Pediatric Research最新文献

{"title":"Heart of the matter: predicting need for PDA surgical ligation from an early echocardiogram.","authors":"John T Wren, Patrick J McNamara","doi":"10.1038/s41390-025-03896-3","DOIUrl":"https://doi.org/10.1038/s41390-025-03896-3","url":null,"abstract":"","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large familial chromosomal duplications without apparent disease phenotypes: how to deal with them in prenatal diagnosis?","authors":"Mauro Lecca, Edoardo Errichiello","doi":"10.1038/s41390-025-03895-4","DOIUrl":"https://doi.org/10.1038/s41390-025-03895-4","url":null,"abstract":"","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving child and adolescent health and well-being in Europe: the imperative for a new regional strategy.","authors":"Sophie Jullien, Martin W Weber, Susanne Carai, João Breda, Natasha Azzopardi-Muscat","doi":"10.1038/s41390-025-03885-6","DOIUrl":"10.1038/s41390-025-03885-6","url":null,"abstract":"<p><p>Despite significant progress during the Millennium Development Goals era, recent trends show stagnation or regression in key health indicators for children and adolescents in Europe. Obesity rates are rising, adolescent mental health is deteriorating, the digital environment poses risks, breastfeeding rates are low, many children face developmental risks, and displaced children encounter significant health challenges. To address these issues, we need a comprehensive strategy for children and adolescents in Europe, leading to increased investment, protection from commercial harm, effective governance, and accountability to improve health outcomes. The World Health Organization (WHO) and the United Nations International Children's Emergency Fund (UNICEF) have embarked jointly to lead the way.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social epidemiology of early adolescent nutrition.","authors":"Jason M Nagata, Christiane K Helmer, Jennifer Wong, Thang Diep, Sydnie K Domingue, Richard Do, Ruthie Ervin, Arjun S Mehta, Abubakr A A Al-Shoaibi, Holly C Gooding, Kyle T Ganson, Alexander Testa, Fiona C Baker, Andrea K Garber","doi":"10.1038/s41390-025-03838-z","DOIUrl":"10.1038/s41390-025-03838-z","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate associations between sociodemographic factors and dietary intake among a diverse population of early adolescents ages 10-13 years in the United States.</p><p><strong>Methods: </strong>We examined data from the Adolescent Brain Cognitive Development (ABCD) Study in Year 2 (2018-2020, ages 10-13 years, N = 10,280). Multivariable linear regression models were conducted to estimate the adjusted associations between sociodemographic factors (age, sex, race and ethnicity, household income, parental education) and dietary intake of various food groups, measured by the Block Kids Food Screener.</p><p><strong>Results: </strong>Older age among early adolescents was associated with slightly less fruit, whole grain, and dairy and more monounsaturated fat consumption. Male sex was associated with a lower intake of fruit, fruit juice, vegetables, whole grains, and fiber and a higher intake of meat/poultry/fish, added sugars, fat, as well as higher glycemic index and glycemic load compared to female sex. Racial and ethnic minority status, lower household income, and lower parental education were generally associated with less fruit and vegetable consumption and more added sugars.</p><p><strong>Conclusion: </strong>These findings can guide public health interventions to reduce diet quality disparities by targeting key populations and addressing differences according to socioeconomic status, sex, and race.</p><p><strong>Impact: </strong>Sociodemographic disparities in diet quality have been studied, but none have explored sociodemographic associations with specific food groups and components (e.g., different types of fat) in early adolescence. In this demographically diverse sample of 10-13-year-old early adolescents in the US, we found sociodemographic disparities in dietary intake across various food groups. Most notably, male sex, racial and ethnic minority status, lower household income, and lower parental education were associated with less fruit and vegetable consumption and more added sugars.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term burden of body mass index since childhood and impaired physical performance in midlife.","authors":"Tingting Du, Lydia Bazzano","doi":"10.1038/s41390-025-03865-w","DOIUrl":"https://doi.org/10.1038/s41390-025-03865-w","url":null,"abstract":"<p><strong>Background: </strong>The impact of long-term burden of body mass index (BMI) since childhood on physical performance in midlife remains unclear. We aimed to investigate the association between cumulative exposure to BMI since childhood and midlife physical performance by using data from the Bogalusa Heart Study (BHS).</p><p><strong>Methods: </strong>This longitudinal study consisted of 749 participants (aged 37.6 to 56.7 years at follow-up) who had been examined at least four times during childhood, with 39.3 years of follow-up.