IF 1.7 4区医学

Pancreas Pub Date : 2025-01-27 DOI: 10.1097/MPA.0000000000002448

Mylena D Bos, N Helge Meyer, Allard G Wijma, Karl Khatib-Chahidi, Evert van den Broek, Cassandra S L Ho, Mark Meerdink, Joost M Klaase, Maximilian Bockhorn, Frederik J H Hoogwater, Maarten W Nijkamp

{"title":"Preoperative Anemia as a Prognostic Risk Factor for Inferior Oncological Survival Following Resection for Pancreatic Ductal Adenocarcinoma.","authors":"Mylena D Bos, N Helge Meyer, Allard G Wijma, Karl Khatib-Chahidi, Evert van den Broek, Cassandra S L Ho, Mark Meerdink, Joost M Klaase, Maximilian Bockhorn, Frederik J H Hoogwater, Maarten W Nijkamp","doi":"10.1097/MPA.0000000000002448","DOIUrl":"10.1097/MPA.0000000000002448","url":null,"abstract":"Objectives: A significant proportion of patients undergoing surgery for pancreatic ductal adenocarcinoma (PDAC) are anemic at the time of resection. In these patients, blood transfusions are omitted due to their potential negative impact on oncological outcomes. The aim of the present study was to determine the prognostic value of preoperative anemia in resected PDAC patients, irrespective of blood transfusion status.Methods: In this retrospective two-center cohort study patients who underwent resection for histologically confirmed PDAC between 2013 and 2022 were included. The prognostic role of preoperative anemia was investigated using Cox proportional-hazard regression analysis. A subgroup analysis was performed in which PDAC patients who received a perioperative blood transfusion were excluded.Results: Among the 280 PDAC patients who were included, 110 (39%) were found to have anemia prior to surgery. Preoperative anemia was associated with increased use of blood transfusions, with a total of 44 patients (16%) requiring transfusion perioperatively. In the whole cohort, preoperative anemia was found to be an independent predictor of lower disease-free survival (DFS) (HR=1.518; 95% CI 1.103-2.090; P =0.011), but not overall survival (OS). However, when patients who received a perioperative blood transfusion were excluded from the analysis, preoperative anemia was independently associated with both lower DFS (HR=1.636; 95% CI 1.113-2.404; P =0.012) and OS (HR=1.484; 95% CI 1.036-2.127; P =0.031).Conclusions: Preoperative anemia was shown to be an independent risk factor for inferior oncological survival after resection for PDAC. These results support the need for increased awareness regarding the potential adverse effects of preoperative anemia on oncological outcomes in PDAC.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Variants in SPINK1, PRSS1 or CFTR are Not Associated with The Development of Post-ERCP Pancreatitis. SPINK1、PRSS1或CFTR基因变异与ercp后胰腺炎的发生无关

IF 1.7 4区医学

Pancreas Pub Date : 2025-01-16 DOI: 10.1097/MPA.0000000000002465

Mike Jp de Jong, Roel Cm van Aard, Romy N Kuipers, René Hm Te Morsche, Foke van Delft, Peter D Siersema

引用次数: 0

Simultaneous Pancreas and Kidney Transplantation From a Small Pediatric Donor with Ipsilateral Implantation Over Aortic Cuff. 儿童小供体同时胰肾移植与主动脉袖上同侧植入。

IF 1.7 4区医学

Pancreas Pub Date : 2025-01-14 DOI: 10.1097/MPA.0000000000002464

Venkata Kanaka Naga Karthik Nasika, Vivek Thakur, Abhinav Reddy, Ashish Sharma, Sarbpreet Singh, Jasmine Sethi

引用次数: 0

Clinical Variability of Pain Localization in Chronic Pancreatitis. 慢性胰腺炎疼痛定位的临床变异性。

IF 1.7 4区医学

Pancreas Pub Date : 2025-01-14 DOI: 10.1097/MPA.0000000000002462

L Kuhlmann, A E Phillips, M Faghih, V K Singh, J Windsor, S S Olesen, A M Drewes

引用次数: 0

A Modified Procedure to Improve Pancreatic Drainage in Chronic Pancreatitis with Pancreatic Head Dominant Disease. 改善慢性胰腺炎伴胰头显性疾病胰腺引流的改良手术。

