Personalized Medicine in Psychiatry最新文献

{"title":"The relationship between the personality trait locus of control and help-seeking behavior in persons with anxiety or depressive disorders","authors":"Sietske Leijstra ,&nbsp;Aartjan T.F. Beekman ,&nbsp;Philip Spinhoven ,&nbsp;Johanna H.M. Hovenkamp-Hermelink","doi":"10.1016/j.pmip.2025.100158","DOIUrl":"10.1016/j.pmip.2025.100158","url":null,"abstract":"<div><h3>Background</h3><div>Help-seeking behavior in patients with psychological disorders may facilitate or hinder access to care. This study aims to determine the relationship between the personality trait locus of control (LOC) and help-seeking among people with anxiety and/or depressive disorders.</div></div><div><h3>Methods</h3><div>Cross-sectional data were derived from The Netherlands Study of Depression and Anxiety. In 1434 participants with a current depression and/or anxiety disorder help-seeking was measured by the Perceived Need for Care Questionnaire. LOC was measured by the Mastery scale.</div></div><div><h3>Results</h3><div>A more internal LOC orientation was associated with less help-seeking. In the group that did seek help, a more external LOC orientation was found to be associated with certain types of help, and with more types of help. After adding neuroticism or depressive symptom severity to the regression models, the predictive value of LOC for help-seeking was no longer significant.</div></div><div><h3>Conclusions</h3><div>This research shows that for people with anxiety and/or depressive disorders LOC orientation was associated with help-seeking. However, this association disappeared after adjusting for depressive symptom severity or neuroticism. As LOC, neuroticism, and depression are correlated and all three concepts are important for understanding patients’ help-seeking behavior, it is worthwhile to further study them in concert in longitudinal designs.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"51 ","pages":"Article 100158"},"PeriodicalIF":0.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the efficacy of antidepressant pharmacotherapy for interpersonal sensitivity in patients with depressive disorders","authors":"Cindy Li,&nbsp;Orhan Yilmaz,&nbsp;Evyn M. Peters","doi":"10.1016/j.pmip.2025.100153","DOIUrl":"10.1016/j.pmip.2025.100153","url":null,"abstract":"<div><div>Interpersonal sensitivity is a transdiagnostic trait vulnerability factor for several psychiatric conditions, most notably atypical depression. Surprisingly little research attention has been devoted to pharmacotherapy for interpersonal sensitivity. We conducted a literature review of randomized controlled trials conducted over five decades to determine which antidepressant medications have demonstrated efficacy on the Hopkins Symptom Checklist interpersonal sensitivity factors. Our search focused on adult samples with unipolar depressive disorders. Compared to placebo, we found consistent evidence for the superiority of selective serotonin reuptake inhibitors and imipramine, as well as monoamine oxidase inhibitors (mainly phenelzine) specifically for patients with atypical or anxious depression. Mianserin did not appear to be effective in two trials. Phenelzine was superior to imipramine, but only for patients with atypical features, mirroring the trends observed for depression treatment effects in those trials. There was inconsistent evidence for the superiority of selective serotonin reuptake inhibitors over tricyclics (mainly imipramine), but no studies reported the converse. Some trials were underpowered with small sample sizes, or did not adequately report statistics. There was a notable absence of studies with newer antidepressants. Although interpersonal sensitivity clearly responds to serotonergic antidepressants, it is not clear from the existing literature if these are more effective than medications lacking such properties. Future research will need to carefully choose pharmacologic agents with nonoverlapping mechanisms to answer this question.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"51 ","pages":"Article 100153"},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143912982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of potential publication bias in U.S. National Institutes of Health-funded trials of psychological treatments for obsessive-compulsive disorder in adults","authors":"Samuel D. Spencer ,&nbsp;Nicholas C. Borgogna ,&nbsp;Tyler Owen ,&nbsp;Catherine E. Rast ,&nbsp;David A.L. Johnson ,&nbsp;Jessica Szu-Chi Cheng ,&nbsp;Ace Castillo ,&nbsp;Eric A. Storch ,&nbsp;Matti Cervin ,&nbsp;Steven D. Hollon","doi":"10.1016/j.pmip.2025.100154","DOIUrl":"10.1016/j.pmip.2025.100154","url":null,"abstract":"<div><div>Cognitive-behavioral therapy (CBT) with exposure and response prevention is the most empirically supported psychological treatment for