Personalized Medicine in Psychiatry最新文献

{"title":"Neurobiology and behavior associated with early neglect: An exploratory comparison of neglected US children and international adoptees","authors":"Eve G. Spratt ,&nbsp;Kathleen T. Brady ,&nbsp;O. Yaw Addo ,&nbsp;Carrie E. Papa ,&nbsp;Cynthia Cupit Swenson ,&nbsp;Bradley S. Miller ,&nbsp;James S. Contompasis ,&nbsp;Michael D. De Bellis","doi":"10.1016/j.pmip.2025.100155","DOIUrl":"10.1016/j.pmip.2025.100155","url":null,"abstract":"<div><h3>Objective</h3><div>This exploratory study investigates the effects of childhood neglect exposure within a family setting and in children adopted from Russian orphanages on markers of stress physiology as well as behavioral and emotional problems in pre-pubertal children.</div><div>Participants: Families of 17 U.S. children with a history of familial neglect (USN), 15 international adoptees from orphanages (IA), and 28 children living with biologic parents with no known history of maltreatment (controls).</div></div><div><h3>Methods</h3><div>Parents completed Child Behavior Checklists (CBCL) and demographic information. Morning salivary cortisol was collected at baseline before a blood draw (for serum biological markers) and at set intervals. The first morning urinary void was obtained to measure arginine vasopressin (AVP), oxytocin (OT), cortisol, and epinephrine levels.</div></div><div><h3>Results</h3><div>IA children had the lowest urinary AVP levels, highest urinary epinephrine, a higher cortisol peak and longer recovery. There were no OT differences between the three groups. The USN group had the lowest urinary epinephrine levels. Both neglect groups had higher behavior problem scores on the CBCL with the USN group having the highest scores. There was a strong consistent association between AVP and 4 out of 6 CBCL outcomes – but not with OT, cortisol or epinephrine.</div></div><div><h3>Conclusions</h3><div>In this study, there were significant differences in both biologic and psychosocial measures between the control group, the USN and the IA groups suggesting that the timing, type and context of neglect may impact biologic and psychosocial sequalae.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"51 ","pages":"Article 100155"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144491631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-regulatory contributions to depressive symptoms in a community sample of youth","authors":"Eleenor Abraham,&nbsp;Tara McAuley","doi":"10.1016/j.pmip.2025.100163","DOIUrl":"10.1016/j.pmip.2025.100163","url":null,"abstract":"<div><h3>Objective</h3><div>Depression is prevalent in youth, with concerning implications for their current and future function. Risk for depression is elevated pending how youth attempt to regulate their affective experiences (emotion regulation; ER) and the effectiveness with which they use higher-order cognitive abilities to work towards and attain their goals (executive functions; EF). According to the impaired disengagement hypothesis, depression may arise when ineffective EFs lead to reliance on maladaptive forms of ER—such as<!--> <!-->rumination. This study investigates rumination, other ER strategies, and EF challenges as correlated predictors of depressive symptoms in youth. Method: A community sample of 191 youth 11–18 years (<em>M</em> = 13.47,<!--> <em>SD</em> = 1.48, 108 females, 48 % White, 5 % Black, 5 % Hispanic, 42 % Other) completed self-report measures of their mental health, ER strategies, and ability to apply EF abilities in their everyday lives. Results: Depression was elevated in youth who identified as female and who endorsed higher levels of EF-challenge, greater dispositional use of maladaptive ER, and lesser dispositional use of adaptive ER. The association of youths’ EF challenges and depressive symptoms was attenuated and no longer significant in a multivariate model that considered the association between their depressive symptoms and<!--> <!-->use of self-blaming rumination, catastrophizing, expressive suppression, and positive reappraisal. Conclusions: Early identification of self-regulatory factors that increase youths’ risk of depression, including the experience of everyday EF challenges and reliance on maladaptive forms of ER, has potential to guide prevention and treatment efforts that mitigate the effects of depression in adolescence and adulthood.