Pharmaceutisch weekblad. Scientific edition最新文献_第8页

Detection of contamination with antineoplastic agents in a hospital pharmacy department. 某医院药剂科抗肿瘤药物污染检测。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-02-21 DOI: 10.1007/BF01989220

P J Sessink, R B Anzion, P H Van den Broek, R P Bos

{"title":"Detection of contamination with antineoplastic agents in a hospital pharmacy department.","authors":"P J Sessink, R B Anzion, P H Van den Broek, R P Bos","doi":"10.1007/BF01989220","DOIUrl":"https://doi.org/10.1007/BF01989220","url":null,"abstract":"The contamination with fluorouracil, cyclophosphamide and methotrexate was studied in a hospital pharmacy department where these drugs were prepared. In the preparation room, air samples were taken before and during preparation of the drugs. Methotrexate was detected in one sample which was collected during preparation (0.3 micrograms/m3). Spot samples were taken in the vertical laminar airflow safety hood before and after preparation of the drugs and after cleaning of the hood. Contamination of the laminar airflow hood was: cyclophosphamide: 1-160 ng/cm2; fluorouracil: 10-62 ng/cm2 and methotrexate: 2-633 ng/cm2. Spot samples from the floor in front of and beneath the laminar airflow hood showed contamination with especially fluorouracil (48-236 micrograms/m2). The gloves used during preparation of the drugs were contaminated mainly with fluorouracil (5-980 ng/cm2). Urine samples from two workers involved in the preparation of the drugs were analysed for unmetabolized cyclophosphamide; it was not detected. Although no uptake of cyclophosphamide was established, it is shown that the methods for measurement of cyclophosphamide, fluorouracil and methotrexate in the preparation room are applicable for the control of occupational exposure to these drugs.","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 1","pages":"16-22"},"PeriodicalIF":0.0,"publicationDate":"1992-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01989220","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12721635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 110

Stability of morphine hydrochloride in a portable pump reservoir. 盐酸吗啡在便携式泵储液器中的稳定性。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-02-21 DOI: 10.1007/BF01989221

P J Roos, J H Glerum, J W Meilink

{"title":"Stability of morphine hydrochloride in a portable pump reservoir.","authors":"P J Roos, J H Glerum, J W Meilink","doi":"10.1007/BF01989221","DOIUrl":"https://doi.org/10.1007/BF01989221","url":null,"abstract":"The stability of morphine hydrochloride in an admixture with sodium chloride 0.9% injection in a portable pump reservoir was investigated. Duplicate samples containing morphine hydrochloride 0.5, 1.5 and 2.5 mg/ml were stored in original 100 ml plastic drug reservoirs at 32 degrees C for 60 days. An amount of 3 ml was removed immediately after preparation and at fixed intervals in the weeks after. All samples were tested for loss of vehicle, for appearance of precipitation and for change in colour or pH. Furthermore, they were analysed for drug concentration using high pressure liquid chromatography. No precipitation or change in colour was observed in any of the sample admixtures. There was no change in the pH values of any of the morphine hydrochloride concentrations from day 4 and later on. Only between day 1 and day 4 a slight, but not significant rise could be detected. There was no loss of morphine hydrochloride of any importance at any concentration in the samples over 60 days when corrected for loss of vehicle. Loss of vehicle (0.8 +/- 0.1 ml a week), on the other hand, gave a rise in morphine hydrochloride concentration.","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"14 1","pages":"23-6"},"PeriodicalIF":0.0,"publicationDate":"1992-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF01989221","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12721636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Pharmaceutical and Biomedical Analysis Meeting. Leiden, The Netherlands, 22, November 1991. Abstracts. 制药和生物医学分析会议。1991年11月22日，荷兰莱顿。摘要。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-02-21

引用次数: 0

Clinical Pharmacological Meeting. Gent, Belgium, 3 April 1992. Abstracts. 临床药理学会议。1992年4月3日，比利时根特。摘要。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1992-01-01

引用次数: 0

Abstracts of papers. Biopharmaceutical meeting. Leiden (The Netherlands), 13 October 1991. 论文摘要。生物制药会议。莱顿(荷兰)，1991年10月13日。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1991-12-13

引用次数: 0

Abstracts of papers. Clinical pharmacological meeting. Utrecht (The Netherlands), 4 October 1991. 论文摘要。临床药理学会议。乌得勒支(荷兰)，1991年10月4日。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1991-12-13

引用次数: 0

Cost of hospital antimicrobial chemotherapy. A method for global cost calculation. 医院抗菌化疗费用。一种全局成本计算方法。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1991-12-13 DOI: 10.1007/BF02015579

I C Gyssens, C A Lennards, Y A Hekster, J W Van der Meer

{"title":"Cost of hospital antimicrobial chemotherapy. A method for global cost calculation.","authors":"I C Gyssens, C A Lennards, Y A Hekster, J W Van der Meer","doi":"10.1007/BF02015579","DOIUrl":"https://doi.org/10.1007/BF02015579","url":null,"abstract":"We will describe the method of cost-identification analysis, which was performed in a Dutch hospital during a review of antimicrobial drugs usage. In the present Dutch hospital budget system, in-patients' drug costs generate no revenues. Efforts to diminish drug costs result in financial benefit for the institution. To maximize cost containment, efforts are to be directed to all cost components. We chose wholesale purchase prices of antimicrobial drugs and national prices for salaries and hospital costs. Global cost comparison shows the most cost effective system of intravenous administration. Push injection is the most economic way to administer intravenous drugs which do not require dilution or prolonged infusion time. For stable solutions, such as metronidazole, ready-to-infuse bags are the most economic system. A global cost calculation is listed for commonly used antimicrobial drugs for in-patients. A cost comparison is given for vancomycin CP and teicoplanin, two antistaphyloccocal drugs, which are probably equieffective. The result of global cost comparison contributes to the decision to include new drugs into the hospital formulary or to replace older ones.","PeriodicalId":19804,"journal":{"name":"Pharmaceutisch weekblad. Scientific edition","volume":"13 6","pages":"248-53"},"PeriodicalIF":0.0,"publicationDate":"1991-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02015579","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12957982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Abstracts of posters. Drug utilization research and pharmacoepidemiology meeting. Leiden (The Netherlands), 13 December 1991. 海报的摘要。药物利用研究与药物流行病学会议。莱顿(荷兰)，1991年12月13日。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1991-12-13

引用次数: 0

Pharmaceuticals and developing countries: problems and prospects. 药品和发展中国家:问题和前景。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1991-12-13 DOI: 10.1007/BF02015578

D C Jayasuriya

引用次数: 2

Compatibility of bupivacaine and iohexol in two mixtures for paediatric regional anaesthesia. 布比卡因和碘己醇在两种小儿局部麻醉混合物中的配伍性。

Pharmaceutisch weekblad. Scientific edition Pub Date : 1991-12-13 DOI: 10.1007/BF02015580

P Van Asten, J H Glerum, E R Spaanderman, J Van Niekerk, A Van Dijk

引用次数: 2