Pediatric Cardiology最新文献

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Novel Computational Model for Recapitulating Patent Ductus Arteriosus Stenting Interventions. 总结动脉导管未闭支架介入的新计算模型。
IF 1.5 4区 医学
Pediatric Cardiology Pub Date : 2025-06-12 DOI: 10.1007/s00246-025-03909-2
Luis René Mata Quiñonez, Leon Cheng, Andrew Marini, Srujana Joshi, Shweta Karnik, Lakshmi P Dasi, Holly D Bauser-Heaton
{"title":"Novel Computational Model for Recapitulating Patent Ductus Arteriosus Stenting Interventions.","authors":"Luis René Mata Quiñonez, Leon Cheng, Andrew Marini, Srujana Joshi, Shweta Karnik, Lakshmi P Dasi, Holly D Bauser-Heaton","doi":"10.1007/s00246-025-03909-2","DOIUrl":"https://doi.org/10.1007/s00246-025-03909-2","url":null,"abstract":"<p><p>Patent Ductus Arteriosus (PDA) stenting is a minimally invasive procedure used to maintain pulmonary blood flow in patients with ductal-dependent cyanotic congenital heart disease. However, because of its high complexity, anatomic variability, and frequent need for reinterventions, improved pre-procedural planning is necessary. In this retrospective study, we developed a physics-based computational framework to simulate PDA stenting using patient-specific data. We applied this method to two patients from a single center: Patient 1 had a type I PDA with a single stent implantation, while Patient 2 had a type II PDA and underwent placement of two stents. We segmented pre-procedural CT scans, modeled guidewire tracking and the bent pre-deployment configurations of the angioplasty balloon and stent, and simulated stent deployment within patient-specific PDA anatomies. Quantitative validation against post-procedural segmentations showed an average distance error of less than 1 mm, demonstrating high accuracy in replicating real-world outcomes. The pipeline effectively captured key mechanical interactions among the stent, balloon, guidewire, and PDA, highlighting phenomena, such as PDA straightening, changes in diameter and orientation, and the displacement of surrounding vasculature during deployment. Future work will integrate semiautomatic tools to predict the best-suited procedural parameters, including stent length, diameter, positioning, and vascular access and predicted risk of complications. Ultimately, our goal is to develop a predictive platform that enhances clinical decision-making, optimizes procedural efficiency, and reduces complications and reinterventions, thereby improving outcomes for pediatric patients undergoing PDA stenting.</p>","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144275566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Initial Experience in the Use of 3D ICE for the Periprocedural Guidance of Percutaneous ASD Closure at a Tertiary Pediatric Center. 三维ICE在三级儿科中心经皮ASD闭合术围手术期指导中的初步应用。
IF 1.5 4区 医学
Pediatric Cardiology Pub Date : 2025-06-11 DOI: 10.1007/s00246-025-03913-6
Justin B Jin, Nazia Husain, Conor P O'Halloran, Paul Tannous, Jeremy Fox, Alan W Nugent, Pei-Ni Jone, Sandhya R Ramlogan
{"title":"An Initial Experience in the Use of 3D ICE for the Periprocedural Guidance of Percutaneous ASD Closure at a Tertiary Pediatric Center.","authors":"Justin B Jin, Nazia Husain, Conor P O'Halloran, Paul Tannous, Jeremy Fox, Alan W Nugent, Pei-Ni Jone, Sandhya R Ramlogan","doi":"10.1007/s00246-025-03913-6","DOIUrl":"https://doi.org/10.1007/s00246-025-03913-6","url":null,"abstract":"<p><p>The dynamic, multiplanar nature of the atrial septum can make ASDs challenging to characterize with 2D imaging. 