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FDG PET-CT vs. CT for Recurrence in Post-treatment Pancreatic Adenocarcinoma (PAC): Comparative Diagnostic Test Accuracy Systematic Review and Meta-analysis. FDG PET-CT与CT治疗后胰腺腺癌(PAC)复发:比较诊断测试准确性系统评价和荟萃分析。
IF 1.7 4区 医学
Pancreas Pub Date : 2025-04-29 DOI: 10.1097/MPA.0000000000002498
Ankush Jajodia, Bipin Nanda, Mostafa Alabousi, Ani Orchanian-Cheff, Satheesh Krishna Jeyaraj, Michael Patlas
{"title":"FDG PET-CT vs. CT for Recurrence in Post-treatment Pancreatic Adenocarcinoma (PAC): Comparative Diagnostic Test Accuracy Systematic Review and Meta-analysis.","authors":"Ankush Jajodia, Bipin Nanda, Mostafa Alabousi, Ani Orchanian-Cheff, Satheesh Krishna Jeyaraj, Michael Patlas","doi":"10.1097/MPA.0000000000002498","DOIUrl":"https://doi.org/10.1097/MPA.0000000000002498","url":null,"abstract":"<p><strong>Objectives: </strong>To perform a systematic review comparing diagnostic test accuracy of FDG PET-CT versus CT for assessing recurrence in post-treatment pancreatic adenocarcinoma (PAC).</p><p><strong>Methods: </strong>Ovid MEDLINE, Ovid Embase, Cochrane Database of Systematic Reviews (Ovid), Cochrane Central Register of Controlled Trials (Ovid), and Web of Science searched until February 2024 for comparative diagnostic accuracy studies assessing PET-CT versus CT in post-treated subjects with PAC to evaluate diagnostic accuracy for recurrence. The reference standard was histopathology when available or clinical follow-up. Data extraction, risk of bias (ROB), and applicability assessment were performed by two authors. QUADAS-C was used for ROB assessment. Bivariate random-effects model meta-analysis, and meta-regression were performed for test comparison with 95% confidence intervals (95%CI).</p><p><strong>Results: </strong>Of 5345 citations retrieved, nine articles met all inclusion criteria, with 400 PAC patients who had 320 recurrences included. Three studies were considered at low risk of bias, while the remaining six studies were at high risk for bias. The sensitivity/specificity (95%CI) and AUC of PET-CT was 89% (83-92%)/83% (73-90%) and 0.927 and for CT was 72% (64-79%)/76% (64-85%) and 0.803. A meta-regression model demonstrated a higher sensitivity for PET-CT than CT alone (P<0.001), with no significant difference in specificity (P=0.243). Risk of bias had no significant impact on CT or PET-CT diagnostic accuracy (P=0.072-0.775).</p><p><strong>Conclusions: </strong>PET-CT exhibited greater sensitivity compared to CT alone, with no significant variance in specificity between the two modalities, for recurrence evaluation in PAC.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Underuse of Pancreatic Enzyme Replacement Therapy Among Patients With Gastroenteropancreatic Neuroendocrine Neoplasms and Exocrine Pancreatic Insufficiency. 胰酶替代疗法在胃肠胰神经内分泌肿瘤和外分泌胰功能不全患者中的应用不足。
IF 1.7 4区 医学
Pancreas Pub Date : 2025-04-01 DOI: 10.1097/MPA.0000000000002477
Udhayvir S Grewal, Apoorva K Chandar
{"title":"Underuse of Pancreatic Enzyme Replacement Therapy Among Patients With Gastroenteropancreatic Neuroendocrine Neoplasms and Exocrine Pancreatic Insufficiency.","authors":"Udhayvir S Grewal, Apoorva K Chandar","doi":"10.1097/MPA.0000000000002477","DOIUrl":"10.1097/MPA.0000000000002477","url":null,"abstract":"","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e387-e388"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk Factors for Early Liver Recurrence After Pancreatic Cancer Resection. 胰腺癌切除术后早期肝脏复发的危险因素。
IF 1.7 4区 医学
Pancreas Pub Date : 2025-04-01 DOI: 10.1097/MPA.0000000000002441
Yoshihiro Shirai, Nana Kimura, Haruyoshi Tanaka, Mina Fukasawa, Ryo Muranushi, Toru Watanabe, Katsuhisa Hirano, Kazuto Shibuya, Isaku Yoshioka, Tsutomu Fujii