IF 1.7 4区医学

Pancreas Pub Date : 2025-01-13 DOI: 10.1097/MPA.0000000000002461

Mohamed A Shaaban, Greg J Beilman

{"title":"A Modified Procedure to Improve Pancreatic Drainage in Chronic Pancreatitis with Pancreatic Head Dominant Disease.","authors":"Mohamed A Shaaban, Greg J Beilman","doi":"10.1097/MPA.0000000000002461","DOIUrl":"https://doi.org/10.1097/MPA.0000000000002461","url":null,"abstract":"Objectives: Chronic pancreatitis is a debilitating and progressive inflammatory disease with an altered quality of life due to severe abdominal pain. Pancreaticoduodenectomy is a surgical option for patients with bulky disease involving the head of the pancreas, especially when this disease has progressed to stricture of the bile duct, duodenum, or both. A long term issue associated with this procedure is stricture of the pancreatic anastomosis. Re-operative and endoscopic interventions are difficult related to difficulty in reaching the anastomosis endoscopically. We describe a variation of this procedure with potential to lead to longer term improvement in drainage of the residual pancreas.Methods: We reviewed electronic medical records of patients undergoing pancreaticoduodenectomy for chronic pancreatitis performed by one surgeon at the University of Minnesota Medical Center, Minneapolis, MN, between 2014 and 2023. Information gathered from the patients' records included preoperative demographics, perioperative outcomes, and postoperative follow up information.Results: The described procedure was performed in eight patients between 2014 and 2023. Three patients have died since surgery at 1.5, 5.5, and 8 years postop, with no deaths related to pancreatitis or surgical complications. Of the remaining five patients, median time from surgery is 7.5 years.Conclusions: We describe a surgical technique which may reduce the risk of pancreaticojejunal stricture in patients undergoing pancreaticoduodenectomy for chronic pancreatitis. In a small series of patients, this procedure can be performed safely with acceptable results.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidental Mucinous Neoplasms of the Pancreas: Performance of the AGA, European, and IAP Guidelines in Advising Further Management after Endoscopic ultrasound-guided fine-needle Aspiration Biopsy. 胰腺偶发粘液瘤：AGA、欧洲和IAP指南在超声内镜引导下细针穿刺活检后进一步治疗建议中的表现

IF 1.7 4区医学

Pancreas Pub Date : 2025-01-13 DOI: 10.1097/MPA.0000000000002456

Débora Pacheco, Otávio Micelli-Neto, Eloy Taglieri, Fernando Issamu Tabushi, Osvaldo Malafaia, Rodrigo Cañada Trofo Surjan, Marcel Autran Machado, Filadélfio Euclides Venco, Rafael Kemp, José Sebastião Dos Santos, José Celso Ardengh

{"title":"Incidental Mucinous Neoplasms of the Pancreas: Performance of the AGA, European, and IAP Guidelines in Advising Further Management after Endoscopic ultrasound-guided fine-needle Aspiration Biopsy.","authors":"Débora Pacheco, Otávio Micelli-Neto, Eloy Taglieri, Fernando Issamu Tabushi, Osvaldo Malafaia, Rodrigo Cañada Trofo Surjan, Marcel Autran Machado, Filadélfio Euclides Venco, Rafael Kemp, José Sebastião Dos Santos, José Celso Ardengh","doi":"10.1097/MPA.0000000000002456","DOIUrl":"https://doi.org/10.1097/MPA.0000000000002456","url":null,"abstract":"Objectives: We compared the performance of AGA-2015, ESG-2018, and IAP-2024 guidelines in referring patients for surgery versus surveillance when applied to incidental after diagnosis by EUS-FNA.Methods: Single-center, retrospective study with prospective data collection. PLs identified incidentally on CT or MRI/MRCP performed for other diseases with inconclusive imaging results were eligible for analysis. After EUS-FNA and microhistological diagnosis, each of the guidelines was applied; sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratios were compared.Results: 140 asymptomatic patients (mean age 64.7 y, 61% female) had a confirmed diagnosis of MN. Of these, 42 (30%) had \"high rik stigmata\" and 16 (11.4%) were malignant. AGA-2015, ESG-2018, and IAP-2024, criteria would have advised surgery unnecessarily in 66%, 15%, and 46%, respectively (P<0.001). AGA-2015, ESG-2018, and IAP-2024, and criteria failed to identify 59%, 46.1%, and 33.3% of HGD/IC, respectively (P=1.00).Conclusion: The AGA-2015 criteria were highly specific, while IAP-2024 had superior sensitivity. All had moderate sensitivity to indicate surgery, and all missed similar numbers of malignant lesions. Performing EUS-FNA before application of guidelines seems appropriate to guide further management of asymptomatic PLs, preventing unnecessary surgery and referring patients appropriately for surveillance. The ESG-2018 guideline proved most accurate for this purpose.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic Cancer Risk in Prediabetes: A Systematic Meta-analysis Approach. 糖尿病前期的胰腺癌风险：系统性元分析方法。

IF 1.7 4区医学

Pancreas Pub Date : 2025-01-01 Epub Date: 2024-09-26 DOI: 10.1097/MPA.0000000000002391

Akhil Jain, Praneeth Reddy Keesari, Yashwitha Sai Pulakurthi, Rewanth Katamreddy, Meekoo Dhar, Rupak Desai

