Pediatric Cardiology最新文献

{"title":"Long-Term Outcomes of Atrial Septal Defect Closure in Adults Older than 50 Years.","authors":"Dinesh Raja Palanisamy, P Harish, Arun Gopalakrishnan, Aswathy Chandran, Kavassery Mahadevan Krishnamoorthy, Harikrishnan Sivadasanpillai","doi":"10.1007/s00246-025-04157-0","DOIUrl":"10.1007/s00246-025-04157-0","url":null,"abstract":"","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":"3532-3540"},"PeriodicalIF":1.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145990407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Prediction of Symptoms and Evaluation of Surgical Indications After Birth Based on Tracheal Morphology of Double Aortic Arch.","authors":"Takeshi Ikegawa, Akio Kato, Motoyoshi Kawataki, Yoshinori Inagaki, Katsuaki Toyoshima, Hideaki Ueda","doi":"10.1007/s00246-026-04209-z","DOIUrl":"10.1007/s00246-026-04209-z","url":null,"abstract":"","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":"3615-3621"},"PeriodicalIF":1.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13687234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147513981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Modification of Temporary Suture-Holding Technique for Transcatheter Repair of Sinus Venosus Atrial Septal Defect.","authors":"Ihsan A Elhalabi, Ziyad M Hijazi","doi":"10.1007/s00246-025-04154-3","DOIUrl":"10.1007/s00246-025-04154-3","url":null,"abstract":"<p><p>Transcatheter repair of superior sinus venosus atrial septal defect (SVASD) and associated partial anomalous pulmonary venous return (PAPVR) using a covered stent has evolved as a less invasive alternative to surgery. Precise control of stent position remains a key technical challenge during the procedure. Previously, our group has reported on the suture technique with improved outcome. Here, we further report on an enhanced/modified suture technique. We report on a 14-year young boy with a superior SVASD associated with PAPVR of the right middle and upper pulmonary veins who underwent a successful transcatheter repair of the defect using a covered stent with a modification of the previously described novel temporary suture-holding technique by our group. The new modified technique (the holding-wire technique-HWT) uses a 150 cm, 0.018\" Terumo® guidewire positioned in the outermost strut of the stent and both ends of the wire are exteriorized from the internal jugular vein to hold the stent temporarily instead of the suture. This allowed precise control and better grip of the attached stent, as well as visualizing the wire on fluoroscopy throughout the procedure. An 80-mm covered stent was deployed and anchored with a 28-mm bare-metal stent proximally, achieving complete exclusion of the atrial communication and rerouted the anomalous vein flow to the left atrium without any obstruction. This simple modification enhances procedural control and safety, and may broaden the clinical applicability of transcatheter SVASD closure.</p>","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":"3604-3608"},"PeriodicalIF":1.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13687183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146011547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative Continuous Propofol Infusion in the Pediatric Cardiac Intensive Care Unit: A 25-Year Retrospective Study.","authors":"Oluwatomini A Fashina, Grace M Arteaga, Sheri S Crow, Joseph A Dearani, Xai Khang, Nicole M Andrijasevic, Danette L Bruns, Ashley V Wong Grossman","doi":"10.1007/s00246-025-04120-z","DOIUrl":"10.1007/s00246-025-04120-z","url":null,"abstract":"<p><p>In pediatric cardiac critical care, patients often require specific anesthesia and sedation considerations due to unique physiological vulnerabilities. This study assessed the incidence of propofol-related infusion syndrome (PRIS) in Pediatric Cardiac Intensive Care Unit (PCICU) patients receiving continuous propofol infusion for non-procedural sedation. We conducted a retrospective review of post-operative congenital heart disease patients < 18 years admitted to the PCICU from 1/1/2000-9/30/2024, who received continuous propofol infusions ≥ 12 hours and/or ≥ 2.4 mg/kg/hour. The primary outcome was the incidence of PRIS. Secondary outcomes included intensive care unit (ICU) length of stay and survival to hospital discharge. Statistical analyses included chi-square tests and the Kruskal-Wallis test, stratified by physiological complexity (single vs. double ventricle) and surgical mortality risk scores (The Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery [STAT] score). A total of 641 patients were included. No statistically significant differences in propofol characteristics were found across physiologic or surgical risk groups. The median infusion rate was 1.2 mg/kg/hour, with a median duration of 22.7 hours. No cases of PRIS occurred. Survival to hospital discharge was 97%. The median ICU length of stay was 7.1 days. In this single center, retrospective study of post-operative congenital heart disease patients, continuous propofol infusion was not associated with any cases of PRIS. These findings support the cautious use of propofol in pediatric cardiac critical care. Further prospective studies are needed to evaluate safety across the heterogenous congenital heart disease population, including those with single ventricle physiology.</p>","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":"3332-3341"},"PeriodicalIF":1.