Pathogens and disease最新文献_第9页

Title: A Comprehensive Review on Classifying Fast-acting and Slow-acting Antimalarial Agents Based on Time of Action and Target Organelle of Plasmodium sp. 题目:基于疟原虫作用时间和靶细胞器分类快效和慢效抗疟药的综述。

IF 3.3 4区医学

Pathogens and disease Pub Date : 2022-05-19 DOI: 10.1093/femspd/ftac015

Monika Marie Bernard, Abhinab Mohanty, V. Rajendran

{"title":"Title: A Comprehensive Review on Classifying Fast-acting and Slow-acting Antimalarial Agents Based on Time of Action and Target Organelle of Plasmodium sp.","authors":"Monika Marie Bernard, Abhinab Mohanty, V. Rajendran","doi":"10.1093/femspd/ftac015","DOIUrl":"https://doi.org/10.1093/femspd/ftac015","url":null,"abstract":"The clinical resistance towards malarial parasites has rendered many antimalarials ineffective, likely due to a lack of understanding of time of action and stage specificity of all life stages. Therefore, to tackle this problem a more incisive comprehensive analysis of the fast and slow-acting profile of antimalarial agents relating to parasite time-kill kinetics and the target organelle on the progression of blood-stage parasites was carried out. It is evident from numerous findings that drugs targeting food vacuole, nuclear components, and endoplasmic reticulum mainly exhibit a fast-killing phenotype within 24h affecting first-cycle activity. Whereas drugs targeting mitochondria, apicoplast, microtubules, parasite invasion and egress exhibit a largely slow-killing phenotype within 96-120h, affecting second-cycle activity with few exemptions as moderately fast-killing. It is essential to understand the susceptibility of drugs on rings, trophozoites, schizonts, merozoites, and the appearance of organelle at each stage of 48h intraerythrocytic parasite cycle. Therefore, these parameters may facilitate the paradigm for understanding the timing of antimalarials action in deciphering its precise mechanism linked with time. Thus, classifying drugs based on the time of killing may promote designing new combination regimens against varied strains of P. falciparum and evaluating potential clinical resistance.","PeriodicalId":19795,"journal":{"name":"Pathogens and disease","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2022-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48308081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Discovery of spirooxindole-pyrrolidine heterocyclic hybrids with potent antifungal activity against fungal pathogens. 具有抗真菌活性的螺旋菌吲哚-吡咯烷杂环杂交种的发现。

IF 3.3 4区医学

Pathogens and disease Pub Date : 2022-05-05 DOI: 10.1093/femspd/ftac013

H. Dowdy, Raju Suresh Kumar, A. Almansour, N. Arumugam, Shatha IbrahimAlaqeel, Shankar Thangamani

引用次数: 0

Vitamin D-induced LL-37 modulates innate immune responses of human primary macrophages during DENV-2 infection. 维生素d诱导的LL-37在DENV-2感染期间调节人原代巨噬细胞的先天免疫反应。

IF 3.3 4区医学

Pathogens and disease Pub Date : 2022-05-05 DOI: 10.1093/femspd/ftac014

J. Castillo, Diana M Giraldo, J. Smit, Izabela A. Rodenhuis-Zybert, S. Urcuqui-Inchima

{"title":"Vitamin D-induced LL-37 modulates innate immune responses of human primary macrophages during DENV-2 infection.","authors":"J. Castillo, Diana M Giraldo, J. Smit, Izabela A. Rodenhuis-Zybert, S. Urcuqui-Inchima","doi":"10.1093/femspd/ftac014","DOIUrl":"https://doi.org/10.1093/femspd/ftac014","url":null,"abstract":"Epidemics of dengue, an acute and potentially severe disease caused by mosquito-borne dengue virus (DENV), pose a major challenge to clinicians and health care services across the sub(tropics). Severe disease onset is associated with a dysregulated inflammatory response to the virus and there are currently no drugs to alleviate disease symptoms. LL-37 is a potent antimicrobial peptide with a wide range of immunoregulatory properties. In this study, we assessed the effect of LL-37 on DENV-2-induced responses in human monocyte-derived macrophages (MDMs). We show that simultaneous exposure of exogenous LL-37 and DENV-2 resulted in reduced replication of the virus in MDMs, while the addition of LL-37 post-exposure to DENV-2 did not. Interestingly, the latter condition reduced the production of IL-6 and increased the expression of genes involved in virus sensing and antiviral response. Finally, we demonstrate that low endogenous levels and limited production of LL-37 in MDMs in response to DENV-2 infection can be increased by differentiating MDMs in the presence of Vitamin D (VitD3). Taken together, this study demonstrates that in addition to its antimicrobial properties, LL-37 has immunomodulatory properties in the curse of DENV infection and its production can be increased by VitD3.","PeriodicalId":19795,"journal":{"name":"Pathogens and disease","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2022-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45428999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Inhibition of infection-induced vascular permeability modulates host leukocyte recruitment to Mycobacterium marinum granulomas in zebrafish. 抑制感染诱导的血管通透性可调节斑马鱼体内马氏分枝杆菌肉芽肿的宿主白细胞募集。

