Perioperative Medicine最新文献

{"title":"Effect of pressure-controlled ventilation and volume-controlled ventilation for laparoscopic surgery in the Trendelenburg position: a systematic review and meta-analysis.","authors":"Cui Wen, Yi Qi, Yingying Xiang, Qianyun Pang, Jingyu Xiao, Ran An","doi":"10.1186/s13741-025-00540-w","DOIUrl":"10.1186/s13741-025-00540-w","url":null,"abstract":"<p><strong>Background: </strong>Volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) are commonly used in laparoscopic surgery in the Trendelenburg position, and pressure-controlled ventilation volume guaranteed (PCV-VG) has been increasingly used recently. However, there is still no consensus on the optimal ventilation mode. Therefore, a systematic review and meta-analysis were conducted to compare the effects of different ventilation modes for laparoscopic surgery in the Trendelenburg position.</p><p><strong>Methods: </strong>Multiple databases were searched for randomized controlled trials published before December 2024 to compare the effects of PCV, PCV-VG, and VCV in patients in the Trendelenburg position who underwent laparoscopic surgery. The primary outcomes included peak airway pressure (Ppeak), plateau airway pressure (Pplat), dynamic compliance (Cdyn), and blood gas analysis.</p><p><strong>Results: </strong>Sixteen studies were included in this meta-analysis. PCV [Ppeak, 15‒40-min post-pneumoperitoneum and Trendelenburg position (T2): mean difference (MD) - 4.28, 95% confidence interval (CI) - 5.91 to - 2.64, P < 0.01; 60-min post-pneumoperitoneum and Trendelenburg position (T3): MD - 4.51, 95% CI - 5.41 to - 3.6, P < 0.01; 120-min post-pneumoperitoneum and Trendelenburg position (T4): MD - 5.63, 95% CI - 7.35 to - 3.91, P < 0.01; Cydn, T2: MD 3.15, 1.53 to 4.77, P = 0.0001; T3: MD 2.78, 95% CI 1.43 to 4.14, P < 0.01] and PCV-VG (Ppeak, T2: MD - 3.99, 95% CI - 7.2 to - 0.78, P = 0.01; T3: MD - 3.46, 95% CI - 6.5 to - 0.42, P = 0.03; Cydn, T3: MD 4.44, 95% CI 2.23 to 6.66, P < 0.01; T4: MD 3.61, 95% CI 1.31 to 5.91, P = 0.002) significantly reduced Ppeak and improved Cydn compared with VCV after pneumoperitoneum and Trendelenburg position. PaO₂, pH, and PaO₂/FiO₂ did not differ between PCV and VCV or between PCV-VG and VCV during intraoperative surgery.</p><p><strong>Conclusions: </strong>Our meta-analysis suggests that in laparoscopic surgery in the Trendelenburg position, PCV or PCV-VG can provide a lower Ppeak and higher Cdyn throughout surgery but cannot offer better oxygenation than VCV. PCV or PCV-VG might be optimal for laparoscopic surgery in the Trendelenburg position.</p>","PeriodicalId":19764,"journal":{"name":"Perioperative Medicine","volume":"14 1","pages":"56"},"PeriodicalIF":2.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anesthetic outcomes in pediatric tonsillectomy: insights from the Palestinian experience.","authors":"Ramzi Shawahna, Shahed Radwan, Dana Alyan, Rawand Obaid, Suha Sholi, Mohammad Jaber, Iyad Maqboul, Hatim Hijaz, Samer Bustame","doi":"10.1186/s13741-025-00537-5","DOIUrl":"https://doi.org/10.1186/s13741-025-00537-5","url":null,"abstract":"<p><strong>Background: </strong>Despite advancements in anesthesia, the anesthetic outcomes in pediatric tonsillectomy remain largely underexplored, notably in resource-limited healthcare systems. This study aimed to assess the anesthetic outcomes in pediatric tonsillectomy, including induction-to-incision time and predictors of duration of surgery.</p><p><strong>Methods: </strong>The study was conducted at one of the major surgical hospitals in the West Bank of Palestine, which is a tertiary referral center known for its comprehensive surgical and anesthetic services. The data were collected retrospectively from pediatric patients who underwent tonsillectomy with or without adenoidectomy in the period between 2021 and 2022. The data were collected using a standardized data collection form.