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13687288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145687717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Paradigm Shift in Congenital Heart Disease: A Scientometric Portrait of the Rise of Computational Intelligence.","authors":"Qingyong Zheng, Molan Li, Yongjia Zhou, Jianguo Xu, Ming Liu, Yating Cui, Junfei Wang, Jinhui Tian","doi":"10.1007/s00246-025-04102-1","DOIUrl":"10.1007/s00246-025-04102-1","url":null,"abstract":"<p><p>The application of artificial intelligence (AI) to congenital heart disease (CHD) has become a rapidly expanding field, promising to transform diagnostics, prognostics, and management. However, a comprehensive map of the global research landscape, its key contributors, thematic structure, and evolutionary trends is currently lacking. This study provides a bibliometric analysis to delineate this dynamic domain. We conducted a systematic search of the Web of Science Core Collection for all publications related to AI in CHD up to December 31, 2024. Bibliometric analyses were performed using VOSviewer and the Bibliometrix R package to map publication trends, international collaboration networks, leading contributors, and the conceptual structure of the field through co-occurrence and thematic mapping. Our analysis of 500 publications revealed an exponential growth in research output since 2020. The United States, China, and the United Kingdom were the most productive countries, forming central hubs in a robust international collaboration network. Harvard University and the University of London were the leading institutions. Thematic analysis identified six dominant research clusters: (1) AI-enhanced surgical/interventional support, (2) prenatal diagnosis via imaging, (3) disease-specific outcome modeling (e.g., Tetralogy of Fallot), (4) advanced imaging analytics with deep learning, (5) comprehensive risk and outcome management, and (6) pediatric cardiology applications. Temporal analysis confirmed a decisive recent shift towards deep learning methodologies, and analysis of highly cited works underscored the impact of AI in imaging and prognostic modeling. The convergence of AI and CHD has matured into a vibrant, clinically-focused research field with a clear technological trajectory towards deep learning. This global research panorama highlights established strengths in imaging and diagnostics while pointing to emerging frontiers in personalized medicine and interventional support. Fostering greater collaboration and focusing on clinical translation, model explainability, and equity will be crucial for realizing the full potential of this AI-driven transformation in improving care for patients with CHD.</p>","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":"3195-3209"},"PeriodicalIF":1.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145564795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid Regression of Myocardial Hypertrophy with First-Line Avalglucosidase Alfa in Infantile-Onset Pompe Disease: A Case Report.","authors":"Natsumi Uemura, Mitsuhiro Fujino, Shinji Higuchi, Kae Nakamura, Takeshi Sasaki, Yuki Kawasaki, Jun Mori, Eiji Ehara, Hisashi Sugiyama","doi":"10.1007/s00246-025-04152-5","DOIUrl":"10.1007/s00246-025-04152-5","url":null,"abstract":"<p><p>A male infant born at 38 weeks of gestation was found to have myocardial hypertrophy on neonatal screening echocardiography, with a left ventricular mass index (LVMI) of 102.1 g/m² (Z-score 3.1). No skeletal muscle weakness was noted. At 2 months, he developed feeding difficulty and progressive myocardial hypertrophy and was rehospitalized at 3 months with severe cardiomegaly (LVMI 419.5 g/m², Z-score 12.3) and respiratory distress. Based on reduced GAA enzymatic activity and genetic testing revealing a pathogenic GAA mutation, infantile-onset Pompe disease (IOPD) was confirmed. Enzyme replacement therapy (ERT) with avalglucosidase alfa 40 mg/kg every 2 weeks was initiated. Myocardial hypertrophy and heart failure symptoms began to improve within 1 week after initiation of ERT. The LVMI had decreased to approximately one-third of the baseline value (148.0 g/m², Z-score 5.2) at 8 weeks, and it had normalized (67.2 g/m², Z-score 1.5) at 16 weeks of ERT. During the 36-month follow-up, the LVMI remained within the normal range and no treatment-related adverse events occurred. Avalglucosidase alfa produced rapid and substantial regression of myocardial hypertrophy in this atypical IOPD case lacking skeletal muscle involvement. These findings may support the early introduction of avalglucosidase alfa as a first-line therapy to reverse cardiac remodeling and improve clinical outcomes in IOPD.</p>","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":"3600-3603"},"PeriodicalIF":1.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145934688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter Management of Pulmonary Vein Stenosis in Children.","authors":"Connie Choi, Ryan Callahan","doi":"10.1007/s00246-025-04130-x","DOIUrl":"10.1007/s00246-025-04130-x","url":null,"abstract":"<p><p>Pediatric intraluminal pulmonary vein stenosis (PVS) is a challenging condition where the diagnosis is confirmed via cardiac catheterization. The patient population is complex with inherent hemodynamic vulnerabilities, and the high rate of restenosis necessitates recurrent, technically demanding transcatheter interventions. Furthermore, decisions made during each procedure can have a lasting impact on future care. To address these challenges, we present a guideline for transcatheter interventions for PVS, informed by both published literature and the Authors' clinical experience.</p>","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":"3244-3257"},"PeriodicalIF":1.