obsessive–compulsive disorder (OCD). Healthcare organizations and practice guidelines recommending CBT for OCD typically rely on meta-analyses that usefully aggregate treatment outcome findings. However, a critical methodological aspect of meta-analyses is the potential impact of publication bias— that is, the tendency for significant findings to be published more frequently than non-significant ones, which can inflate overall effect sizes and lead to inaccurate conclusions about treatment efficacy. Identifying unpublished studies is difficult without a complete record of all studies actually conducted. To address this issue, we searched databases of United States National Institutes of Health (NIH) grants between 1980–2018 that funded comparator randomized controlled trials (RCTs) examining the efficacy of psychological treatments for adults with OCD and determined whether identified grants resulted in publications. Results indicated that 100 % of the ten identified grants resulted in publications, suggesting an absence of publication bias in this area of the literature. Quantitative aggregation of findings from the ten identified grants revealed a large effect size (<em>g</em> = 0.74, 95 % CI = [0.48, 0.99)], <em>τ</em> = 0.44). for comparisons between identified psychological treatments and a range of comparator conditions for reducing OCD symptomology measured by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Findings are discussed in the context of meta<em>-</em>science issues and methodological challenges related to publication bias in hopes of improving clinical research methods and intervention development for treatments of OCD.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"51 ","pages":"Article 100154"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approaches to mitigate weight gain associated with antipsychotic use","authors":"Faith Tran ,&nbsp;Alexaundria Barnes ,&nbsp;Rebecca Urbonas ,&nbsp;Zina Meriden","doi":"10.1016/j.pmip.2025.100151","DOIUrl":"10.1016/j.pmip.2025.100151","url":null,"abstract":"<div><h3>Background</h3><div>Antipsychotics are vital in the management of multiple psychiatric disorders. Weight gain is a common adverse effect that can impact quality of life and long-term adherence to treatment. The goal of this literature review is to explore posited mechanisms for antipsychotic-induced weight gain (AIWG) and review proposed nonpharmacological and pharmacological interventions to mitigate this weight gain.</div></div><div><h3>Methods</h3><div>An electronic literature search was performed on PubMed to identify full-text, English-language articles that discussed AIWG. Selected articles were published between 2000 and 2024.</div></div><div><h3>Results</h3><div>Findings from 68 articles were reviewed and discussed. 27 strategies/agents of varying efficacies were identified. Non-pharmacologic interventions exhibit data in being effective against AIWG. Switching to an antipsychotic with a more favorable side-effect profile can be an appropriate option, but it is associated with an increased risk of relapse. Metformin is the most widely accepted and researched adjunctive treatment, followed by liraglutide and samidorphan. Dulaglutide, semaglutide, topiramate, betahistine, amantadine hydrochloride, berberine, probiotics, dietary fiber, nanoparticle formulation, and reboxetine show promising results in the attenuation of AIWG but need further research to understand their efficacy, metabolic effects, and safety. Melatonin, vitamin D, orlistat, modafinil, and naltrexone currently have very little data and have yet to exhibit compelling results. Lorcaserin, rimonabant, and sibutramine have all been removed from the market in the United States and are not recommended.</div></div><div><h3>Conclusion</h3><div>Data on AIWG is diverse, but scarce. Further research is needed to better understand the pathophysiology of AIWG and explore long-term effectiveness and safety of promising pharmacologic therapies in this vulnerable patient population.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"51 ","pages":"Article 100151"},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Panic disorder is common in medical students: Assessing the prevalence of panic disorder among medical students using the panic disorder screener (PADIS)","authors":"Laith Ashour ,&nbsp;Lama Al-Mehaisen ,&nbsp;Nada Freihat ,&nbsp;Qusai Al-Anasweh ,&nbsp;Hala Al-Miqdadi ,&nbsp;Mohammad Al Khreisha ,&nbsp;Osama Alrjoob ,&nbsp;Afnan Rababa ,&nbsp;Malak Al-Rabe’e ,&nbsp;Al-Mo’tasem Bellah Al-Rahamneh ,&nbsp;Moutaz Amayrh ,&nbsp;Ala’ Al-Doaikat ,&nbsp;Hamzeh Hatamleh ,&nbsp;Fayez Zedat","doi":"10.1016/j.pmip.2025.100152","DOIUrl":"10.1016/j.pmip.2025.100152","url":null,"abstract":"<div><div>This study aims to determine the prevalence of panic disorder among medical students. Using the Panic Disorder