Pharmacopsychiatria最新文献_第4页

[Transitory cerebellar ataxia from high dosage combination thymoleptic therapy]. [大剂量联合消毒药治疗引起的短暂性小脑性共济失调]。

Pharmacopsychiatria Pub Date : 1983-03-01 DOI: 10.1055/s-2007-1017451

H W Schied, M Bartels

{"title":"[Transitory cerebellar ataxia from high dosage combination thymoleptic therapy].","authors":"H W Schied, M Bartels","doi":"10.1055/s-2007-1017451","DOIUrl":"https://doi.org/10.1055/s-2007-1017451","url":null,"abstract":"Transitory ataxias have repeatedly been observed and reported in connection with antidepressant medication. However, it is remarkable that exact descriptions of this particular form of ataxia are rarely included. Also, hypotheses concerning the etiology and pathophysiology of these disorders are generally lacking. They are usually given the imprecise designation of \"extrapyramidal\" ataxias. Two cases are presented here in which therapy-resistant endogenous depressions were treated with maprotiline/dibenzepine and maprotiline/clomipramine, respectively. In both cases, marked neurological side effects in the form of cerebellar ataxia developed. The symptoms, which occurred despite usual dosage, remitted after maprotiline treatment was discontinued for one patient and after dose reduction of both drugs for the other. The atactical and dysmetric symptoms described here are thought to result from a reversible intoxication of mainly cerebellar structures. In an attempt to explain the genesis of these ataxias, a neurophysiological and a neuropharmacological hypothesis are considered and predisposing factors as well as therapeutic consequences are discussed.","PeriodicalId":19840,"journal":{"name":"Pharmacopsychiatria","volume":"16 2","pages":"64-7"},"PeriodicalIF":0.0,"publicationDate":"1983-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2007-1017451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17916212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effect and efficacy - on the function of models for the assessment of therapeutic efficacy. 效果与疗效——对疗效评估模型功能的探讨。

Pharmacopsychiatria Pub Date : 1983-03-01 DOI: 10.1055/s-2007-1017448

W M Herrmann, U Kern

引用次数: 1

[Prognostic value of the early response of psychiatric patients to neuroleptics for the subsequent course of treatment]. [精神病患者对抗精神病药的早期反应对后续治疗的预后价值]。

Pharmacopsychiatria Pub Date : 1983-03-01 DOI: 10.1055/s-2007-1017447

H J Möller, W Kissling, D von Zerssen

引用次数: 20

Reduced serum dopamine-beta-hydroxylase activity in paranoid schizophrenics. 偏执型精神分裂症患者血清多巴胺- β -羟化酶活性降低。

Pharmacopsychiatria Pub Date : 1983-01-01 DOI: 10.1055/s-2007-1017442

M Arató, G Bagdy, F Blümel, A Perényi, Z Rihmer

引用次数: 18

High-dose haloperidol increases CSF opioid activity in patients with chronic schizophrenia. 大剂量氟哌啶醇增加慢性精神分裂症患者脑脊液阿片活性。

Pharmacopsychiatria Pub Date : 1983-01-01 DOI: 10.1055/s-2007-1017440

R Rimón, L Terenius, I Averbuch, R H Belmaker

引用次数: 9

[Effects of neuroleptics on liver function, the hematopoietic system, blood pressure and temperature regulation. Comparison of clozapine, perazine and haloperidol by evaluating medical records]. 抗精神病药对肝功能、造血系统、血压和体温调节的影响。氯氮平、佩拉嗪和氟哌啶醇的比较[j]。

Pharmacopsychiatria Pub Date : 1983-01-01 DOI: 10.1055/s-2007-1017443

D Bauer, H J Gaertner

{"title":"[Effects of neuroleptics on liver function, the hematopoietic system, blood pressure and temperature regulation. Comparison of clozapine, perazine and haloperidol by evaluating medical records].","authors":"D Bauer, H J Gaertner","doi":"10.1055/s-2007-1017443","DOIUrl":"https://doi.org/10.1055/s-2007-1017443","url":null,"abstract":"The frequency of disturbances of the liver function, of leucopoiesis, blood pressure and temperature regulation under clozapine in comparison with perazine and haloperidol in 478 patients (partly being treated repeatedly) was investigated by means of case histories of the Psychiatric Clinic of Tübingen from October 1974 up to June 1978. Within the time of the investigation no case of jaundice arose, however non-symptomatic increases of the liver values could be observed. The three drugs did not differ in this respect. Within the time of the investigation no case of agranulocytosis was observed. Only one leucopenia under clozapine, one under perazine, and six under haloperidol occurred. Concerning cardio-vascular effects of the neuroleptic medication, in 4.1% of the patients under clozapine therapy, 4.3% under haloperidol therapy and 10.3% under perazine therapy hypotension could be observed. Under clozapine 15.2% of the patients showed a rise of temperature, under perazine 3.2% and under haloperidol 2.8% of the patients. 83.3% of cases with elevated temperature under clozapine occurred during the first two weeks of treatment.","PeriodicalId":19840,"journal":{"name":"Pharmacopsychiatria","volume":"16 1","pages":"23-9"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2007-1017443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17198087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Pharmacokinetics of amitriptyline N-oxide in rats after single and prolonged oral administration. 单次和长期口服氨替林n -氧化物在大鼠体内的药代动力学。

