发布求助
文献互助 智能选刊 最新文献

Pancreas最新文献

筛选
英文 中文
Prediction of Admission to Intensive Care Unit and 1-Year Mortality After Acute Pancreatitis With Walled-Off Pancreatic Necrosis: A Retrospective, Single-Center Cohort Study. 预测急性胰腺炎并发胰腺壁脱落坏死后入住重症监护病房和 1 年死亡率：一项回顾性单中心队列研究。
IF 2.9 4区 医学
Pancreas Pub Date : 2024-05-01 Epub Date: 2024-02-26 DOI: 10.1097/MPA.0000000000002314
Mohamed Ebrahim, Mikkel Parsberg Werge, Srdan Novovic, Nadia Emad Lotfi Amin, John Gásdal Karstensen, Henrik Løvendahl Jørgensen
{"title":"Prediction of Admission to Intensive Care Unit and 1-Year Mortality After Acute Pancreatitis With Walled-Off Pancreatic Necrosis: A Retrospective, Single-Center Cohort Study.","authors":"Mohamed Ebrahim, Mikkel Parsberg Werge, Srdan Novovic, Nadia Emad Lotfi Amin, John Gásdal Karstensen, Henrik Løvendahl Jørgensen","doi":"10.1097/MPA.0000000000002314","DOIUrl":"10.1097/MPA.0000000000002314","url":null,"abstract":"<p><strong>Background and aims: </strong>Pancreatic walled-off necrosis (WON) carries significant mortality and morbidity risks, often necessitating intensive care unit (ICU) admission. This retrospective study aimed to evaluate whether routine biochemical parameters at the time of the index endoscopic procedure could predict ICU admission and 1-year mortality following endoscopic treatment of WON.</p><p><strong>Materials and methods: </strong>We retrospectively identified 201 consecutive patients who underwent endoscopic drainage for WON between January 1, 2010, and December 31, 2020. Associations between routine biochemical blood tests and outcomes were assessed using logistic regression models.</p><p><strong>Results: </strong>Within 1 year of the index endoscopy, 31 patients (15.4%) died, and 40 (19.9%) were admitted to the ICU due to sepsis. Preoperative electrolyte disturbances were more prevalent among ICU-admitted patients and nonsurvivors. Hyperkalemia, hypoalbuminemia, and elevated urea were significant predictors of 1-year mortality, while hypernatremia, elevated serum creatinine, and hypoalbuminemia predicted ICU admission. Predictive models exhibited good discriminative ability, with an AUC of 0.84 (95% CI,0,75-0.93) for 1-year mortality and 0.86 (95%CI, 0.79-0.92) for ICU admission.</p><p><strong>Conclusions: </strong>Preoperative imbalances in routine blood tests effectively predict adverse outcomes in endoscopically treated WON patients.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e386-e394"},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of Intratumor Heterogeneity in Pancreatic Ductal Adenocarcinoma Progression and Treatment. 肿瘤内异质性对胰腺导管腺癌进展和治疗的影响
IF 1.7 4区 医学
Pancreas Pub Date : 2024-05-01 DOI: 10.1097/MPA.0000000000002342
Othman Saleh, Hani Shihadeh, Ahmad Yousef, Hana Erekat, Fatima Abdallh, Ahmad Al-Leimon, Rawan Elsalhy, Abdalrahman Altiti, Majd Dajani, Majd M AlBarakat
{"title":"The Effect of Intratumor Heterogeneity in Pancreatic Ductal Adenocarcinoma Progression and Treatment.","authors":"Othman Saleh, Hani Shihadeh, Ahmad Yousef, Hana Erekat, Fatima Abdallh, Ahmad Al-Leimon, Rawan Elsalhy, Abdalrahman Altiti, Majd Dajani, Majd M AlBarakat","doi":"10.1097/MPA.0000000000002342","DOIUrl":"10.1097/MPA.0000000000002342","url":null,"abstract":"<p><strong>Background and objectives: </strong>Pancreatic cancer is one of the most lethal malignancies. Even though many substantial improvements in the survival rates for other major cancer forms were made, pancreatic cancer survival rates have remained relatively unchanged since the 1960s. Even more, no standard classification system for pancreatic cancer is based on cellular biomarkers. This review will discuss and provide updates about the role of stem cells in the progression of PC, the genetic changes associated with it, and the promising biomarkers for diagnosis.