Personalized Medicine in Psychiatry最新文献

{"title":"Neuropsychological endophenotypes of substance use vulnerability in freelance professional artists: implications for personalized medicine","authors":"Lucila Ortiz Vazquez ,&nbsp;Yaveth Ruvalcaba Delgadillo ,&nbsp;Victor Hugo Carrera Escobedo ,&nbsp;Fernando Jáuregui Huerta","doi":"10.1016/j.pmip.2026.100189","DOIUrl":"10.1016/j.pmip.2026.100189","url":null,"abstract":"<div><h3>Objective</h3><div>To delineate the neuropsychological endophenotypes driving alcohol and substance use vulnerability among freelance professional artists, examining the interplay of personality dysregulation, intellectual capacity, and gender-moderated pathways.</div></div><div><h3>Method</h3><div>We conducted a deep clinical phenotyping of 42 freelance professional artists in Mexico (50% women; mean age = 28.5). We integrated standardized measures of personality pathology (MMPI-2), intelligence (WAIS-IV), and alcohol risk (AUDIT) using Mexican population norms. Data were analyzed via hierarchical regression and two-step cluster analysis.</div></div><div><h3>Results</h3><div>Alcohol risk was predicted by traits of low behavioral control (social responsibility; β = −0.28) and high self-perceived addiction potential (β = 0.59), whereas WAIS-IV intelligence indices exerted no universal protective or risk effects. Critically, gender moderated risk expression: hypomania and trauma-related externalizing traits strongly predicted AUDIT scores in men (r = 0.47) but not in women (r = 0.14), who exhibited more internalizing profiles. Cluster analysis identified three etiologically distinct endophenotypes: a high-risk disinhibited profile (62.5% male) characterized by unconventional thought, executive deficits (working memory), and severe alcohol misuse; a high-resource impulsive profile with superior intelligence but elevated hypomania; and a regulated profile (66.7% female) exhibiting high social responsibility and minimal risk.</div></div><div><h3>Conclusion</h3><div>Substance use vulnerability in the freelance creative workforce is driven by personality dysregulation and executive functioning deficits rather than intellectual capacity or creative talent per se. Identifying these gender-specific, trauma-informed endophenotypes provides a critical background for personalized medicine, enabling tailored therapeutic interventions that move beyond generic addiction protocols.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"56 ","pages":"Article 100189"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148178741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision suicide prevention requires mechanism-based therapeutics","authors":"Marianne Goodman ,&nbsp;James Murrough ,&nbsp;Georgios Voloudakis ,&nbsp;Panos Roussos","doi":"10.1016/j.pmip.2026.100188","DOIUrl":"10.1016/j.pmip.2026.100188","url":null,"abstract":"","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"56 ","pages":"Article 100188"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148178823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objective assessment of PTSD severity via smartphone-based ocular biomarkers","authors":"Veronica Choi ,&nbsp;Anthony M. Dutcher ,&nbsp;Katherine Beavis ,&nbsp;L. Caitlin Limonciello ,&nbsp;Cassandra A. Gearhart ,&nbsp;Megan E. Parmenter ,&nbsp;Andrew Teer ,&nbsp;Mark S. Greenberg ,&nbsp;David B. Zakariaie ,&nbsp;Kaloyan S. Tanev","doi":"10.1016/j.pmip.2026.100187","DOIUrl":"10.1016/j.pmip.2026.100187","url":null,"abstract":"<div><h3>Background</h3><div>Post-traumatic stress disorder (PTSD) is a prevalent psychiatric condition, yet no current assessment approach, whether clinician interview or self-report, incorporates objective physiological measurement. The absence of a validated biomarker is a fundamental gap.</div></div><div><h3>Methods</h3><div>We evaluated smartphone-based pupillometry (Senseye Diagnostic Tool, iPhone) in 38 trauma-exposed veterans in an intensive outpatient program. Pupil-to-iris ratio (PIR) was measured during pupillary light reflex (PLR) and affective image viewing (AIV) tasks across treatment and follow-up visits (96 PLR, 88 AIV sessions; same-day PCL-5, BDI-II, BAI). Continuous, hierarchical, and within-person mixed-effects regressions isolated PTSD-specific variance and tested within-person symptom tracking.