Pediatric Research最新文献

{"title":"Editor’s Focus","authors":"","doi":"10.1038/s41390-025-03955-9","DOIUrl":"10.1038/s41390-025-03955-9","url":null,"abstract":"","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":"97 3","pages":"865-865"},"PeriodicalIF":3.1,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143909696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tele-Neonatology—an exciting and potentially transformative tool for improving delivery room care","authors":"Mario Rüdiger, Michael Wagner, Joyce E. O’Shea","doi":"10.1038/s41390-025-03886-5","DOIUrl":"10.1038/s41390-025-03886-5","url":null,"abstract":"","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":"97 3","pages":"866-867"},"PeriodicalIF":3.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143909692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor’s Focus","authors":"","doi":"10.1038/s41390-025-04018-9","DOIUrl":"10.1038/s41390-025-04018-9","url":null,"abstract":"","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":"97 2","pages":"453-453"},"PeriodicalIF":3.1,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bytes and bites: social media use and dietary behaviours among adolescents across 41 countries.","authors":"Asaduzzaman Khan, Jie Feng, Veronique Chachay, Jaclyn H Tsang, Wendy Y Huang, Cindy H P Sit, Victor Minichiello","doi":"10.1038/s41390-025-04030-z","DOIUrl":"https://doi.org/10.1038/s41390-025-04030-z","url":null,"abstract":"<p><strong>Background: </strong>To examine the associations of problematic and excessive social media use (SMU) with dietary behaviours of adolescents.</p><p><strong>Methods: </strong>We analysed the 2017/2018 Health Behaviour in School-aged Children survey data, involving 222,865 adolescents (51.8% girls) from 41 countries. A dietary intake score was derived using consumption of fruits, vegetables, sweets, and sugary soft-drinks. Breakfast intake was categorised as daily or non-daily. Excessive SMU assessed how often respondents had online contact through social media, and problematic SMU was assessed through symptoms of addiction.</p><p><strong>Results: </strong>Regression analyses showed that adolescents reporting problematic SMU had 54% lower odds in boys (OR 0.46; 95% CI 0.42-0.51) and 64% lower odds in girls (OR 0.36; 0.33-0.40) of reporting good dietary intake compared with poor intake. Excessive SMU was also associated with lower odds of reporting good dietary intake. Problematic SMU associated inversely with daily fruit and vegetable intake, while excessive SMU was positively associated with daily fruit and vegetable intake across sex. Both types of SMU were linked to increased intake of sweets and sugary drinks and decreased breakfast consumption.</p><p><strong>Conclusions: </strong>Problematic SMU was associated with poor dietary habits, while excessive SMU showed mixed findings. Prospective research is warranted to understand the causal mechanisms.</p><p><strong>Impact: </strong>Problematic and excessive social media use (SMU) was associated with poor dietary habits with problematic SMU being more detrimental than excessive SMU. This research contributes to the literature by demonstrating that problematic and excessive SMU correlate differently with adolescent dietary habits, highlighting the need for targeted approaches to promote healthier eating. Adolescents should be encouraged to use social media responsibly, while social media companies should promote local fresh food options to enhance healthy dietary habits.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprognostication in neonatal encephalopathy due to presumed hypoxic-ischemic encephalopathy.","authors":"Mehmet N Cizmeci, Rhandi Christensen, Andrea van Steenis, Linda S de Vries","doi":"10.1038/s41390-025-04058-1","DOIUrl":"10.1038/s41390-025-04058-1","url":null,"abstract":"<p><p>Over the last two decades, significant progress has been made in the management of neonatal encephalopathy due to presumed hypoxic-ischemic encephalopathy. One key area that requires improvement is timely and accurate neuroprognostication in this population to identify infants who may benefit from early interventions and harness the maximum neuroplastic capacity of the developing brain. Improved neuroprognostication also has the potential to foster more effective communication of findings to caregivers. In this review, we explore whether improved neuroprognostication is possible by assessing clinical, biochemical, electrographic, neurophysiological, and neuroimaging biomarkers and their role in neuroprognostication. IMPACT STATEMENT: Over the last two decades, significant progress has been made in the management of neonatal encephalopathy due to presumed hypoxic-ischemic encephalopathy. One key area that requires improvement is timely and accurate neuroprognostication in this population to identify infants who may benefit from early interventions and harness the maximum neuroplastic capacity of the developing brain. In this review article, we discuss general concepts and principles of neuroprognostication and the role of each prognostic marker.