Pancreas最新文献

{"title":"Comparison of Biliary Drainage Techniques for MBO: A Meta-Analysis.","authors":"Feng Qiu, Tianchi Yang, Wei Han","doi":"10.1097/MPA.0000000000002504","DOIUrl":"https://doi.org/10.1097/MPA.0000000000002504","url":null,"abstract":"<p><strong>Background: </strong>Malignant biliary obstruction (MBO) impacts patient health and quality of life. Biliary drainage techniques, including percutaneous transhepatic biliary drainage (PTBD) and endoscopic biliary drainage (EBD), are commonly used, yet their relative advantages remain unclear.</p><p><strong>Objective: </strong>To compare the effectiveness and complications of EBD and PTBD in treating MBO.</p><p><strong>Methods: </strong>A systematic literature search in databases such as PubMed and EMBASE identified case-control trials comparing EBD and PTBD from January 2010 to the present. Five studies comprising 721 participants were analyzed. Outcome measures included technical success rate, incidence of complications, post-drainage pancreatitis, bleeding, major complications, hospital stay duration, and implant metastasis rates. Statistical analysis was conducted using RevMan 5.3 software.</p><p><strong>Results: </strong>There was no significant difference between the two groups regarding major complications, bleeding incidents, hospital stay, or implantation metastasis rates. However, PTBD showed a significantly lower incidence of complications and post-drainage pancreatitis compared to EBD.</p><p><strong>Conclusion: </strong>PTBD may offer advantages over EBD in managing MBO, including fewer complications and reduced incidence of pancreatitis, suggesting PTBD as a potentially safer and more effective treatment option. Nonetheless, further large-scale, high-quality studies are needed to validate these findings.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144507322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long Non-Coding RNA n336928 Facilitates the Progression of Pancreatic Neuroendocrine Neoplasms via NF-κB Pathway Mediated by EZH2.","authors":"Mujie Ye, Ping Yu, Yi Ding, Jialing Pan, Jianshu Liu, Qin Long, Ye Tian, Qiyun Tang","doi":"10.1097/MPA.0000000000002525","DOIUrl":"https://doi.org/10.1097/MPA.0000000000002525","url":null,"abstract":"<p><p>Pancreatic neuroendocrine neoplasms (pNENs) are among the most frequently occurring neuroendocrine neoplasms (NENs). In this study, we aimed to investigate the role and impact of LncRNA-n336928 (n336928) in pNENs. We evaluated changes in cell proliferation using CCK-8, colony formation, and EDU assays, and assessed the effects on cell migration and invasion through transwell assays. RNA-seq analysis was performed to explore the potential mechanisms underlying n336928-induced pNEN progression. Subcutaneous tumorigenesis models were constructed to verify the function of n336928 in vivo. Our findings indicate that overexpression of n336928 significantly accelerated the proliferation, migration, and invasion of pNEN cell lines, while concurrently suppressing apoptosis. Furthermore, transcriptome sequencing revealed that the NF-κB pathway was activated in pNEN cells following n336928 overexpression. We have established that the upregulation of n336928 promotes the progression of pNENs via the NF-κB signaling pathway, thereby implicating it in the occurrence and development of pNENs.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifetime Smoking History and Marijuana co-use in Patients With Alcohol-related Acute Pancreatitis.","authors":"Esther A Adeniran, Sungjin Kim, Stephen J Pandol, Dhiraj Yadav, Georgios I Papachristou, James L Buxbaum, Joseph R Pisegna, Christie Y Jeon","doi":"10.1097/MPA.0000000000002523","DOIUrl":"10.1097/MPA.0000000000002523","url":null,"abstract":"<p><strong>Objectives: </strong>Smoking increases the risk of the first episode of acute pancreatitis (AP), its recurrence, and progression to chronic pancreatitis. Co-use of cigarettes with marijuana may exacerbate health risks, complicating pancreatitis management. Our study aims to investigate the lifetime smoking history and co-use of cigarettes and marijuana in AP patients.