3D imaging instantly profiles defect(s) in a single, en face view. 2D ICE-guided ASD device closure in the pediatric population has been reported, but 3D ICE-guided closure has not, and the correlation of 3D ICE measurements with fluoroscopic balloon-sizing diameter (BSD) remains unstudied. We describe our initial experience with 3D ICE in the periprocedural evaluation of percutaneous ASD closure. Consecutive patients undergoing percutaneous ASD closure at our institution from July 2022 to July 2023 were included. BSD was measured by the primary interventionalist, and non-invasive ASD dimensions were measured by two investigators intra-procedurally. Correlations were assessed between maximal BSD versus maximal ASD diameter by 2D (TEE, ICE) and 3D modalities (TEE, ICE). Fifteen patients underwent percutaneous ASD closure, and 11/15 (73%) underwent ICE (2D and 3D). Three cases omitted ICE due to equipment unavailability, and one due to inadequate imaging windows related to spinal rods. 10 of 11 patients also underwent TEE, while one had ASD closure by fluoroscopy and ICE alone due to provider preference. Six of ten TEEs (60%) included 3D imaging based on weight cut-off. The median age of ICE patients was 6 years (IQR: 7.5), with a median weight of 20.5 kg (IQR: 35.8). 3D ICE was attempted in all; image quality assessed as 'fair' or 'good' by two reviewers in 8/11 patients. Intraprocedural imaging correlated strongly with BSD [3D ICE vs. BSD (n = 7): ICC = 0.915, p < 0.001)]. Median pre-device deployment evaluation time by ICE was 14 min (IQR: 8.25), and 5 min (IQR: 3.0) post-device deployment. 3D ICE is a viable adjunctive imaging tool for guiding ASD closure procedures within the pediatric cohort, offering safety, efficiency, and congruence with established imaging modalities. Maximal ASD dimensions by 3D ICE correlate well with BSD.</p>","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Open Atrial Septectomy on Placental Support: A Novel and Logistic Approach for Hypoplastic Left Heart Syndrome with Intact Atrial Septum. 胎盘支持下的开放式房间隔切除术:一种治疗房间隔完整左心发育不全综合征的新方法。
IF 1.5 4区 医学
Pediatric Cardiology Pub Date : 2025-06-10 DOI: 10.1007/s00246-025-03922-5
Sameh M Said, Yasin Essa, Ali H Mashadi, Geetha Rajendran, Angela Silber, Alexander Mittnacht, Bianca-Nandini Jambhekar, Sangeeta Kumaraswami, Alexandra Linder, Katherine Glover, Melanie Leong, Matthew Pinto, Aalok R Singh, Kar-Mei Chan, Bhupen Mehta, Supriya Jain, Eric Fethke, Erika B Rosenzweig
{"title":"Open Atrial Septectomy on Placental Support: A Novel and Logistic Approach for Hypoplastic Left Heart Syndrome with Intact Atrial Septum.","authors":"Sameh M Said, Yasin Essa, Ali H Mashadi, Geetha Rajendran, Angela Silber, Alexander Mittnacht, Bianca-Nandini Jambhekar, Sangeeta Kumaraswami, Alexandra Linder, Katherine Glover, Melanie Leong, Matthew Pinto, Aalok R Singh, Kar-Mei Chan, Bhupen Mehta, Supriya Jain, Eric Fethke, Erika B Rosenzweig","doi":"10.1007/s00246-025-03922-5","DOIUrl":"https://doi.org/10.1007/s00246-025-03922-5","url":null,"abstract":"<p><p>Hypoplastic left heart syndrome with intact inter-atrial septum continues to be a challenge with high mortality, despite representing only 6% of those with hypoplastic left heart syndrome. No standard management exists for these patients, and centers vary in their approach depending on expertise and available resources. Interventions range from fetal transcatheter balloon atrial septostomy with or without stent placement-to-postnatal transcatheter, surgical, and/or hybrid strategies. In the current report, we present the first successful Ex utero, Intrapartum Treatment (EXIT)-to-open atrial septectomy-to-rapid stage I Norwood palliation in a neonate with hypoplastic left heart syndrome and intact inter-atrial septum. Creation of unrestrictive atrial communication (open atrial septectomy) was performed at 38 weeks gestation with partial delivery of the fetus who was kept under placental support till the septectomy was completed and without the use of cardiopulmonary bypass. 24-h later, stage I Norwood palliation was completed successfully. In conclusion, Open atrial septectomy under placental support (EXIT) is a logistic approach for hypoplastic left heart syndrome with intact atrial septum. It provides a controlled environment for left atrial decompression and can be followed swiftly with stage I palliation. This rapid sequence first stage palliation may have the potential for producing better results in this challenging subgroup of patients.</p>","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How Should We Grade the Quality of a Transthoracic Echocardiogram: Results from a Survey from the Association for European Pediatric and Congenital Cardiology (AEPC) Imaging Working Group. 我们应该如何评价经胸超声心动图的质量:来自欧洲儿科和先天性心脏病学会(AEPC)成像工作组的一项调查结果。
