Pharmacopsychiatria最新文献_第6页

Response to maprotiline treatment in depressive patients relationship to urinary MHPG excretion and plasma drug level. 抑郁症患者对马普替林治疗的反应与尿MHPG排泄和血浆药物水平的关系。

Pharmacopsychiatria Pub Date : 1982-09-01 DOI: 10.1055/s-2007-1019532

H J Gaertner, G Golfinopoulos, U Breyer-Pfaff

引用次数: 16

The development and validity of familial subtypes in primary unipolar depression. 原发性单极抑郁症家族亚型的发展和有效性。

Pharmacopsychiatria Pub Date : 1982-07-01 DOI: 10.1055/s-2007-1019527

G Winokur

{"title":"The development and validity of familial subtypes in primary unipolar depression.","authors":"G Winokur","doi":"10.1055/s-2007-1019527","DOIUrl":"https://doi.org/10.1055/s-2007-1019527","url":null,"abstract":"Primary unipolar depression may be divided into three familial subtypes. The first of these is depression spectrum disease (DSD). It is defined as an ordinary depression in an individual who has a family history of alcoholism and/or antisocial personality. Such a person mayaiso have a family history of primary depression but none of mania. The second subtype is familial pure depressive disease (FPDD). This is adepression in an individual who has a family history of primary depression but no family history of alcoholism, antisocial personality, or mania. The third type is sporadic depressive disease (SDD). This is an ordinary depression in an individual who has no family history of alcoholism, antisocial personality, primary unipolar depression or mania. Sporadic depressive disease has a late age of onset, usually in the late 305 or early 40s, whereas familial pure depressive disease and depression spectrum disease have an onset in the early 305. Depression spectrum disease manifests itself by a stormy personaliife, particularly with mari tal difficulties. Multiple episodes are seen most frequently in familial pure depressive disease. The dexamethasone suppression test differentiates between the three groups with familial pure depressive disease usually showing abnormal suppression, depression spectrum disease rarely showing abnormal suppression and sporadic depressive disease showing abnormal suppression in around 40% of the cases. It is noteworthy that both depression spectrum disease and secondary depression rarely show abnormal suppression with the dexamethasone suppression test. Thus, they are similar in this way. Likewise, familial pure depressive disease and bipolar depression in the large majority of cases show abnormal suppression. Thus, they are similar.","PeriodicalId":19840,"journal":{"name":"Pharmacopsychiatria","volume":"15 4","pages":"142-6"},"PeriodicalIF":0.0,"publicationDate":"1982-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2007-1019527","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18007798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 46

Trends in lithium treatment and research during the last decade. 近十年来锂处理和研究的趋势。

Pharmacopsychiatria Pub Date : 1982-07-01 DOI: 10.1055/s-2007-1019524

M Schou

引用次数: 11

A second generation catecholamine hypothesis. 第二代儿茶酚胺假说。

Pharmacopsychiatria Pub Date : 1982-07-01 DOI: 10.1055/s-2007-1019521

W E Bunney, B L Garland

引用次数: 5

Recent observations on new potential and established antidepressant drugs. 最近对新的潜在和已建立的抗抑郁药物的观察。

Pharmacopsychiatria Pub Date : 1982-07-01 DOI: 10.1055/s-2007-1019522

A Carlsson

引用次数: 8

A possible role of serotonin receptors in antidepressant drug action. 血清素受体在抗抑郁药物作用中的可能作用。

Pharmacopsychiatria Pub Date : 1982-07-01 DOI: 10.1055/s-2007-1019525

S H Snyder, S J Peroutka

{"title":"A possible role of serotonin receptors in antidepressant drug action.","authors":"S H Snyder, S J Peroutka","doi":"10.1055/s-2007-1019525","DOIUrl":"https://doi.org/10.1055/s-2007-1019525","url":null,"abstract":"Summary Recently research into the mechanism of action of antidepres sant drugs has focused on mechanisms that could account for the delayed onset of therapeutic action. Chronic treatment with antidepressants elicits a delayed reduction in numbers of beta-adrenergic receptor binding sites as weil as norepinephrine sensitive adenylate cyclase. Besides catecholamines, serotonin mechanisms have been thought to playa major role in the ac tions of antidepressants. We have characterized two discrete serotonin receptors using ligand binding techniques. SI-recep tors are labelIed selectively by 3 H-serotonin and S2-receptors bind 3H-spiroperidol, while 3 H-LSD has equal affinities for SI and S2 receptors. Relative potencies of drugs in competing for SI-receptors show some correlations with effects on adenylate cyclase. Taken together with the regulation of SI-receptors by guanine nucleotides, a characteristic of adenylate cyclase linked receptors, we suggested, that S1-receptors may have some association with adenylate cyclase. S2\"receptors, on the other hand, are not regulated by guanine nucleotides. Relative potencies of drugs in competing for S2 receptors parallel closely their ability to block serotonin related behavioral syndromes elicited by a variety of drugs. Thus the behavioral effects of most serotonin related drugs appear to be by S2-receptors. Chronic but not acute administration of both tricyclic antide pressants and monoamineoxidase inhibitors lowers the num bers of S2 -receptors. For most drugs these effects are more pronounced than the reduction in numbers of beta-adrenergic receptors. This effect is selective, since neuroleptics such as chlorpromazine and haloperidol are ineffective. Only a few antidepressants reduce numbers of SI -receptors and these ef fects","PeriodicalId":19840,"journal":{"name":"Pharmacopsychiatria","volume":"15 4","pages":"131-4"},"PeriodicalIF":0.0,"publicationDate":"1982-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2007-1019525","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18159790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Further investigations into the relationship between depressive disorders and anxiety state. 抑郁障碍与焦虑状态关系的进一步研究。