</p><p><strong>Results: </strong>Of the 238 pediatric patients included in this study, 231 (97.1%) were operated for adenotonsillar hypertrophy, and 7 (2.9%) were operated for recurrent/chronic tonsillitis. The mean age of the patients was 5.6 ± 3.1 years. Of the patients, 151 (63.4%) were male, 13 (5.5%) had an allergy to foods or drugs 13 (5.5%) had other comorbidities, and 21 (8.8%) had a past surgical history. Of the patients, 230 (96.6%) received propofol and 183 (76.9%) received fentanyl as anesthesia induction agents. The mean induction to incision time was 5.2 ± 1.1 min, and the mean duration of surgery was 26.4 ± 5.4 min. Of the patients, 53 (22.3%) received antibiotics during surgery. The induction to incision time was significantly longer for male patients (5.4 ± 1.3 vs. 5.0 ± 0.7, p-value = 0.022). The duration of surgery was significantly longer for female patients, 5 years and older, who had allergies, had chronic tonsillitis, and received antibiotics during the surgery. Multiple linear regression showed that longer duration of surgery could be predicted by being operated for recurrent/chronic tonsillitis (β = 0.15) and receiving antibiotics during the surgery (β = 0.13).</p><p><strong>Conclusion: </strong>The findings of this study revealed that patient-specific factors influenced induction-to-incision time and duration of surgery. The findings of this study highlight the need for tailored preoperative assessment and individualized perioperative management to optimize resource utilization and improve surgical efficiency in resource-limited settings.</p>","PeriodicalId":19764,"journal":{"name":"Perioperative Medicine","volume":"14 1","pages":"54"},"PeriodicalIF":2.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative arrhythmias in geriatric lung cancer patients undergoing thoracoscopic surgery: an exploration of prevalence and influencing factors.","authors":"Xiaoyu Chen, Yan Wu, Xiaofang Zheng","doi":"10.1186/s13741-025-00538-4","DOIUrl":"https://doi.org/10.1186/s13741-025-00538-4","url":null,"abstract":"<p><strong>Background: </strong>Arrhythmias are a frequent complication in the postoperative period following surgical procedures. This study aims to investigate the incidence and contributing factors of arrhythmias in elderly patients with lung cancer who have undergone thoracoscopic surgery, thereby providing scientific evidence to support clinical treatment and nursing care.</p><p><strong>Methods: </strong>This retrospective cohort study included elderly patients diagnosed with lung cancer who underwent treatment at our hospital between June 1, 2022, and October 31, 2024. Patients were categorized into two groups based on the development of postoperative arrhythmias following thoracoscopic surgery: the arrhythmia group and the non-arrhythmia group. A comparative analysis of the clinical data was conducted between these two groups.</p><p><strong>Results: </strong>A total of 208 patients were enrolled, with an incidence of postoperative arrhythmias of 19.71% (41/208). Logistic regression analysis identified age ≥ 70 years (OR = 2.586, 95% CI: 1.805-3.221), hypertension (OR = 2.761, 95% CI: 2.103-3.588), history of smoking (OR = 2.070, 95% CI: 1.741-2.446), TNM stage II (OR = 3.181, 95% CI: 2.842-3.690), postoperative pulmonary infection (OR = 2.122, 95% CI: 1.836-2.690), and postoperative constipation (OR = 2.495, 95% CI: 1.988-3.072) as independent risk factors for postoperative arrhythmias (all p < 0.05).</p><p><strong>Conclusion: </strong>The incidence of postoperative arrhythmias in elderly patients with lung cancer following thoracoscopic surgery is relatively high. Targeted interventions addressing the identified risk factors are essential to mitigate the risk of postoperative arrhythmias.</p>","PeriodicalId":19764,"journal":{"name":"Perioperative Medicine","volume":"14 1","pages":"55"},"PeriodicalIF":2.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study of the efficacy and safety of remimazolam and midazolam for general anesthesia in elderly patients: a randomized controlled trial.","authors":"Yang Wan-Jun, Geng Zhi-Long, Gao Yuan-Yuan, Cui Chao-Yuan, Chen Zheng-Ze, Tian Zi-Wei, Guo Xi-Lin, Zhang Ya-Nan, Wang Lu, Huo Rui, Ma Chen-Wei, Niu Jing","doi":"10.1186/s13741-025-00525-9","DOIUrl":"https://doi.org/10.1186/s13741-025-00525-9","url":null,"abstract":"<p><strong>Background: </strong>Elderly patients are a vulnerable group with high perioperative risks. Thus, reducing the duration of anesthesia is important. Remimazolam is a benzodiazepine sedative commonly used for the induction and maintenance of general anesthesia given its rapid induction and rapid recovery. Most reports have focused on nonelderly patients.</p><p><strong>Aim: </strong>To compare the time to loss of consciousness, length of PACU stay and incidence of adverse events in patients older than 65 years who received remimazolam for general anesthesia with those of patients who received midazolam.