</p><p><strong>Results: </strong>BMI in childhood, adulthood, as a cumulative burden of BMI in childhood, or as a cumulative burden from childhood to adulthood were inversely associated with midlife Short Physical Performance Battery (SPPB) scores, 4-m gait speed, and 6-min walking distance. Individuals with higher BMI as adults but not as children did not have lower SPPB scores (OR,1.67; 95% CI, 0.85-3.27), while individuals with consistently high BMI from childhood to adulthood (2.13 1.18-3.82) and individuals with high childhood BMI (2.12 [1.10-4.10]) but low adult BMI had significantly increased risk compared with individuals with low child and low adult BMI.</p><p><strong>Conclusion: </strong>Cumulative burden of BMI from childhood to midlife associated with worse midlife physical performance. Maintaining a healthy body weight throughout life may play a role in preventing or delaying the onset of functional decline.</p><p><strong>Impact: </strong>We examined the impact of long-term burden of body mass index (BMI) since childhood on subsequent physical performance in midlife. We found that ①BMI in childhood and cumulative burden of BMI since childhood were associated with poor physical function in midlife; ② Individuals with high childhood BMI but low adult BMI have poor midlife physical performance; ③ Subjects with both high childhood and adulthood BMI have worse midlife physical performance. Our findings have important implications for active monitoring BMI from childhood and turning the focus of functional decline prevention to primary and primordial prevention.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human breast milk-derived exosomes and their positive role on neonatal intestinal health.","authors":"Gen Chen, Xiangdong Ouyang, Yide Mu, Yuqiong Chen","doi":"10.1038/s41390-025-03813-8","DOIUrl":"https://doi.org/10.1038/s41390-025-03813-8","url":null,"abstract":"<p><p>Although the role of breast milk in promoting neonatal growth and maintaining intestinal homeostasis is well established, underlying mechanisms by which it protects the intestine from damage remain to be elucidated. Human breast milk-derived exosomes (HMDEs) are newly discovered active signaling vesicles with a diameter of 30-150 nm, which are key carriers of biological information exchange between mother and child. In addition, due to their ability to cross the gastrointestinal barrier, low immunogenicity, good biocompatibility and stability, HMDEs play an important role in regulating intestinal barrier integrity in newborns. In addition, HMDEs possess specific properties that are reformable and modifiable, offering promising strategies for the prevention and treatment of neonatal intestinal diseases. However, challenges such as purification, complex content, and quality control hinder their clinical application. This paper provides a comprehensive review of the biogenesis and properties of HMDEs, their isolation and purification, composition, and effects on neonatal intestinal barrier function, and further explores their potential biomedical applications. IMPACT: Breast milk helps maintain intestinal homeostasis in newborns and can prevent diseases, especially necrotizing enterocolitis (NEC). Breast milk contains abundant exosomes, which are important carriers of maternal and infant biological information exchange. Breast milk have the advantages of low immunogenicity, good biocompatibility and good stability, which helps to maintain the integrity of the intestinal barrier. Exosomes can be modified, which is expected to provide a more effective strategy for the prevention and treatment of intestinal diseases.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early immune modulation in cerebral palsy medical management of cerebral palsy series.","authors":"E J Molloy","doi":"10.1038/s41390-025-03798-4","DOIUrl":"https://doi.org/10.1038/s41390-025-03798-4","url":null,"abstract":"","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Association between BNP and all-cause mortality in critically ill children: a cohort study based on the PIC database\".","authors":"Gabriella Bottari","doi":"10.1038/s41390-025-03883-8","DOIUrl":"https://doi.org/10.1038/s41390-025-03883-8","url":null,"abstract":"","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No causal association between gut microbiota and kawasaki disease: a two-sample mendelian randomization study.","authors":"Sibao Wang, Gang Luo, Zhixian Ji, Silin Pan","doi":"10.1038/s41390-025-03878-5","DOIUrl":"https://doi.org/10.1038/s41390-025-03878-5","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Despite prior observational studies suggesting a link between gut microbiota to Kawasaki disease (KD), these findings remain debated. This study aimed to assess the association between gut microbiota and KD on a genetic level using a two-sample Mendelian randomization (MR) analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This two-sample MR analysis utilized summary statistics from the largest genome-wide association study meta-analysis on gut microbiota conducted by the MiBioGen consortium. The causal relationship between gut microbiota and KD evaluated using multiple methods, including inverse variance weighted (IVW), MR Egger, weighted median, simple mode, weighted mode, and MR-PRESSO. Reverse MR analysis was conducted on bacteria identified as causally linked to KD in the initial MR study. Cochran's Q and Rucker's Q tests assessed the heterogeneity among instrumental variables.