</div></div><div><h3>Results</h3><div>Constriction PIR correlated with PCL-5 severity (R2 = 0.109, p = 0.001), concentrated in avoidance (R2 = 0.171) and negative alterations in cognitions/mood (R2 = 0.224, both p &lt; 0.001) rather than arousal. After adjusting for demographics and comorbidity, PTSD clusters explained an additional 16.4% of variance (p &lt; 0.001), about seven times the comorbid contribution. Dark Mean PIR was elevated in PTSD + sessions (p = 0.019). Within-person, participants’ own PCL-5 changes tracked concurrent changes in Dark Mean PIR (β = 0.0024, p = 0.006) and Constriction PIR (β = 0.0014, p = 0.031), independent of BDI-II and BAI. AIV trended similarly but was not significant.</div></div><div><h3>Conclusions</h3><div>Smartphone pupillometry shows promise as an objective, physiologically grounded approach to PTSD assessment. These proof-of-concept findings show that the biomarker captures PTSD-specific variance independent of comorbid psychopathology and tracks within-person symptom change. Validation in larger, more diverse samples is required to establish clinical utility.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"56 ","pages":"Article 100187"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148178740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Affective Computing in Youth Psychopathology: Protocol for the Adolescent Communication of Emotions Study","authors":"Rachel E. Lee ,&nbsp;Caitlyn J. Kim ,&nbsp;Calliana J. Faulk ,&nbsp;Dhilani Premaratne ,&nbsp;Yuen Yvonne Yu ,&nbsp;Rebecca Greenberg ,&nbsp;Meg Lyons ,&nbsp;Jessica Foy ,&nbsp;Samantha X.L. Tan ,&nbsp;Adam C. Garcia ,&nbsp;Te Qi ,&nbsp;Marianna Messerli ,&nbsp;Robert J. Zhou ,&nbsp;Caroline E. Barron ,&nbsp;Lauren K. Steinbeck ,&nbsp;Casey J. Zampella ,&nbsp;Leandra N. Berry ,&nbsp;Robin P. Kochel ,&nbsp;Andrew D. Wiese ,&nbsp;Julia Parish-Morris ,&nbsp;Eric A. Storch","doi":"10.1016/j.pmip.2026.100181","DOIUrl":"10.1016/j.pmip.2026.100181","url":null,"abstract":"<div><div>The identification of objective, scalable markers of socio-emotional behavior represents a major challenge in pediatric mental health diagnostics. Few approaches exist to reliably and objectively quantify social reciprocity and negative emotional states, which characterize many psychiatric and neurodevelopmental conditions, including anxiety, depression, obsessive–compulsive disorder, and autism. Advances in computer vision, natural language analytics, and psychophysiology enable fine-grained, objective measurement of socio-emotional behavior along these transdiagnostic dimensions, yet their application to youth remains limited. This article presents multimodal affective computing as an innovative approach with the potential to quantify objective markers of psychiatric and neurodevelopmental conditions in adolescents. The Affective Computing in Youth Psychopathology (ACES) study is a multi-site investigation designed to develop and validate novel behavioral and physiological markers of socio-emotional functioning across autistic and non-autistic youth with or without anxiety or depression. The study combines a standardized experimental battery to elicit spontaneous emotional and social behavior with a clinical battery to capture diagnostic status and clinical characteristics. By integrating clinical assessments and experimental paradigms with advanced multimodal phenotyping, ACES seeks to identify transdiagnostic markers of social and emotional behavior during adolescence, a critical window for the emergence of many psychiatric conditions. We describe the rationale, design, and analytic framework of ACES, highlighting how innovative affective computing technologies can provide objective and scalable assessment tools that ultimately advance precision psychiatry.