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145743720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous Coronary Intervention in Pediatric Post Heart Transplant Recipients with Advanced CAV: Delaying the Inevitable.","authors":"Matthew S Purlee, John-Anthony Coppola, Lindsey M Brinkley, Dalia Lopez-Colon, James C Fudge, Himesh V Vyas, Dipankar Gupta","doi":"10.1007/s00246-025-04107-w","DOIUrl":"10.1007/s00246-025-04107-w","url":null,"abstract":"<p><p>Coronary allograft vasculopathy (CAV) is a leading cause of allograft failure in pediatric heart transplant recipients. Percutaneous coronary intervention (PCI) is performed to manage atherosclerotic coronary artery disease. However, there is currently limited data regarding use and long-term benefit of PCI due to the diffuse nature of coronary disease in CAV. We sought to evaluate our experience utilizing PCI for CAV. Patients followed at our center who were transplanted as pediatric patients who developed CAV and subsequently underwent PCI were included. Demographic variables were collected, including pre- and post-transplant, pre- and post-PCI, and follow-up data. Categorical variables are presented as N (%) and continuous variables as median (IQR). Kaplan-Meier survival estimates approximated freedom from retransplantation or death. Our cohort had 17 patients who underwent 21 PCI procedures. Of these, 9 (52.9%) were males, 10 (58.8%) were white, and the median age at transplant was 13.6 years [10.4,16.4]. The median age at CAV detection was 16.2 [13.8,19.1] years, and the median time from transplant to first PCI was 7.7 years [5.5,9.2]. Five patients had congenital heart disease, 12 had cardiomyopathy as indication for transplantation. At last follow-up, 4 patients required a repeat PCI, 3 patients underwent retransplant, and 5 patients died. Kaplan-Meier estimates show freedom from death or retransplantation of 88% at 1 years, 64% at 3 years, and 57% at 5 years after initial PCI. In our cohort with advanced CAV, PCI showed favorable immediate outcomes with freedom from death or retransplant in 57% patients at 5 years.</p>","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":"3278-3286"},"PeriodicalIF":1.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145945446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National Trends and Disparities in Congenital Heart Disease Mortality in the United States, 1999-2024.","authors":"Sandesh Raja, Mahdi Muneer S Albrahim, Bader Fahad Aldhafeeri, Abrar Abdulrahman Omar, Bashayer Abdulhameed Alqadeeb, Maha Mohammed Alhuways, Abdullah Abdulaziz Bangaryd, Munia Ghassan Alqahtany, Ahmed Baqer Alfaraj, Rayan Saleh Almughyir, Sama T AlRasheed, Mohammed Alfaifi","doi":"10.1007/s00246-025-04156-1","DOIUrl":"10.1007/s00246-025-04156-1","url":null,"abstract":"","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":"3520-3531"},"PeriodicalIF":1.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145959626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement Between Echocardiography and Cardiac MRI in Assessing Function, Strain, and Fibrosis in Pediatric Hypertrophic Cardiomyopathy: A Preliminary Study.","authors":"Nida Gülderen Kalay Şentürk, Ali Karakaş, Sevim Aslı Ehlil, Emine Şebnem Memiş Durmaz, Hazal Cansu Çulpan, İlker Kemal Yücel, Reyhan Dedeoğlu","doi":"10.1007/s00246-025-04151-6","DOIUrl":"10.1007/s00246-025-04151-6","url":null,"abstract":"<p><p>Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease in children and is associated with arrhythmia, heart failure, and sudden cardiac death. Early detection of myocardial dysfunction and fibrosis is essential for risk stratification. Transthoracic echocardiography (TTE) is the primary diagnostic tool but has limitations, while cardiac magnetic resonance imaging (MRI) provides superior structural and fibrosis assessment. Speckle-tracking echocardiography (STE) offers sensitive markers of subclinical dysfunction, yet comparative pediatric data are limited. To investigate the concordance between TTE, STE, and MRI in pediatric HCM and to evaluate relationships between fibrosis, diastolic function, and strain parameters. Patients were categorized as sarcomeric (genetic/idiopathic) or phenocopy/non-sarcomeric (metabolic, syndromic, or endocrine) HCM according to guideline-based classification. Twenty-five HCM patients were included in this cross-sectional prospective study. All underwent clinical evaluation, TTE, and ECG; MRI was performed when eligible. Sarcomeric and phenocopy subgroups were analyzed separately. Septal thickness, LV mass, EF, and volumes were measured by TTE and MRI, while global and segmental strain values were obtained by 2D-STE. Diastolic function and fibrosis (LGE) were also assessed. Strong agreement was observed between TTE and MRI for septal thickness and LV mass, while EF differed. Complete concordance was found between 2D-STE and MRI for EF and volumes. Global strain values correlated highly, but segmental variability was noted, with strong agreement in the apical lateral segment. GLS was pathological in 77% of sarcomeric and 83% of non-sarcomeric patients. No significant difference in diastolic function was observed according to fibrosis. 2D-STE may serve as a reliable alternative to MRI for serial EF and volume monitoring in pediatric HCM. Despite segmental variability, strong global strain correlation supports complementary use. The observation that diastolic dysfunction may precede fibrosis highlights its role as an early clinical marker.</p>","PeriodicalId":19814,"journal":{"name":"Pediatric Cardiology","volume":" ","pages":"3492-3501"},"PeriodicalIF":1.3,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146011582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}