{"title":"Risk Factors for Early Liver Recurrence After Pancreatic Cancer Resection.","authors":"Yoshihiro Shirai, Nana Kimura, Haruyoshi Tanaka, Mina Fukasawa, Ryo Muranushi, Toru Watanabe, Katsuhisa Hirano, Kazuto Shibuya, Isaku Yoshioka, Tsutomu Fujii","doi":"10.1097/MPA.0000000000002441","DOIUrl":"10.1097/MPA.0000000000002441","url":null,"abstract":"<p><strong>Background: </strong>Liver recurrence after resection is one of the most common types of recurrence and is a risk factor for poor prognosis. The aim of this study was to identify risk factors for initial liver recurrence.</p><p><strong>Materials and methods: </strong>A total of 109 patients with resectable pancreatic ductal adenocarcinoma who underwent resection between 2015 and 2022 were included. The influence of clinicopathologic variables on liver recurrence was analyzed to create a novel scoring system to predict liver recurrence.</p><p><strong>Results: </strong>The liver recurrence rate was 24%, with 17% recurrence within 1 year. Patients with liver recurrence had an extremely poor prognosis within 1 year (MST 12.4 [95% CI, 5.7-19.1]). In multivariate analysis, R-PV, large tumor diameter ≥45 mm, and venous invasion were independent risk factors for early liver recurrence. When each of these risk factors was scored as 1 point, the 1-year liver recurrence rates by score were 0 (0%), 1 (9%), 2 (30%), and 3 (84%).</p><p><strong>Conclusion: </strong>The risk factors for postoperative early liver recurrence were R-PV, a tumor diameter ≥45 mm, and pathological venous invasion. Surgery for pancreatic cancer with these factors may require special treatment, such as hepatic arterial injection.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e324-e330"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High Diagnostic Yield of Fine Needle Biopsy for Pancreatic Serous Cystadenomas-A Multicenter Study. 细针活检对胰腺浆液性囊腺瘤的高诊断率-一项多中心研究。
IF 1.7 4区 医学
Pancreas Pub Date : 2025-04-01 DOI: 10.1097/MPA.0000000000002442
Grace E Kim, Michael Mercado, Margarita Riojas Barrett, Miles Breese, Shifa Umar, Fares Ayoub, Dennis Chen, Mohamed O Othman, Uzma D Siddiqui
{"title":"High Diagnostic Yield of Fine Needle Biopsy for Pancreatic Serous Cystadenomas-A Multicenter Study.","authors":"Grace E Kim, Michael Mercado, Margarita Riojas Barrett, Miles Breese, Shifa Umar, Fares Ayoub, Dennis Chen, Mohamed O Othman, Uzma D Siddiqui","doi":"10.1097/MPA.0000000000002442","DOIUrl":"10.1097/MPA.0000000000002442","url":null,"abstract":"<p><strong>Background: </strong>Distinguishing serous cystadenoma (SCA), a benign pancreatic cyst, from potentially malignant mucinous pancreatic cystic lesions carries significant clinical and prognostic implications. While endoscopic ultrasound-guided fine needle aspiration is the standard diagnostic tool, its low diagnostic yield often results in additional workup.</p><p><strong>Objective: </strong>This study evaluates diagnostic yield of fine needle biopsy (FNB) on lesions suggestive of serous cystadenoma on endoscopic ultrasound (EUS).</p><p><strong>Materials and methods: </strong>Patients with microcystic EUS appearance were identified database search from 2015 to 2022 and procedure information was obtained through a retrospective chart review from 2 large academic centers. Prior cross sectional imaging diagnosis was also obtained. All microcystic lesions with classic \"honeycomb\" appearance for SCA a on EUS were targeted for FNB and their pathology evaluated.</p><p><strong>Results: </strong>Thirty-one patients with suspected SCA who underwent EUS-FNB were included. EUS FNB was successful in obtaining diagnosis in 96.8% of patients. Serous cystadenoma was diagnosed via EUS FNB in 27 of 31 patients (87.1%). Of the remaining 4 patients, there was 1 invasive pancreatic ductal adenocarcinoma, 1 pancreatic neuroendocrine tumor, 1 intraductal papillary mucinous neoplasm, and 1 nondiagnostic sample.</p><p><strong>Conclusions: </strong>EUS-FNB sampling for histopathology is a safe and accurate diagnostic tool for pancreatic SCA. When microcytic lesions are found on endoscopic ultrasound, our study results suggest that fine needle biopsy for histopathology should be considered as the initial diagnostic evaluation tool given the demonstrated improved diagnostic yield for SCA.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e349-e352"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical Trends in Chronic Pancreatitis From 2014 to 2021. 2014 年至 2021 年慢性胰腺炎的手术趋势。
IF 1.7 4区 医学
Pancreas Pub Date : 2025-04-01 DOI: 10.1097/MPA.0000000000002438
Andrew Turunen, Sushil Kumar Garg