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"51 ","pages":"Article 100163"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the influence of cognitive bias delaying the diagnosis and treatment of Anti-NMDA receptor encephalitis","authors":"Gary J. Iacobucci ,&nbsp;Raphael J. Leo ,&nbsp;Cynthia Pristach","doi":"10.1016/j.pmip.2025.100164","DOIUrl":"10.1016/j.pmip.2025.100164","url":null,"abstract":"<div><div>Anti-NMDAR encephalitis is an autoimmune condition that often mimics psychiatric conditions on first presentation. Although immunotherapy can be effective in treatment, delayed recognition and diagnosis prolongs the acute phase of illness which carries higher risk of morbidity. In addition to the complex and varied clinical manifestations, one overlooked factor that may influence clinical judgment, diagnosis, and treatment is a provider’s implicit biases, particularly as they pertain to sociocultural preconceptions of patients’ demographics. Here, we describe the clinical presentations, hospital courses, investigations, and treatment in two illustrative cases of anti-NMDAR encephalitis. We discuss the confluence of clinical factors that differentially confounded each clinical picture leading to delayed diagnosis. Additionally, we describe the possible influence of cognitive biases that perpetuated misdiagnoses. We emphasize that clinicians ought to be aware that bias takes different forms and can lead to delayed diagnosis or misdiagnosis resulting in significant morbidity. Consequently, we suggest simple strategies for mitigating the impact of specific biases both generally and specifically for encephalitis.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"51 ","pages":"Article 100164"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Panic disorder is common in medical students: Assessing the prevalence of panic disorder among medical students using the panic disorder screener (PADIS)","authors":"Laith Ashour ,&nbsp;Lama Al-Mehaisen ,&nbsp;Nada Freihat ,&nbsp;Qusai Al-Anasweh ,&nbsp;Hala Al-Miqdadi ,&nbsp;Mohammad Al Khreisha ,&nbsp;Osama Alrjoob ,&nbsp;Afnan Rababa ,&nbsp;Malak Al-Rabe’e ,&nbsp;Al-Mo’tasem Bellah Al-Rahamneh ,&nbsp;Moutaz Amayrh ,&nbsp;Ala’ Al-Doaikat ,&nbsp;Hamzeh Hatamleh ,&nbsp;Fayez Zedat","doi":"10.1016/j.pmip.2025.100152","DOIUrl":"10.1016/j.pmip.2025.100152","url":null,"abstract":"<div><div>This study aims to determine the prevalence of panic disorder among medical students. Using the Panic Disorder Screener (PADIS) Scale for the screening of panic disorder (PD), we conducted a cross-sectional study targeting medical students from 2nd to 6th year at Al-Balqa Applied University, Jordan, with a sample of 361 students. Using convenience sampling method, the questionnaires were disseminated to medical students via social media educational groups and direct contact with the students. To analyze which factors predict PD among medical students, we used a Multiple Firth Logistic regression model, and to check the construct validity of the PADIS scale we used Confirmatory Factor Analysis (CFA), alongside Cronbach’s alpha standardized coefficient for reliability. The scale construct was validated with acceptable CFA fit indices (TLI = 0.996, CFI = 0.999, RMSEA = 0.027, and SRMR = 0.019) and accepted internal consistency (Cronbach’s alpha = 0.733). Interestingly, 140 students reported having recurrent panic attacks (38.8 %). Nevertheless, 103 students (28.5 %) fully satisfied the diagnostic criteria for PD, indicating its high prevalence within this population. The most common method used to overcome the attack was deep breathing or special maneuvers (44 %). According to the regression results, PD was significantly less likely to be present among those who hadn’t experience panic attacks before attending medical school (Odds Ratio (OR) = 0.43; 95 % CI = [0.2–0.91]; P = 0.028), more likely to be in females (OR = 3.12; 95 % CI = [1.53–6.6]; P = 0.002), and significantly more prevalent among students from lower years compared to 6th year students. Interventions should be applied in medical faculties, as PD is not uncommon in this population.