</p><p><strong>Materials and methods: </strong>The search process used PubMed, Cochrane Library, and Scopus databases to identify the relevant and related articles. Articles had to be published in English to be considered.</p><p><strong>Results: </strong>The increasing number of studies in recent years has revealed that the diversity of cancer-associated fibroblasts is far greater than previously acknowledged, which highlights the need for further research to better understand the various cancer-associated fibroblast subpopulations. Despite the huge diversity in pancreatic cancer, some common features can be noted to be shared among patients. Mutations involving CDKN2, P53, and K-RAS can be seen in a big number of patients, for example. Similarly, some patterns of genes and biomarkers expression and the level of their expression can help in predicting cancer behavior such as metastasis and drug resistance. The current trend in cancer research, especially with the advancement in technology, is to sequence everything in hopes of finding disease-related mutations.</p><p><strong>Conclusion: </strong>Optimizing pancreatic cancer treatment requires clear classification, understanding CAF roles, and exploring stroma reshaping approaches.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"53 5","pages":"e450-e465"},"PeriodicalIF":1.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140904879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aryl hydrocarbon receptor knockout accelerates PanIN formation and fibro-inflammation in a mutant Kras-driven pancreatic cancer model. 在突变 Kras 驱动的胰腺癌模型中，敲除芳基烃受体可加速 PanIN 的形成和纤维炎症。
IF 2.9 4区 医学
Pancreas Pub Date : 2024-05-01 DOI: 10.1097/mpa.0000000000002357
Morgan T Walcheck, Patrick B Schwartz, Noah D Carrillo, Kristina A Matkowsky, Manabu Nukaya, Christopher A Bradfield, Sean M Ronnekleiv-Kelly
{"title":"Aryl hydrocarbon receptor knockout accelerates PanIN formation and fibro-inflammation in a mutant Kras-driven pancreatic cancer model.","authors":"Morgan T Walcheck, Patrick B Schwartz, Noah D Carrillo, Kristina A Matkowsky, Manabu Nukaya, Christopher A Bradfield, Sean M Ronnekleiv-Kelly","doi":"10.1097/mpa.0000000000002357","DOIUrl":"https://doi.org/10.1097/mpa.0000000000002357","url":null,"abstract":"The pathogenesis of pancreas cancer (PDAC) remains poorly understood, hindering efforts to develop a more effective therapy for PDAC. Recent discoveries show the aryl hydrocarbon receptor (AHR) plays a crucial role in the development of several cancers, and can be targeted for therapeutic effect. However, its involvement in the pathogenesis of PDAC remains unclear. To address this gap, we evaluated the role of AHR in the development of PDAC pre-cancerous lesions in vivo.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"11 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140836297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severity of gallstone, sludge or microlithiasis induced pancreatitis - all of the same? 胆结石、淤血或微结石诱发胰腺炎的严重程度--都一样吗？
IF 2.9 4区 医学
Pancreas Pub Date : 2024-05-01 DOI: 10.1097/mpa.0000000000002349
Simon Sirtl, Katharina Bretthauer, Mahmood Ahmad, Eric Hohmann, Vanessa F Schmidt, Prince Allawadhi, Marlies Vornhülz, Sarah Klauss, Elisabetta Goni, Jakob Vielhauer, Elisabeth Orgler, Didem Saka, Mathilda Knoblauch, Felix O Hofmann, Jörg Schirra, Christian Schulz, Georg Beyer, Ujjwal M Mahajan, Julia Mayerle, Michal Zorniak
