Pancreas最新文献_第2页

Risk Factors of Acute Pancreatitis in Young Adults: A Nationwide Population-Based Cohort Study in South Korea. 年轻人患急性胰腺炎的风险因素：韩国全国人口队列研究。

IF 1.7 4区医学

Pancreas Pub Date : 2025-01-01 Epub Date: 2024-07-30 DOI: 10.1097/MPA.0000000000002394

Namyoung Park, Jae Min Lee, Jin Myung Park, Sang Hyub Lee, Kyung-Do Han, Kwang Ro Joo, Ji Kon Ryu, Yong-Tae Kim

{"title":"Risk Factors of Acute Pancreatitis in Young Adults: A Nationwide Population-Based Cohort Study in South Korea.","authors":"Namyoung Park, Jae Min Lee, Jin Myung Park, Sang Hyub Lee, Kyung-Do Han, Kwang Ro Joo, Ji Kon Ryu, Yong-Tae Kim","doi":"10.1097/MPA.0000000000002394","DOIUrl":"10.1097/MPA.0000000000002394","url":null,"abstract":"Objectives: This study aimed to identify the risk factors for acute pancreatitis (AP) in young adults in their 20s based on data from the nationwide cohort in South Korea.Materials and methods: From the 2009 national health examination database of South Korea, a total of 471,098 individuals between the ages of 20 and 29 were analyzed. To identify the newly developed AP, the linked claims database was used.Results: The incidence rates of AP were 18.8 and 9.8 per 100,000 person-years in male and female participants, respectively. Alcohol consumption and smoking were associated with the heightened risk of AP. The risk of AP development was increased as daily alcohol consumption increased. In addition, ex-smokers and current smokers showed higher AP risk than never smokers. Hypertriglyceridemia and obesity were associated with the increased AP risk as well. Compared with female participants, male participants showed a higher risk of AP in univariate analysis but showed a lower risk of AP in multivariate analysis.Conclusions: In the young adult population, alcohol consumption, smoking, hypertriglyceridemia, and obesity were associated with an elevated risk of developing AP. It is important to identify and manage the modifiable AP risk factors in young adults to minimize the socioeconomic burden of AP.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e39-e44"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accurately Predict Outcomes in Patients With Acute Necrotizing Pancreatitis With Walled-Off Necrosis. 准确预测急性坏死性胰腺炎伴壁脱落坏死患者的预后。

IF 1.7 4区医学

Pancreas Pub Date : 2025-01-01 Epub Date: 2024-06-04 DOI: 10.1097/MPA.0000000000002374

Shangzhu Chen, Chengdong Tang

引用次数: 0

Risk Factors of Negative Diagnosis of Magnetic Resonance Cholangiopancreatography in Acute Biliary Pancreatitis Patients With Choledocholithiasis. 急性胆源性胰腺炎合并胆总管结石患者 MRCP 阴性诊断的风险因素。

IF 1.7 4区医学

Pancreas Pub Date : 2025-01-01 Epub Date: 2024-08-06 DOI: 10.1097/MPA.0000000000002395

Si-Hai Chen, Wen-Qing Wang, Xiao Fei, Yin Zhu, Xu Shu, Chen Yu, Qian Liao, Hui-Fang Xiong