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"51 ","pages":"Article 100152"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between the personality trait locus of control and help-seeking behavior in persons with anxiety or depressive disorders","authors":"Sietske Leijstra ,&nbsp;Aartjan T.F. Beekman ,&nbsp;Philip Spinhoven ,&nbsp;Johanna H.M. Hovenkamp-Hermelink","doi":"10.1016/j.pmip.2025.100158","DOIUrl":"10.1016/j.pmip.2025.100158","url":null,"abstract":"<div><h3>Background</h3><div>Help-seeking behavior in patients with psychological disorders may facilitate or hinder access to care. This study aims to determine the relationship between the personality trait locus of control (LOC) and help-seeking among people with anxiety and/or depressive disorders.</div></div><div><h3>Methods</h3><div>Cross-sectional data were derived from The Netherlands Study of Depression and Anxiety. In 1434 participants with a current depression and/or anxiety disorder help-seeking was measured by the Perceived Need for Care Questionnaire. LOC was measured by the Mastery scale.</div></div><div><h3>Results</h3><div>A more internal LOC orientation was associated with less help-seeking. In the group that did seek help, a more external LOC orientation was found to be associated with certain types of help, and with more types of help. After adding neuroticism or depressive symptom severity to the regression models, the predictive value of LOC for help-seeking was no longer significant.</div></div><div><h3>Conclusions</h3><div>This research shows that for people with anxiety and/or depressive disorders LOC orientation was associated with help-seeking. However, this association disappeared after adjusting for depressive symptom severity or neuroticism. As LOC, neuroticism, and depression are correlated and all three concepts are important for understanding patients’ help-seeking behavior, it is worthwhile to further study them in concert in longitudinal designs.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"51 ","pages":"Article 100158"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of potential publication bias in U.S. National Institutes of Health-funded trials of psychological treatments for obsessive-compulsive disorder in adults","authors":"Samuel D. Spencer ,&nbsp;Nicholas C. Borgogna ,&nbsp;Tyler Owen ,&nbsp;Catherine E. Rast ,&nbsp;David A.L. Johnson ,&nbsp;Jessica Szu-Chi Cheng ,&nbsp;Ace Castillo ,&nbsp;Eric A. Storch ,&nbsp;Matti Cervin ,&nbsp;Steven D. Hollon","doi":"10.1016/j.pmip.2025.100154","DOIUrl":"10.1016/j.pmip.2025.100154","url":null,"abstract":"<div><div>Cognitive-behavioral therapy (CBT) with exposure and response prevention is the most empirically supported psychological treatment for obsessive–compulsive disorder (OCD). Healthcare organizations and practice guidelines recommending CBT for OCD typically rely on meta-analyses that usefully aggregate treatment outcome findings. However, a critical methodological aspect of meta-analyses is the potential impact of publication bias— that is, the tendency for significant findings to be published more frequently than non-significant ones, which can inflate overall effect sizes and lead to inaccurate conclusions about treatment efficacy. Identifying unpublished studies is difficult without a complete record of all studies actually conducted. To address this issue, we searched databases of United States National Institutes of Health (NIH) grants between 1980–2018 that funded comparator randomized controlled trials (RCTs) examining the efficacy of psychological treatments for adults with OCD and determined whether identified grants resulted in publications. Results indicated that 100 % of the ten identified grants resulted in publications, suggesting an absence of publication bias in this area of the literature. Quantitative aggregation of findings from the ten identified grants revealed a large effect size (<em>g</em> = 0.74, 95 % CI = [0.48, 0.99)], <em>τ</em> = 0.44). for comparisons between identified psychological treatments and a range of comparator conditions for reducing OCD symptomology measured by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Findings are discussed in the context of meta<em>-</em>science issues and methodological challenges related to publication bias in hopes of improving clinical research methods and intervention development for treatments of OCD.