{"title":"Severity of gallstone, sludge or microlithiasis induced pancreatitis - all of the same?","authors":"Simon Sirtl, Katharina Bretthauer, Mahmood Ahmad, Eric Hohmann, Vanessa F Schmidt, Prince Allawadhi, Marlies Vornhülz, Sarah Klauss, Elisabetta Goni, Jakob Vielhauer, Elisabeth Orgler, Didem Saka, Mathilda Knoblauch, Felix O Hofmann, Jörg Schirra, Christian Schulz, Georg Beyer, Ujjwal M Mahajan, Julia Mayerle, Michal Zorniak","doi":"10.1097/mpa.0000000000002349","DOIUrl":"https://doi.org/10.1097/mpa.0000000000002349","url":null,"abstract":"Severity of microlithiasis and sludge-induced pancreatitis in comparison to gallstone-induced pancreatitis has never been studied for a lack of definition. In order to understand whether bile duct obstruction or other mechanisms contribute to biliary pancreatitis severity we performed a monocentric, retrospective cohort study.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"6 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140836306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening of amino acids as a safe energy source for isolated rat pancreatic acini. 筛选氨基酸作为离体大鼠胰腺皮质的安全能量来源。
IF 2.9 4区 医学
Pancreas Pub Date : 2024-05-01 DOI: 10.1097/mpa.0000000000002350
Anastasiia M Zub, Bohdan O Manko, Volodymyr V Manko
{"title":"Screening of amino acids as a safe energy source for isolated rat pancreatic acini.","authors":"Anastasiia M Zub, Bohdan O Manko, Volodymyr V Manko","doi":"10.1097/mpa.0000000000002350","DOIUrl":"https://doi.org/10.1097/mpa.0000000000002350","url":null,"abstract":"Amino acids play an essential role in protein synthesis, metabolism and survival of pancreatic acini. Adequate nutritional support is important for acute pancreatitis treatment. However, high concentrations of arginine and lysine may induce acute pancreatitis. The study aimed to identify the most suitable L-amino acids as safe energy sources for pancreatic acinar cells.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"8 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140836396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Hypophosphatemia as a Prognostic Marker in Acute Pancreatitis. 作为急性胰腺炎预后标志的早期低磷血症
IF 2.9 4区 医学
Pancreas Pub Date : 2024-05-01 DOI: 10.1097/mpa.0000000000002344
Connor F Stewart, Esther A Adeniran, Dhiraj Yadav, Fred S Gorelick, Rodger A Liddle, Bechien Wu, Stephen J Pandol, Christie Y Jeon
{"title":"Early Hypophosphatemia as a Prognostic Marker in Acute Pancreatitis.","authors":"Connor F Stewart, Esther A Adeniran, Dhiraj Yadav, Fred S Gorelick, Rodger A Liddle, Bechien Wu, Stephen J Pandol, Christie Y Jeon","doi":"10.1097/mpa.0000000000002344","DOIUrl":"https://doi.org/10.1097/mpa.0000000000002344","url":null,"abstract":"Acute pancreatitis (AP) is a complex disease representing a significant portion of gastrointestinal-related hospitalizations in the U.S. Understanding risk factors of AP might provide attractive therapeutic targets. We evaluated hypophosphatemia as a risk factor for worse outcomes in AP.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"44 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140836312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipase-to-Amylase Ratio for the Prediction of Clinically Relevant Postoperative Pancreatic Fistula following Pancreaticoduodenectomy. 预测胰十二指肠切除术后临床相关胰瘘的脂肪酶与淀粉酶比率
IF 2.9 4区 医学
Pancreas Pub Date : 2024-05-01 DOI: 10.1097/mpa.0000000000002345
Juanita N Chui, William A Ziaziaris, Christopher B Nahm, Talia Fuchs, Sumit Sahni, Christopher S H Lim, Anthony J Gill, Jaswinder S Samra DPhil, Anubhav Mittal
