Pharmacopsychiatria最新文献_第5页

[Stimulant therapy in children]. [儿童兴奋剂治疗]。

Pharmacopsychiatria Pub Date : 1982-11-01 DOI: 10.1055/s-2007-1019534

H C Steinhausen

引用次数: 0

Symptoms of depression in Parkinson's disease. 帕金森病的抑郁症状。

Pharmacopsychiatria Pub Date : 1982-11-01 DOI: 10.1055/s-2007-1019537

H P Vogel

引用次数: 34

[Clinical double blind comparison of diclofensine and placebo in geriatric patients with depressive syndromes]. [双氯芬辛与安慰剂治疗老年抑郁症的临床双盲比较]。

Pharmacopsychiatria Pub Date : 1982-11-01 DOI: 10.1055/s-2007-1019539

W Jansen, G W Brückner, S Henauer, L M Omer

{"title":"[Clinical double blind comparison of diclofensine and placebo in geriatric patients with depressive syndromes].","authors":"W Jansen, G W Brückner, S Henauer, L M Omer","doi":"10.1055/s-2007-1019539","DOIUrl":"https://doi.org/10.1055/s-2007-1019539","url":null,"abstract":"The objective of this double-blind trial was to assess the effect of diclofensine on geriatric patients with depressive syndromes in comparison to placebo. 40 patients (age 60-75 years) were treated for 3 weeks with a mean daily dose of 57.5 mg diclofensine or placebo. Diclofensine was found effective in 18 (= 90%) cases (placebo 60%) after 2.9 days on an average (placebo, 4.2 days), mostly having a mood elevating effect and in only 2 cases (placebo 1) having a stimulatory effect. The results of the global assessments, the Hamilton depression scale, the d2-test, the block design test and the mood scale (Befindlichkeitsskala) demonstrated a statistically significant superiority of diclofensine over placebo. The critical flicker frequency, on the other hand, was not able to differentiate significantly between the two drugs. The tolerance was considered as very good in all cases. Unwanted effects were observed in 13 patients (= 65%) of the diclofensine group and in 9 patients (= 45%) of the placebo group. They disappeared in most cases within one week after their appearance. According to this trial diclofensine can be described as a well tolerated drug without pronounced anticholinergic side effects, capable of improving depressive states faster and more effectively than placebo.","PeriodicalId":19840,"journal":{"name":"Pharmacopsychiatria","volume":"15 6","pages":"205-9"},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2007-1019539","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17813168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Central action of amitriptyline N-oxide. 氨替林n -氧化物的中枢作用。

Pharmacopsychiatria Pub Date : 1982-11-01 DOI: 10.1055/s-2007-1019536

J Maj, J Vetulani, J Michaluk, Z Rogóz, G Skuza

{"title":"Central action of amitriptyline N-oxide.","authors":"J Maj, J Vetulani, J Michaluk, Z Rogóz, G Skuza","doi":"10.1055/s-2007-1019536","DOIUrl":"https://doi.org/10.1055/s-2007-1019536","url":null,"abstract":"The central action of amitriptyline N-oxide (AMINO) has been compared with amitriptyline (AMI) in biochemical and pharmacological studies in rats and mice. It has been found in rats that both drugs prevent 6-OH-dopamine-induced depletion of brain noradrenaline (NA). At the same time AMINO increases and AMI lowers the NA level, both being without effect on 3-methoxy-4-hydroxyphenylglycol concentrations in the brain. AMINO and AMI potentiate the depletion of 5-hydroxytryptamine (5-HT) induced by p-chloroamphetamine in the rat brain and it may be considered as evidence that both drugs do not inhibit 5-HT uptake in vivo. Neither AMINO nor AMI affects the rat brain level of 5-HT but at higher doses they elevate the 5-hydroxy-indoleacetic acid concentrations. AMINO antagonizes the head twitch reaction induced by 5-hydroxytryptophan in mice and tryptamine convulsions in rats. The hyperthermia induced by fenfluramine (in rats at a high ambient temperature) as well as the stimulation of the hind limb flexor reflex in spinal rats, induced by fenfluramine or LSD, are also inhibited. AMINO antagonizes the 5-HT-induced increase in blood pressure in pithed rats. All the above effects are similar to those induced by AMI, only the active doses of AMINO are higher. The results presented indicate that AMINO, like AMI, inhibits NA uptake and is a 5-HT antagonist.","PeriodicalId":19840,"journal":{"name":"Pharmacopsychiatria","volume":"15 6","pages":"187-91"},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2007-1019536","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17250204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