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"51 ","pages":"Article 100154"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on the relationship of asthma and mental disorders","authors":"João Freitas ,&nbsp;Filipa Novais","doi":"10.1016/j.pmip.2025.100157","DOIUrl":"10.1016/j.pmip.2025.100157","url":null,"abstract":"<div><div>Asthma is a complex, chronic condition affecting airway function, often accompanied by wheezing and breathlessness. Recent research has begun to explore the associations between asthma and mental disorders, particularly anxiety and depression. This review focuses on the emerging evidence suggesting a bidirectional relationship, where asthma may exacerbate mental health conditions and vice versa. Several hypotheses may explain these connections, including overlapping inflammatory pathways, altered interoceptive perception, and shared psychosocial stressors. We also explore how asthma phenotypes, different asthma treatment modalities, and breathing patterns may mediate the relationship between asthma and mental disorders such as anxiety and depressive disorders. Additionally, this review presents insights from the field of Psychoneuroimmunology and discusses the potential benefits of non-pharmacological approaches such as mindfulness, yoga, and breathing exercises. Overall, this narrative review emphasizes the need for an interdisciplinary approach to asthma management, stressing the importance of the biopsychosocial model in understanding shared pathogenic mechanisms across disorders involving psychoneuroimmunological pathways. Through this perspective, one can better understand the connections between respiratory and psychological health. This review also attempts to reveal some of the disagreements in the field, showing that more research is required to understand the risk profile that asthmatics carry when it comes to mental disorders.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"51 ","pages":"Article 100157"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of patient expectation, motivation, and satisfaction on outcomes of neurosurgical deep brain stimulation in treatment-resistant depression and obsessive–compulsive disorder","authors":"Teodora Sabkova ,&nbsp;Volker A. Coenen ,&nbsp;Thomas E. Schläpfer","doi":"10.1016/j.pmip.2025.100162","DOIUrl":"10.1016/j.pmip.2025.100162","url":null,"abstract":"<div><h3>Background</h3><div>Treatment-resistant major depressive disorder (MDD) and treatment-resistant obsessive–compulsive disorder (OCD) are the two main application areas of Deep Brain Stimulation (DBS) in psychiatry. DBS in treatment-resistant OCD patients is part of the guidelines, while this procedure in treatment-resistant depressive patients, is still being regarded as being under development.</div></div><div><h3>Objectives</h3><div>This study aimed to explore the role of patient-related factors—specifically, expectation, motivation, and satisfaction—in the context of DBS outcomes in patients with treatment-resistant depression and OCD. The focus was on descriptively examining how these factors present before and after the surgery, and how they may relate to patients’ perception of treatment efficacy.</div></div><div><h3>Methods</h3><div>A total of 58 patients participated in the study. Three measurement instruments were used for the investigation − the Client Motivation for Therapy Scale, the Stanford Expectancy Treatment Scale and the Credibility/Expectancy Questionnaire.</div></div><div><h3>Results</h3><div>Negative expectations decreased significantly, and realistic expectations increased postoperatively in both groups. Correlations between expectation levels and perceived treatment efficacy were observed at various time points. No significant differences in motivational behavior were found between the groups. Overall satisfaction with DBS was high across groups, with 81 % indicating they would choose the treatment again.</div></div><div><h3>Conclusions</h3><div>The findings highlight the relevance of patient factors such as motivation, expectation, and satisfaction in the treatment of psychiatric patients undergoing DBS. These aspects, while not predictive in a causal sense, offer valuable insights into patient engagement and perceived benefit. Managing patient expectations, as in many invasive therapies, remains a key component of therapeutic success.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"51 ","pages":"Article 100162"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-roe psychiatry: part I − A systematic review and multilevel meta-analysis investigating the impact of unwanted pregnancy and denied abortion on mental health","authors":"Debra P. Bruns ,&nbsp;Erika Botello ,&nbsp;Victoria L. King ,&nbsp;Natalie Remiszewski ,&nbsp;Laura Holland ,&nbsp;Linda L. Carpenter ,&nbsp;William M. McDonald ,&nbsp;Alik S. Widge ,&nbsp;Gerhard Hellemann ,&nbsp;Charles B. Nemeroff ,&nbsp;Nina V. Kraguljac","doi":"10.1016/j.pmip.2025.100159","DOIUrl":"10.1016/j.pmip.2025.100159","url":null,"abstract":"<div><h3>Objective</h3><div>To study the impact of unwanted pregnancies and abortion denials on maternal mental health and the mental health of children born from an unwanted pregnancy.