IF 1.5 4区 医学
Pediatric Cardiology Pub Date : 2025-06-10 DOI: 10.1007/s00246-025-03914-5
Inga Voges, Massimiliano Cantinotti, Owen Miller, Gerald Greil, Heynric Grotenhuis, Almudena Ortiz-Garrido, Francesca Raimondi, Colin J McMahon
{"title":"How Should We Grade the Quality of a Transthoracic Echocardiogram: Results from a Survey from the Association for European Pediatric and Congenital Cardiology (AEPC) Imaging Working Group.","authors":"Inga Voges, Massimiliano Cantinotti, Owen Miller, Gerald Greil, Heynric Grotenhuis, Almudena Ortiz-Garrido, Francesca Raimondi, Colin J McMahon","doi":"10.1007/s00246-025-03914-5","DOIUrl":"https://doi.org/10.1007/s00246-025-03914-5","url":null,"abstract":"<p><p>The aim of this study was to assess the current status about quality grading, resources, and training in pediatric echocardiography, to define gaps in this field, and to develop potential strategies for quality improvement. A structured questionnaire was sent out to pediatric cardiologists within the Association for European Pediatric and Congenital Cardiology (AEPC). The questionnaire contained questions regarding assessment of quality, training and feedback in the field of pediatric echocardiography. Thirty-one European pediatric cardiologists from 17 countries participated. Most participants agreed (n = 28, 90%) that it is important to have standards for echocardiography quality grading for trainees. Objective instruments, however, are largely not available. Among a list of criteria on how to grade quality, quantitative or qualitative criteria with additional formative feedback was ranked highest by the respondents (53%). Although the correct diagnosis, followed by the correct use of two-dimensional (2D) imaging and the correct use of color Doppler across all valves and septae were listed as most important when performing transthoracic echocardiography, a matrix of the eight most important parameters was designed. The results show that quality grading in pediatric echocardiography varies highly among European centers. The matrix provided is a visual instrument whereby trainees can gauge the evolution in their skill as echocardiographers.</p>","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144258682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virtual Reality in Neonatal Ductal Stenting: A New Era in Preprocedural Planning for Ductus Arteriosus Stenting in Complex Congenital Heart Defects with Duct-Dependent Pulmonary Circulation. 新生儿导管支架植入术中的虚拟现实技术:导管依赖肺循环的复杂先天性心脏缺损动脉导管支架植入术前规划的新时代。
IF 1.5 4区 医学
Pediatric Cardiology Pub Date : 2025-06-06 DOI: 10.1007/s00246-025-03908-3
Judyta Szeliga, Karolina Cabaj-Włodarczyk, Sebastian Góreczny
{"title":"Virtual Reality in Neonatal Ductal Stenting: A New Era in Preprocedural Planning for Ductus Arteriosus Stenting in Complex Congenital Heart Defects with Duct-Dependent Pulmonary Circulation.","authors":"Judyta Szeliga, Karolina Cabaj-Włodarczyk, Sebastian Góreczny","doi":"10.1007/s00246-025-03908-3","DOIUrl":"https://doi.org/10.1007/s00246-025-03908-3","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Ductus arteriosus (DA) stenting is a well-established interventional alternative to surgical systemic-to-pulmonary shunts in neonates with congenital heart defects and ductal-dependent pulmonary circulation (DDPC). While it avoids sternotomy and cardiopulmonary