槲皮素在体内的抗炎和外周镇痛活性

Pharmacological research communications Pub Date : 1988-12-01 DOI:10.1016/S0031-6989(88)80847-6

A. Tubaro , P. Del Negro , E. Ragazzi , S. Zampiron , R. Della Loggia

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引用次数: 49

摘要

在体内巴豆油耳试验中，埃斯维丁确定了水肿和粒细胞浸润的减少。该药物对乙酰胆碱扭体试验具有抑制作用，LD50为1450 mg/kg。口服2000mg /kg。在我们的实验条件下，橙皮素具有抗炎和镇痛作用。

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Anti-inflammatory and peripheral analgesic activity of esculetin in vivo

Esculetin determined a reduction in oedema and granulocyte infiltration in the Croton oil ear test in vivo. The drug was able to inhibit Acethylcholine-writhing test and showed a LD50 of 1450 mg/kg i.p. and > 2000 mg/kg by mouth. In our experimental conditions, esculetin has an anti-inflammatory and analgesic effect.

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Pharmacological research communications

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