</div></div><div><h3>Methods</h3><div>Using PRISMA guidelines, we performed a systematic search of PubMed up to June 2022. We grouped articles as follows: Unwanted pregnancies and maternal mental health, mental health of children born from an unwanted pregnancy, abortion denials and maternal mental health, mental health of children born after abortion denial. Where sufficient data were available, a random-effects multi-level <em>meta</em>-analysis using the natural logarithm of the odds ratio (logOR) was performed to measure the effect size.</div></div><div><h3>Results</h3><div>The logOR of overall negative maternal mental health outcomes with unwanted pregnancies compared to wanted or wanted/ unintended pregnancies was 0.50 (95 % CI: 0.39–0.61; p &lt; 0.01), corresponding to an odds ratio of 1.65. Data on mental health diagnoses of women denied an abortion or children born from unwanted pregnancies was scant. No studies were identified that investigated mental health of children born after abortion denial.</div></div><div><h3>Conclusions</h3><div>Data show that unwanted pregnancies significantly increase the risk of adverse mental health outcomes in the mothers (e.g. suicidality, depression, alcohol use). This is a major public health concern and will inevitably lead to additional demands on our already overwhelmed mental healthcare system. It is critical to provide access to the full spectrum of reproductive healthcare, strengthen our mental health care delivery system, and expand public health initiatives geared at primary prevention of unwanted pregnancies.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"51 ","pages":"Article 100159"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of methamphetamine abstinence on social cognition and oxytocin regulation: A study in patients undergoing rehabilitation","authors":"Mariana Judith Ceja-Vega ,&nbsp;Yaveth Ruvalcaba-Delgadillo ,&nbsp;Fernando Jáuregui-Huerta","doi":"10.1016/j.pmip.2025.100156","DOIUrl":"10.1016/j.pmip.2025.100156","url":null,"abstract":"<div><div>Social cognition, essential for interpreting and responding to social cues, is often impaired by psycho-stimulants like methamphetamine, which disrupt neural pathways critical for social interaction and emotional processing. Oxytocin, a neuropeptide involved in social bonding and emotion regulation, is similarly impacted by substances that alter dopaminergic systems, influencing social behavior and cognitive functions. This study investigates the effects of methamphetamine abstinence on social cognition and serum oxytocin levels in individuals undergoing rehabilitation, aiming to understand the progression of cognitive deficits and neuroendocrine dysregulation over a six-month follow-up interval. Thirty-seven male participants, 25 of whom were methamphetamine users in a controlled rehabilitation environment and 12 matched healthy controls, were assessed. Social cognition was evaluated using Facial Emotion Recognition and Theory of Mind (ToM) tasks at early and late abstinence stages. Serum oxytocin levels were measured through ELISA at both stages, and statistical analyses examined group differences and within-group changes over time. Methamphetamine users exhibited significant declines in social cognition from early to late abstinence, with lower performance in ToM and facial emotion recognition (notably for anger, fear, and sadness) compared to controls. Additionally, oxytocin levels showed a significant decrease over the abstinence period, with methamphetamine users maintaining lower levels than controls. Findings suggest that cognitive impairments in social processing persist as abstinence progresses, accompanied by a parallel decline in oxytocin levels. These results underscore the need for targeted interventions to address the intertwined challenges of cognitive and hormonal dysregulation in methamphetamine recovery, highlighting oxytocin’s potential role in therapeutic strategies.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"51 ","pages":"Article 100156"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}