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Pharmacological research communications最新文献

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Editorial announcement 编辑公告
Pharmacological research communications Pub Date : 1988-12-01 Epub Date: 2007-09-04 DOI: 10.1016/S0031-6989(88)80722-7
Rodolfo Paoletti (Executive Editor)
{"title":"Editorial announcement","authors":"Rodolfo Paoletti (Executive Editor)","doi":"10.1016/S0031-6989(88)80722-7","DOIUrl":"https://doi.org/10.1016/S0031-6989(88)80722-7","url":null,"abstract":"","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 12","pages":"Page 1015"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80722-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137426971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence that a gabaergic mechanism influences the development of obesity in obese zucker rats gabaergy机制影响肥胖zucker大鼠肥胖发展的证据
Pharmacological research communications Pub Date : 1988-12-01 Epub Date: 2007-09-04 DOI: 10.1016/S0031-6989(88)80739-2
Squadrito F., Sturniolo R., Arcadi F., Arcoraci V., Caputi A.P.
{"title":"Evidence that a gabaergic mechanism influences the development of obesity in obese zucker rats","authors":"Squadrito F., Sturniolo R., Arcadi F., Arcoraci V., Caputi A.P.","doi":"10.1016/S0031-6989(88)80739-2","DOIUrl":"10.1016/S0031-6989(88)80739-2","url":null,"abstract":"","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 12","pages":"Pages 1087-1088"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80739-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14111182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Disopyramide pharmacokinetics in the elderly after single oral administration 老年人单次口服双双酰胺的药代动力学
Pharmacological research communications Pub Date : 1988-12-01 Epub Date: 2007-09-04 DOI: 10.1016/S0031-6989(88)80724-0
Padrini Roberto , Bernini Vitaliano , Piovan Donatella , Moretto Raffaella , Bova Sergio , Cargnelli Gabriella
{"title":"Disopyramide pharmacokinetics in the elderly after single oral administration","authors":"Padrini Roberto ,&nbsp;Bernini Vitaliano ,&nbsp;Piovan Donatella ,&nbsp;Moretto Raffaella ,&nbsp;Bova Sergio ,&nbsp;Cargnelli Gabriella","doi":"10.1016/S0031-6989(88)80724-0","DOIUrl":"10.1016/S0031-6989(88)80724-0","url":null,"abstract":"<div><p>Disopyramide (D) kinetics were studied after single oral dose (200 mg) in ten elderly male patients (mean age: 75.5 yrs) without clinical or laboratory signs of hepatic, renal or cardiac disease, and in six healthy male subjects. They were all non smokers and had not taken alcohol for at least 10 days. Peak plasma concentration and area under the curve (AUCo-oo) were 54% and 51% respectively higher in the elderly group, whereas plasma half life was virtually the same in both groups (about 9 hrs).</p><p>The major D metabolite, mono-N-desisopropyldisopyramide (MND), showed a tendency towards an increase of AUCo-24h and T1/2 but did not reach the 5% significance level. Eight of the ten elderly patients but only tow of the six young subjects complained of anticholinergic side effects. On the basis of the pharmacokinetic changes observed (and provided that plasma protein binding is unchanged), D oral dose should be reduced by 1/3, without modifying the dosage interval.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 12","pages":"Pages 1025-1034"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80724-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14341169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Modifications of quiescence and functional activity of glial cultured cells by phospholipase A2-prostaglandin system inhibition 磷脂酶a2 -前列腺素系统抑制对胶质细胞静息和功能活性的影响
Pharmacological research communications Pub Date : 1988-12-01 Epub Date: 2007-09-04 DOI: 10.1016/S0031-6989(88)80730-6
Ciccarelli R., Di Iorio P., Ballerini P., Tacconelli L.
{"title":"Modifications of quiescence and functional activity of glial cultured cells by phospholipase A2-prostaglandin system inhibition","authors":"Ciccarelli R.,&nbsp;Di Iorio P.,&nbsp;Ballerini P.,&nbsp;Tacconelli L.","doi":"10.1016/S0031-6989(88)80730-6","DOIUrl":"10.1016/S0031-6989(88)80730-6","url":null,"abstract":"","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 12","pages":"Pages 1069-1070"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80730-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14341175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A stereospecific binding site regulates the C1− ion channel in rat skeletal muscle 一个立体特异性结合位点调节大鼠骨骼肌中的C1 -离子通道
Pharmacological research communications Pub Date : 1988-12-01 Epub Date: 2007-09-04 DOI: 10.1016/S0031-6989(88)80734-3
D. Conte Camerino , V. Tortorella , G. Bettoni , S.H. Bryant , A. De Luca , M. Mambrini , D. Tricarico , G. Grasso
{"title":"A stereospecific binding site regulates the C1− ion channel in rat skeletal muscle","authors":"D. Conte Camerino ,&nbsp;V. Tortorella ,&nbsp;G. Bettoni ,&nbsp;S.H. Bryant ,&nbsp;A. De Luca ,&nbsp;M. Mambrini ,&nbsp;D. Tricarico ,&nbsp;G. Grasso","doi":"10.1016/S0031-6989(88)80734-3","DOIUrl":"10.1016/S0031-6989(88)80734-3","url":null,"abstract":"","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 12","pages":"Pages 1077-1078"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80734-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13608257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Pharmacological block of chloride channels during development affects contractile and electrical properties of rat skeletal muscle 发育过程中氯离子通道的药物阻断影响大鼠骨骼肌的收缩和电特性
Pharmacological research communications Pub Date : 1988-12-01 Epub Date: 2007-09-04 DOI: 10.1016/S0031-6989(88)80735-5