{"title":"Risk Factors of Negative Diagnosis of Magnetic Resonance Cholangiopancreatography in Acute Biliary Pancreatitis Patients With Choledocholithiasis.","authors":"Si-Hai Chen, Wen-Qing Wang, Xiao Fei, Yin Zhu, Xu Shu, Chen Yu, Qian Liao, Hui-Fang Xiong","doi":"10.1097/MPA.0000000000002395","DOIUrl":"10.1097/MPA.0000000000002395","url":null,"abstract":"Objectives: Detecting choledocholithiasis in acute biliary pancreatitis (ABP) is crucial. Magnetic resonance cholangiopancreatography (MRCP) and endoscopic ultrasonography (EUS) identify common bile duct stones. EUS offers better accuracy than MRCP but with sedation risks. We studied MRCP negative diagnosis risk factors in ABP patients with choledocholithiasis for improved diagnostic selection.Methods: This retrospective study included 2321 ABP patients. After exclusions, 337 ABP patients with negative MRCP results were analyzed, including 75 with positive EUS findings. Univariate and multivariate logistic regression identified MRCP negative diagnosis risk factors.Results: Patients with positive EUS findings were older (62.0 vs 55.0) and had higher cholecystectomy rates (18.7% vs 7.3%). Univariate analysis showed cholecystectomy history, age, and sex as potential risk factors. Then, after adjusting the other potential risk factors (direct bilirubin, alanine transaminase, γ-glutamyl transpeptidase, and alkaline phosphatase), a history of cholecystectomy (odds ratio, 2.859; 95% confidence interval [CI], 1.312-6.23), older age (1.03; 95% CI, 1.009-1.052), and male (2.016; 95% CI, 1.152-3.528) were independent risk factors of negative diagnosis of MRCP in ABP patients with choledocholithiasis.Conclusions: Cholecystectomy history, older age, and male sex increase MRCP negative diagnosis risk in ABP patients with choledocholithiasis. Patients with these risk factors should undergo EUS first for better diagnostic outcomes.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e45-e50"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatitis during COVID-19 pandemic in US. some comments. 美国COVID-19大流行期间的胰腺炎。一些评论。

IF 1.7 4区医学

Pancreas Pub Date : 2024-12-17 DOI: 10.1097/MPA.0000000000002404

Salvatore Chirumbolo

引用次数: 0

Current understanding of therapeutic and diagnostic applications of exosomes in pancreatic cancer. 外泌体在胰腺癌治疗和诊断中的应用现状。

IF 1.7 4区医学

Pancreas Pub Date : 2024-12-11 DOI: 10.1097/MPA.0000000000002414

Neda Shakerian, Aida Tafazoli, Amir Razavinia, Zahra Sadrzadeh Aghajani, Nikoo Bana, Maysam Mard-Soltani, Bahman Khalesi, Zahra Sadat Hashemi, Saeed Khalili

{"title":"Current understanding of therapeutic and diagnostic applications of exosomes in pancreatic cancer.","authors":"Neda Shakerian, Aida Tafazoli, Amir Razavinia, Zahra Sadrzadeh Aghajani, Nikoo Bana, Maysam Mard-Soltani, Bahman Khalesi, Zahra Sadat Hashemi, Saeed Khalili","doi":"10.1097/MPA.0000000000002414","DOIUrl":"https://doi.org/10.1097/MPA.0000000000002414","url":null,"abstract":"Abstract: Unusual symptoms, rapid progression, lack of reliable early diagnostic biomarkers, and lack of efficient treatment choices are the ongoing challenges of pancreatic cancer. Numerous research studies have demonstrated the correlation between exosomes and various aspects of pancreatic cancer. In light of these facts, exosomes possess the potential to play functional roles in the treatment, prognosis, and diagnosis of the pancreatic cancer. In the present study, we reviewed the most recent developments in approaches for exosome separation, modification, monitoring, and communication. Moreover, we discussed the clinical uses of exosomes as less invasive liquid biopsies and drug carriers and their contribution to the control of angiogenic activity of pancreatic cancer. Better investigation of exosome biology would help to effectively engineer therapeutic exosomes with certain nucleic acids, proteins, and even exogenous drugs as their cargo. Circulating exosomes have shown promise as reliable candidates for pancreatic cancer early diagnosis and monitoring in high-risk people without clinical cancer manifestation. Although we have tried to reflect the status of exosome applications in the treatment and detection of pancreatic cancer, it is evident that further studies and clinical trials are required before exosomes may be employed as a routine therapeutic and diagnostic tools for pancreatic cancer.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heterogeneity in Pancreatitis: Recognizing Heterogeneity and Its Role in the Management of Pancreatitis. Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. 胰腺炎的异质性：认识异质性及其在胰腺炎治疗中的作用。国家糖尿病、消化和肾脏疾病研究所研讨会摘要。

