Pharmacopsychiatria最新文献_第7页

[Comparison of the Hamilton Depression Rating Scale and the Self Rating Scale BS (v. Zerssen) within a double blind study on the antidepressant effects of trazodone verus amitriptyline (author's transl)]. [汉密尔顿抑郁评定量表和自评定量表BS (v. Zerssen)在曲唑酮与阿米替林抗抑郁作用双盲研究中的比较[作者译]。

Pharmacopsychiatria Pub Date : 1982-05-01 DOI: 10.1055/s-2007-1019517

D Kieback

{"title":"[Comparison of the Hamilton Depression Rating Scale and the Self Rating Scale BS (v. Zerssen) within a double blind study on the antidepressant effects of trazodone verus amitriptyline (author's transl)].","authors":"D Kieback","doi":"10.1055/s-2007-1019517","DOIUrl":"https://doi.org/10.1055/s-2007-1019517","url":null,"abstract":"From October 1977 until March 1978 a prospective study was performed on 30 depressive patients of both sexes, age 20 to 60 years. In a double-blind design patients received either amitriptyline or trazodone for 28 days. The course of therapy was controlled six times by means of the Hamilton Rating Scale for Depression (HRS) and the Zerssen-Contentment Scale (BS). The following results were obtained: By the statistical analysis of the HRs scores no difference in the antidepressant properties of trazodone and amitriptyline can be demonstrated. The same result is obtained by use of the BS scores. Therefore the antidepressant efficacy of the two medications can be called equal. When comparing day 10 to day 0, a correlation between the two data pools of RSp = 0.719 (p less than 0.01) according to Spearmen was found. Upon comparing the 28th day with the pre-treatment day, RSp comes out to be 0.809. When applying Anova no significant correlation for the pre-treatment day can be demonstrated (RL = 0.260); yet at the end of the study the correlation comes out to be extremely high (RL = 0.940, p less than 0.1). When considering each day of the study, RL results to be 0.808 (p less than 0.001). Thus, a high correlation can be demonstrated for the HRS and BS.","PeriodicalId":19840,"journal":{"name":"Pharmacopsychiatria","volume":" ","pages":"97-102"},"PeriodicalIF":0.0,"publicationDate":"1982-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2007-1019517","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40713137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

[Reliability and validity of the Visual Analogue Scale (VAS) (author's transl)]. [视觉模拟量表(Visual Analogue Scale, VAS)的信度和效度(作者译)]。

Pharmacopsychiatria Pub Date : 1982-05-01 DOI: 10.1055/s-2007-1019515

E Fähndrich, M Linden

引用次数: 66

A double-blind clinical trial of nomifensine vs. amitriptyline in depressed patients. 诺非芬与阿米替林在抑郁症患者中的双盲临床试验。

Pharmacopsychiatria Pub Date : 1982-05-01 DOI: 10.1055/s-2007-1019514

G B Cassano, L Conti, G Massimetti, P Fornaro, J Levine

引用次数: 2

[Bromocriptin in organic depression (author's transl)]. [溴隐亭在器质性抑郁症中的作用[作者简介]。

Pharmacopsychiatria Pub Date : 1982-05-01 DOI: 10.1055/s-2007-1019518

H Schubert, W W Fleischhacker, I Demel

引用次数: 4

Bromperidol maintenance in schizophrenia. 溴哌啶醇维持治疗精神分裂症。

Pharmacopsychiatria Pub Date : 1982-05-01 DOI: 10.1055/s-2007-1019516

J P McEvoy, W H Wilson, T A Ban, J O Brannen, S Berney

引用次数: 2

[Psychological and physiological effects of cloxazolam and diazepam under anxiety-evoking and control conditions on healthy subjects (author's transl)]. [氯沙唑仑和地西泮在焦虑诱发和控制条件下对健康受试者的心理和生理影响[作者译]。

Pharmacopsychiatria Pub Date : 1982-03-01 DOI: 10.1055/s-2007-1019508

W Boucsein, G Wendt-Suhl

{"title":"[Psychological and physiological effects of cloxazolam and diazepam under anxiety-evoking and control conditions on healthy subjects (author's transl)].","authors":"W Boucsein, G Wendt-Suhl","doi":"10.1055/s-2007-1019508","DOIUrl":"https://doi.org/10.1055/s-2007-1019508","url":null,"abstract":"The physical and psychophysiological effects of an orally administered single dose of 3 mg cloxazolam as compared to 5 mg diazepam and a placebo were investigated for 144 healthy male subjects using a double blind technique. In a pre-experimental test, the Ss were classified as either emotional stabiles or labiles, and in the experimental program of one four and half hour period were tested under either stress or control conditions. In order to create appropriate conditions for testing the tranquilizers, three stress situations that would induce anxiety were used: anticipation of an electric shock, preparation of a public speech and one due to failure in an achievement test. By combining these methods it was possible to sustain for 30 minutes in healthy Ss a state of anxiety or emotional activation which seemed suitable as a model for clinical anxiety. Under 5 mg diazepam rather week, but tranquilizer-typical effects were registered in both subjective and objective measures: an increase in self-confidence in emotional labiles, mood improvement, lower electrodermal responses and tranquilizer-typical EEG-pattern, but also subjective deactivating effects. The HR-increase elicited by anxiety induction was not influenced by Diazepam. Under 3 mg cloxazolam very similar effects to those under diazepam were apparent in the subjective measures; there was however, no mood improvement. Cloxazolam was judged as more strongly deactivating and fatigue inducing than diazepam. Cloxazolam was clearly different from diazepam with respect to its physiological effects, especially showing an obvious heart rate increase in the control group, which requires further investigation.","PeriodicalId":19840,"journal":{"name":"Pharmacopsychiatria","volume":"15 2","pages":"48-56"},"PeriodicalIF":0.0,"publicationDate":"1982-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2007-1019508","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17188909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Evaluating mepindolol in a test model of examination anxiety in students. 美品多洛尔在学生考试焦虑测试模型中的评价。