Pharmacopsychiatria Pub Date : 1983-01-01 DOI: 10.1055/s-2007-1017444

M Melzacka, L Danek

{"title":"Pharmacokinetics of amitriptyline N-oxide in rats after single and prolonged oral administration.","authors":"M Melzacka, L Danek","doi":"10.1055/s-2007-1017444","DOIUrl":"https://doi.org/10.1055/s-2007-1017444","url":null,"abstract":"Amitriptyline N-oxide (AMINO) was given to male Wistar rats orally in single and multiple doses, and the levels of the drug and its main metabolite amitriptyline (AMI) were assayed in blood and brain by HPLC. After the single dose of AMINO (20 mg/kg), the levels of the parent compound and of AMI in the brain were higher than in blood. In the brain Cmax of AMINO and AMI were similar, whereas in the blood Cmax of AMI was considerably lower than that of the parent compound. After chronic treatment with AMINO (10 mg/kg twice daily, at 12 h intervals, for 14 days) the brain level of AMI reached the value of approx. 4 micrograms/g of tissue and remained nearly stable for 12 h after the last dose. Brain Cmax of AMINO was approx. 2 micrograms/g; the drug was eliminated more rapidly than AMI and 24 h after the last dose it was not detectable. The blood level of AMINO exceeded the level of AMI, but the difference was less marked than that observed after a single dose. The brain and blood levels of both drugs were considerably higher than those observed in the acute experiment. When AMI was given to rats chronically (dosage and schedule as above) its blood and brain levels were 2-5 times higher than the corresponding levels of AMI after treatment with AMINO, and its elimination was more rapid. Our results indicate that after oral administration of AMINO to rats AMI is formed in significant amounts, its brain level is high and becomes more stable after chronic treatment.","PeriodicalId":19840,"journal":{"name":"Pharmacopsychiatria","volume":"16 1","pages":"30-4"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2007-1017444","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17880086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

[Influence of personality traits on reaction performance in volunteers after a single administration of placebo, crotylbarbital and caffeine]. [人格特质对志愿者单次服用安慰剂、巴比妥和咖啡因后反应表现的影响]。

Pharmacopsychiatria Pub Date : 1983-01-01 DOI: 10.1055/s-2007-1017441

F P Meyer, T Walther, H Walther

引用次数: 5

Withdrawal phenomena after long-term administration of benzodiazepines. A review of recent investigations. 长期服用苯二氮卓类药物后的戒断现象。最近调查的回顾。

Pharmacopsychiatria Pub Date : 1983-01-01 DOI: 10.1055/s-2007-1017439

J Schöpf

引用次数: 26

Mianserin and maprotiline as compared to amitriptyline in severe endogenous depression. A new methodological approach to the clinical evaluation of the efficacy of antidepressants. 米安色林和马普替林与阿米替林在重度内源性抑郁症中的比较。一种新的抗抑郁药物临床疗效评价方法。

Pharmacopsychiatria Pub Date : 1982-11-01 DOI: 10.1055/s-2007-1019538

C Cording-Tömmel, D von Zerssen

{"title":"Mianserin and maprotiline as compared to amitriptyline in severe endogenous depression. A new methodological approach to the clinical evaluation of the efficacy of antidepressants.","authors":"C Cording-Tömmel, D von Zerssen","doi":"10.1055/s-2007-1019538","DOIUrl":"https://doi.org/10.1055/s-2007-1019538","url":null,"abstract":"Present methodological problems in assessing the clinical efficacy of putative antidepressants require testing of various new strategies. The approach presented by the authors allows \"natural\" clinical treatments to be evaluated scientifically; double-blind conditions are replaced by other measures of bias control. In this paper, the clinical effectiveness of mianserin in homogenous groups of inpatients with severe endogenous depression is compared with that of maprotiline and amitriptyline. The frequency of change of the respective antidepressant by the physicians in charge as well as patients' self-evaluations based on v. Zerssen's Mood Scale served as outcome criteria. No difference in efficacy was found between maprotiline and amitriptyline, whereas mianserin was significantly less effective. The number of patients complaining of side effects from the two tetracyclic compounds was no less than in the case of amitriptyline. There were, however, qualitative differences; with maprotiline, myoclonic jerks were observed in some cases. The hypothesis that mianserin may possess sedative-anxiolytic rather than antidepressive properties is discussed in conjunction with methodological and theoretical implications.","PeriodicalId":19840,"journal":{"name":"Pharmacopsychiatria","volume":"15 6","pages":"197-204"},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-2007-1019538","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18171923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14