Circulating Chromogranin A Is Associated With Disease Extent, Progression, and Recurrence in Patients With Nonfunctioning Pancreatic Neuroendocrine Tumor.

IF 1.7 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Pancreas Pub Date : 2025-04-01 DOI:10.1097/MPA.0000000000002428

Nicholas J Zyromski, Kyle A Lewellen, Thomas K Maatman, Sean P McGuire

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引用次数: 0

Abstract

Objectives: Nonfunctioning pancreatic neuroendocrine tumors (NF-PNETs) are rare tumors with heterogeneous biology. Radiology and serum biomarkers are used for postresection surveillance; however, no universally established protocol exists. Serum chromogranin A (CgA) concentration is elevated in NF-PNET and generally correlates with burden of disease; many CgA studies include mixed gastrointestinal and pancreatic populations. We sought to review the NF-PNET literature with focus on postresection surveillance and hypothesized that CgA is useful for surveillance after NF-PNET resection.

Materials and methods: Comprehensive English literature review by PICO criteria (P, human NF-PNET patients; I, pancreatectomy; C, none; O, CgA correlation with disease recurrence).

Results: Four studies yielded granular data for resected NF-PNET patients. From 333 patients, 113 recurred and 110 (97%) had elevated CgA. Additional 7 studies with mixed gastro-entero-pancreatic NET included 269 NF-PNET patients. In these patients, CgA uniformly predicted disease extent.

Conclusions: Serum CgA correlates with disease extent in NF-PNET and is useful for surveillance after resection of NF-PNET.

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循环嗜铬粒蛋白A与无功能胰腺神经内分泌肿瘤（NF-PNET）患者的疾病程度、进展和复发相关。

目的：无功能胰腺神经内分泌肿瘤（NF-PNET）是一种罕见的具有异质性生物学特征的肿瘤。放射学和血清生物标志物用于切除后监测；然而，没有普遍建立的协议存在。NF-PNET患者血清嗜铬粒蛋白A （CgA）浓度升高，通常与疾病负担相关；许多CgA研究包括胃肠道和胰腺混合人群。我们试图回顾NF-PNET的文献，重点关注切除后的监测，并假设CgA对NF-PNET切除后的监测有用。方法：采用PICO标准(P-human NF-PNET患者；I-pancreatectomy;C -没有;O- CgA与疾病复发的相关性)。结果：四项研究获得了NF-PNET切除患者的详细数据。333例患者中，113例复发，110例（97%）CgA升高。另外7项胃-肠-胰混合NET研究包括269例NF-PNET患者。在这些患者中，CgA一致预测疾病程度。结论：血清嗜铬粒蛋白A与NF-PNET病变程度相关，可用于NF-PNET切除术后的监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pancreas 医学-胃肠肝病学

CiteScore

4.70

自引率

3.40%

发文量

289

审稿时长

1 months

期刊介绍： Pancreas provides a central forum for communication of original works involving both basic and clinical research on the exocrine and endocrine pancreas and their interrelationships and consequences in disease states. This multidisciplinary, international journal covers the whole spectrum of basic sciences, etiology, prevention, pathophysiology, diagnosis, and surgical and medical management of pancreatic diseases, including cancer.