</p><p><strong>Methods: </strong>This study was conducted at a university hospital between February 2022 and March 2023. We included 100 patients aged 65 years or older who were scheduled for surgery under general anesthesia. Patients were divided into 2 groups, namely, the midazolam group and the remimazolam group, with 50 patients in each group. The primary outcome was the time to loss of consciousness. The secondary outcomes included the time to extubation and length of PACU stay. We also recorded the percentage of flumazenil used and incidence of adverse events.</p><p><strong>Results: </strong>Clinical data from 96 patients who were scheduled for surgery under general anesthesia were included in the final analysis, with 46 patients in the remimazolam group and 50 patients in the midazolam group. The time to loss of consciousness was 304 (222, 330) s in the remimazolam group and 95 (67, 25) s in the midazolam group, and the difference was significant (p = 0.000). The time to extubation was 24.93 ± 11.617 min in the remimazolam group and 34.88 ± 19.740 min in the midazolam group, revealing a significant difference (p = 0.003). The length of PACU stay was 55 (48, 64) min in the remimazolam group and 65 (55, 85) min in the midazolam group, and the difference was significant (p = 0.001). The percentage of flumazenil used was 6% in the remimazolam group and 20% in the midazolam group, and the difference was significant (p = 0.003).</p><p><strong>Conclusion: </strong>General anesthesia with remimazolam has been shown to be effective and safe for surgery in elderly patients. The time to extubation was significantly shorter, length of PACU stay was shorter, and percentage of flumazenil used was lower in the remimazolam group than in the midazolam group.</p>","PeriodicalId":19764,"journal":{"name":"Perioperative Medicine","volume":"14 1","pages":"53"},"PeriodicalIF":2.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dosage of epidural morphine analgesia after lower abdominal cancer surgery: a randomized clinical trial among the older adults.","authors":"Muhammad Shawqi, Sahar Abdel-Baky Mohamed, Essam Sharkawy, Diab Hetta","doi":"10.1186/s13741-025-00521-z","DOIUrl":"https://doi.org/10.1186/s13741-025-00521-z","url":null,"abstract":"<p><strong>Background: </strong>Epidural morphine is considered one of the most potent drugs used for postoperative analgesia; however, its side effects are dose-related and exaggerated in elderly people. In this study, we aimed to determine which of three doses within that range (1.5 mg, 3 mg, or 4.5 mg) can provide adequate pain relief.</p><p><strong>Methods: </strong>A total of 102 patients were assessed for allocation into one of four groups to receive either placebo (group Morphine 0, N = 22), 1.5 mg of epidural morphine (Morphine 1.5, N = 22), 3 mg of epidural morphine (Morphine 3, N = 22), or 4.5 mg of epidural morphine (Morphine 4.5, N = 22) before skin incision, 24 h after surgery and 48 h after surgery. Cumulative intravenous IV-PCA morphine consumption, VAS pain scores, modified Ramsay Sedation Scores, nausea, vomiting, and pruritus were evaluated.</p><p><strong>Results: </strong>The VAS pain scores at activity of patients who received epidural morphine at doses of 3 mg and 4.5 mg were significantly lower than the placebo and 1.5 mg groups, VAS Score at 72 h was (2 ± 0.8) and (1.7 ± 1) vs (4.3 ± 1.1) and (4 ± 1) respectively, p value = 0.000. The mean total IV-PCA morphine consumption (mg) was significantly higher in patients who received received epidural 0.9% sodium chloride alone compared to 1.5 mg, 3 mg and 4.5 mg epidural morphine groups (38.1 ± 4.8 mg vs 27.2 ± 5.6 mg, 9.2 ± 3.5 mg, and 6.3 ± 3.3 mg respectively), p value = 0.000). However, the difference between the 3 mg and the 4.5 mg groups was not statistically significant in both of VAS scores and IV-PCA morphine consumption (P value > 0.05 for 3 mg vs. 4.5 mg). Patients who received 4.5 mg of epidural morphine experienced a significant increase in the level of sedation, measured by the Ramsay sedation scale, in comparison with 1.5 mg, 3 mg and placebo epidural morphine groups in the first 24 h, the Scale for this group was (2.5 ± 0.5) vs (2.1 ± 0.2, 2.1 ± 0.2, and 2.2 ± 0.5 respectively); p value = 0.000. No relationship between postoperative nausea and the dosage of epidural morphine was found.