Screener (PADIS) Scale for the screening of panic disorder (PD), we conducted a cross-sectional study targeting medical students from 2nd to 6th year at Al-Balqa Applied University, Jordan, with a sample of 361 students. Using convenience sampling method, the questionnaires were disseminated to medical students via social media educational groups and direct contact with the students. To analyze which factors predict PD among medical students, we used a Multiple Firth Logistic regression model, and to check the construct validity of the PADIS scale we used Confirmatory Factor Analysis (CFA), alongside Cronbach’s alpha standardized coefficient for reliability. The scale construct was validated with acceptable CFA fit indices (TLI = 0.996, CFI = 0.999, RMSEA = 0.027, and SRMR = 0.019) and accepted internal consistency (Cronbach’s alpha = 0.733). Interestingly, 140 students reported having recurrent panic attacks (38.8 %). Nevertheless, 103 students (28.5 %) fully satisfied the diagnostic criteria for PD, indicating its high prevalence within this population. The most common method used to overcome the attack was deep breathing or special maneuvers (44 %). According to the regression results, PD was significantly less likely to be present among those who hadn’t experience panic attacks before attending medical school (Odds Ratio (OR) = 0.43; 95 % CI = [0.2–0.91]; P = 0.028), more likely to be in females (OR = 3.12; 95 % CI = [1.53–6.6]; P = 0.002), and significantly more prevalent among students from lower years compared to 6th year students. Interventions should be applied in medical faculties, as PD is not uncommon in this population.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"51 ","pages":"Article 100152"},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home-based transcranial direct current stimulation (tDCS) in major depressive disorder: Enhanced network synchronization with active relative to sham and deep learning-based predictors of remission","authors":"Wenyi Xiao ,&nbsp;Jijomon C. Moncy ,&nbsp;Rachel D. Woodham ,&nbsp;Sudhakar Selvaraj ,&nbsp;Nahed Lajmi ,&nbsp;Harriet Hobday ,&nbsp;Gabrielle Sheehan ,&nbsp;Ali-Reza Ghazi-Noori ,&nbsp;Peter J. Lagerberg ,&nbsp;Rodrigo Machado-Vieira ,&nbsp;Jair C. Soares ,&nbsp;Allan H. Young ,&nbsp;Cynthia H.Y. Fu","doi":"10.1016/j.pmip.2024.100147","DOIUrl":"10.1016/j.pmip.2024.100147","url":null,"abstract":"<div><h3>Aim</h3><div>To investigate neural oscillatory networks in major depressive disorder (MDD), effects of home-based transcranial direct current stimulation (tDCS) treatment, and predictors of treatment remission.</div></div><div><h3>Methods</h3><div>In a randomized controlled trial, EEG data were acquired from 21 MDD participants (16 women, mean age 36.63 ± 9.71 years) with moderate to severe depressive episodes (mean HAMD score 18.42 ± 1.80). Participants were randomized to active (n = 11) or sham tDCS (n = 8). Home-based tDCS treatment was administered for 10 weeks, with 5 sessions per week for 3 weeks, then 3 sessions per week for 7 weeks. Active tDCS was 2 mA, and sham tDCS was 0 mA with brief ramp-up/down periods. Clinical remission was defined as HAMD score ≤ 7. Resting-state EEG data were collected at baseline and at the 10-week end of treatment using a portable 4-channel EEG device. EEG band power and functional connectivity (phase locking value, PLV) were analyzed. Deep learning identified predictors of treatment remission from baseline PLV features.</div></div><div><h3>Results</h3><div>The active tDCS group showed higher gamma PLV in frontal and temporal regions compared to the sham group. Positive correlations between changes in delta, theta, alpha, and beta PLV and depression improvement were observed in the active group. Combining PLV features from theta, alpha, and beta achieved the highest treatment remission prediction accuracy: 71.94 % (sensitivity 52.88 %, specificity 83.06 %).</div></div><div><h3>Conclusions</h3><div>Synchronized brain activity in gamma PLV may be a mechanism of active tDCS. Baseline resting-state EEG could predict treatment remission. Home-based EEG measures are feasible and useful predictors of clinical outcomes.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"49 ","pages":"Article 100147"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143562665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gene therapy for obsessive–compulsive disorder: Basic research and clinical prospects","authors":"Fatemeh Bamarinejad ,&nbsp;Marzieh Shokoohi ,&nbsp;Atefeh Bamarinejad","doi":"10.1016/j.pmip.2025.100149","DOIUrl":"10.1016/j.pmip.2025.100149","url":null,"abstract":"<div><h3>Background</h3><div>Obsessive-Compulsive Disorder (OCD) is a prevalent psychiatric condition known for its resistance to conventional treatments. Despite available pharmacological and psychotherapeutic interventions, a significant number of patients do not respond adequately to these approaches. Recent genome-wide association studies (GWAS) have identified genetic links to OCD, sparking interest in exploring gene therapy as an alternative treatment method.