An early clinical phase II evaluation of paroxetine, a new potent and selective 5HT-uptake inhibitor in patients with depressive illness. 帕罗西汀是一种新的有效的选择性5ht摄取抑制剂，用于抑郁症患者的早期临床II期评估。

Pharmacopsychiatria Pub Date : 1982-11-01 DOI: 10.1055/s-2007-1019535

C Børup, B Meidahl, I M Petersen, A Vangtorp, P le Fèvre Honoré

{"title":"An early clinical phase II evaluation of paroxetine, a new potent and selective 5HT-uptake inhibitor in patients with depressive illness.","authors":"C Børup, B Meidahl, I M Petersen, A Vangtorp, P le Fèvre Honoré","doi":"10.1055/s-2007-1019535","DOIUrl":"https://doi.org/10.1055/s-2007-1019535","url":null,"abstract":"Paroxetine, a new, potent and selective serotonin (5-HT) uptake inhibitor has been evaluated in an open study for its clinical effect as well as its effect on the 5-HT concentration in whole blood in 19 patients with depressive illness. Paroxetine was administered in daily doses of 20 to 60 mg. The global evaluation after six to eight weeks showed a marked improvement in 11 patients, a moderate improvement in four and no change in four patients. Assessment with the Hamilton Rating Scale for Depression in ten patients showed a reduction from a mean score of 22.7 to 6.6 in six weeks. Maximal reduction was, however, first seen in three of the patients after 8 to 12 weeks. No correlation between the antidepressant effect and plasma concentrations of paroxetine was found. The only side effects noted with paroxetine were that two patients complained of dry mouth in the beginning of the treatment and a further patient experienced a burning sensation together with periodical light headache. Generally laboratory examinations did not show any trend towards pathological values except in one patient, where a moderate leucopenia was observed. Crista puncture/biopsy showed, however, no specific bone marrow reaction. The 5-HT concentration in whole blood was reduced to about 0.02 micrograms/ml indicating a total depletion of 5-HT from the thrombocytes. The present study indicates that paroxetine possesses a good antidepressive effect in combination with a very low frequency of side effects.","PeriodicalId":19840,"journal":{"name":"Pharmacopsychiatria","volume":"15 6","pages":"183-6"},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2007-1019535","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17282212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Lithium treatment and thyroid function. A survey of 237 patients in long-term lithium treatment. 锂治疗和甲状腺功能。对237例长期锂治疗患者的调查。

Pharmacopsychiatria Pub Date : 1982-09-01 DOI: 10.1055/s-2007-1019528

A Amdisen, C J Andersen

{"title":"Lithium treatment and thyroid function. A survey of 237 patients in long-term lithium treatment.","authors":"A Amdisen, C J Andersen","doi":"10.1055/s-2007-1019528","DOIUrl":"https://doi.org/10.1055/s-2007-1019528","url":null,"abstract":"In a cross-sectional study of 237 patients treated with lithium for more than six months, 10 patients had serum thyroid stimulating hormone (TSH) values above 35 mU/l and concomitantly low triiodothyronine (T3) and abnormally low serum thyroxine (T4). Eight patients had TSH values of 10.0-34.9 mU/l, while T3 and T4 were within or close to the normal ranges. Most of the patients had TSH values of 0.9-9.9 mU/l and normal or close to normal T3 and T4 values. Three male patients had TSH below 0.9 mU/l, but normal T3 and T4 values. A retrospective investigation three years later showed that all patients with TSH above 35 mU/l had clinically diagnosed overt hypothyroidism and treated accordingly with either replacement therapy with thyroxine or discontinuation of the lithium treatment. The thyroid parameters normalized spontaneously in 2 out of 3 patients who had their lithium treatment discontinued, while one still needed replacement therapy 1 1/2 years after withdrawal of lithium. Five patients had been put on replacement therapy before the cross-sectional study. The frequency of overt hypothyroidism thus indicated a prevalence about ten times as high as should be expected. An overrepresentation of women was found in the group with TSH values above 10 mU/l, whereas the group with TSH values of 0.9-10.0 mU/l showed no such sex predomination. The age distribution was equal in all groups. TSH appeared to be the most efficient parameter in revealing undetected hypothyroidism in the present investigation of patients in long-term lithium treatment.","PeriodicalId":19840,"journal":{"name":"Pharmacopsychiatria","volume":"15 5","pages":"149-55"},"PeriodicalIF":0.0,"publicationDate":"1982-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2007-1019528","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18191496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