</p><p><strong>Methods: </strong>We analyzed smoking history and marijuana use data from a multicenter case-crossover study of alcohol-associated AP patients (n=145) recruited from June 2020 to June 2024. Lifetime cigarette use was categorized as: history of smoking <1 pack-per day [PPD], ≥1 PPD, and non-smokers. Age-based smoking prevalence was estimated across two birth cohorts (1956-1979 and 1980-1998). Risk factors for co-use were also assessed.</p><p><strong>Results: </strong>Of the 143 participants enrolled and who completed smoking history interview, 76% were current smokers and 24% were former smokers. Median cumulative pack-years of smoking until enrollment was 20.4 years in ≥1 PPD smokers vs. 4.2 years in <1 PPD smokers ( P <0.001). Peak smoking prevalence was higher in females born in 1980-1998 than females born in 1956-1979 (100% vs. 67%), while males showed an opposite trend (61% for 1956-1979 vs 52% for 1980-1998). Of all participants, 20% reported co-use of cigarettes and marijuana, 22% cigarette-only use, and 14% marijuana-only use. Trauma and stressor-related disorders were associated with a lower likelihood of co-use than cigarette-only use (AOR: 0.19, 95% CI: 0.05-0.63, P =0.010).</p><p><strong>Conclusions: </strong>Smoking is highly prevalent in patients with alcohol-associated AP, many of whom also use marijuana. Tailored smoking cessation interventions are needed for AP patients.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"rs928508 of miR-30c-5p is Associated with the Risk of Post-ERCP Pancreatitis.","authors":"Yunyun Sun, Xia Li, Liang Chen, Jun Zhang","doi":"10.1097/MPA.0000000000002527","DOIUrl":"https://doi.org/10.1097/MPA.0000000000002527","url":null,"abstract":"<p><strong>Objective: </strong>Endoscopic retrograde cholangiopancreatography (ERCP) is a widely utilized endoscopic technique for the diagnosis and therapy of biliary and pancreatic diseases. It usually leads to different complications including post-ERCP pancreatitis (PEP). This study aimed to evaluate the correlation between miR-30c-5p rs928508 polymorphism and the risk of PEP and to analyze the effect of it on serum miR-30c-5p level.</p><p><strong>Methods: </strong>Patients with PEP were collected as a case group, while patients without complications were gathered as a control group. miR-30c-5p levels were measured using qRT-PCR, and rs928508 genotyping was performed using the TaqMan method. Logistic regression analysis was used to recognize independent risk factors for PEP.</p><p><strong>Results: </strong>The case group had significantly lower miR-30c-5p levels, especially in AG/GG genotype carriers. rs928508 was correlated with increased PEP risk under GG vs. AA (OR=2.170, 95%CI=1.118-4.210), AG/GG vs. AA (P=0.032, OR=1.840, 95%CI=1.048-3.231) and G vs. A (P=0.026, OR=1.433, 95%CI=1.043-1.969) models. Meanwhile, AG (OR=33.023, 95%CI=1.026-8.906), GG (OR=3.344, 95%CI=1.070-10.450), and AG/GG (OR=3.138, 95%CI=1.103-8.932) genotypes were correlated with high severity of PEP. Multivariate analysis suggested that drinking (OR=2.091, 95%CI=1.102-3.968), difficult cannulation (OR=2.198, 95%CI=1.301-3.712), pancreatic duct visualization (OR=5.468, 95%CI=2.945-10.151), pancreatic duct stenting history (OR=3.415, 95%CI=1.742-6.693), and AG/GG genotypes of rs928508 (OR=2.137, 95%CI=1.114-4.100) were independent risk factors for PEP onset.</p><p><strong>Conclusion: </strong>miR-30c-5p rs928508 polymorphism is correlated with an enhanced risk and severity of PEP.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence and Characteristics of Autoimmune Pancreatitis among Patients Presenting with Pancreatitis to a Quaternary Referral Centre in Melbourne, Australia.","authors":"Dilini Abeywickrama, Michael MacIsaac, Simon Hew","doi":"10.1097/MPA.0000000000002521","DOIUrl":"https://doi.org/10.1097/MPA.0000000000002521","url":null,"abstract":"","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal Burden in Patients with Pancreatic Insufficient Cystic Fibrosis Before and After Elexacaftor/Tezacaftor/Ivacaftor Use.","authors":"Sasha-Jane Abi-Aad, Carolena Trocchia, Maua Mosha, Jacob A Mark, Daniel H Leung, Racha Khalaf","doi":"10.1097/MPA.0000000000002522","DOIUrl":"10.1097/MPA.0000000000002522","url":null,"abstract":"<p><strong>Background: </strong>The advent of highly effective modulator therapies (HEMT), namely elexacaftor, tezacaftor and ivacaftor (ETI), has resulted in substantial improvements in lung function, growth, and quality of life, for people with cystic fibrosis (PwCF). However, the understanding of the impact of ETI on gastrointestinal (GI) disease burden is evolving. This study aims to describe and compare the prevalence of GI manifestations, prescribed GI medications, and GI procedures between two time periods pre and post-ETI approval in children with CF (CwCF).