bypass, the procedure remains technically demanding, especially in cases involving tortuous or misaligned ductal anatomy. Such anatomical complexity is associated with increased procedural difficulty and a higher rate of reinterventions. Although echocardiography, computed tomography (CT), and angiography remain key imaging modalities, they may be limited in providing comprehensive spatial context. Virtual reality (VR) has recently emerged as a promising tool that enables interactive 3D visualisation of cardiovascular structures and may enhance preprocedural assessment. This study aimed to evaluate the feasibility and potential benefits of CT-derived VR-based 3D modelling for preprocedural planning in neonates undergoing DA stenting for DDPC. The study compared VR-derived anatomical and procedural assessments with conventional angiographic imaging. Between March 2021 and August 2023, six neonates with DDPC underwent preprocedural contrast-enhanced CT and were included in this single-centre retrospective study. Three additional patients referred for DA stenting without CT were excluded. Dedicated VR software (VMersive, Poland) was used to automatically generate interactive 3D models from CT datasets without manual segmentation. The models were evaluated using immersive VR headsets and controller-based tools for precise anatomical assessment. DA morphology, tortuosity classification, total ductal length [L1], straight-line distance [L2], curvature index (CI), optimal fluoroscopic projection, and vascular access were analysed in VR and compared with angiographic data. Paired t-tests were used for statistical comparison, with significance set at p &lt; 0.05. All six VR models were successfully created in under 5 min. Morphological and tortuosity classification: VR-based assessments were consistent with angiographic classification (Type I-III), confirming reliability. Length and curvature: VR-derived [L1] values were significantly longer than angiographic measurements (mean: 28.93 mm vs. 24.14 mm; p = 0.038). Curvature index was significantly higher in VR (mean: 0.46 vs. 0.29; p &lt; 0.001), especially in Type III ducts, suggesting that angiography underestimates vascular tortuosity. Projection planning: Median angular deviation between VR-recommended and final procedural projections was 12° (range: 6-30°, p = 0.259). In cases requiring multiple contrast injections, final projections closely matched VR suggestions, indicating VR's potential to reduce radiation exposure and procedural time. Vascular access: VR-predicted access matched initial operator choice in 3/6 cases (50%), rising to 5/6 (83%) when reinterventions were included. Adjacent structures: VR allowed simultaneous visualisation of D","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Neurodevelopmental Outcomes in Patients Who Undergo Hybrid Stage I Palliation Compared to Norwood Stage I Palliation for Hypoplastic Left Heart Syndrome. 左心发育不全综合征患者接受混合I期姑息治疗与诺伍德I期姑息治疗的早期神经发育结局
IF 1.5 4区 医学
Pediatric Cardiology Pub Date : 2025-06-06 DOI: 10.1007/s00246-025-03911-8
Courtney Thomas, Karen Uzark, Sunkyung Yu, Jeffrey D Zampi, Sara M Trucco, Erica Sood, Caren Goldberg
{"title":"Early Neurodevelopmental Outcomes in Patients Who Undergo Hybrid Stage I Palliation Compared to Norwood Stage I Palliation for Hypoplastic Left Heart Syndrome.","authors":"Courtney Thomas, Karen Uzark, Sunkyung Yu, Jeffrey D Zampi, Sara M Trucco, Erica Sood, Caren Goldberg","doi":"10.1007/s00246-025-03911-8","DOIUrl":"https://doi.org/10.1007/s00246-025-03911-8","url":null,"abstract":"<p><p>Children with congenital heart disease are at increased risk of neurodevelopmental impairment and those with hypoplastic left heart syndrome (HLHS) are among the highest risk group. The first stage of palliation for HLHS, typically performed in the newborn period, is either a Norwood stage I procedure (NS1P) or hybrid stage 1 procedure (HS1P). Our study sought to evaluate the neurodevelopmental outcomes of patients who undergo HS1P compared to NS1P using multicenter registry data. The National Pediatric Cardiology Quality Improvement Collaborative (NPC-QIC) registry was used to identify infants who had either NS1P or HS1P and completed the Ages and Stages Questionnaires-3 (ASQ-3) at age 6 months. Patient and clinical characteristics and ASQ-3 results were compared between HS1P and NS1P groups. A 6-month ASQ-3 was completed in 459 patients, 42 patients following HS1P and 417 following NS1P. Patients who underwent HS1P were more likely to have a birth weight less than 2.5 kg (14.6% vs. 4.2%, p = 0.01) and have a genetic or chromosomal anomaly (19% vs. 8.2%, p = 0.04). Gross motor skills were the most impaired of the measured domains for the entire cohort. There were no significant differences in impairment in any ASQ-3 domain between the groups, even when the analysis was adjusted for pre-operative mechanical ventilation, non-cardiac anomaly, and center. Despite patients who undergo HS1P representing a heterogenous group with other medical comorbidities, their early neurodevelopmental outcomes were comparable to patients who underwent NS1P.</p>","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Factors for Adverse Outcomes in a Fontan Population. Fontan人群不良结果的危险因素。
IF 1.5 4区 医学
Pediatric Cardiology Pub Date : 2025-06-06 DOI: 10.1007/s00246-025-03902-9
Giancarlo Licitra, Lindsey C Ivey, Cheryl L Raskind-Hood, Fred H Rodriguez, Yuting Guo, Abeed Sarker, Wendy M Book
{"title":"Risk Factors for Adverse Outcomes in a Fontan Population.","authors":"Giancarlo Licitra, Lindsey C Ivey, Cheryl L Raskind-Hood, Fred H Rodriguez, Yuting Guo, Abeed Sarker, Wendy M Book","doi":"10.1007/s00246-025-03902-9","DOIUrl":"https://doi.org/10.1007/s00246-025-03902-9","url":null,"abstract":"<p><p>Improved survival following Fontan surgery is tempered by late Fontan failure. Heterogeneous multi-organ complications contribute to eventual Fontan failure varying over time. The prevalence of Fontan-related complications and their association with adverse outcomes were evaluated. A Fontan cohort of 668 pediatric (n = 490) and adult (n = 178) patients from two healthcare systems were linked to 2010-2019 healthcare encounters and death certificates. Bivariate analyses examined covariates by the primary composite outcome of heart transplant, hepatocellular carcinoma (HCC) or death. Multivariate logistic regression explored associations of risk factors with the primary composite outcome and a secondary outcome of hospitalization. Kaplan-Meier curves compared freedom from the primary composite outcome stratified by number of concurrent risk factors at initial encounter. Of 668 Fontan patients, 12.3% developed the primary composite outcome (21.3% adults, 9.0% children). Clinical risk factors increased with age and time, and were significantly associated with HCC, a component of the primary outcome. Patients with 3 + risk factors had significantly worse survival (log-rank p < 0.01). Heart failure (HF) was the strongest independent predictor of outcomes (aOR 5.90, p < 0.01). Dysrhythmia, cyanosis, and HF were associated with more hospitalizations. The primary composite outcome was 4-fold higher with 3 + risk factors (aOR 3.71, 95% CI 2.26-6.16), significant in children (aOR 3.01, 95% CI 1.17-7.0), and adults (aOR 2.58, 95% CI 1.04-7.48). Complications increase as Fontan patients age and are associated with transplant, HCC, death, and hospitalizations in a pediatric and adult cohort. Early identification and intervention for Fontan-related complications may improve late outcomes.</p>","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: The Use of Pulmonary Vasodilators in Pediatric Patients with Single-Ventricle Palliation: A Ten-Year Experience in a Tertiary Care Center. 更正:在单心室姑息治疗的儿科患者中使用肺血管扩张剂:一个三级医疗中心的十年经验。