Pharmacopsychiatria Pub Date : 1982-07-01 DOI: 10.1055/s-2007-1019526

M Roth, C Q Mountjoy, D Caetano

{"title":"Further investigations into the relationship between depressive disorders and anxiety state.","authors":"M Roth, C Q Mountjoy, D Caetano","doi":"10.1055/s-2007-1019526","DOIUrl":"https://doi.org/10.1055/s-2007-1019526","url":null,"abstract":"Results of two investigations into the relationship between anxiety states and depressive disorders are summarized. In the first study (117 patients), which was confined to neurotic forms of depressive and/or anxious affective disorder, analysis of the findings derived from systematic clinical examination and eight rating scales, seven of them supposedly unidimensional measures of the severity of emotional disturbance, made it possible to achieve clear separation of the patient population into two groups both in the full sample and in two randomly derived subsamples. A number of rating scales have been shown to be effective tools for diagnostic discrimination within the affective disorders. The second enquiry (152 patients) covered the entire range of disorders of affect. Multivariate analyses of data derived from Present State Examination (P.S.E.) differentiated the patient population into three main groups: 1) endogenous depression; 2) neurotic depression; and 3) anxiety neuroses. There was 84% agreement between the classification of patients into the groups \"anxiety state\" and \"depressive disorder\" and separation of the 152 patients also was achieved with the aid of ratings on the Maudsley Personality Inventory and the Cattell 16 PF Battery.","PeriodicalId":19840,"journal":{"name":"Pharmacopsychiatria","volume":"15 4","pages":"135-41"},"PeriodicalIF":0.0,"publicationDate":"1982-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2007-1019526","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18159791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

The biochemical discrimination of subtypes of depressive disorders: an outline of our studies on norepinephrine metabolism and psychoactive drugs in the endogenous depressions since 1967. 抑郁症亚型的生化鉴别:1967年以来内源性抑郁症中去甲肾上腺素代谢和精神活性药物的研究综述。

Pharmacopsychiatria Pub Date : 1982-07-01 DOI: 10.1055/s-2007-1019523

J J Schildkraut

引用次数: 5

Guidelines for pharmaco-EEG studies in man. Expert group, organized of the Federal Health Office, Institute for Drugs, Berlin (West), Germany. 人类药物-脑电图研究指南。专家组，由德国柏林(西)药物研究所联邦卫生局组织。

Pharmacopsychiatria Pub Date : 1982-05-01

引用次数: 0

Relationship between EEG dynamics and pharmacokinetics of the benzodiazepine lormetazepam. 苯二氮卓类药物氯美他泮脑电动力学与药代动力学的关系。

Pharmacopsychiatria Pub Date : 1982-05-01 DOI: 10.1055/s-2007-1019513

M Kurowski, H Ott, W M Herrmann

{"title":"Relationship between EEG dynamics and pharmacokinetics of the benzodiazepine lormetazepam.","authors":"M Kurowski, H Ott, W M Herrmann","doi":"10.1055/s-2007-1019513","DOIUrl":"https://doi.org/10.1055/s-2007-1019513","url":null,"abstract":"Clinical experience with benzodiazepines shows that observable effects like sedation do not persist as long as predicted by pharmacokinetic data. As a pharmacodynamic parameter closely related to effects of tranquillizers we used the quantitative pharmaco-EEG to compare time courses of these parameters with plasma level time courses. The subjects received single oral doses (1, 2 and 3 mg) of the benzodiazepine lormetazepam. Plasma levels were detected by radioimmunoassay. After fast absorption dose-dependent plasma level peaks could be determined 2 hours after administration. Applying an open two-compartment body model the drug was excreted with an elimination half-life of 10.3 hours. EEG power reached maximum changes after 1 hour in the delta, theta, alpha 2 and beta 1 frequency bands, as well as in the dominant alpha-frequency, and declined after that with different speeds to previous levels. Three to five hours after drug administration no significant changes could be detected. Vigilance sensitive EEG changes (delta, alpha 2) diminished earlier than indicated by plasma level half-lives. In contrast the decline of relative beta-power parallels plasma level time courses more closely under the 3 mg dose. In the present investigation, the computerized EEG appears to be a suitable indicator of monitoring time courses of sedative effects after single oral doses of benzodiazepines.","PeriodicalId":19840,"journal":{"name":"Pharmacopsychiatria","volume":"15 3","pages":"77-83"},"PeriodicalIF":0.0,"publicationDate":"1982-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2007-1019513","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17192106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21