</p><p><strong>Methods: </strong>This is a retrospective cohort study utilizing TriNetX, a multicenter database. The study includes patients between 6 to 21 years old with ICD-10 diagnostic codes for CF and a prescription for pancreatic enzyme replacement therapy (PERT) to match disease severity. We included 4 years before and 4 years after the release of ETI combination therapy.</p><p><strong>Results: </strong>When comparing CwCF taking PERT, on or off ETI, the prevalence of diagnostic codes for chronic pancreatitis, constipation, unspecified noninfective gastroenteritis, and colitis significantly decreased after ETI use (all P < 0.0001). The prevalence of other luminal disorders, liver disorders, and acute pancreatitis did not differ between the two groups. The prevalence of prescribed medications including mucolytics, vitamins, PPI, and antidiarrheal was similar for both groups except for a reduction in prescribed laxatives (p-value = 0.0001). The prevalence of GI procedures was also similar in both groups.</p><p><strong>Conclusion: </strong>The reduction in constipation and non-infective gastroenteritis and colitis is important as GI symptoms are linked to the quality of life of CwCF. There remains a great clinical need to evaluate the effects of ETI on GI disorders, especially as the age of initial use of this therapy decreases, and the duration of use increases.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Acute Myeloid Leukemia following Treatment for Metastatic Poorly Differentiated Pancreatic Neuroendocrine Carcinoma: A Cautionary Sequel to an Exceptional Response.","authors":"Elizabeth S Nakasone, Stacey A Cohen","doi":"10.1097/MPA.0000000000002520","DOIUrl":"https://doi.org/10.1097/MPA.0000000000002520","url":null,"abstract":"","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein N-Glycosylation Traits Combined with CA19-9 Accurately Distinguish Pancreatic Cancer Cases From Healthy Controls and Benign Pancreatic Diseases.","authors":"Aleksander M Bogdanski, Derk C F Klatte, Monique E van Leerdam, Christa M Cobbaert, Bart E P B Ballieux, Jeanin E van Hooft, Kristin E Clift, Manfred Wuhrer, Wilma E Mesker, Yan Bi, Michael B Wallace, Yuri E M van der Burgt","doi":"10.1097/MPA.0000000000002517","DOIUrl":"https://doi.org/10.1097/MPA.0000000000002517","url":null,"abstract":"<p><strong>Objectives: </strong>New methods are needed to detect pancreatic ductal adenocarcinoma (PDAC) earlier to improve outcomes. We previously reported that a panel of protein N-glycosylation traits (NGTs) discriminated PDAC from healthy-controls with an area under the curve (AUC) of 0.81-0.88. However, it remained unclear whether this panel accurately differentiates PDAC from other benign pancreatic disorders. Our study aims to evaluate the performance of the NGT panel in combination with CA19-9, in a diverse cohort, including PDAC cases, healthy-controls and controls with benign pancreatic disorders.</p><p><strong>Methods: </strong>Protein N-glycosylation profiles were determined in plasma samples using an in-house developed mass spectrometry assay. CA19-9 levels were measured using routine immunoassay test. Results of total plasma NGTs and CA19-9 were evaluated separately as well as in combination. Logistic regression was performed to calculate odds ratios (ORs), AUC, sensitivity and specificity to determine the performance of NGTs and CA19-9 in distinguishing PDAC from controls.</p><p><strong>Results: </strong>In total 221 individuals were included: 45 (20.4%) with PDAC, and 176 (79.6%) controls (53 healthy and 123 with benign pancreatic disease). The AUC for differentiating PDAC from the total control cohort based on the combination of the NGT panel and CA19-9 was 0.94 (95% CI, 0.90-0.97), with a sensitivity of 0.89 (95% CI, 0.78-0.98) and specificity of 0.86 (95% CI, 0.81-0.91). Comparison of PDAC cases with healthy-controls only, resulted in an AUC of 0.96 (95% CI, 0.93-0.99), with a sensitivity of 0.84 (95% CI, 0.73-0.93) and specificity of 0.98 (95% CI, 0.94-1.00).