IF 2.7 4区医学

Pathogens and disease Pub Date : 2022-04-29 DOI: 10.1093/femspd/ftac009

Julia Y Kam, Tina Cheng, Danielle C Garland, Warwick J Britton, David M Tobin, Stefan H Oehlers

{"title":"Inhibition of infection-induced vascular permeability modulates host leukocyte recruitment to Mycobacterium marinum granulomas in zebrafish.","authors":"Julia Y Kam, Tina Cheng, Danielle C Garland, Warwick J Britton, David M Tobin, Stefan H Oehlers","doi":"10.1093/femspd/ftac009","DOIUrl":"10.1093/femspd/ftac009","url":null,"abstract":"Mycobacterial granuloma formation involves significant stromal remodeling including the growth of leaky, granuloma-associated vasculature. These permeable blood vessels aid mycobacterial growth, as antiangiogenic or vascular normalizing therapies are beneficial host-directed therapies in preclinical models of tuberculosis across host-mycobacterial pairings. Using the zebrafish-Mycobacterium marinum infection model, we demonstrate that vascular normalization by inhibition of vascular endothelial protein tyrosine phosphatase (VE-PTP) decreases granuloma hypoxia, the opposite effect of hypoxia-inducing antiangiogenic therapy. Inhibition of VE-PTP decreased neutrophil recruitment to granulomas in adult and larval zebrafish, and decreased the proportion of neutrophils that extravasated distal to granulomas. Furthermore, VE-PTP inhibition increased the accumulation of T cells at M. marinum granulomas. Our study provides evidence that, similar to the effect in solid tumors, vascular normalization during mycobacterial infection increases the T cell:neutrophil ratio in lesions which may be correlates of protective immunity.","PeriodicalId":19795,"journal":{"name":"Pathogens and disease","volume":"80 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053305/pdf/ftac009.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9326783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tannerella forsythia strains differentially induce interferon gamma-induced protein 10 (IP-10) expression in macrophages due to lipopolysaccharide heterogeneity. 由于脂多糖的异质性，单宁菌在巨噬细胞中诱导干扰素γ诱导蛋白10 (IP-10)的表达存在差异。

IF 3.3 4区医学

Pathogens and disease Pub Date : 2022-04-29 DOI: 10.1093/femspd/ftac008

Sreedevi Chinthamani, Rajendra P Settem, Kiyonobu Honma, Graham P Stafford, Ashu Sharma

{"title":"Tannerella forsythia strains differentially induce interferon gamma-induced protein 10 (IP-10) expression in macrophages due to lipopolysaccharide heterogeneity.","authors":"Sreedevi Chinthamani, Rajendra P Settem, Kiyonobu Honma, Graham P Stafford, Ashu Sharma","doi":"10.1093/femspd/ftac008","DOIUrl":"https://doi.org/10.1093/femspd/ftac008","url":null,"abstract":"Tannerella forsythia is strongly implicated in the development of periodontitis, an inflammatory disease that destroys the bone and soft tissues supporting the tooth. To date, the knowledge of the virulence attributes of T. forsythia species has mainly come from studies with a laboratory adapted strain (ATCC 43037). In this study, we focused on two T. forsythia clinical isolates, UB4 and UB20, in relation to their ability to activate macrophages. We found that these clinical isolates differentially induced proinflammatory cytokine expression in macrophages. Prominently, the expression of the chemokine protein IP-10 (CXCL10) was highly induced by UB20 as compared to UB4 and the laboratory strain ATCC 43037. Our study focused on the lipopolysaccharide component (LPS) of these strains and found that UB20 expressed a smooth-type LPS, unlike UB4 and ATCC 43037 each of which expressed a rough-type LPS. The LPS from UB20, via activation of TLR4, was found to be a highly potent inducer of IP-10 expression via signaling through STAT1 (signal transducer and activator of transcription-1). These data suggest that pathogenicity of T. forsythia species could be strain dependent and the LPS heterogeneity associated with the clinical strains might be responsible for their pathogenic potential and severity of periodontitis.","PeriodicalId":19795,"journal":{"name":"Pathogens and disease","volume":"80 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9053306/pdf/ftac008.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9277979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Polymicrobial interaction in biofilm: mechanistic Insights. 生物膜中的多微生物相互作用：机理见解。

IF 3.3 4区医学

Pathogens and disease Pub Date : 2022-04-27 DOI: 10.1093/femspd/ftac010

Pratima Gupta, Anmol Kulshrestha

引用次数: 10

Invasive candidiasis in Africa, what is the current picture? 侵袭性念珠菌病在非洲的现状如何?