{"title":"Pancreatic Cancer Risk in Prediabetes: A Systematic Meta-analysis Approach.","authors":"Akhil Jain, Praneeth Reddy Keesari, Yashwitha Sai Pulakurthi, Rewanth Katamreddy, Meekoo Dhar, Rupak Desai","doi":"10.1097/MPA.0000000000002391","DOIUrl":"10.1097/MPA.0000000000002391","url":null,"abstract":"Objectives: Pancreatic cancer and prediabetes pose significant public health challenges. Given the lack of strong evidence we performed a meta-analysis to assess the risk of pancreatic cancer in prediabetes.Materials and methods: We performed a thorough search of the major databases over the last 10 years to identify relevant articles. The pooled odds ratio (OR) and hazard ratio (HR) were combined to calculate the effect size (ES).Results: We analyzed 5 studies including 5,425,111 prediabetic individuals and 16,096,467 normoglycemic population across 5 countries with a median follow-up of 8.5 years. We identified a noteworthy association between prediabetes and pancreatic cancer, reporting an unadjusted ES of 1.36 (95% confidence interval [CI] 1.05-1.77, P = 0.02) and an adjusted ES of 1.40 (1.23-1.59, P < 0.01). Subgroup analyses by age revealed variations in risk, with studies involving participants aged 60 and above exhibiting a higher ES (ES 1.83, 95% CI 1.28-2.62, P < 0.01). Geographical differences were also observed, with Japanese studies reporting a higher risk (ES 1.89, 95% CI 1.15-3.10, P < 0.01) compared with those from the United States (ES 1.32, 95% CI 1.13-1.53, P < 0.01).Conclusions: We identified 40% higher risk of pancreatic cancer in patients with prediabetes than those with normal blood glucose necessitating urgent attention for further research and policy change.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e51-e56"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Dose Tacrolimus-Induced Acute Pancreatitis After Kidney Transplantation: A Case Report. 肾移植术后大剂量他克莫司诱发的急性胰腺炎：病例报告。

IF 1.7 4区医学

Pancreas Pub Date : 2025-01-01 Epub Date: 2024-06-24 DOI: 10.1097/MPA.0000000000002382

Mengyuan Peng, Tianjiao Lin, Zhimin Song, Tao Huang, Xinting Pan

引用次数: 0

Decrease in Bioelectrical Impedance Phase Angle Is Associated With Days Until Death in Pancreatic Cancer. 生物电阻抗相位角的减小与胰腺癌患者的死亡天数有关

IF 1.7 4区医学

Pancreas Pub Date : 2025-01-01 Epub Date: 2024-06-03 DOI: 10.1097/MPA.0000000000002377

Karina Pozo, Luis Alberto Gobbo, Rafael Mello Fontolan Vieira, Amanda Mendes Cavalcante, Isis Grigoletto, Ercy Mara Cipulo Ramos

引用次数: 0

Ex-Vivo 3D Cellular Models of Pancreatic Ductal Adenocarcinoma: From Embryonic Development to Precision Oncology. 胰腺导管腺癌的体外三维细胞模型：从胚胎发育到精准肿瘤学。

IF 1.7 4区医学

Pancreas Pub Date : 2025-01-01 Epub Date: 2024-07-30 DOI: 10.1097/MPA.0000000000002393

Ivana Acimovic, Viktorie Gabrielová, Stanislava Martínková, Michal Eid, Jakub Vlažný, Petr Moravčík, Jan Hlavsa, Lukáš Moráň, Riza Can Cakmakci, Peter Staňo, Vladimír Procházka, Zdeněk Kala, Jan Trnka, Petr Vaňhara

{"title":"Ex-Vivo 3D Cellular Models of Pancreatic Ductal Adenocarcinoma: From Embryonic Development to Precision Oncology.","authors":"Ivana Acimovic, Viktorie Gabrielová, Stanislava Martínková, Michal Eid, Jakub Vlažný, Petr Moravčík, Jan Hlavsa, Lukáš Moráň, Riza Can Cakmakci, Peter Staňo, Vladimír Procházka, Zdeněk Kala, Jan Trnka, Petr Vaňhara","doi":"10.1097/MPA.0000000000002393","DOIUrl":"10.1097/MPA.0000000000002393","url":null,"abstract":"Abstract: Pancreas is a vital gland of gastrointestinal system with exocrine and endocrine secretory functions, interweaved into essential metabolic circuitries of the human body. Pancreatic ductal adenocarcinoma (PDAC) represents one of the most lethal malignancies, with a 5-year survival rate of 11%. This poor prognosis is primarily attributed to the absence of early symptoms, rapid metastatic dissemination, and the limited efficacy of current therapeutic interventions. Despite recent advancements in understanding the etiopathogenesis and treatment of PDAC, there remains a pressing need for improved individualized models, identification of novel molecular targets, and development of unbiased predictors of disease progression. Here we aim to explore the concept of precision medicine utilizing 3-dimensional, patient-specific cellular models of pancreatic tumors and discuss their potential applications in uncovering novel druggable molecular targets and predicting clinical parameters for individual patients.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e57-e71"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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