</p><p><strong>Conclusion: </strong>Epidural morphine 3 mg as a bolus every 24 h with add on IV patient control analgesia (PCA) morphine, set to deliver 1.5 mg boluses on demand without background infusion with a lockout period of 45 min, could achieve effective and adequate analgesia lasting up to 72 h postoperatively without increasing in the level of sedation or other side effects in older adults after a lower abdominal cancer surgery.</p>","PeriodicalId":19764,"journal":{"name":"Perioperative Medicine","volume":"14 1","pages":"52"},"PeriodicalIF":2.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher rate of undetected intraoperative damage of latex-free surgical gloves worn by scrub nurses.","authors":"Leon Euler-Schmidt, Artur Barsumyan, Jan Adriaan Graw, Christian Soost, Yvonne Stephan, Rene Burchard","doi":"10.1186/s13741-025-00539-3","DOIUrl":"https://doi.org/10.1186/s13741-025-00539-3","url":null,"abstract":"<p><strong>Background: </strong>Surgical gloves are a medical product and a cornerstone of prevention from surgical site infections and staff injury. This study aimed to investigate the integrity of surgical gloves worn by scrub nurses during selected procedures in both general and trauma surgery. The frequency of defects such as perforations or tears was identified. Furthermore, differences in durability between latex and latex-free gloves were analyzed.</p><p><strong>Methods: </strong>In a 3-month period, a total of 139 surgical glove pairs, both latex and latex-free, used during general or trauma surgery in an academic teaching hospital were collected immediately after procedures. The gloves were subjected to watertightness testing following European norm ISO EN 455:2022 standards. Only gloves visually presumed to be intact were tested for any concealed perforations.</p><p><strong>Results: </strong>The number of perforated glove pairs was similar in both departments (general surgery 25% (n = 14 of 57) vs. trauma surgery 28% (n = 23 of 82), p = 0.79). However, differences in perforation rates by glove models (latex vs. latex-free) were noticed. The likelihood of perforation was increased by a factor of 4.24 with the use of latex-free gloves (χ^2 = 8.48, p = 0.004).</p><p><strong>Conclusions: </strong>Perforation of surgical gloves worn by scrub nurses is a common event during various surgical procedures in general and trauma surgery. In several cases, members of the surgical team do not notice a perforation of a glove. The risk of undetected damage to a surgical glove is significantly higher when latex-free gloves are used. Further research is needed to investigate if the use of a second layer of gloves could reduce this perioperative risk for surgical staff and patients.</p>","PeriodicalId":19764,"journal":{"name":"Perioperative Medicine","volume":"14 1","pages":"51"},"PeriodicalIF":2.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global research trends in perioperative care for diabetic patients: a bibliometric and visualized study.","authors":"Jiangru Kang, Xin Chai, Tao Jia, Huiru Hu, Rong Fu, Huang Nie","doi":"10.1186/s13741-025-00532-w","DOIUrl":"https://doi.org/10.1186/s13741-025-00532-w","url":null,"abstract":"<p><p>Perioperative management in diabetic patients is important since their postoperative mortality and morbidity are higher than that of non-diabetic patients, which will exacerbate the burden on public health. We selected relevant publications from the WoSCC-SCIE between 2007 and 2024, utilizing VOSviewer and CiteSpace to analyze the collected information and generate knowledge maps. A total of 3167 articles from 792 journals and 83 countries/regions were included for analysis. Overall, there has been a continuous increase in publication volume. From the result of academic collaboration between different countries/regions and institutions, the USA occupies a central position in research strength. A total of 18,101 authors participated in research on \"perioperative management in diabetic patients\" with Dr. Guillermo E. Umpierrez from Emory University School of Medicine being the most productive author. We conclude that perioperative adverse clinical outcomes in diabetic patients and perioperative blood glucose management have consistently been research hotspots in this field. Additionally, continuous glucose monitoring and insulin administration under computer guidance, as well as the use of merging medications are likely to be frontier directions for future research. Research on perioperative care for diabetic patients has been further deepened worldwide, which will be crucial in further improving perioperative care for diabetic patients and enhancing postoperative recovery.