preference for adjusting the medication.</p><p><strong>Conclusions: </strong>Both early MPA and IMA seem to have a positive effect on outcomes such as pain intensity, functional limitations and psychological factors for patients at risk of developing chronic pain. We critically reflect on the results of the primary research question by discussing the limitations in detail and conclude that further research should ensure that the control conditions reflect standard care and that the follow-up period is long enough.</p><p><strong>Trial registration: </strong>German Clinical Trials Register (DRKS-ID: DRKS00015443).</p>","PeriodicalId":19908,"journal":{"name":"Pain and Therapy","volume":" ","pages":"1081-1102"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Biomarkers in Acute Pain: A Narrative Review.","authors":"Thalis Asimakopoulos, Athanasia Tsaroucha, Maria Kouri, Alberto Pasqualucci, Giustino Varrassi, Matteo Luigi Giuseppe Leoni, Martina Rekatsina","doi":"10.1007/s40122-025-00718-6","DOIUrl":"10.1007/s40122-025-00718-6","url":null,"abstract":"<p><p>Acute pain, a critical aspect of patient care, presents a challenge due to its subjective nature and complex biological underpinnings. Biomarkers for acute pain promise a paradigm shift in how pain is perceived, diagnosed, and managed. The study of genetic, inflammatory, and neurotransmission markers associated with pain experience may hold the key for the development of personalized and effective pain management strategies. This narrative review explores the neurobiological pathways of acute pain, encompassing inflammatory responses and neurotransmission mechanisms. It synthesizes current research on the identification and clinical application of biomarkers, emphasizing their potential to enhance diagnostic precision, treatment effectiveness, and risk prediction. We underscore the promising role of acute pain biomarkers in identifying patients at risk for developing acute and potentially chronic pain, predicting patients' response to pharmacological interventions, and aiding in the development of novel therapeutic and pain preventive strategies. The evolving landscape of biomarker research not only deepens our understanding of pain mechanisms but also lays the foundation for more tailored and patient-specific healthcare interventions.</p>","PeriodicalId":19908,"journal":{"name":"Pain and Therapy","volume":" ","pages":"775-789"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Treatment Satisfaction and Medication Understanding Among Patients Taking a Novel Oral Pain Reliever: A Questionnaire-Based Cross-Sectional Study.","authors":"Makio Takahashi, Sho Kodama, Maiko Akahane, Shuhei Yamamoto, Takashi Yonemoto, Haruhiko Seki","doi":"10.1007/s40122-025-00709-7","DOIUrl":"10.1007/s40122-025-00709-7","url":null,"abstract":"<p><strong>Introduction: </strong>Patient satisfaction is important in pain management. Satisfaction with prescribed pain relievers and continued use of these drugs may be affected by a patient's understanding of their efficacy and safety. We investigated the association between patients' satisfaction and understanding of their prescribed medication for three oral pain relievers (lasmiditan, mirogabalin, and tramadol) that recently became available in Japan.</p><p><strong>Methods: </strong>This questionnaire-based, cross-sectional study included adult patients taking these oral pain relievers after April 2023. The primary endpoint was overall satisfaction (five-point rating) and the secondary endpoint was overall understanding (five-point rating) of the oral pain relievers.</p><p><strong>Results: </strong>In total, 328 patients (lasmiditan, 36.9%; mirogabalin, 55.5%, tramadol, 8.8%; four patients had been prescribed more than one medication) were included, and 71.6% of patients reported high satisfaction (score 4, 5) with their oral pain relievers (lasmiditan, 62.0%; mirogabalin, 76.1%; tramadol, 85.2%). The proportion of patients in the total population who reported a high understanding (score 4, 5) of their oral pain relievers was 68.0% (lasmiditan, 77.7%; mirogabalin, 63.3%; tramadol, 55.6%). In the total population and the lasmiditan and mirogabalin subgroups, the patient satisfaction level was significantly associated with scores on medication understanding (Cochran-Armitage test, p < 0.0001 for all). Discontinuation rates were higher in patients who were unsatisfied with their treatment than those who were satisfied (38.7% and 9.8%, respectively).</p><p><strong>Conclusion: </strong>This study showed that a higher level of understanding of oral pain relievers is associated with higher satisfaction, which may be associated with lower discontinuation rates.</p><p><strong>Clinical trial registration: </strong>UMIN000052629.</p>","PeriodicalId":19908,"journal":{"name":"Pain and Therapy","volume":" ","pages":"931-945"},"PeriodicalIF":4.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}