IF 1.5 4区 医学
Pediatric Cardiology Pub Date : 2025-06-06 DOI: 10.1007/s00246-025-03900-x
Rita Blandino, Lucia Manuri, Pasqualina Bruno, Laura Ragni, Enrico Piccinelli, Mara Pilati, Micol Rebonato, Gianluca Brancaccio, Gianfranco Butera, Antonella Santilli, Lorenzo Galletti, Roberta Iacobelli
{"title":"Correction: The Use of Pulmonary Vasodilators in Pediatric Patients with Single-Ventricle Palliation: A Ten-Year Experience in a Tertiary Care Center.","authors":"Rita Blandino, Lucia Manuri, Pasqualina Bruno, Laura Ragni, Enrico Piccinelli, Mara Pilati, Micol Rebonato, Gianluca Brancaccio, Gianfranco Butera, Antonella Santilli, Lorenzo Galletti, Roberta Iacobelli","doi":"10.1007/s00246-025-03900-x","DOIUrl":"10.1007/s00246-025-03900-x","url":null,"abstract":"","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Systemic Ventricular Morphology on Age-Adjusted (zlog-)NT-proBNP in Children with Univentricular Hearts. 单室心脏患儿全身心室形态学对年龄校正(zlog-)NT-proBNP的影响。
IF 1.5 4区 医学
Pediatric Cardiology Pub Date : 2025-06-03 DOI: 10.1007/s00246-025-03898-2
Jonas Palm, Carolin Niedermaier, Stefan Holdenrieder, Georg Hoffmann, Frank Klawonn, Jürgen Hörer, Masamichi Ono, Peter Ewert
{"title":"Impact of Systemic Ventricular Morphology on Age-Adjusted (zlog-)NT-proBNP in Children with Univentricular Hearts.","authors":"Jonas Palm, Carolin Niedermaier, Stefan Holdenrieder, Georg Hoffmann, Frank Klawonn, Jürgen Hörer, Masamichi Ono, Peter Ewert","doi":"10.1007/s00246-025-03898-2","DOIUrl":"https://doi.org/10.1007/s00246-025-03898-2","url":null,"abstract":"<p><p>As a marker of cardiac wall stress, NT-proBNP offers high prognostic and diagnostic potential in patients with a functional single ventricle (fSV). Its levels depend on both age and stage of palliation. However, the impact of systemic ventricular morphology on this biomarker remains unclear. Children undergoing staged palliation, i.e. systemic-to-pulmonary shunt (SPS), ductal stenting (DS) and/or pulmonary artery banding (PAB) as stage 1, bidirectional cavopulmonary shunt (BCPS) as stage 2 or extracardiac total cavopulmonary connection (TCPC) as stage 3 at our institution between 2011 and 2023 were identified. Those, who had NT-proBNP determined at most 7 days before intervention or surgery were included. Furthermore, patients at least 6 months after TCPC with ambulatory measured NT-proBNP were enrolled. NT-proBNP levels were evaluated using its age-adjusted z-score (\"zlog-NT-proBNP\"), allowing comparison irrespective of the distinctive physiological decline with age. Overall, 618 children met the eligibility criteria. Thereof, 356 patients had a systemic right ventricle (SRV) and 262 a systemic left ventricle (SLV). At each stage of palliation, age-adjusted zlog-NT-proBNP was significantly higher in patients with an SRV compared to an SLV: before SPS/DS/PAB (median 3.43 vs 2.62, p < 0.001); before BCPS (median 3.33 vs 2.04, p < 0.001); before TCPC (median 1.50 vs 0.66, p < 0.001); and after TCPC (median 1.62 vs 0.81, p < 0.001). Systemic ventricular morphology highly affects (zlog-)NT-proBNP levels in fSV patients at each stage of palliation. When interpreting NT-proBNP levels in these patients, clinicians and future studies should take into account that children with an SRV reveal higher NT-proBNP levels than those with an SLV.</p>","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144209033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Mental Health Curriculum Pilot for Pediatric Cardiology Fellows: Preparing the Subspecialist to Expand the Team. 小儿心脏病学研究员的新型心理健康课程试点:让亚专科医生为扩大团队做好准备。
IF 1.5 4区 医学
Pediatric Cardiology Pub Date : 2025-06-01 Epub Date: 2024-06-05 DOI: 10.1007/s00246-024-03532-7
Amanda D McCormick, Sonal T Owens, Heang M Lim, Carolyn Vitale, Catherine Dusing, Kelly E Rea, Jessica Pierce, Nasuh Malas, Melissa K Cousino
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