{"title":"Lipase-to-Amylase Ratio for the Prediction of Clinically Relevant Postoperative Pancreatic Fistula following Pancreaticoduodenectomy.","authors":"Juanita N Chui, William A Ziaziaris, Christopher B Nahm, Talia Fuchs, Sumit Sahni, Christopher S H Lim, Anthony J Gill, Jaswinder S Samra DPhil, Anubhav Mittal","doi":"10.1097/mpa.0000000000002345","DOIUrl":"https://doi.org/10.1097/mpa.0000000000002345","url":null,"abstract":"Postoperative pancreatic fistula(POPF) represents a leading cause of morbidity and mortality following major pancreatic resections. This study aimed to evaluate the use of post-operative drain fluid lipase-to-amylase ratio(LAR) for the prediction of clinically relevant fistulae(CR-POPF).","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"1 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140836169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Syndecan-1 Levels and Early Positive Fluid Balance Are Associated with Disease Severity in Acute Pancreatitis. Syndecan-1水平和早期体液平衡阳性与急性胰腺炎的病情严重程度有关。
IF 2.9 4区 医学
Pancreas Pub Date : 2024-05-01 DOI: 10.1097/mpa.0000000000002366
Antti Turunen, Krista Kuuliala, Antti Kuuliala, Pauli Puolakkainen, Leena Kylänpää, Johanna Hästbacka, Outi Lindström
{"title":"Syndecan-1 Levels and Early Positive Fluid Balance Are Associated with Disease Severity in Acute Pancreatitis.","authors":"Antti Turunen, Krista Kuuliala, Antti Kuuliala, Pauli Puolakkainen, Leena Kylänpää, Johanna Hästbacka, Outi Lindström","doi":"10.1097/mpa.0000000000002366","DOIUrl":"https://doi.org/10.1097/mpa.0000000000002366","url":null,"abstract":"To study fluid balance and endothelial glycocalyx degradation, reflected by syndedan-1 and heparan sulfate (HS) levels, in early stages of acute pancreatitis (AP).","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"1 1","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140842352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Second Primary Neuroendocrine Tumors: A Case Series. 第二原发性神经内分泌肿瘤：病例系列。
IF 1.7 4区 医学
Pancreas Pub Date : 2024-05-01 DOI: 10.1097/MPA.0000000000002348
Pamela O Emengo, Michelle K Kim, Celia M Divino
{"title":"Second Primary Neuroendocrine Tumors: A Case Series.","authors":"Pamela O Emengo, Michelle K Kim, Celia M Divino","doi":"10.1097/MPA.0000000000002348","DOIUrl":"10.1097/MPA.0000000000002348","url":null,"abstract":"","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"53 5","pages":"e467-e469"},"PeriodicalIF":1.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140904856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Demonstration of the Tumorigenic Role of APC in Pancreatic Solid Pseudopapillary Neoplasm Widens the Spectrum of FAP-Associated Neoplasms. 胰腺实体假乳头状瘤中 APC 致癌作用的分子证据拓宽了 FAP 相关肿瘤的范围
IF 2.9 4区 医学
Pancreas Pub Date : 2024-05-01 DOI: 10.1097/MPA.0000000000002347
Amedeo Sciarra, Alina Lungu, Charles Bénière, Sofia Facchi, Maria Grazia Tibiletti, Anna Maria Chiaravalli, Ian Fournier, Jean-Philippe Rey, Igor Letovanec, Stefano La Rosa
{"title":"Molecular Demonstration of the Tumorigenic Role of APC in Pancreatic Solid Pseudopapillary Neoplasm Widens the Spectrum of FAP-Associated Neoplasms.","authors":"Amedeo Sciarra, Alina Lungu, Charles Bénière, Sofia Facchi, Maria Grazia Tibiletti, Anna Maria Chiaravalli, Ian Fournier, Jean-Philippe Rey, Igor Letovanec, Stefano La Rosa","doi":"10.1097/MPA.0000000000002347","DOIUrl":"10.1097/MPA.0000000000002347","url":null,"abstract":"","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"53 5","pages":"e466-e467"},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140904890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信