Pediatric Research最新文献

{"title":"Obesity is a growing problem and a modifiable factor affecting lung health.","authors":"Matthew J Hegewald","doi":"10.1038/s41390-025-03887-4","DOIUrl":"https://doi.org/10.1038/s41390-025-03887-4","url":null,"abstract":"","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neonatal resuscitation video review - has the time for wider adoption come?","authors":"Anne Lee Solevåg, Maxi Kaufmann, Ruben Witlox, Charles Christoph Roehr","doi":"10.1038/s41390-025-03857-w","DOIUrl":"https://doi.org/10.1038/s41390-025-03857-w","url":null,"abstract":"","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repetitive neonatal pain increases spinal cord DNA methylation of the µ-opioid receptor.","authors":"Mathilde Baudat, Elbert A J Joosten, Sinno H P Simons, Daniël L A van den Hove, Renzo J M Riemens","doi":"10.1038/s41390-025-03892-7","DOIUrl":"https://doi.org/10.1038/s41390-025-03892-7","url":null,"abstract":"<p><strong>Background: </strong>Repetitive neonatal painful procedures experienced in the neonatal intensive care unit (NICU) are known to alter the development of the nociceptive system and have long-lasting consequences. Recent evidence indicates that NICU stay affects the methylation of the opioid receptor mu 1 encoding gene (Mor-1). Additionally, a preclinical model of neonatal procedural pain established lower adult post-operative MOR-1 levels in the spinal cord. Thus, we hypothesized that neonatal procedural pain increases the DNA methylation status of Mor-1 in the spinal cord and dorsal root ganglia (DRGs).</p><p><strong>Methods: </strong>To this end, repetitive neonatal procedural pain was induced in animals, during the first postnatal week, a period equivalent to preterm human brain development. On postnatal day 10 methylation of Mor-1 promotor was assessed in the spinal cord and the DRG using bisulfite pyrosequencing.</p><p><strong>Results: </strong>Our findings demonstrated that neonatal procedural pain increased spinal cord Mor-1 promotor DNA methylation in the ipsilateral side as compared to the contralateral side, an effect that was not observed in the control animals, nor in the DRG.</p><p><strong>Conclusion: </strong>This study is the first to highlight a localized and noxious-stimuli-dependent effect of repetitive neonatal procedural pain on Mor-1 promotor methylation and emphasizes the need to explore the effects of repetitive neonatal procedural pain on the epigenome.</p><p><strong>Impact: </strong>This study reveals that repetitive neonatal procedural pain is associated with increased DNA methylation of the Mor-1 promoter in the spinal cord of neonatal rats. This is the first study to identify an effect of neonatal procedural pain on DNA methylation, emphasizing the critical need for further investigation into the epigenetic consequences of neonatal procedural pain. These insights could lead to better management and treatment strategies to mitigate the long-term impacts of early pain exposure on neurodevelopment and behavior.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving UK data on avoidable perinatal brain injury: review of data dictionaries and consultation.","authors":"Jan W van der Scheer, Victoria Komolafe, Kirstin Webster, Stamatina Iliodriomiti, Charles C Roehr, Asma Khalil, Tim Draycott, Louise Dewick, George Dunn, Rachel Walsh, Philip Steer, Alessandra Giusti, Mark L Cabling, Nick Fahy, Mary Dixon-Woods","doi":"10.1038/s41390-025-03842-3","DOIUrl":"https://doi.org/10.1038/s41390-025-03842-3","url":null,"abstract":"<p><strong>Background: </strong>High quality data is important to understanding epidemiology and supporting improvement efforts in perinatal brain injury. It is not clear which data items relevant to brain injury are captured across UK sources of routinely collected data, nor what needs to be done to ensure that those sources are fit for purpose in improving care.</p><p><strong>Methods: </strong>We reviewed data dictionaries of four main UK perinatal data sources and consulted a multi-professional group (N = 27) with expertise in neonatal/maternity care, statistics, and clinical negligence.</p><p><strong>Results: </strong>None of the data sources we reviewed currently captures, on its own, the range of items relevant to brain injury. Data items lack common definitions and ongoing linkage across the different sources. Our consultation identified the need for standardising the definition of avoidable perinatal brain injury, resolving inconsistencies in capturing data, improving linkage of data across existing data sources, and co-designing a strategy for meaningful use of data.</p><p><strong>Conclusions: </strong>Limited standardisation and linkage across UK data sources are key problems in using data to guide improvement efforts aimed at reducing risk of avoidable perinatal brain injury. A programme involving co-design with healthcare professionals and families to improve capture and use of data is now needed.</p><p><strong>Impact: </strong>Limited standardisation and linkage across UK data sources currently challenge the use of data as the basis of efforts to reduce risk of avoidable perinatal brain injury. A harmonisation programme involving consultation and co-design with healthcare professionals, families, and other specialists is needed to enable better capture and use of data in this key area. There is need to standardise the definition of avoidable perinatal brain injury, resolve inconsistencies in capturing data, improve linkage of data collected across existing data sources, and co-design a strategy for meaningful use of data.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different effects of vitamins on hypoxic and normal fetal lungs.","authors":"Fuat Emre Canpolat, Hayriye Gözde Kanmaz Kutman","doi":"10.1038/s41390-025-03903-7","DOIUrl":"https://doi.org/10.1038/s41390-025-03903-7","url":null,"abstract":"","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased serum GM-CSF at diagnosis of biliary atresia is associated with improved biliary drainage.","authors":"Sarah A Taylor, Sanjiv Harpavat, Kyle D Gromer, Victor Andreev, Kathleen M Loomes, Jorge A Bezerra, Chaowapong Jarasvaraparn, Kasper Wang, Simon Horslen, Philip Rosenthal, Jeffrey Teckman, Pamela L Valentino, Vicky L Ng, Saul J Karpen, Ronald J Sokol, Estella M Alonso, Cara L Mack","doi":"10.1038/s41390-025-03804-9","DOIUrl":"https://doi.org/10.1038/s41390-025-03804-9","url":null,"abstract":"<p><strong>Background: </strong>The immune heterogeneity of biliary atresia (BA) presents a challenge for development of prognostic biomarkers. This study aimed to identify early immune signatures associated with biliary drainage after Kasai Portoenterostomy (KPE).