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The IVW estimates indicated no significant genetic causal relationship with KD for various taxa, including genus Bifidobacterium (p = 0.774, OR 95% CI = 0.876 [0.355-2.163]), genus FamilyXIIIAD3011group (p = 0.945, OR 95% CI = 0.979 [0.539-1.780]), genus LachnospiraceaeUCG004 (p = 0.987, OR 95%CI = 1.005 [0.542-1.863]), genus RuminococcaceaeNK4A214group (p = 0.453, OR 95%CI = 1.469 [0.538-4.009]), genus RuminococcaceaeUCG002 (p = 0.835, OR 95% CI = 1.092 [0.478-2.494]), genus LachnospiraceaeUCG001 (p = 0.996, OR 95%CI = 0.998 [0.482-2.066]), genus Bacteroides (p = 0.595, OR 95%CI = 0.831 [0.419-1.648]), genus Olsenella (p = 0.414, OR 95%CI = 1.312 [0.684-2.516]), genus Lactococcus (p = 0.870, OR 95%CI = 0.962 [0.600-1.541]), family Rhodospirillaceae (p = 0.995, OR 95%CI = 1.002 [0.550-1.827]), family FamilyXIII (p = 0.894, OR 95%CI = 1.093 [0.298-4.009]), family BacteroidalesS24 (p = 0.604, OR 95%CI = 0.849 [0.456-1.578]), family Ruminococcaceae (p = 0.524, OR 95%CI = 0.692 [0.223-2.148]), and class Bacilli (p = 0.905, OR 95%CI = 0.967 [0.561-1.667]). The reverse MR analysis revealed no significant causal effect of KD on gut microbiota. No significant heterogeneity of instrumental variables or horizontal pleiotropy was observed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This bidirectional causal inference analysis did not reveal a genetic causal relationship between gut microbiota and KD. Confounding factors may have influenced the observed associations in previous observational studies. Further research with advanced MR methods and larger GWAS datasets is needed to confirm these findings.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Impact: &lt;/strong&gt;This study employs Mendelian randomization to investigate the causal relationship between gut microbiota and Kawasaki disease, and finds no evidence of a genetic association between them. This represents the first Mendelian randomization study to examine the causal link between gut microbiota and Kawasaki disease, offering valuable insights into the potential mechanisms underlying previous observational f","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucocorticoids on bone remodeling in systemic lupus erythematosus mice.","authors":"Sheng Hao, Yuyun Zhang, Xiaowei Tong, Fangkai Ding, Runjie Wang, Jing Zhang, Dan Feng, Xiaoling Niu, Wenyan Huang","doi":"10.1038/s41390-025-03861-0","DOIUrl":"https://doi.org/10.1038/s41390-025-03861-0","url":null,"abstract":"<p><strong>Background: </strong>Systemic lupus erythematosus requires glucocorticoids for management. This study investigates how glucocorticoids influence bone in a SLE mouse model, focusing on bone mineral density (BMD), microstructure, and remodeling markers.</p><p><strong>Methods: </strong>MRL/lpr and C57BL/6 mice were administered dexamethasone or saline as a control for 4-weeks. Bone assessments included analyses of BMD, bone structure, and serum levels of RANKL and OPG.</p><p><strong>Results: </strong>Dexamethasone decreased BMD and altered cortical and trabecular bone thickness in both MRL/lpr and C57BL/6 mice. In C57BL/6 mice, cortical bone exhibited increased catabolism while trabecular bone showed signs of increased anabolism, whereas MRL/lpr mice did not show significant changes in bone turnover. Both strains experienced weight loss, with a significant decrease in femur length observed only in C57BL/6 mice. Dexamethasone exacerbated BMD reduction in MRL/lpr mice and halted its increase in C57BL/6 mice. C57BL/6 mice exhibited notable changes in cortical and trabecular bone structure, while MRL/lpr mice didn't. After receiving dexamethasone, both strains showed higher serum RANKL levels, especially in C57BL/6 mice. OPG decreased in both strains.</p><p><strong>Conclusion: </strong>Both glucocorticoids and SLE contribute to abnormal bone remodeling through RANKL/OPG pathway.</p><p><strong>Impact: </strong>Glucocorticoid (GC) treatment in a mouse model of systemic lupus erythematosus (SLE) leads to significant changes in bone parameters, including decreased bone mineral density (BMD) and alterations in bone structure. Those change are associated with the modulation of RANKL and OPG expression. Both GC and inflammation in SLE contribute to BMD reduction, and GC may have a certain protective effect on bone in the early stage of chronic inflammation. GC can upregulate RANKL expression and downregulate OPG expression in vivo. During a state of chronic inflammation, RANKL expression increases. However, OPG may not exert a significant influence on inflammatory stimulation.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}