IF 1.7 4区医学

Pancreas Pub Date : 2024-12-11 DOI: 10.1097/MPA.0000000000002403

Melena D Bellin, Dana K Andersen, Venkata Akshintala, Dianna Born, Robert C Coghill, Jeffrey Easler, Evan L Fogel, Christopher E Forsmark, A Jay Freeman, Steven J Hughes, Amy Jensen, Omer Liran, Linda Martin, Stephen J Pandol, Tonya M Palermo, Georgios I Papachristou, Walter G Park, Anna Evans Phillips, Sarah Jane Schwarzenberg, Vikesh K Singh, Frederico G S Toledo, Jill VanDalfsen, David C Whitcomb, Bechien Wu, Dhiraj Yadav

{"title":"Heterogeneity in Pancreatitis: Recognizing Heterogeneity and Its Role in the Management of Pancreatitis. Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.","authors":"Melena D Bellin, Dana K Andersen, Venkata Akshintala, Dianna Born, Robert C Coghill, Jeffrey Easler, Evan L Fogel, Christopher E Forsmark, A Jay Freeman, Steven J Hughes, Amy Jensen, Omer Liran, Linda Martin, Stephen J Pandol, Tonya M Palermo, Georgios I Papachristou, Walter G Park, Anna Evans Phillips, Sarah Jane Schwarzenberg, Vikesh K Singh, Frederico G S Toledo, Jill VanDalfsen, David C Whitcomb, Bechien Wu, Dhiraj Yadav","doi":"10.1097/MPA.0000000000002403","DOIUrl":"https://doi.org/10.1097/MPA.0000000000002403","url":null,"abstract":"Abstract: Both the clinical management and study of recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) is complicated by significant heterogeneity in the etiology, mechanisms, symptoms, and complications of pancreatitis. The National Institutes of Diabetes and Digestive and Kidney Disease (NIDDK) recently convened a workshop to address current knowledge and knowledge gaps in the field. Preclinical models that better replicate human disease are important for development of new therapies. Pain is often the most common and most difficult symptom to treat, as the causes are multifactorial and effective treatment may vary depending on whether pain is neuropathic or nociceptive in origin, and the placebo effect can complicate evaluation of the efficacy of medical and procedural interventions. Novel technologies like functional MRI and virtual reality may offer novel means for assessing and treating pain, respectively. Clinical trial designs will need to consider best approaches to addressing the heterogeneity of CP, including careful attention to designing eligibility criteria, and establishing accepted and validated core outcomes criteria for the field. The latter may be informed by consensus in pain research. Recruitment of participants into clinical trials has been challenging, often requiring multiple centers. Establishment of a clinical trials network would facilitate greater opportunities for therapeutic trials in pancreatitis.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D: A Multi-faceted Prognostic Determinant of Acute Pancreatitis Outcome. 维生素D：急性胰腺炎预后的多方面决定因素。

IF 1.7 4区医学

Pancreas Pub Date : 2024-12-11 DOI: 10.1097/MPA.0000000000002405

Osman Cagin Buldukoglu, Serkan Ocal, Ayhan Hilmi Cekin

引用次数: 0

Enhancing Pancreatic Cancer Therapy with Targeted CD133-Exosome Delivery of PD-L1 siRNA: A Preclinical Investigation. 通过CD133-外泌体靶向递送PD-L1 siRNA加强胰腺癌治疗：临床前研究。

IF 1.7 4区医学

Pancreas Pub Date : 2024-12-05 DOI: 10.1097/MPA.0000000000002419

Young Chul Yoon, Dosang Lee, Jung Hyun Park, Ok-Hee Kim, Ho Joong Choi, Say-June Kim