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommended nutrition for preterm infants-on track, but more research is needed.","authors":"William W Hay","doi":"10.1038/s41390-025-04062-5","DOIUrl":"10.1038/s41390-025-04062-5","url":null,"abstract":"<p><p>In this issue of Pediatric Research, Naseh, et al. document that extremely to very preterm infants fed recommended macronutrient intakes using early parenteral nutrition and early and reasonably rapidly advanced enteral feeding of supplemented maternal and donor milk have relatively common outcomes of brain size and morphology at term gestational age and cognition at 2 years of age. Growth rates, ranges of data, and data for individual infants would have been helpful to better assess the impact of the feeding approaches and macronutrient intakes on growth and development of the study infants, but the success of Naseh, et al.'s feeding approaches and meeting recommended macronutrient intakes is encouraging. IMPACT: Preterm infants who are fed recommended macronutrient intakes using early parenteral nutrition and early enteral feeding of supplemented maternal and donor milk have relatively common brain size and morphology at term gestation and cognition at 2 years. These results expand the literature documenting that following rational feeding guidelines produces more optimal nutritional outcomes of preterm infants. Early enteral feeding helps produce more optimal nutrition for preterm infants. More research is needed to produce more optimal intravenous amino acid and lipid products and more optimal feeding approaches, and assess longer term growth, neurodevelopment, and cogniation.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long term follow up for children with congenital heart disease. For want of a nail the Kingdom was lost.","authors":"Nadia Badawi, Natalie Fairbairn, Himanshu Popat","doi":"10.1038/s41390-025-04032-x","DOIUrl":"https://doi.org/10.1038/s41390-025-04032-x","url":null,"abstract":"","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Everolimus and Sunitinib potentially work as therapeutic drugs for infantile hemangiomas.","authors":"Rongfang Xie, Zhujue Taohuang, Rosalind Kieran, Zhiyu Li, Luying Wang, Changxian Dong, Jianfeng Ge, Xusheng Wang, Miaomiao Li","doi":"10.1038/s41390-025-04028-7","DOIUrl":"https://doi.org/10.1038/s41390-025-04028-7","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Infantile hemangiomas (IH) are common vascular tumors in infants, with no well-defined therapeutic agents currently available. Recent studies have explored molecular mechanisms involved in IH progression, but the lack of immortalized hemangioma-derived endothelial cell (iHemEC) models has limited drug discovery efforts.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We established an immortalized hemangioma-derived endothelial cell (iHemEC) expressing hemangioma markers and screened 18 potential drugs. Transcriptome profiling and Gene Set Enrichment Analysis (GSEA) were applied to assess the molecular effects of Everolimus and Sunitinib.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Sunitinib, Elimusertib, HIF-1 inhibitor-4, Rebastinib, and Everolimus inhibited iHemEC with lower IC&lt;sub&gt;50&lt;/sub&gt; than Propranolol and Rapamycin. GSEA showed that PI3K/AKT/mTOR pathway was only downregulated in Everolimus treated cells. Chromosome instability was found specifically in Sunitinib treated cells, which has been reported to cause DNA damage. DNA damage induced ROS and extracellular ROS production was only observed in Sunitinib treated cells. Additionally, Sunitinib can trigger P53 activation and BCL2 downregulation with a dose of 0.2 µM which is fifty times lower than the dose of Everolimus at 10 µM.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;We successfully developed an iHemEC model for in vitro drug screening and mechanistic study. Everolimus and Sunitinib emerged as promising therapeutic candidates for IH, providing a valuable basis for future research.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical perspectives: &lt;/strong&gt;Infantile hemangiomas (IH) are very common tumors in the neonatal period, with an incidence of approximately 2% to 10% among newborns, there are no well-defined therapeutic agents for IH, nor are there established human immortalized cell lines for in vitro studies. We establish an immortalized hemangioma-derived endothelial cell (iHemEC) which highly express markers of hemangioma. Drug screening was performed on iHemEC, Everolimus and Sunitinib were found efficiently induce cell death to iHemEC with much lower IC&lt;sub&gt;50&lt;/sub&gt; than front line drug Propranolol. Bulk RNAseq and WB analysis showed that Everolimus specifically inhibit PI3K/AKT/mTOR pathway, however Sunitinib induce chromosome instability and DNA damage. Both drugs can trigger P53 dependent cell death. Our study successfully developed an iHemEC cell line suitable for in vitro drug screening and mechanistic study. Sunitinib, VEGFR inhibitor, potentially can applied for the treatment of IH.