</p>","PeriodicalId":19764,"journal":{"name":"Perioperative Medicine","volume":"14 1","pages":"50"},"PeriodicalIF":2.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12042523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of ciprofol on respiratory-related adverse incidence in patients with obesity during painless gastroscopy: a prospective, randomized clinical trial.","authors":"Yanjing Zhang, Danru Xie, Feifei Li, Mengjiao Che, Yaoheng Yang, Geng Li, Yiwen Zhang","doi":"10.1186/s13741-025-00529-5","DOIUrl":"https://doi.org/10.1186/s13741-025-00529-5","url":null,"abstract":"<p><strong>Background: </strong>Ciprofol is an intravenous anesthetic agent which in low doses produces sedation. It was developed via structural modification of propofol. Ciprofol is claimed to reduce respiratory depression. The object of the present study was to investigate whether or not ciprofol did actually reduce respiratory depression or not in patients with obesity undergoing gastroscopy.</p><p><strong>Methods: </strong>A total of 84 patients with obesity scheduled for gastroscopy were enrolled. The participants were randomly allocated to receive sedation with ciprofol (group C) or propofol (group P). The primary outcome was the incidence of respiratory-related adverse events (AEs), whereas the secondary outcomes were the incidence of further intraoperative and postoperative AEs; procedure and anesthesia success rates; Narcotrend index (NI); induction dosage; procedure time; recovery time; discharge time; and satisfaction ratings from the patients, anesthesiologists, and endoscopists.</p><p><strong>Results: </strong>The incidence of respiratory-related AEs was significantly lower in group C than in group P (17.5% vs. 57.5%; P < 0.001). The occurrence of hypotension and movement during procedural events in group C was markedly reduced compared with that in group P (P = 0.024 and 0.007, respectively). No notable differences were observed in the occurrence of additional AEs or in the success rates of the procedure and anesthesia between the two groups (P > 0.05). The three-point satisfaction levels were comparable between the groups (P > 0.05).</p><p><strong>Conclusions: </strong>0.4 mg/kg of ciprofol provides anesthesia comparable with 2.0 mg/kg of propofol. However, it is related to reduced respiratory-related AEs and hypotension during gastroscopy in patients with obesity; thus, ciprofol is preferred to propofol for anesthesia in obese patients.</p><p><strong>Trial registration: </strong>This study was registered in the Chinese Clinical Trial Registry (KYLS20230625; first registration date: 29/06/2023).</p>","PeriodicalId":19764,"journal":{"name":"Perioperative Medicine","volume":"14 1","pages":"49"},"PeriodicalIF":2.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12038989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of prolonged time to tracheal extubation and its associated factors among adult patients undergoing elective surgery at Jimma Medical Center, Jimma, Oromia, Ethiopia, 2024.","authors":"Gemechisa Akuma Wayesa, Mitiku Berhanu Wedajo, Wondu Reta Demissie, Admasu Belay Gizaw, Assefa Hika Gudeta, Guteta Gudina Gula","doi":"10.1186/s13741-025-00520-0","DOIUrl":"https://doi.org/10.1186/s13741-025-00520-0","url":null,"abstract":"<p><strong>Purpose: </strong>Extubation refers to removing the breathing tube from the patient's airway after surgery under general anesthesia with tracheal intubation. Extubation procedures typically take less than 15 min, and if they take more, they are prolonged. Whether or not to extubate a patient depends on several factors, including the patient's preoperative status, the type of surgery, anesthetic methods, and expected recovery after the procedure. Thus, the study's objective was to determine the incidence of prolonged extubation and its associated factors among adult patients undergoing surgery at Jimma Medical Center.</p><p><strong>Methods: </strong>A prospective observational study through a consecutive sampling technique was conducted. Ethical clearance and approval were obtained from the institutional review board of Jimma University. Data on the extubation time and possible associated factors for a prolonged extubation time were collected using a data collection checklist. After being entered into EpiData 4.6 and exported into SPSS 25, descriptive analyses and logistic regression were carried out. In multivariate variables, p ≤ 0.05 was declared as statistical significance.