{"title":"Enhancing Pancreatic Cancer Therapy with Targeted CD133-Exosome Delivery of PD-L1 siRNA: A Preclinical Investigation.","authors":"Young Chul Yoon, Dosang Lee, Jung Hyun Park, Ok-Hee Kim, Ho Joong Choi, Say-June Kim","doi":"10.1097/MPA.0000000000002419","DOIUrl":"10.1097/MPA.0000000000002419","url":null,"abstract":"Objectives: This study assessed the anticancer potential of genetically modified exosomes engineered to express CD133-binding peptides on their surface and carry PD-L1 siRNA for the treatment of murine model of metastatic pancreatic cancer.Methods: CD133-targeting exosomes (tEx) were generated by harvesting conditioned media from adipose-derived stem cells (ASCs) that had undergone transformation using pDisplay vectors encoding CD133-binding peptide sequences. Subsequently, siPD-L1-loaded CD133-targeting Exosomes, referred to as tEx(s), were created by incorporating PD-L1 siRNA into the tEx using Exofect kit.Results: tEx(s) demonstrated superior targetability compared to other materials, including Ex, Ex(p), and tEx. This was substantiated by higher Total Radiant Efficiency (TRE) observed in metastatic liver and pancreatic tissues following intravenous administration of tEx(s) ( P < 0.05). Furthermore, the intravenous delivery of tEx(s) resulted in the most pronounced upregulation of pro-apoptotic markers (BIM and c-caspase 3) and the least downregulation of the anti-apoptotic markers (Mcl-1 and Bcl-xL) which has been demonstrated in various methods, including RT-PCR, Western blot analysis, and immunohistochemistry in the metastatic lesions in the livers ( P < 0.05).Conclusions: PD-L1 siRNA-loaded CD133-targeting exosomes demonstrated remarkable anticancer efficacy, characterized by specific binding to CD133-positive pancreatic cancer cells and suppression of PD-L1 expression within these cells.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142731258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ERCP Directed Transpapillary Pancreatic Duct Stenting for Disconnected Pancreatic Duct after Pancreatic Enucleation. ERCP引导下经乳头胰管支架置入术治疗胰去核术后胰管断裂。

IF 1.7 4区医学

Pancreas Pub Date : 2024-12-03 DOI: 10.1097/MPA.0000000000002433

Lu Zou, Shuai Huang, Wenguang Wu

引用次数: 0

High Diagnostic Yield of Fine Needle Biopsy for Pancreatic Serous Cystadenomas - a Multi-Center Study. 细针活检对胰腺浆液性囊腺瘤的高诊断率-一项多中心研究。

IF 1.7 4区医学

Pancreas Pub Date : 2024-12-02 DOI: 10.1097/MPA.0000000000002442

Grace E Kim, Michael Mercado, Margarita Riojas Barrett, Miles Breese, Shifa Umar, Fares Ayoub, Dennis Chen, Mohamed O Othman, Uzma D Siddiqui

{"title":"High Diagnostic Yield of Fine Needle Biopsy for Pancreatic Serous Cystadenomas - a Multi-Center Study.","authors":"Grace E Kim, Michael Mercado, Margarita Riojas Barrett, Miles Breese, Shifa Umar, Fares Ayoub, Dennis Chen, Mohamed O Othman, Uzma D Siddiqui","doi":"10.1097/MPA.0000000000002442","DOIUrl":"https://doi.org/10.1097/MPA.0000000000002442","url":null,"abstract":"Background: Distinguishing serous cystadenoma, a benign pancreatic cyst, from potentially malignant mucinous pancreatic cystic lesions carries significant clinical and prognostic implications; and while endoscopic ultrasound-guided fine needle aspiration is the standard diagnostic tool, its low diagnostic yield often results in additional workup.Objective: This study evaluates diagnostic yield of fine needle biopsy (FNB) on lesions suggestive of serous cystadenoma on endoscopic ultrasound.Methods: Patients with microcystic EUS appearance were identified through retrospective chart review in two institutions. Prior cross sectional imaging diagnosis was also obtained. All microcystic lesions with classic \"honeycomb\" appearance for serous cystadenoma on EUS were targeted for FNB and their pathology evaluated. Patients were identified through database search from 2015 to 2022 and procedure information was obtained through a retrospective chart review from two large academic centers.Results: Thirty-one patients with suspected serous cystadenoma who underwent EUS-FNB were included. EUS FNB was successful in obtaining diagnosis in 96.8% of patients. Serous cystadenoma was diagnosed via EUS FNB in 27 of 31 patients (87.1%). Of the remaining four patients, there was one invasive pancreatic ductal adenocarcinoma, one pancreatic neuroendocrine tumor, one intraductal papillary mucinous neoplasm, and one nondiagnostic sample.Conclusion: EUS-FNB sampling for histopathology is a safe and accurate diagnostic tool for pancreatic serous cystadenoma. When microcytic lesions are found on endoscopic ultrasound, our study results suggest that fine needle biopsy for histopathology should be considered as the initial diagnostic evaluation tool given the demonstrated improved diagnostic yield for serous cystadenoma.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0