</p><p><strong>Conclusions: </strong>Both plasma NGTs and CA19-9 distinguish PDAC from a diverse-control cohort. The accuracy further improves when these readouts are combined, showing promise for future early detection methods.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Myocardial Infarction and Stroke after a First Episode of Acute Pancreatitis: A Self-Controlled Case Series Study.","authors":"Line Davidsen, Niels Henrik Bruun, Mathias E Cook, Asbjørn M Drewes, Søren S Olesen","doi":"10.1097/MPA.0000000000002518","DOIUrl":"https://doi.org/10.1097/MPA.0000000000002518","url":null,"abstract":"<p><strong>Objectives: </strong>Acute pancreatitis induces systemic inflammation and promotes a prothrombotic environment, which may increase the risk of cardiovascular events. However, the temporal relationship between acute pancreatitis and subsequent cardiovascular events remains unexplored. We aimed to examine whether the risk of acute myocardial infarction and stroke is increased following an episode of acute pancreatitis.</p><p><strong>Methods: </strong>We conducted a Danish Nationwide population-based cohort study, including all incident cases of acute pancreatitis (≥18 years) from 2002 to 2017. The primary outcome was acute myocardial infarction or stroke. Using a self-controlled case series design, we compared the incidence of myocardial infarction or stroke during a risk interval (90 days following acute pancreatitis discharge) with two control intervals (365 days before and 91-365 days after the acute pancreatitis episode).</p><p><strong>Results: </strong>Among 33,124 patients with incident acute pancreatitis, 366 cases of myocardial infarction and 624 cases of stroke were identified within one year of the acute pancreatitis episode. The incidence rate ratios (IRR) for myocardial infarction during the 90-day risk interval was 1.87 (95% confidence interval (CI), 1.42-2.47), with the highest risk observed during the first 10 days (IRR, 4.08; 95% CI, 2.58-6.44), followed by a gradual decline. The IRR for stroke during the risk interval was 2.12 (95% CI, 1.74-2.58), peaking in the first 10 days (IRR, 3.40; 95% CI, 2.33-4.96) and gradually declining.</p><p><strong>Conclusions: </strong>Our study reveals a temporary increase in the risk of myocardial infarction and stroke after hospitalization for a first episode of acute pancreatitis.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical Resection of Murine PDAC Alters Hepatic Metastases and Immune Microenvironment.","authors":"Anthony Sorrentino, Carolina Alcantara Hirsch, Beny Shapiro, Erica Ma, Emma Kurz, Mansour E Riachi, Sarah Kaslow, Ting Chen, Wenqing Cao, Ryte Damaseviciute, Sandra Vogt, Juan Kochen Rossi, Kwok-Kin Wong, Ammar A Javed, Rafael Winograd, Christopher L Wolfgang, Dafna Bar-Sagi","doi":"10.1097/MPA.0000000000002516","DOIUrl":"https://doi.org/10.1097/MPA.0000000000002516","url":null,"abstract":"<p><strong>Objective: </strong>Identify how surgical resection of pancreatic ductal adenocarcinoma (PDAC) affects systemic minimal residual disease (MRD).</p><p><strong>Methods: </strong>Pancreatic tumors were generated by orthotopic implantation of tumor cells into the pancreas of immunocompetent mice. Tumor resection was carried out via distal pancreatectomy and splenectomy. Liver metastases and microenvironment immune changes were analyzed in resected vs. non-resected mice.</p><p><strong>Results: </strong>Resection was accompanied by proliferative expansion of liver metastases and an increase in hepatic metastatic burden. Postoperative immune changes predominantly manifested as a time-dependent increase in eosinophils and decrease in neutrophils. The postoperative hepatic eosinophilia was protective of further metastatic progression. The parenchymal findings were detectable in the circulation, and the trends observed in the mouse model modeled those seen in PDAC patients postoperatively.</p><p><strong>Conclusion: </strong>Collectively, we describe a preclinical resection model that offers a means to investigate MRD. Using this model, we delineated effects of surgical resection on metastatic outgrowth and uncovered a protective link between the postoperative hepatic eosinophilia and further metastatic progression.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144128377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}