R. De Pasquale , C. Circosta , F. Occhiuto , S. De Stefano , S. De Rosa
{"title":"Central nervous system activity of terpenoids from marine sponge","authors":"R. De Pasquale , C. Circosta , F. Occhiuto , S. De Stefano , S. De Rosa","doi":"10.1016/S0031-6989(88)80833-6","DOIUrl":"10.1016/S0031-6989(88)80833-6","url":null,"abstract":"<div><p>Some terpenoids extracted from marine sponge: triacetylated disidein, 2-tetraprenyl benzoquinol and 4 hydroxy-3-tetraprenylbenzoic acid 2-polyprenyl benzoquinols, avarol and furospongin-1 were tested by multidimensional Irwin screening and with some tests for analgesic and muscle relaxant activity. The three prenylhydroquinols derivatives and avarol show a good analgesic activity and low toxicity.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 ","pages":"Pages 23-26"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80833-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14043415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Meucci, T. Florio, M. Grimaldi, E. Landolfi, G. Magri, G. Schettini
{"title":"Role of G-proteins in mediating dihydropyridine receptor coupling with voltage sensitive calcium channels","authors":"O. Meucci, T. Florio, M. Grimaldi, E. Landolfi, G. Magri, G. Schettini","doi":"10.1016/S0031-6989(88)80737-9","DOIUrl":"10.1016/S0031-6989(88)80737-9","url":null,"abstract":"","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 12","pages":"Pages 1083-1084"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80737-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13986584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Perfumi M. , do Caro G. , Panocka I. , Polidori C. , Massi M.
{"title":"Effects of kassinin, a tachykinin of the skin of the African frog Kassina senegalensis, on body fluid homeostasis in rats","authors":"Perfumi M. , do Caro G. , Panocka I. , Polidori C. , Massi M.","doi":"10.1016/S0031-6989(88)80843-9","DOIUrl":"10.1016/S0031-6989(88)80843-9","url":null,"abstract":"<div><p>In Wistar rats loaded with SC hypartonic NaCl solution kassinin producos an inhibition of cell-dehydration drinking which lasts soveral hours. The long duration of the effect does not depend on a renal excretion of sodium but, hypothetically, on a redistribution of electrolytes between the extra- and the intra-cellular compartments of body fluids.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 ","pages":"Pages 67-70"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80843-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14376290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Tubaro , P. Del Negro , E. Ragazzi , S. Zampiron , R. Della Loggia
{"title":"Anti-inflammatory and peripheral analgesic activity of esculetin in vivo","authors":"A. Tubaro , P. Del Negro , E. Ragazzi , S. Zampiron , R. Della Loggia","doi":"10.1016/S0031-6989(88)80847-6","DOIUrl":"10.1016/S0031-6989(88)80847-6","url":null,"abstract":"<div><p>Esculetin determined a reduction in oedema and granulocyte infiltration in the Croton oil ear test in vivo. The drug was able to inhibit Acethylcholine-writhing test and showed a LD50 of 1450 mg/kg i.p. and > 2000 mg/kg by mouth. In our experimental conditions, esculetin has an anti-inflammatory and analgesic effect.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 ","pages":"Pages 83-85"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80847-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14396385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Flavonoids modify calcium ions and calcitonin plasma levels in the rat","authors":"A. Saija , N. D'Amico , R. De Pasquale , G. Costa","doi":"10.1016/S0031-6989(88)80729-X","DOIUrl":"10.1016/S0031-6989(88)80729-X","url":null,"abstract":"","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 12","pages":"Pages 1067-1068"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80729-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14341173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabbrielli G. , Loggini F. , Cioni P.L. , Giannaccini B. , Mancuso E.
{"title":"Activity of lavandino essential oil against non-tubercular opportunistic rapid grown mycobacteria","authors":"Gabbrielli G. , Loggini F. , Cioni P.L. , Giannaccini B. , Mancuso E.","doi":"10.1016/S0031-6989(88)80836-1","DOIUrl":"10.1016/S0031-6989(88)80836-1","url":null,"abstract":"<div><p>Four samples of lavandino essential oil were investigated for their antimycobacterial activity, and were found to be very effective against some strains of non-tubercolar Mycobacteria (NTM). The mechanism of this effect is discussed.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 ","pages":"Pages 37-40"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80836-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14376282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Rossi , M. Melegari , A. Bianchi , A. Albasini , G. Vampa
{"title":"Sedative, anti-inflammatory and anti-diuretic effects induced in rats by essential oils of varieties of Anthemis nobilis: A comparative study","authors":"T. Rossi , M. Melegari , A. Bianchi , A. Albasini , G. Vampa","doi":"10.1016/S0031-6989(88)80844-0","DOIUrl":"10.1016/S0031-6989(88)80844-0","url":null,"abstract":"<div><p>The pharmacological properties of essential oils obtained from two varieties of <u>Anthemis nobilis</u> was studied. The two variaties, named “white-headed” or double flowered and “yellow-headed”, present considerable morphological differences and yield essential oils with different composition. These essential oils proved to possess interesting anti-inflammatory and sedative properties, especially that derived from the “White-headed” variety.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 ","pages":"Pages 71-74"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80844-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14376289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Accumulation and distribution of thiophenes in Tagetes patula","authors":"B. Tosi, A. Donini, A. Bonora, A. Bruni","doi":"10.1016/S0031-6989(88)80855-5","DOIUrl":"10.1016/S0031-6989(88)80855-5","url":null,"abstract":"","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 ","pages":"Pages 117-121"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80855-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14377593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}