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"55 ","pages":"Article 100181"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147397143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Interleukin-6 may contribute to treatment resistance and outcome in bipolar depression","authors":"Anna Jevtic ,&nbsp;James M. Sinacore ,&nbsp;Heather Wheeler ,&nbsp;Angelos Halaris","doi":"10.1016/j.pmip.2026.100180","DOIUrl":"10.1016/j.pmip.2026.100180","url":null,"abstract":"<div><h3>Background</h3><div>Immune system activation has been implicated in the pathophysiology of psychiatric disorders. Pro-inflammatory cytokine elevations, including interleukin-6 (IL-6), have been reported in bipolar disorder (BD), although results are mixed. Elevated IL-6 has been associated with symptom severity, poor treatment response, and may be influenced by single nucleotide polymorphisms (SNPs). This ancillary study examined IL-6 SNPs in treatment-resistant bipolar depression (TRBDD) to assess their relationship with inflammatory modulation and treatment outcomes.</div></div><div><h3>Methods</h3><div>This secondary analysis was derived from a 10-week, double-blind, randomized, placebo-controlled trial of escitalopram (ESC) plus celecoxib (CBX) versus ESC plus placebo (PBO) in 43 patients with TRBDD. Plasma IL-6 was measured at baseline and week 8 by ELISA. Genome-wide genotyping identified two SNPs on the IL-6 promoter (rs1800795, rs1800796). Associations between genotype, IL-6 expression, and treatment response were assessed using multiple regression and ANCOVA.</div></div><div><h3>Results</h3><div>At baseline, mean IL-6 levels were elevated in TRBDD compared to healthy controls (p = 0.007). No significant correlation was observed between baseline IL-6 and either SNP. For rs1800795, IL-6 levels differed across genotypes (CC: 1.21, GC: 1.99, GG: 1.48 ng/ml). Patients with the G allele showed lower Hamilton Depression Rating Scale (HAMD) scores in the CBX arm, suggesting greater treatment response. For rs1800796, the sample was skewed toward the CC genotype, limiting interpretation; however, higher IL-6 levels and improved outcomes with CBX were observed in CC carriers.</div></div><div><h3>Conclusions</h3><div>Although limited by sample size, these findings suggest IL-6 polymorphisms may influence inflammatory profiles and antidepressant response in TRBDD, with CBX augmentation showing potential benefit.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"55 ","pages":"Article 100180"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147397145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple marginalized identities: Multilevel analysis of COVID-19 impacts on youth mental and behavioral health","authors":"Jennifer D. Runkle ,&nbsp;Kelsey Herbst ,&nbsp;Sohpia C. Ryan ,&nbsp;Martie P. Thompson ,&nbsp;Margaret M. Sugg","doi":"10.1016/j.pmip.2026.100178","DOIUrl":"10.1016/j.pmip.2026.100178","url":null,"abstract":"<div><h3>Objective</h3><div>The COVID-19 pandemic exacerbated youth mental and behavioral health challenges in the United States, disproportionately impacting minoritized groups. Few studies examine how intersecting social determinants jointly shape these outcomes, particularly in underserved regions. This study applied an intersectional framework to assess pandemic-related changes and identify highest-risk strata.</div></div><div><h3>Methods</h3><div>We applied a Multilevel Analysis of Individual Heterogeneity and Discriminatory Accuracy model to emergency department data (2010–2022) to estimate pre- and post-pandemic prevalence of depression, anxiety, self-harm, and attention-deficit/hyperactivity disorder among youth (ages 5–26) in western North Carolina (WNC) (n = 934,938) and statewide (n = 11,973,484). Intersectional strata were defined by COVID-19 period, sex, race/ethnicity, insurance type, and age. Predicted prevalence identified highest-risk strata for each outcome and region.</div></div><div><h3>Results</h3><div>Lowest-risk strata were consistently pre-COVID, elementary-aged children with self-pay insurance, often male and from minoritized racial/ethnic groups. Highest-risk strata for depression and anxiety were post-COVID, young adult females with insurance across multiple racial/ethnic groups, with prevalence up to 11.9% (depression) and 12.9% (anxiety) in WNC. For self-harm, post-COVID adolescent females with insurance had the highest risk, with slightly higher prevalence in WNC (1.5%) than NC (1.4%). ADHD showed distinct patterns, with highest prevalence among male adolescents with Medicaid (7.1% in WNC, 11.4% statewide).</div></div><div><h3>Conclusions</h3><div>Intersectional analysis revealed both shared and region-specific disparities. WNC showed higher top-risk prevalence for depression, anxiety, and self-harm, while statewide strata showed higher ADHD risk. Findings support regionally tailored prevention strategies, including rural workforce expansion, culturally responsive care, and standardized diagnostic practices.