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Pharmacological research communications最新文献

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Effects of gangliosides on the formation of eicosanoids in rat brain cerebral ischemia and reperfusion 神经节苷类对大鼠脑缺血再灌注后类二十烷酸形成的影响
Pharmacological research communications Pub Date : 1988-12-01 DOI: 10.1016/S0031-6989(88)80850-6
Bertazzo A., Petroni A., Sarti S., Colombo C., Galli C.
{"title":"Effects of gangliosides on the formation of eicosanoids in rat brain cerebral ischemia and reperfusion","authors":"Bertazzo A., Petroni A., Sarti S., Colombo C., Galli C.","doi":"10.1016/S0031-6989(88)80850-6","DOIUrl":"10.1016/S0031-6989(88)80850-6","url":null,"abstract":"","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 ","pages":"Pages 95-98"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80850-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14376293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-inflammatory activity of benzopyrones that are inhibitors of cyclo- and lipo-oxygenase 环氧化酶和脂氧化酶抑制剂苯并吡酮类药物的抗炎活性
Pharmacological research communications Pub Date : 1988-12-01 DOI: 10.1016/S0031-6989(88)80849-X
R. Della Loggia , E. Ragazzi , A. Tubaro , G. Fassina , R. Vertua
{"title":"Anti-inflammatory activity of benzopyrones that are inhibitors of cyclo- and lipo-oxygenase","authors":"R. Della Loggia ,&nbsp;E. Ragazzi ,&nbsp;A. Tubaro ,&nbsp;G. Fassina ,&nbsp;R. Vertua","doi":"10.1016/S0031-6989(88)80849-X","DOIUrl":"10.1016/S0031-6989(88)80849-X","url":null,"abstract":"<div><p>The anti-inflammatory activity of three benzo-pyrones with prevalent lipooxigenase-inhibitory activity was studied using the Croton oil ear test in mice, in comparison with nordihydroguaieretic acid (NDGA) and indomethacin. Kaempferol, quercetin and NOGA possess a strong and prolonged anti-inflammatory effect, whereas the action of indomethacin appears relevant, but not long-lasting. In contrast the anti-inflammatory activity of esculetin is rather weak, but persistent.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 ","pages":"Pages 91-94"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80849-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14280996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
Inhibitory activity of 2-benzimidazolylurea on gastric acid secretion in rats 2-苯并咪唑脲对大鼠胃酸分泌的抑制作用
Pharmacological research communications Pub Date : 1988-12-01 DOI: 10.1016/S0031-6989(88)80725-2
S. Trivulzio
{"title":"Inhibitory activity of 2-benzimidazolylurea on gastric acid secretion in rats","authors":"S. Trivulzio","doi":"10.1016/S0031-6989(88)80725-2","DOIUrl":"10.1016/S0031-6989(88)80725-2","url":null,"abstract":"<div><p>2-Benzimidazolylurea (BIU) decreases gastric acid secretion. The antisecretive activity appears to be associated with antihistaminic and antimuscarinic effects.</p><p>The antihistaminic activity of BIU appears from its inhibitory effects on betazole stimulated gastric acid secretion and from its inhibitory activity on the isolated guinea pig auricle stimulated by betazole.</p><p>The antimuscarinic activity of BIU appears from several experiments: this molecule decreases gastric acid secretion stimulated by carbachol in rats, depresses the neostigmine-stimulated motility of duodenum in the anaesthetized cat, lessens the hypertonus of isolated guinea pig trachea caused by pylocarpine and also inhibits guinea pig ileum activity stimulated by acetylcholine.</p><p>BIU probably depresses gastric acid secretion by interferring with both histamine and acetylcholine receptors.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 12","pages":"Pages 1035-1046"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80725-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14341170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
5-HT3 receptors antagonists block morphine- and nicotine- but not amphetamine-induced place-preference conditioning 5-HT3受体拮抗剂阻断吗啡和尼古丁，但不阻断安非他明诱导的位置偏好条件反射
Pharmacological research communications Pub Date : 1988-12-01 DOI: 10.1016/S0031-6989(88)80752-5
E. Acquas, E. Carboni, P. Leone, G. Di Chiara
{"title":"5-HT3 receptors antagonists block morphine- and nicotine- but not amphetamine-induced place-preference conditioning","authors":"E. Acquas,&nbsp;E. Carboni,&nbsp;P. Leone,&nbsp;G. Di Chiara","doi":"10.1016/S0031-6989(88)80752-5","DOIUrl":"10.1016/S0031-6989(88)80752-5","url":null,"abstract":"","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 12","pages":"Pages 1113-1114"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80752-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14341182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 25
Debrisoquine oxidation in schizophrenic patients treated with neuroleptics 抗精神病药治疗精神分裂症患者的碎片喹氧化
Pharmacological research communications Pub Date : 1988-12-01 DOI: 10.1016/S0031-6989(88)80747-1
E. Spina , A.L. Buemi , A.P. Caputi , J. Benitez , J. Cobaleda , M.A. Garcia , A. Llerena , B. Piña
{"title":"Debrisoquine oxidation in schizophrenic patients treated with neuroleptics","authors":"E. Spina ,&nbsp;A.L. Buemi ,&nbsp;A.P. Caputi ,&nbsp;J. Benitez ,&nbsp;J. Cobaleda ,&nbsp;M.A. Garcia ,&nbsp;A. Llerena ,&nbsp;B. Piña","doi":"10.1016/S0031-6989(88)80747-1","DOIUrl":"10.1016/S0031-6989(88)80747-1","url":null,"abstract":"","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 12","pages":"Pages 1103-1104"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80747-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14042082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Role of G-proteins in mediating dihydropyridine receptor coupling with voltage sensitive calcium channels g蛋白介导二氢吡啶受体偶联与电压敏感钙通道的作用
Pharmacological research communications Pub Date : 1988-12-01 DOI: 10.1016/S0031-6989(88)80737-9
O. Meucci, T. Florio, M. Grimaldi, E. Landolfi, G. Magri, G. Schettini
{"title":"Role of G-proteins in mediating dihydropyridine receptor coupling with voltage sensitive calcium channels","authors":"O. Meucci,&nbsp;T. Florio,&nbsp;M. Grimaldi,&nbsp;E. Landolfi,&nbsp;G. Magri,&nbsp;G. Schettini","doi":"10.1016/S0031-6989(88)80737-9","DOIUrl":"10.1016/S0031-6989(88)80737-9","url":null,"abstract":"","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 12","pages":"Pages 1083-1084"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80737-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13986584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effects of kassinin, a tachykinin of the skin of the African frog Kassina senegalensis, on body fluid homeostasis in rats 非洲蛙皮肤的一种快速激肽卡西尼对大鼠体液稳态的影响
Pharmacological research communications Pub Date : 1988-12-01 DOI: 10.1016/S0031-6989(88)80843-9
Perfumi M. , do Caro G. , Panocka I. , Polidori C. , Massi M.