</p><p><strong>Result: </strong>Three-hundred eight adult patients were enrolled in the current study. Of these, the incidence of prolonged extubation was 24.7% (95% CI [20.0-29.9]). The identified associated factors were age ≥ 55 years (AOR = 5.7, 95% CI [2.62, 12.69], p ≤ 001); ASAPS > II (AOR = 4.27, 95% CI [1.59, 11.45], p = 004); BMI ≥ 30 kg/m² (AOR = 6.6, 95% CI [2.37, 18.36], p ≤ 001); the use of benzodiazepine (AOR = 3.43, 95% CI [1.42, 8.25], p = 0.006); using of isoflurane (AOR = 0.35, 95% CI [0.15, 0.78], p = 0.011); prone position (AOR = 4.68, 95% CI [1.56, 14.07], p = 0.006); extubation in afternoon (AOR = 2.69, 95% CI [1.26, 5.74]; p = 0.011); and duration of surgery ≥ 210 min (AOR = 5.2, 95% CI [2.32, 11.72], p ≤ 0.001).</p><p><strong>Conclusions: </strong>The study found that prolonged time to extubation occurred in one-fourth of the patients. The independent factors statistically associated with prolonged extubation were older ages, higher ASA class, obesity (≥ 30 kg/m²), the use of benzodiazepine, halothane for maintenance, prone position, extubation in the afternoon, and longer procedures (≥ 210 min).</p>","PeriodicalId":19764,"journal":{"name":"Perioperative Medicine","volume":"14 1","pages":"48"},"PeriodicalIF":2.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of frailty on functional recovery after cardiac surgery-a case control study.","authors":"M Abdelmonem, M Elsayed, D Awadallah, O Don, R H Bennett, O G Mackay, S Pookayil, C Archer, M Mahgoub, M J Bennett","doi":"10.1186/s13741-025-00526-8","DOIUrl":"https://doi.org/10.1186/s13741-025-00526-8","url":null,"abstract":"<p><strong>Background: </strong>Good functional recovery after cardiac surgery can be reported as 'days alive and out of hospital' in the first 30 days after a procedure (DAOH₃₀) and 'days at home' in the first year (DAH₃₆₅), which integrate several clinically important outcomes, including death, hospital length of stay, quality of recovery and hospital readmission. They depend on the preservation or early recovery of physiological and functional capacity, both of which may be lost in patients living with frailty.</p><p><strong>Case presentation: </strong>We measured frailty with a multidimensional approach, incorporating 30 variables spanning comorbidity, sensory, cognitive, psychosocial, disability and pharmaceutical domains, which together make up the Patient Frailty Index (pFI). We further explored the impact of socioeconomic factors on functional recovery using the Welsh Index of Multiple Deprivation (WIMD). The outcome measures included duration of level 3 and level 2 care, duration of hospital stay, readmission and both short- and longer-term mortality. A total of 669 patients were included in the final analysis. A total of 224 (33.5%) of the patients were 'frail'. They were more likely to have chronic obstructive pulmonary disease, heart failure and diabetes and to be in the lowest decile for deprivation. Frailty was not associated with either sex or advanced age. Patients deemed to be 'frail' had a longer stay in intensive care, required level 3 cardiovascular and respiratory support for longer and stayed longer in the hospital. They spent fewer days at home in the first 30 days, largely due to days requiring advanced cardiovascular support, and fewer days at home in the first year, with most days lost to patients who died in the first year following their surgery. A moderation analysis examined whether the WIMD modified the effect of frailty on recovery after cardiac surgery. The interaction term, after confirming there were no collinearity concerns, was not significant, either for DAOH₃₀ or DAH₃₆₅, indicating no evidence of moderation.</p><p><strong>Conclusions: </strong>Short- and medium-term measures of good functional recovery were lower in 'frail' patients, and longer-term survival was also significantly reduced. An accumulation of deficits assessment of frailty, incorporating multiple domains, builds a more accurate picture of increasing vulnerability and can be acquired from patients' electronic health records. In a surgical population that is increasingly comorbid, these findings should inform decisions on preoperative priority setting, prehabilitation, postoperative resources and discharge planning.</p>","PeriodicalId":19764,"journal":{"name":"Perioperative Medicine","volume":"14 1","pages":"46"},"PeriodicalIF":2.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12016124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}