{"title":"Surgical Trends in Chronic Pancreatitis From 2014 to 2021.","authors":"Andrew Turunen, Sushil Kumar Garg","doi":"10.1097/MPA.0000000000002438","DOIUrl":"10.1097/MPA.0000000000002438","url":null,"abstract":"<p><strong>Objectives: </strong>We analyzed annual surgical trends for benign chronic pancreatitis (CP), studying specifically mortality, morbidity, and pancreatic fistula rates. We also aimed to identify predictors of pancreatic fistula formation.</p><p><strong>Materials and methods: </strong>For this analysis, we used data from the American College of Surgeons National Surgical Quality Improvement Program from 2014 to 2021. The study included patients who underwent surgery for benign CP. Data collected included patient demographics, preoperative variables, and postoperative outcomes. Data were analyzed with univariate and multivariate analyses, with significance defined as P  ≤ 0.05.</p><p><strong>Results: </strong>Over the study period, the number of pancreatic surgical procedures increased by 49.3%, although surgery specifically for CP declined by 31.7%. The rate of pancreatic fistula formation decreased 44.9%, and mortality decreased 31.9%. Significant predictors of a pancreatic fistula included no diabetes, preoperative sepsis, soft texture of the pancreatic gland, and greater patient weight.</p><p><strong>Conclusion: </strong>Surgery for benign CP decreased substantially despite the established efficacy of surgical intervention for long-term pain management. The concurrent decline in mortality and rates of pancreatic fistula formation suggest advances over the study years in surgical and postoperative care.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e310-e316"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142731264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circulating Chromogranin A Is Associated With Disease Extent, Progression, and Recurrence in Patients With Nonfunctioning Pancreatic Neuroendocrine Tumor. 循环嗜铬粒蛋白A与无功能胰腺神经内分泌肿瘤(NF-PNET)患者的疾病程度、进展和复发相关。
IF 1.7 4区 医学
Pancreas Pub Date : 2025-04-01 DOI: 10.1097/MPA.0000000000002428
Nicholas J Zyromski, Kyle A Lewellen, Thomas K Maatman, Sean P McGuire
{"title":"Circulating Chromogranin A Is Associated With Disease Extent, Progression, and Recurrence in Patients With Nonfunctioning Pancreatic Neuroendocrine Tumor.","authors":"Nicholas J Zyromski, Kyle A Lewellen, Thomas K Maatman, Sean P McGuire","doi":"10.1097/MPA.0000000000002428","DOIUrl":"10.1097/MPA.0000000000002428","url":null,"abstract":"<p><strong>Objectives: </strong>Nonfunctioning pancreatic neuroendocrine tumors (NF-PNETs) are rare tumors with heterogeneous biology. Radiology and serum biomarkers are used for postresection surveillance; however, no universally established protocol exists. Serum chromogranin A (CgA) concentration is elevated in NF-PNET and generally correlates with burden of disease; many CgA studies include mixed gastrointestinal and pancreatic populations. We sought to review the NF-PNET literature with focus on postresection surveillance and hypothesized that CgA is useful for surveillance after NF-PNET resection.</p><p><strong>Materials and methods: </strong>Comprehensive English literature review by PICO criteria (P, human NF-PNET patients; I, pancreatectomy; C, none; O, CgA correlation with disease recurrence).</p><p><strong>Results: </strong>Four studies yielded granular data for resected NF-PNET patients. From 333 patients, 113 recurred and 110 (97%) had elevated CgA. Additional 7 studies with mixed gastro-entero-pancreatic NET included 269 NF-PNET patients. In these patients, CgA uniformly predicted disease extent.</p><p><strong>Conclusions: </strong>Serum CgA correlates with disease extent in NF-PNET and is useful for surveillance after resection of NF-PNET.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e281-e286"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Epidural Analgesia on In-hospital Outcomes in Patients With Acute Pancreatitis: A Systematic Review and Meta-analysis of Randomized Clinical Trials. 硬膜外镇痛对急性胰腺炎患者住院结局的影响:随机临床试验的系统回顾和荟萃分析
IF 1.7 4区 医学
Pancreas Pub Date : 2025-04-01 DOI: 10.1097/MPA.0000000000002444
Bobak Moazzami, Zinat Mohammadpour, Zohyra E Zabala, Saurabh Chawla