[Psychological test methods in pharmacopsychiatry]. [药物精神病学中的心理测试方法]。

Pharmacopsychiatria Pub Date : 1982-09-01 DOI: 10.1055/s-2007-1019533

D G Kieback

{"title":"[Psychological test methods in pharmacopsychiatry].","authors":"D G Kieback","doi":"10.1055/s-2007-1019533","DOIUrl":"https://doi.org/10.1055/s-2007-1019533","url":null,"abstract":"From October 1977 until March 1978 a prospective study was performed on 30 depressive patients of both sexes, age 20 to 60 years. In a double-blind design patients received either amitriptyline or trazodone for 28 days. The course of therapy was controlled six times by means of the Hamilton Rating Scale for Depression (HRS) and the Zerssen-Contentment Scale (BS). The following results were obtained: By the statistical analysis of the HRS scores no difference in the antidepressant properties of trazodone and amitriptyline can be demonstrated. The same result is obtained by use of the BS scores. Therefore the antidepressant efficacy of the two medications can be called equal. When comparing day 10 to day 0, a correlation between the two data pools of Rsp = 0.719 (p less than 0.01) according to Spearman was found. Upon comparing the 28th day with the pre-treatment day, Rsp is 0.809. When applying ANOVA no significant correlation for the pre-treatment day can be demonstrated (RL = 0.260); yet at the end of the study the correlation becomes extremely high (RL = 0.940, p less than 0.1). When considering each day of the study, RL results to be 0.808 (p less than 0.001). Thus, a high correlation can be demonstrated for the HRS and BS. The conclusion may be drawn that this design is of special value in comparing the antidepressant properties of new pharmacologic substances.","PeriodicalId":19840,"journal":{"name":"Pharmacopsychiatria","volume":"15 5","pages":"175-80"},"PeriodicalIF":0.0,"publicationDate":"1982-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2007-1019533","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17810788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Quality control of amitriptyline and nortriptyline plasma level assessments: a multicenter study. 阿米替林和去甲替林血浆水平评估的质量控制:一项多中心研究。

Pharmacopsychiatria Pub Date : 1982-09-01 DOI: 10.1055/s-2007-1019529

P Baumann, U Breyer-Pfaff, H J Kuss, B Müller-Oerlinghausen, M Sandoz

{"title":"Quality control of amitriptyline and nortriptyline plasma level assessments: a multicenter study.","authors":"P Baumann, U Breyer-Pfaff, H J Kuss, B Müller-Oerlinghausen, M Sandoz","doi":"10.1055/s-2007-1019529","DOIUrl":"https://doi.org/10.1055/s-2007-1019529","url":null,"abstract":"Numerous studies report about the relationship between the clinical effectiveness of amitriptyline (At) and the plasma level of this drug and of its most important metabolite, nortriptyline (Nt). These agents are therefore very frequently examined for clinical applications and for research programmes in specialized laboratories. The experience with antiepileptic drugs suggests the necessity of quality controls for antidepressants also. Therefore, five institutions in Western Europe performed two such experiments within a year. Two kinds of blood samples were sent for analysis: 1. plasma samples spiked with different quantities of At and Nt from an untreated subject; 2. plasma samples from patients treated with clinical doses of At. Each laboratory happened to use a different analytical method: TLC, HPLC, GC-NPD, GC-FID and GC-MS. The results clearly show the usefulness and the necessity of quality controls for this category of drugs as well. They form the basis for the improvement of the methods of each laboratory in particular. In this context, intralaboratory quality controls are also possible, if one disposes of two different methods. The findings of this study suggest that published reports on relationships between clinical and pharmacological parameters should be considered critically as to possible methodological bias.","PeriodicalId":19840,"journal":{"name":"Pharmacopsychiatria","volume":"15 5","pages":"156-60"},"PeriodicalIF":0.0,"publicationDate":"1982-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2007-1019529","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18191497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A controlled double-blind study of femoxetine and amitriptyline in patients with endogenous depression. 非莫西汀和阿米替林治疗内源性抑郁症的对照双盲研究。

Pharmacopsychiatria Pub Date : 1982-09-01 DOI: 10.1055/s-2007-1019531

P N Reebye, C Yiptong, J Samsoon, F Schulsinger, J Fabricius

引用次数: 21

Bromocriptine in tardive dyskinesia. 溴隐亭在迟发性运动障碍中的作用。

Pharmacopsychiatria Pub Date : 1982-09-01 DOI: 10.1055/s-2007-1019530

J E Häggström, U Andersson, L M Gunne

引用次数: 4