{"title":"Effects of kassinin, a tachykinin of the skin of the African frog Kassina senegalensis, on body fluid homeostasis in rats","authors":"Perfumi M. ,&nbsp;do Caro G. ,&nbsp;Panocka I. ,&nbsp;Polidori C. ,&nbsp;Massi M.","doi":"10.1016/S0031-6989(88)80843-9","DOIUrl":"10.1016/S0031-6989(88)80843-9","url":null,"abstract":"<div><p>In Wistar rats loaded with SC hypartonic NaCl solution kassinin producos an inhibition of cell-dehydration drinking which lasts soveral hours. The long duration of the effect does not depend on a renal excretion of sodium but, hypothetically, on a redistribution of electrolytes between the extra- and the intra-cellular compartments of body fluids.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 ","pages":"Pages 67-70"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80843-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14376290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Anti-inflammatory and peripheral analgesic activity of esculetin in vivo 槲皮素在体内的抗炎和外周镇痛活性
Pharmacological research communications Pub Date : 1988-12-01 DOI: 10.1016/S0031-6989(88)80847-6
A. Tubaro , P. Del Negro , E. Ragazzi , S. Zampiron , R. Della Loggia
{"title":"Anti-inflammatory and peripheral analgesic activity of esculetin in vivo","authors":"A. Tubaro ,&nbsp;P. Del Negro ,&nbsp;E. Ragazzi ,&nbsp;S. Zampiron ,&nbsp;R. Della Loggia","doi":"10.1016/S0031-6989(88)80847-6","DOIUrl":"10.1016/S0031-6989(88)80847-6","url":null,"abstract":"<div><p>Esculetin determined a reduction in oedema and granulocyte infiltration in the Croton oil ear test in vivo. The drug was able to inhibit Acethylcholine-writhing test and showed a LD50 of 1450 mg/kg i.p. and &gt; 2000 mg/kg by mouth. In our experimental conditions, esculetin has an anti-inflammatory and analgesic effect.</p></div>","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 ","pages":"Pages 83-85"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80847-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14396385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 49
Dopamine D-2 receptors in the ventral tegmental area mediate behavioural and electrocortical sleep of dopaminergic drugs in rats 大鼠腹侧被盖区多巴胺D-2受体介导多巴胺能药物的行为和皮层电睡眠
Pharmacological research communications Pub Date : 1988-12-01 DOI: 10.1016/S0031-6989(88)80741-0
Giacinto Bagetta, Elisabetta Priolo, Giuseppe Nistico
{"title":"Dopamine D-2 receptors in the ventral tegmental area mediate behavioural and electrocortical sleep of dopaminergic drugs in rats","authors":"Giacinto Bagetta,&nbsp;Elisabetta Priolo,&nbsp;Giuseppe Nistico","doi":"10.1016/S0031-6989(88)80741-0","DOIUrl":"10.1016/S0031-6989(88)80741-0","url":null,"abstract":"","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 12","pages":"Pages 1091-1092"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80741-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14042079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Involvement of the Na+-H+ antiporter on the effect of protein kinase-C activation on dopamine synthesis in rat corpus striatum Na+-H+反向转运蛋白参与大鼠纹状体蛋白激酶c激活对多巴胺合成的影响
Pharmacological research communications Pub Date : 1988-12-01 DOI: 10.1016/S0031-6989(88)80745-8
S. Amoroso , L. Annuziato , M. Taglialatela , G.F. Di Renzo , L.M.T. Canzoniero , G. Galizia , A. Marino
{"title":"Involvement of the Na+-H+ antiporter on the effect of protein kinase-C activation on dopamine synthesis in rat corpus striatum","authors":"S. Amoroso ,&nbsp;L. Annuziato ,&nbsp;M. Taglialatela ,&nbsp;G.F. Di Renzo ,&nbsp;L.M.T. Canzoniero ,&nbsp;G. Galizia ,&nbsp;A. Marino","doi":"10.1016/S0031-6989(88)80745-8","DOIUrl":"10.1016/S0031-6989(88)80745-8","url":null,"abstract":"","PeriodicalId":19810,"journal":{"name":"Pharmacological research communications","volume":"20 12","pages":"Pages 1099-1100"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6989(88)80745-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14042081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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