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"55 ","pages":"Article 100178"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lithium toxicity with GLP-1RA co-prescription: clinical considerations and recommendations","authors":"Sonia Seth ,&nbsp;Seethalakshmi Ramanathan","doi":"10.1016/j.pmip.2025.100177","DOIUrl":"10.1016/j.pmip.2025.100177","url":null,"abstract":"<div><div>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and Lithium carbonate are widely prescribed drugs for type 2 diabetes mellitus and bipolar disorder, respectively. The pharmacokinetic interaction between these commonly prescribed drugs has not yet been documented in the literature, despite their extended clinical usage. Here, we present a clinical case in which Lithium carbonate and Tirzepatide administration was temporally associated with Lithium toxicity. We discuss potential mechanisms including volume-depleting gastrointestinal effects leading to dehydration affecting lithium renal clearance, and elevating serum lithium levels. Finally, we propose clinical recommendations and guidelines including frequent monitoring of Li levels and renal function markers in patients who are prescribed GLP-1 RAs and lithium concurrently.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"55 ","pages":"Article 100177"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145884885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latinos interest in knowing and using genetic risk information about obsessive compulsive disorder","authors":"Amanda R. Merner ,&nbsp;Stacey Pereira ,&nbsp;Hannah C. Moore ,&nbsp;Renee M. Frederick ,&nbsp;Dayan Berrones ,&nbsp;Josselyn S. Muñoz ,&nbsp;Vanessa Zavala Cruz ,&nbsp;Jacey L. Anderberg ,&nbsp;Humberto Nicolini ,&nbsp;Mariel Paz y Miño","doi":"10.1016/j.pmip.2025.100171","DOIUrl":"10.1016/j.pmip.2025.100171","url":null,"abstract":"<div><div>There is limited research examining the perspectives on the use of genetic testing in psychiatric care among individuals of non-European ancestry. Adults with obsessive–compulsive disorder (OCD) of Latin American ancestry (n = 1,513) completed a survey assessing their interest in receiving genetic testing for OCD, their level of comfort with disclosing this information, views on the use of genetic testing to inform reproductive decisions, and their concerns about stigma and discrimination. Most participants indicated they would be interested in learning their genetic liability for OCD; however, their level of comfort with sharing this information varied. Participants also reported high levels of mental health stigma and experiences with discrimination based on their OCD. Taken together, findings suggest there is interest among the Latino community to engage with genetic testing should it become available; however, there also are concerns that must be addressed to ensure responsible and ethical implementation in this population.</div></div>","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"55 ","pages":"Article 100171"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147397146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Historical roots of depressive symptoms in older adults: Gam Saan songs","authors":"Benjamin K.P. Woo ,&nbsp;Jamie O.P. Chung","doi":"10.1016/j.pmip.2025.100176","DOIUrl":"10.1016/j.pmip.2025.100176","url":null,"abstract":"","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"55 ","pages":"Article 100176"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet and depression risk: Addressing methodological reflections","authors":"Patricio Molero ,&nbsp;Francesco De Lorenzi ,&nbsp;Adam Gędek ,&nbsp;Celina Strater ,&nbsp;Elena Popescu ,&nbsp;Felipe Ortuño ,&nbsp;Willem Van Der Does ,&nbsp;Miguel Angel Martínez-González ,&nbsp;Marc L. Molendijk","doi":"10.1016/j.pmip.2025.100175","DOIUrl":"10.1016/j.pmip.2025.100175","url":null,"abstract":"","PeriodicalId":19837,"journal":{"name":"Personalized Medicine in Psychiatry","volume":"55 ","pages":"Article 100175"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145760700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}