{"title":"The Effect of Epidural Analgesia on In-hospital Outcomes in Patients With Acute Pancreatitis: A Systematic Review and Meta-analysis of Randomized Clinical Trials.","authors":"Bobak Moazzami, Zinat Mohammadpour, Zohyra E Zabala, Saurabh Chawla","doi":"10.1097/MPA.0000000000002444","DOIUrl":"10.1097/MPA.0000000000002444","url":null,"abstract":"<p><strong>Objectives: </strong>Acute pancreatitis (AP) can lead to severe complications and high mortality. Previous studies suggest that epidural analgesia (EA) may improve outcomes in AP. This systematic review and meta-analysis aimed to evaluate the efficacy of EA on in-hospital outcomes in AP patients.</p><p><strong>Methods: </strong>Electronic databases (PubMed, Medline-Ovid, Scopus, CINAHL, Web of Science) were systematically searched until May 2024 for RCTs comparing EA with other pain strategies in AP patients. Variables were pooled using weighted mean difference (WMD) or risk ratio (RR) with 95% confidence intervals (CIs). Data analysis employed random-effects the Mantel-Haenszel method and I 2 statistic was used for heterogeneity.</p><p><strong>Results: </strong>Five RCTs with 260 participants were included. Meta-analysis showed no significant differences in in-hospital mortality (RR, 0.69; 95% CI [0.29-1.65]; P  = 0.40), mechanical ventilation (RR, 0.82; 95% CI [0.61-1.10]; P  = 0.19), sepsis (RR, 0.88; 95% CI [0.42-1.86]; P  = 0.74), hospital/ICU stay (WMD, 0.49 days; 95% CI [-1.13 to 2.10]; P  = 0.55), and pain score (WMD, 1.49; 95% CI [-0.42 to 3.40]; P  = 0.13). Opioid requirements were significantly lower, with one study reporting MME of 15 mg/d compared to 52 mg/d in the control group ( P  = 0.001). Heterogeneity was low to moderate for most outcomes but high for pain score ( I2  = 92%). Small number of studies, risk of bias, and sample size limited overall certainity.</p><p><strong>Conclusions: </strong>EA did not significantly improve in-hospital outcomes in AP patients. However, findings suggested potential benefits in pain management. High-quality randomized trials are needed to understand the potential benefits of EA in this population.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e369-e377"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protocol and Study Population of a Prospective Study of Patients With Chronic Pancreatitis and Exocrine Pancreatic Insufficiency: Preliminary Findings From the PACT-CP Registry Show Reduced Health-related Quality of Life. 慢性胰腺炎和外分泌胰腺功能不全患者的前瞻性研究方案和研究人群:PACT-CP登记的初步结果显示与健康相关的生活质量降低。
IF 1.7 4区 医学
Pancreas Pub Date : 2025-04-01 DOI: 10.1097/MPA.0000000000002460
Jodie A Barkin, Samer Al-Kaade, Rahul Pannala, Yasmin Hernandez-Barco, Janine Twal, Jennifer Pack, Dianne Nguyen, Valerie J Powell, Cindy Frommer, Carmine D'Urzo, David C Whitcomb
{"title":"Protocol and Study Population of a Prospective Study of Patients With Chronic Pancreatitis and Exocrine Pancreatic Insufficiency: Preliminary Findings From the PACT-CP Registry Show Reduced Health-related Quality of Life.","authors":"Jodie A Barkin, Samer Al-Kaade, Rahul Pannala, Yasmin Hernandez-Barco, Janine Twal, Jennifer Pack, Dianne Nguyen, Valerie J Powell, Cindy Frommer, Carmine D'Urzo, David C Whitcomb","doi":"10.1097/MPA.0000000000002460","DOIUrl":"10.1097/MPA.0000000000002460","url":null,"abstract":"","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e384-e386"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GATA6 Amplification Is Associated With Improved Survival in TP53-Mutated Unresectable Pancreatic Cancer. GATA6扩增与tp53突变不可切除胰腺癌患者生存率提高相关
IF 1.7 4区 医学
Pancreas Pub Date : 2025-04-01 DOI: 10.1097/MPA.0000000000002431
Edward Zhou, Jung-In Yang, Amber N Habowski, Astrid Deschênes, Pascal Belleau, Taehoon Ha, Chris J Tzanavaris, Jeff Boyd, Christopher A Hollweg, Xinhua Zhu, David A Tuveson, Daniel A King