IF 3.3 4区医学

Pathogens and disease Pub Date : 2022-04-22 DOI: 10.1093/femspd/ftac012

C. A. Okoye, E. Nweze, C. Ibe

{"title":"Invasive candidiasis in Africa, what is the current picture?","authors":"C. A. Okoye, E. Nweze, C. Ibe","doi":"10.1093/femspd/ftac012","DOIUrl":"https://doi.org/10.1093/femspd/ftac012","url":null,"abstract":"Invasive candidiasis is a serious, progressive, and potentially deadly infection that can affect the brain, heart, bones, eyes, and other parts of the body. It is associated with risk factors such as the use of indwelling medical devices and prolonged hospital stay, and broad-spectrum antibiotics use. It is especially seen in immunocompromised individuals such as patients with prolonged hospital stay, gastrointestinal surgery, haematological malignancies, and respiratory diseases. We have conducted a systematic search of literature using a select group of database and appropriate search words and found that in Africa, there are 18,293 documented/reported cases of invasive candidiasis in the last few decades (1976-2021) and 16,636(91%) were cases of candidaemia. South Africa had the highest number of reported cases - 15,002(82%), which may be due to underreporting of cases in other countries. HIV positive persons with invasive candidiasis in Africa accounted for 1,052(5.8%). C. albicans was the most frequently isolated species 6,328(32.6%), followed by Candida parapsilosis 5,910(30.4%), and Candida auris 1,505(7.8%). Due to the affordability and availability of blood culture, it was used for diagnosis in most of the studies examined, while a few studies combined other techniques and just 3 studies from 2 countries used serological tests. Echinocandins are recommended as first-line therapy but are only available in 12 countries and are highly priced. The use of fluconazole because of its availability and relatively inexpensive nature has led to increased resistance of Candida species to the drug.","PeriodicalId":19795,"journal":{"name":"Pathogens and disease","volume":"1 1","pages":""},"PeriodicalIF":3.3,"publicationDate":"2022-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"60710566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A framework for educating and empowering students by teaching about history and consequences of bias in STEM 通过教授STEM中偏见的历史和后果来教育和增强学生能力的框架

IF 3.3 4区医学

Pathogens and disease Pub Date : 2022-04-07 DOI: 10.1093/femspd/ftac006

C. Moreau, Andrea M. Darby, A. Demery, Lina M Arcila Hernández, Clara L. Meaders

引用次数: 0

Expression and structure of the Chlamydia trachomatis DksA ortholog 沙眼衣原体DksA同源基因的表达和结构

IF 3.3 4区医学

Pathogens and disease Pub Date : 2022-04-07 DOI: 10.1093/femspd/ftac007

Cameron Mandel, Hong Yang, G. W. Buchko, J. Abendroth, N. Grieshaber, Travis Chiarelli, S. Grieshaber, Anders Omsland

{"title":"Expression and structure of the Chlamydia trachomatis DksA ortholog","authors":"Cameron Mandel, Hong Yang, G. W. Buchko, J. Abendroth, N. Grieshaber, Travis Chiarelli, S. Grieshaber, Anders Omsland","doi":"10.1093/femspd/ftac007","DOIUrl":"https://doi.org/10.1093/femspd/ftac007","url":null,"abstract":"Abstract Chlamydia trachomatis is a bacterial obligate intracellular parasite and a significant cause of human disease, including sexually transmitted infections and trachoma. The bacterial RNA polymerase-binding protein DksA is a transcription factor integral to the multicomponent bacterial stress response pathway known as the stringent response. The genome of C. trachomatis encodes a DksA ortholog (DksACt) that is maximally expressed at 15–20 h post infection, a time frame correlating with the onset of transition between the replicative reticulate body (RB) and infectious elementary body (EB) forms of the pathogen. Ectopic overexpression of DksACt in C. trachomatis prior to RB–EB transitions during infection of HeLa cells resulted in a 39.3% reduction in overall replication (yield) and a 49.6% reduction in recovered EBs. While the overall domain organization of DksACt is similar to the DksA ortholog of Escherichia coli (DksAEc), DksACt did not functionally complement DksAEc. Transcription of dksACt is regulated by tandem promoters, one of which also controls expression of nrdR, encoding a negative regulator of deoxyribonucleotide biosynthesis. The phenotype resulting from ectopic expression of DksACt and the correlation between dksACt and nrdR expression is consistent with a role for DksACt in the C. trachomatis developmental cycle.","PeriodicalId":19795,"journal":{"name":"Pathogens and disease","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2022-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43034569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Retraction to: mitogen-activated protein kinases regulate mycobacterium avium-induced tumor necrosis factor-α release from macrophages. 缩回:丝裂原活化蛋白激酶调节巨噬细胞中巨噬杆菌诱导的肿瘤坏死因子-α的释放。

IF 3.3 4区医学

Pathogens and disease Pub Date : 2022-02-09 DOI: 10.1093/femspd/ftac041

引用次数: 0