Pancreas最新文献_第10页

Epidemiology and Prognostic Nomogram for Predicting Long-Term Disease-Specific Survival in Patients With Pancreatic Carcinoid Tumor: A SEER-Based Study. 预测胰腺类癌患者长期疾病特异性生存的流行病学和预后提名图：基于 SEER 的研究。

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-01 Epub Date: 2024-03-13 DOI: 10.1097/MPA.0000000000002320

Hai Lin, Yufang Li, Yutong Chen, Linjuan Zeng, Bixiang Li, Shili Chen

{"title":"Epidemiology and Prognostic Nomogram for Predicting Long-Term Disease-Specific Survival in Patients With Pancreatic Carcinoid Tumor: A SEER-Based Study.","authors":"Hai Lin, Yufang Li, Yutong Chen, Linjuan Zeng, Bixiang Li, Shili Chen","doi":"10.1097/MPA.0000000000002320","DOIUrl":"10.1097/MPA.0000000000002320","url":null,"abstract":"Objectives: Pancreatic carcinoid tumor (PCT) is described as a malignant form of carcinoid tumors. However, the epidemiology and prognostic factors for PCT are poorly understood.Materials and methods: The data of 2447 PCT patients were included in this study from the Surveillance, Epidemiology, and End Results database and randomly divided into a training cohort (1959) and a validation cohort (488). The epidemiology of PCT was calculated, and independent prognostic factors were identified to construct a prognostic nomogram for predicting long-term disease-specific survival (DSS) among PCT patients.Results: The incidence of PCT increased remarkably from 2000 to 2018. The 1-, 5-, and 10-year DSS rates were 96.4%, 90.3%, and 86.5%, respectively. Age at diagnosis, stage, surgery, radiotherapy, and chemotherapy were identified as independent prognostic factors to construct a prognostic nomogram. The C -indices; area under the receiver operating characteristic curves for predicting 1-, 5-, and 10-year DSS, and calibration plots of the nomogram in both cohorts indicated a high discriminatory accuracy, preferable survival predictive ability, and optimal concordances, respectively.Conclusions: The incidence of PCT has increased rapidly since 2000. In addition, we established a practical, effective, and accurate prognostic nomogram for predicting the long-term DSS of PCT patients.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e424-e433"},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140294220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical significance of MUC-4 and associated proteins in Pancreatic and Periampullary Cancers. 胰腺癌和髓周癌中 MUC-4 及其相关蛋白的临床意义。

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-01 DOI: 10.1097/mpa.0000000000002340

Sumaira Rashid, Nidhi Singh, Safoora Rashid, Prasenjit Das, Surabhi Gupta, Shyam S Chauhan, Hem Chandra Sati, Nihar Ranjan Dash, Atul Sharma, Sharmistha Dey, Anoop Saraya

引用次数: 0

Research progress on the mechanism of acute hypertriglyceridemic pancreatitis. 急性高甘油三酯性胰腺炎机制的研究进展。

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-01 DOI: 10.1097/mpa.0000000000002364

Yiteng Meng, Peiyu Han, Xiaoyu Ma, Yiting He, Hetian Chen, Hongbo Ren

{"title":"Research progress on the mechanism of acute hypertriglyceridemic pancreatitis.","authors":"Yiteng Meng, Peiyu Han, Xiaoyu Ma, Yiting He, Hetian Chen, Hongbo Ren","doi":"10.1097/mpa.0000000000002364","DOIUrl":"https://doi.org/10.1097/mpa.0000000000002364","url":null,"abstract":"The incidence rate of hypertriglyceridemia pancreatitis (HTGP) has experienced a notable increase in recent years, with eclipsing alcohol as the second leading cause of acute pancreatitis (AP). HTGP is often associated with more severe local and systemic complications. Recognized as a metabolic disorder hypertriglyceridemia (HTG), holds significant relevance in the pathogenesis of HTGP, yet its mechanisms are not fully understood. Both primary (genetic) and secondary (acquired) factors contribute to elevated triglyceride (TG) levels, which concurrently influence the progression of HTGP. This article presents a comprehensive review of the evolving research on HTGP pathogenesis, encompassing lipid synthesis and metabolism, calcium signal transduction, inflammatory mediators, endoplasmic reticulum stress, autophagy, mitochondrial injury by fatty acids, oxidative stress response, genetic factors, and gene mutations. By unraveling the intricate mechanisms underlying HTGP, this article aims to enhance physicians' understanding of the disease and facilitate the development of potential targeted pharmacological interventions for patients.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"90 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140828886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality of Life Following TPIAT: A Patient Experience Survey. TPIAT 治疗后的生活质量：患者体验调查。