A. De Luca , D. Conte Camerino , G. Vrbovà , A. Connold
{"title":"Pharmacological block of chloride channels during development affects contractile and electrical properties of rat skeletal muscle","authors":"A. De Luca ,&nbsp;D. Conte Camerino ,&nbsp;G. Vrbovà ,&nbsp;A. Connold","doi":"10.1016/S0031-6989(88)80735-5","DOIUrl":"10.1016/S0031-6989(88)80735-5","url":null,"abstract":"","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 12","pages":"Pages 1079-1080"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80735-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13608258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional interaction between GABA receptors and type I benzo-diazepine recognition sites in the spinal cord of the rat GABA受体与大鼠脊髓I型苯并二氮卓类药物识别位点的功能相互作用
Pharmacological research communications Pub Date : 1988-12-01 Epub Date: 2007-09-04 DOI: 10.1016/S0031-6989(88)80740-9
B. Longoni, M.G. Corda, G. Biggio
{"title":"Functional interaction between GABA receptors and type I benzo-diazepine recognition sites in the spinal cord of the rat","authors":"B. Longoni,&nbsp;M.G. Corda,&nbsp;G. Biggio","doi":"10.1016/S0031-6989(88)80740-9","DOIUrl":"10.1016/S0031-6989(88)80740-9","url":null,"abstract":"","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 12","pages":"Pages 1089-1090"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80740-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13986586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TLC determination of flavonoid accumulation in clonal populations of Passiflora incarnata L. 西番莲无性系群体黄酮积累的TLC测定。
Pharmacological research communications Pub Date : 1988-12-01 Epub Date: 2009-02-19 DOI: 10.1016/S0031-6989(88)80854-3
Menghini A., Mancini L.A.
{"title":"TLC determination of flavonoid accumulation in clonal populations of Passiflora incarnata L.","authors":"Menghini A.,&nbsp;Mancini L.A.","doi":"10.1016/S0031-6989(88)80854-3","DOIUrl":"10.1016/S0031-6989(88)80854-3","url":null,"abstract":"<div><p>Flavonoid production and accumulation during the ontogenic cycle of <em>Passiflora incarnate</em> L. was studied. The highest concentration of isovitexin accurred between pre-flowering and flowering stages. The greatest accumulation of flavonoids took place in the leaveas. Furthermore some pharmacodiagnostic characteristics of the drug of <em>P. incarnata</em> were specified using a Scanning Electron Microscope.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 ","pages":"Pages 113-116"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80854-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14377592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
A study of the diterpene alkaloids of Aconitum napellus ssp. neomontanum During its onthogenetic cycle 黑头乌头二萜生物碱的研究。在其本体形成周期中
Pharmacological research communications Pub Date : 1988-12-01 Epub Date: 2009-02-19 DOI: 10.1016/S0031-6989(88)80856-7
Maria Laura Colombo , Margherita Bravin , Franca Tome
{"title":"A study of the diterpene alkaloids of Aconitum napellus ssp. neomontanum During its onthogenetic cycle","authors":"Maria Laura Colombo ,&nbsp;Margherita Bravin ,&nbsp;Franca Tome","doi":"10.1016/S0031-6989(88)80856-7","DOIUrl":"10.1016/S0031-6989(88)80856-7","url":null,"abstract":"<div><p>Qualitative and quantitative variations in the diterpene alkaloids content in the neomontanum subspecies of Aconitum napellus, growing near lake of Como, were studied throughout its complete onthogenetic cycle. Aconitine, N-deethylaconitine and two compounds with m.w.- 688 and m.w. = 629 have been detected in the various organs of plant almost at any time during the vegetative cycle.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 ","pages":"Pages 123-128"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80856-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14377594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Localization of the active principles of the male fern (Dryopteris filixmas (L.) Schott.) by fluorescence microscopy 雄性蕨类植物(Dryopteris filixmas (L.))活性原理的定位肖特)荧光显微镜
Pharmacological research communications Pub Date : 1988-12-01 Epub Date: 2009-02-19 DOI: 10.1016/S0031-6989(88)80858-0
G.G. Franchi, S. Ferri
{"title":"Localization of the active principles of the male fern (Dryopteris filixmas (L.) Schott.) by fluorescence microscopy","authors":"G.G. Franchi,&nbsp;S. Ferri","doi":"10.1016/S0031-6989(88)80858-0","DOIUrl":"10.1016/S0031-6989(88)80858-0","url":null,"abstract":"<div><p>The active principles of the male fern, <em>Dryopteris filix-mas</em> (L.) Schott., consisting of a mixture of phloroglucinol derivatives called “crude filicin”, are localized by means of fluorescence microscopy under U.V. 365 nm and monochromatic blue 435-490 nm lights.</p><p>Crude filicin is autofluorescent, and therefore may be easily localized in the internal glandular hairs of the intercellular spaces of rhizome and leaf bases parenchyma, without pre-treatment of sections.</p><p>Localization is confirmed both morphologically and chemically, and is possible on a fresh material, as well as on a desiccated one.</p><p>The test allows also a complete anatomical examination of sections, and may be useful, for its easiness and quickness, in further taxonomic or pharmacognostic studies.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 ","pages":"Pages 135-138"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80858-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14377596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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