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Impact: &lt;/strong&gt;Developed a novel immortalized hemangioma-derived endothelial cell (iHemEC) model that replicates key IH features, overcoming limitations of primary cell models. Identified Sunitinib and Everolimus as promising therapeutic candidates with superior efficacy, supported by transcriptome and protein analyses. Revealed distinct drug mechanisms, with Everolimus targeting PI3K/AKT/mTOR and Sunit","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyclohexanone and metabolites exposure in critically Ill neonates and children.","authors":"Suneetha Desiraju, Emily Zhao, Jordan Kuiper, Cynthia F Salorio, David Graham, Jessie P Buckley, Mark W Russell, Eric M Graham, Danielle Gottlieb Sen, Gregory Ellis, Maureen Gilmore, Lauren Jantzie, Sandra E Juul, Kamala Simkhada, Allen D Everett, Melania M Bembea","doi":"10.1038/s41390-025-04027-8","DOIUrl":"https://doi.org/10.1038/s41390-025-04027-8","url":null,"abstract":"<p><strong>Background: </strong>Cyclohexanone is a volatile organic compound known to be toxic to humans and animals, used in the medical setting as a solvent sealer for intravenous (IV) fluid administration devices. We aimed to determine exposure sources as well as plasma and urine levels of cyclohexanone and metabolites in critically ill infants and children.</p><p><strong>Methods: </strong>We prospectively enrolled children in a single center pediatric intensive care unit (ICU) (n = 66), and conducted a secondary analysis of a multicenter trial in premature neonates (n = 69). Cyclohexanone and its predominant metabolites, trans-1,2-cyclohexanediol and trans-1,4-cyclohexanediol, were measured serially in medical fluids, plasma, and urine.</p><p><strong>Results: </strong>Cyclohexanone was detected in all IV solutions used in standard ICU care (IV fluids, medications, dialysate and red blood cell bags, n = 53 fluid samples). Cyclohexanone and metabolites were higher in urine versus plasma in both cohorts. In premature neonates, plasma and urine cyclohexanone concentrations were highest on day of randomization, while metabolite concentrations were highest on days 7-14.</p><p><strong>Conclusions: </strong>Currently, cyclohexanone may represent an inevitable exposure to children who require intensive care inclusive of IV fluid and medication administration devices. Further studies are needed to develop replacement or mitigation strategies for cyclohexanone exposure in the vulnerable neonatal and pediatric ICU populations.</p><p><strong>Impact: </strong>Direct bloodstream exposure to cyclohexanone in the hospital environment has been poorly described in the healthcare setting. Cyclohexanone was present in all tested types of intravenous solutions used in standard intensive care (intravenous fluids, medications, dialysate and stored red blood cell bags). In a single center pediatric intensive care unit cohort and a multicenter neonatal intensive care unit cohort, cyclohexanone and its metabolites were detected in every blood and urine sample tested. In a multicenter neonatal intensive care unit cohort, plasma and urine cyclohexanone concentrations were highest on day 1 of admission and metabolite concentrations were highest on days 7-14.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomics and multiomics in the age of precision medicine.","authors":"Srinivasan Mani, Seema R Lalani, Mohan Pammi","doi":"10.1038/s41390-025-04021-0","DOIUrl":"10.1038/s41390-025-04021-0","url":null,"abstract":"<p><p>Precision medicine is a transformative healthcare model that utilizes an understanding of a person's genome, environment, lifestyle, and interplay to deliver customized healthcare. Precision medicine has the potential to improve the health and productivity of the population, enhance patient trust and satisfaction in healthcare, and accrue health cost-benefits both at an individual and population level. Through faster and cost-effective genomics data, next-generation sequencing has provided us the impetus to understand the nuances of complex interactions between genes, diet, and lifestyle that are heterogeneous across the population. The emergence of multiomics technologies, including transcriptomics, proteomics, epigenomics, metabolomics, and microbiomics, has enhanced the knowledge necessary for maximizing the applicability of genomics data for better health outcomes. Integrative multiomics, the combination of multiple 'omics' data layered over each other, including the interconnections and interactions between them, helps us understand human health and disease better than any of them separately. Integration of these multiomics data is possible today with the phenomenal advancements in bioinformatics, data sciences, and artificial intelligence. Our review presents a broad perspective on the utility and feasibility of a genomics-first approach layered with other omics data, offering a practical model for adopting an integrated multiomics approach in pediatric health care and research. IMPACT: Precision medicine provides a paradigm shift from a conventional, reactive disease control approach to proactive disease prevention and health preservation. Phenomenal advancements in bioinformatics, data sciences, and artificial intelligence have made integrative multiomics feasible and help us understand human health and disease better than any of them separately. The genotype-first approach or reverse phenotyping has the potential to overcome the limitations of the phenotype-first approach by identifying new genotype-phenotype associations, enhancing the subclassification of diseases by widening the phenotypic spectrum of genetic variants, and understanding functional mechanisms of genetic variations.</p>","PeriodicalId":19829,"journal":{"name":"Pediatric Research","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}