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-01 DOI: 10.1097/mpa.0000000000002353

Laura Barthold, Kerrington D Smith, Sushela S Chaidarun, Dawn A Fischer, Timothy B Gardner

引用次数: 0

A Case Series of Choroidal and Orbital Neuroendocrine Tumors: Metastasis: Two Patients Treated With Peptide Radionuclide Therapy. 脉络膜和眼眶神经内分泌肿瘤的病例系列：转移：2 名患者接受 PRRT 治疗。

IF 1.7 4区医学

Pancreas Pub Date : 2024-05-01 Epub Date: 2024-03-14 DOI: 10.1097/MPA.0000000000002316

Tony Zibo Zhuang, Chris Bergstrom, Bassel F El-Rayes, Walid L Shaib

引用次数: 0

The Population-level Prevalence of Exocrine Pancreas Insufficiency and the Subsequent Risk of Pancreatic Cancer. 胰腺外分泌功能不全的人群患病率及其罹患胰腺癌的风险。

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-01 DOI: 10.1097/mpa.0000000000002359

Oyedotun Babajide, Aakash Desai, Chinelo Eruchalu, Mary Sedarous, Deborah Adekunle, Michael Youssef, Muftah Mahmud, Philip N Okafor

引用次数: 0

THE ADDED VALUE OF BLOOD GLUCOSE MONITORING IN HIGH-RISK INDIVIDUALS UNDERGOING PANCREATIC CANCER SURVEILLANCE. 对接受胰腺癌监测的高危人群进行血糖监测的附加价值。

IF 2.9 4区医学

Pancreas Pub Date : 2024-04-10 DOI: 10.1097/mpa.0000000000002335

Aleksander M Bogdanski, Anke M Onnekink, Akin Inderson, Bas Boekestijn, Bert A Bonsing, Hans F A Vasen, Jeanin E van Hooft, Jurjen J Boonstra, J Sven D Mieog, Martin N J M Wasser, Shirin Feshtali, Thomas P Potjer, Derk C F Klatte, Monique E van Leerdam

引用次数: 0

Clinical and Economic Implications of Interventions in Pancreatic Fluid Collections: An Assessment From a National Claims Database. 胰液收集干预措施的临床和经济影响：来自全国索赔数据库的评估。

IF 2.9 4区医学

Pancreas Pub Date : 2024-04-10 DOI: 10.1097/mpa.0000000000002317

Shyam Varadarajulu, Michael J Cangelosi, Geri R Cramer, Kevin Kuipers, Stacey Reimer, Ann K Roy

引用次数: 0

An Elemental Diet Reduces Chylous Ascites of Patients Undergoing Pancreatoduodenectomy in the Setting of Early Enteral Feeding. 在早期肠内喂养的情况下，元素饮食可减少胰十二指肠切除术患者的乳糜腹水。

IF 2.9 4区医学

Pancreas Pub Date : 2024-04-01 Epub Date: 2024-02-14 DOI: 10.1097/MPA.0000000000002309

Masaru Matsumura, Yoshihiro Mise, Nobuyuki Takemura, Yoshihiro Ono, Takafumi Sato, Hiromichi Ito, Yosuke Inoue, Yu Takahashi, Akio Saiura