Pharmacopsychiatria Pub Date : 1982-03-01 DOI: 10.1055/s-2007-1019507

P Krope, A Kohrs, H Ott, W Wagner, K Fichte

{"title":"Evaluating mepindolol in a test model of examination anxiety in students.","authors":"P Krope, A Kohrs, H Ott, W Wagner, K Fichte","doi":"10.1055/s-2007-1019507","DOIUrl":"https://doi.org/10.1055/s-2007-1019507","url":null,"abstract":"The effect of a single dose of beta-blocker (5 or 10 mg mepindolol) during a written examination was investigated in two double-blind studies (N : 49 and 55 students, respectively). The question was whether the beta-blocker would in comparison to placebo diminish examination anxiety and improve the performance of highly complex tasks, while leaving the performance of less complex tasks unchanged. A reduction in examination anxiety after beta-blocker intake could not be demonstrated with a multi-level test model (which included the parameters self-rated anxiety, motor behaviour, task performance and physiology), although pulse rates were lowered significantly. An improvement in performance could not be observed, while - by the same token - the performance was not impaired by the beta-blocker. A hypothesis according to which a beta-blocker has an anxiolytic effect and improves performance, dependent on the level of habitual examination anxiety, was tested post hoc, but could not be confirmed. Ten of the subjects treated with 10 mg mepindolol, complained of different side effects, including dizziness, fatigue and headache.","PeriodicalId":19840,"journal":{"name":"Pharmacopsychiatria","volume":"15 2","pages":"41-7"},"PeriodicalIF":0.0,"publicationDate":"1982-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2007-1019507","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17188908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Neurotransmitter parameters in plasma and urine of affective patients in depression and in normothymia after drug treatment. 抑郁症和正常心境障碍患者药物治疗后血浆和尿液中的神经递质参数。

Pharmacopsychiatria Pub Date : 1982-03-01 DOI: 10.1055/s-2007-1019510

M Markianos, E Varsou, E Evangelou, E Bistolaki

引用次数: 1

Interaction of changes in hospital environment and neurotropic co-medication in chronic psychiatric inpatient. A placebo controlled double-blind study. 慢性精神病住院患者医院环境变化与嗜神经药物联合用药的相互作用一项安慰剂对照双盲研究。

Pharmacopsychiatria Pub Date : 1982-03-01 DOI: 10.1055/s-2007-1019509

E Lehmann, J H Kretschmar, H Brauer, B Reinhardt

{"title":"Interaction of changes in hospital environment and neurotropic co-medication in chronic psychiatric inpatient. A placebo controlled double-blind study.","authors":"E Lehmann, J H Kretschmar, H Brauer, B Reinhardt","doi":"10.1055/s-2007-1019509","DOIUrl":"https://doi.org/10.1055/s-2007-1019509","url":null,"abstract":"Chronic psychiatric patients (N = 42) predominantly diagnosed as schizophrenics, who had been hospitalized for the mean of 9 years were treated in a double-blind study with a neurotropic drug (tamitinol dihydrochloride coated tablets of 300 mg t.i.d.) and placebo. Test drugs were administered concomitantly to the existing drug therapy during two treatment periods of 6 weeks each with an interval of two months free of test medication. In the second treatment period patients moved to a new building. It was expected that neurotropic drug effects can be made clearer after the transfer requiring patient's reorientation in a new environment than before the transfer. Assessment of efficacy was made using observer ratings (Psychic and Somatic Findings of the A.M.P. System, WING Behaviour Rating Scale) and patient's self ratings (Adjective Check List. List of Somatic Symptoms) and clinical laboratory parameters. Results show that neurotropic co-medication reduced the \"neurological syndrome\" and the \"psychoorganic syndrome\" (A.M.P. System). An amelioration of the \"neurological syndrome\" was observed at the end of the first and at the end of the second medication phase (p less than or equal to 0.10) whilst the improvement of the \"psychoorganic syndrome\" was particularly evident as expected after the transfer to the new building (p less than or equal to 0.001) Patients receiving placebo described themselves as more active than patients receiving the test drug. (Adjective Check List: p less than or equal to 0.10). No subjective or objective side effects (List of somatic symptoms and laboratory parameters) were evident due to the test medication which was tolerated by all patients.","PeriodicalId":19840,"journal":{"name":"Pharmacopsychiatria","volume":"15 2","pages":"57-60"},"PeriodicalIF":0.0,"publicationDate":"1982-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2007-1019509","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18091234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pimozide versus Haloperidol in acute schizophrenia. A double blind controlled study. 匹莫齐特与氟哌啶醇治疗急性精神分裂症。一项双盲对照研究。

Pharmacopsychiatria Pub Date : 1982-03-01 DOI: 10.1055/s-2007-1019512

S Haas, H Beckmann

引用次数: 46