</p><p><strong>Methods: </strong>Serum samples, liver slides, and clinical data were obtained from patients enrolled in the NIDDK-supported Childhood Liver Disease Research Network. Serum cytokines and hepatic immune cell subsets were measured at diagnosis and compared among 3 groups: 38 infants with BA (20 with evidence of bile flow after KPE; 18 without) and 17 non-BA cholestatic infants.</p><p><strong>Results: </strong>BA participants had lower numbers of lipid associated macrophages (LAM), and increased serum levels of Eotaxin-3, interleukin (IL) 12p70, and IL-8 versus non-BA groups (p < 0.05 for all). Among BA participants, monocyte like macrophages and serum levels of granulocyte-macrophage colony stimulating factor (GM-CSF) were increased in BA participants with good biliary drainage (p = 0.004 and p < 0.001 respectively). Levels of GM-CSF, IL-16, c-reactive protein, TNF-β predicted successful biliary drainage with an area under the receiver operating curve of 0.84 (p < 0.001).</p><p><strong>Conclusion: </strong>These findings suggest that distinct macrophage-associated immune networks at diagnosis may impact biliary drainage after KPE. Identification of early prognostic immune-modulatory markers has potential to improve patient stratification for medical and surgical therapies.</p><p><strong>Impact statement: </strong>We identify serum cytokines, particularly GM-CSF, that are associated with future biliary drainage in patients with biliary atresia. Characterization of macrophage-associated immune networks provides novel insight into early disease mechanism that may impact patient outcomes. Early prognostic biomarkers markers in biliary atresia can help in patient stratification for medical and surgical therapies.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of climate change on vulnerable populations in pediatrics: opportunities for AI, digital health, and beyond-a scoping review and selected case studies.","authors":"Elizabeth A Campbell, Felix Holl, Harleen K Marwah, Hamish S Fraser, Sansanee S Craig","doi":"10.1038/s41390-024-03719-x","DOIUrl":"https://doi.org/10.1038/s41390-024-03719-x","url":null,"abstract":"<p><p>Climate change critically impacts global pediatric health, presenting unique and escalating challenges due to children's inherent vulnerabilities and ongoing physiological development. This scoping review intricately intertwines the spheres of climate change, pediatric health, and Artificial Intelligence (AI), with a goal to elucidate the potential of AI and digital health in mitigating the adverse child health outcomes induced by environmental alterations, especially in Low- and Middle-Income Countries (LMICs). A notable gap is uncovered: literature directly correlating AI interventions with climate change-impacted pediatric health is scant, even though substantial research exists at the confluence of AI and health, and health and climate change respectively. We present three case studies about AI's promise in addressing pediatric health issues exacerbated by climate change. The review spotlights substantial obstacles, including technical, ethical, equitable, privacy, and data security challenges in AI applications for pediatric health, necessitating in-depth, future-focused research. Engaging with the intricate nexus of climate change, pediatric health, and AI, this work underpins future explorations into leveraging AI to navigate and neutralize the burgeoning impact of climate change on pediatric health outcomes. IMPACT: Our scoping review highlights the scarcity of literature directly correlating AI interventions with climate change-impacted pediatric health that disproportionately affects vulnerable populations, even though substantial research exists at the confluence of AI and health, and health and climate change respectively. We present three case studies about AI's promise in addressing pediatric health issues exacerbated by climate change. The review spotlights substantial obstacles, including technical, ethical, equitable, privacy, and data security challenges in AI applications for pediatric health, necessitating in-depth, future-focused research.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart of the matter: predicting need for PDA surgical ligation from an early echocardiogram.","authors":"John T Wren, Patrick J McNamara","doi":"10.1038/s41390-025-03896-3","DOIUrl":"https://doi.org/10.1038/s41390-025-03896-3","url":null,"abstract":"","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large familial chromosomal duplications without apparent disease phenotypes: how to deal with them in prenatal diagnosis?","authors":"Mauro Lecca, Edoardo Errichiello","doi":"10.1038/s41390-025-03895-4","DOIUrl":"https://doi.org/10.1038/s41390-025-03895-4","url":null,"abstract":"","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143067161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving child and adolescent health and well-being in Europe: the imperative for a new regional strategy.","authors":"Sophie Jullien, Martin W Weber, Susanne Carai, João Breda, Natasha Azzopardi-Muscat","doi":"10.1038/s41390-025-03885-6","DOIUrl":"10.1038/s41390-025-03885-6","url":null,"abstract":"<p><p>Despite significant progress during the Millennium Development Goals era, recent trends show stagnation or regression in key health indicators for children and adolescents in Europe. Obesity rates are rising, adolescent mental health is deteriorating, the digital environment poses risks, breastfeeding rates are low, many children face developmental risks, and displaced children encounter significant health challenges. To address these issues, we need a comprehensive strategy for children and adolescents in Europe, leading to increased investment, protection from commercial harm, effective governance, and accountability to improve health outcomes. The World Health Organization (WHO) and the United Nations International Children's Emergency Fund (UNICEF) have embarked jointly to lead the way.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}