</div></div><div><h3>Main body</h3><div>Gene therapy involves correcting or replacing defective genes to target the root cause of the disorder. Preliminary studies have shown promising results, focusing on genes such as Brain Derived Neurotrophic Factor (BDNF), oxytocin receptor (OXTR), SLITRK5, and SLC6A4. Continued exploration of genes like SHANK3 and IMOOD, as well as animal models like SLITRK5 knockout mice, offer insights into potential therapeutic targets. However, ethical and technical challenges must be addressed before wider implementation can occur. Ethical considerations include the multifactorial nature of psychiatric disorders, the need for comprehensive treatment, and issues surrounding informed consent, particularly in cases where patients lack insight into their condition. Technical challenges involve safe gene delivery to the brain, potential off-target effects, and achieving optimal gene expression levels.</div></div><div><h3>Conclusions</h3><div>Gene therapy for OCD is still in the early stages of research and development. While current research is still in its infancy, the identification of specific genes and pathways associated with OCD offers a foundation for future therapeutic interventions. Despite the ethical and technical challenges that remain, advancements in genetic engineering and the establishment of animal models provide a hopeful outlook for the development of effective gene therapy strategies. As the field progresses, Further research is essential to fully realize the potential of gene therapy in managing OCD and related psychiatric conditions.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"49 ","pages":"Article 100149"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The burden of chronic anxiety and depression symptomatology on 20-year cardiovascular disease incidence: The ATTICA study (2002–2022)","authors":"Vasiliki C. Baourda ,&nbsp;Christina Chrysohoou ,&nbsp;Fotios Barkas ,&nbsp;Evrydiki Kravvariti ,&nbsp;Evangelos Liberopoulos ,&nbsp;Konstantinos Tsioufis ,&nbsp;Petros P. Sfikakis ,&nbsp;Christos Pitsavos ,&nbsp;Demosthenes Panagiotakos","doi":"10.1016/j.pmip.2025.100150","DOIUrl":"10.1016/j.pmip.2025.100150","url":null,"abstract":"<div><h3>Background</h3><div>The aim of this study was to explore the associations between symptoms of depression and anxiety on 20-year cardiovascular disease (CVD) incidence among apparently healthy Greek adults.</div></div><div><h3>Methods</h3><div>In the context of a population-based, prospective health survey, the ATTICA study (2002–2022), 853 adult participants without previous CVD history [453 men (45 ± 13 years) and 400 women (44 ± 18 years)] underwent evaluations regarding psychological factors (depression through ZDRS and anxiety through STAI scales), lifestyle factors (smoking, diet, physical activity) and medical conditions (obesity, hypertension, hypercholesterolemia, diabetes mellitus) at both baseline and 10-year follow-up examinations. CVD incidence was assessed based on medical records and hospital data. Cox proportional hazard models were developed to evaluate the association between psychological symptoms on the 20-year CVD incidence, after adjusting for various characteristics.</div></div><div><h3>Results</h3><div>The results indicated that the chronic burden of depression and anxiety was independently associated with increased CVD risk during the 20-year follow-up period (crude hazard ratios of cumulative at baseline and at 10-year follow-up depressive symptoms score on CVD incidence was 1.04 95%CI (1.03, 1.05), and for anxiety score was 1.03 95%CI (1.02, 1.04)); the hazard ratios were higher especially for younger participants and those who did not adhere steadily to the Mediterranean diet during the follow-up period.</div></div><div><h3>Conclusions</h3><div>Based on our findings, standardized psychological assessments focusing on depression and anxiety should be integrated as a distinct and additional component within the preventive strategies for CVD implemented by health authorities at the population level.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"49 ","pages":"Article 100150"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mindfulness-based cognitive therapy as an adjunctive treatment for treatment-resistant depression: A systematic review","authors":"Michele F Rodrigues,&nbsp;Larissa Junkes,&nbsp;Jose Appolinario,&nbsp;Antonio E Nardi","doi":"10.1016/j.pmip.2025.100148","DOIUrl":"10.1016/j.pmip.2025.100148","url":null,"abstract":"<div><h3>Background</h3><div>Treatment-Resistant Depression is a significant mental health challenge characterized by an inadequate response to standard treatments. Mindfulness-Based Cognitive Therapy has shown promise for depression, but its effectiveness for Treatment-Resistant Depression remains unclear.