{"title":"GATA6 Amplification Is Associated With Improved Survival in TP53-Mutated Unresectable Pancreatic Cancer.","authors":"Edward Zhou, Jung-In Yang, Amber N Habowski, Astrid Deschênes, Pascal Belleau, Taehoon Ha, Chris J Tzanavaris, Jeff Boyd, Christopher A Hollweg, Xinhua Zhu, David A Tuveson, Daniel A King","doi":"10.1097/MPA.0000000000002431","DOIUrl":"10.1097/MPA.0000000000002431","url":null,"abstract":"<p><strong>Objectives: </strong>GATA6 expression is recognized as a favorable prognostic marker of pancreatic cancer, whereas TP53 is a poor prognostic marker. We evaluated treatment outcomes by genetic alterations in TP53 and GATA6 to determine the prognostic and predictive impact of co-alterations.</p><p><strong>Materials and methods: </strong>A single institution retrospective analysis was performed on patients diagnosed with pancreatic ductal adenocarcinoma between 2014 and 2023. TP53 genotype and GATA6 amplification status were included in an analysis of overall survival (OS) and progression-free survival (PFS). Previously published patient-derived organoids were used to investigate correlation between genetic status and drug sensitivity.</p><p><strong>Results: </strong>Patients with TP53 mutations had worse OS compared with the wild-type TP53 population. Patients with GATA6 amplification had better OS and a trend toward better PFS than the nonamplified population. Among patients with a TP53 mutation, patients with GATA6 co-alteration had longer OS compared with those who were not GATA6 amplified. In contrast, among patients who were TP53 wild-type, the presence or absence of a GATA6 amplification did not impact OS or PFS. GATA6 genotype was not associated chemotherapy drug response in an organoid pharmacotyping model.</p><p><strong>Conclusions: </strong>We found that GATA6 amplification appeared to attenuate poor prognosis observed in TP53-mutant patients regardless of the type of standard chemotherapy received, suggesting the GATA6 amplification is a prognostic biomarker but not a predictive biomarker of standard-of-care chemotherapy.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"54 4","pages":"e303-e309"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Association Between Chronic Aspirin Treatment and the Clinical Course and Outcomes of Acute Pancreatitis. 慢性阿司匹林治疗与急性胰腺炎临床病程和预后的关系。
IF 1.7 4区 医学
Pancreas Pub Date : 2025-04-01 DOI: 10.1097/MPA.0000000000002434
Yael Levy, Maya Fischman, Amir Klein, Adi Elias, Zaher S Azzam, Itai Ghersin
{"title":"The Association Between Chronic Aspirin Treatment and the Clinical Course and Outcomes of Acute Pancreatitis.","authors":"Yael Levy, Maya Fischman, Amir Klein, Adi Elias, Zaher S Azzam, Itai Ghersin","doi":"10.1097/MPA.0000000000002434","DOIUrl":"10.1097/MPA.0000000000002434","url":null,"abstract":"<p><strong>Background and aim: </strong>Animal model studies have shown that pretreatment with the anti-inflammatory drug Aspirin had a positive effect on acute pancreatitis outcomes. The impact of Aspirin on acute pancreatitis outcomes in humans is unknown. We aimed to determine the association between chronic Aspirin treatment and the clinical course and outcomes of acute pancreatitis in a large cohort.</p><p><strong>Materials and methods: </strong>This retrospective single-center observational study included all adult patients admitted with a primary diagnosis of acute pancreatitis between January 2008 and June 2021. Patients were divided into 2 groups: chronic Aspirin treatment group and non-Aspirin treatment group. The differences in baseline comorbidities were adjusted for by propensity score matching.</p><p><strong>Results: </strong>The study included 2308 patients, of whom 596 (25.8%) were chronically treated with Aspirin. Overall, chronic Aspirin treatment was associated with increased 30-day mortality with an odds ratio (OR) of 1.91 (95% confidence interval [CI], 1.21-2.97; P = 0.005). It was also associated with severe pancreatitis (OR, 2.61; 95% CI, 2.00-3.39; P < 0.001). In the propensity matched cohort, 30-day mortality rates (OR, 0.53; 95% CI, 0.20-1.31; P = 0.2) and severe pancreatitis rates (OR, 1.2; 95% CI, 0.83-1.75; P = 0.3) were similar between the two groups.</p><p><strong>Conclusions: </strong>Among patients with acute pancreatitis, chronic Aspirin treatment was not associated with decreased disease severity or reduced 30-day mortality rate.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"54 4","pages":"e378-e381"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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