{"title":"An Elemental Diet Reduces Chylous Ascites of Patients Undergoing Pancreatoduodenectomy in the Setting of Early Enteral Feeding.","authors":"Masaru Matsumura, Yoshihiro Mise, Nobuyuki Takemura, Yoshihiro Ono, Takafumi Sato, Hiromichi Ito, Yosuke Inoue, Yu Takahashi, Akio Saiura","doi":"10.1097/MPA.0000000000002309","DOIUrl":"10.1097/MPA.0000000000002309","url":null,"abstract":"Objectives: The elemental diet (ED) is a formula to support nutritional status without increasing chylous burden. This study evaluates the efficacy of early ED feeding after pancreatoduodenectomy (PD).Materials and methods: A prospective phase II study of consecutive patients who underwent PD with early ED feeding was conducted. Patient backgrounds, surgical outcomes, and ED feeding tolerability were compared with a historical cohort of 74 PD patients with early enteral feeding of a low residue diet (LRD).Results: The ED group comprised 104 patients. No patient in the ED group discontinued enteral feeding because of chylous ascites (CAs), whereas 17.6% of the LRD group experienced refractory CAs that disrupted further enteral feeding. The CAs rate was significantly decreased in the ED group compared with the LRD group (3.9% and 48.7%, respectively; P < 0.001). There was no significant difference in the incidence of major complications (ED: 17.3%, LRD: 18.9%; P = 0.844). Postoperative prognostic nutritional index was similar between the 2 groups ( P = 0.764). In multivariate analysis, enteral feeding formula, and sex were independent risk factors for CAs (LRD: P < 0.001, odds ratio, 22.87; female: P = 0.019, odds ratio, 2.78).Conclusions: An ED reduces postoperative CAs of patients undergoing PD in the setting of early enteral feeding.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e343-e349"},"PeriodicalIF":2.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139735806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cost-effectiveness Analysis of Single-Use Duodenoscope Applied to Endoscopic Retrograde Cholangiopancreatography. 应用于内镜逆行胰胆管造影术的一次性使用十二指肠镜的成本效益分析。

IF 2.9 4区医学

Pancreas Pub Date : 2024-04-01 Epub Date: 2024-03-13 DOI: 10.1097/MPA.0000000000002311

David Nicolás-Pérez, Antonio Zebenzuy Gimeno-García, Rafael Joaquín Romero-García, Iván Castilla-Rodríguez, Manuel Hernandez-Guerra

{"title":"Cost-effectiveness Analysis of Single-Use Duodenoscope Applied to Endoscopic Retrograde Cholangiopancreatography.","authors":"David Nicolás-Pérez, Antonio Zebenzuy Gimeno-García, Rafael Joaquín Romero-García, Iván Castilla-Rodríguez, Manuel Hernandez-Guerra","doi":"10.1097/MPA.0000000000002311","DOIUrl":"10.1097/MPA.0000000000002311","url":null,"abstract":"Objectives: Secondary infections due to transmission via the duodenoscope have been reported in up to 3% of endoscopic retrograde cholangiopancreatographies. The use of single-use duodenoscopes has been suggested. We investigate the cost-effectiveness of these duodenoscopes use in cholangiopancreatography.Materials and methods: A cost-effectiveness analysis was implemented to compare the performance of cholangiopancreatographies with reusable duodenoscopes versus single-use duodenoscopes. Effectiveness was analyzed by calculating quality-adjusted life years (QALY) from the perspective of the National Health System. Possibility of crossover from single-use to reusable duodenoscopes was considered. A willingness-to-pay of €25,000/QALY was set, the incremental cost-effectiveness ratio (ICER) was calculated, and deterministic and probabilistic sensitivity analyses were performed.Results: Considering cholangiopancreatographies with single-use and reusable duodenoscopes at a cost of €2900 and €1333, respectively, and a 10% rate of single-use duodenoscopes, ICER was greater than €3,000,000/QALY. A lower single-use duodenoscope cost of €1211 resulted in an ICER of €23,583/QALY. When the unit cost of the single-use duodenoscope was €1211, a crossover rate of more than 9.5% made the use of the single-use duodenoscope inefficient.Conclusions: Single-use duodenoscopes are cost-effective in a proportion of cholangiopancreatographies if its cost is reduced. Increased crossover rate makes single-use duodenoscope use not cost-effective.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"53 4","pages":"e357-e367"},"PeriodicalIF":2.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140189924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0