</div></div><div><h3>Objective</h3><div>This systematic review evaluated the effectiveness and safety of Mindfulness-Based Cognitive Therapy as an adjunctive treatment for Treatment-Resistant Depression.</div></div><div><h3>Methods</h3><div>We searched MEDLINE, Embase, Web of Science, <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span>, and PsycInfo up to June 15, 2024, without language restrictions. Randomized controlled trials comparing Mindfulness-Based Cognitive Therapy plus treatment as usual to treatment as usual alone in individuals with Treatment-Resistant Depression were included. The primary outcome was depressive symptom severity. Secondary outcomes included quality of life, rumination, mindfulness skills, and self-compassion.</div></div><div><h3>Results</h3><div>The review included 13 studies with a total of 864 participants. Preliminary evidence suggests that Mindfulness-Based Cognitive Therapy significantly may help reduce depressive symptoms compared to treatment as usual or active controls, with effect sizes ranging from moderate to large (Cohen’s d = 0.54 to 1.04) in well-designed studies. Some improvements were also noted in quality of life (d = 0.36 to 0.51), rumination (d = 0.39), mindfulness skills (d = 0.73), and self-compassion (d = 0.21 to 0.64).</div></div><div><h3>Conclusions</h3><div>While encouraging, the current evidence suggests that Mindfulness-Based Cognitive Therapy maybe a promising intervention for Treatment-Resistant Depression However, methodological limitations, including heterogeneity in study designs and TRD definitions, preclude definitive conclusions. Future research should prioritize well-designed randomized controlled trials to establish its efficacy and optimal implementation.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"49 ","pages":"Article 100148"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of meta-cognitive and emotional beliefs, and negative repetitive thinking in the relationship between emotional abuse and psychological distress in psychiatric outpatients: A serial multiple mediation model","authors":"Mehdi Rezaei ,&nbsp;Hadi Samadieh ,&nbsp;Mohammad Mahdi Shariat Bagheri ,&nbsp;Ezatolah Ghadamour","doi":"10.1016/j.pmip.2024.100146","DOIUrl":"10.1016/j.pmip.2024.100146","url":null,"abstract":"<div><h3>Background</h3><div>Although meta-cognitive and emotional beliefs are linked to higher psychological distress, little is known about the potential antecedents of these beliefs. On the other hand, the emotional schema model and metacognitive therapy posit that negative meta-cognitive and emotional beliefs generate negative repetitive thinking (NRTs) that lead to the development of psychological distress. In a meta-cognitive integrative model, we examined: (a) whether the link between emotional abuse and psychological distress was mediated serially by meta-cognitive beliefs (MCBs) and NRTs; (b) whether the relationship between emotional abuse and psychological distress was mediated serially by negative beliefs about emotional (NBEs) and NRTs.</div></div><div><h3>Methods</h3><div>Between 2021 and 2024, 514 outpatients (<em>M</em> _age = 29.29; <em>SD</em> = 10.88) completed the Emotional Abuse Questionnaire (EAQ), Metacognitions Questionnaire (MCQ-30), Leahy Emotional Schema Scale (LESS), Perseverative Thinking Questionnaire (PTQ), and Kessler Psychological Distress Scale (<em>K</em>10). The PROCESS SPSS macro was used to conduct serial multiple mediation analysis.</div></div><div><h3>Results</h3><div>The multilevel mediation model demonstrated that the positive relationship between emotional abuse and psychological distress was partially mediated by MCBs, NBEs, and NRTs, and serially mediated by MCBs and then NRTs. The results also showed that the link between emotional abuse and psychological distress was mediated serially by NBEs and NRTs after controlling for age and gender. The model explained much of the variance in psychological distress (R² = 0.52).</div></div><div><h3>Conclusion</h3><div>The current study contributes to the literature by validating a conceptual model to confirm the association between emotional abuse and psychological distress. The hypothesized model in the present study also suggested the salience of the emotional schema model and metacognitive model in predicting psychological distress. Our results also support that NRTs are strategies utilized to cope with MCBs and NBEs.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"49 ","pages":"Article 100146"},"PeriodicalIF":0.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143103991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}