Pancreas最新文献_第9页

Handgrip Strength Predicts Survival in Patients With Pancreatic Cancer. 手握强度可预测胰腺癌患者的生存期

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-01 Epub Date: 2024-03-21 DOI: 10.1097/MPA.0000000000002319

Julia Freckelton, Ashray Rajagopalan, Gregory T Moore, Daniel Croagh

{"title":"Handgrip Strength Predicts Survival in Patients With Pancreatic Cancer.","authors":"Julia Freckelton, Ashray Rajagopalan, Gregory T Moore, Daniel Croagh","doi":"10.1097/MPA.0000000000002319","DOIUrl":"10.1097/MPA.0000000000002319","url":null,"abstract":"Objectives: Pancreatic ductal adenocarcinoma (PDAC) is a common cancer with a poor prognosis and is associated with a high prevalence of cachexia, a metabolic syndrome of muscle wasting due to complex mechanisms. In addition to loss of muscle mass, cancer patients also experience functional deterioration. The aim of this study is to determine whether there is an association between muscle mass and function and clinical outcomes, particularly survival.Methods: We performed a prospective cohort study including all patients with PDAC at Monash Health from March 2016 to December 2017. We conducted body composition analysis for myopenia and handgrip strength testing. We constructed Kaplan-Meier curves to estimate whether myopenia and low hand grip strength were associated with poorer survival.Results: Myopenia was not associated with a significant difference in PDAC-specific survival (log-rank P = 0.60). However, low handgrip strength was associated with significantly worse PDAC-specific survival compared with other patients (log-rank hazard ratio, 1.88; 95% confidence interval, 1.15-3.09; P = 0.004).Conclusions: The relationship between survival in PDAC and handgrip strength, but not anatomical muscle mass, suggests that functional testing of strength may be important in prognostication of patients with PDAC, alongside existing tools such as the Eastern Cooperative Oncology Group performance status.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e405-e409"},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in Plasma Fatty Acid Composition Related to Chronic Pancreatitis: A Pilot Study. 与慢性胰腺炎有关的血浆脂肪酸组成差异：一项试点研究

IF 1.7 4区医学

Pancreas Pub Date : 2024-05-01 Epub Date: 2024-03-13 DOI: 10.1097/MPA.0000000000002318

Kristyn Gumpper-Fedus, Olivia Crowe, Phil A Hart, Valentina Pita-Grisanti, Ericka Velez-Bonet, Martha A Belury, Mitchell L Ramsey, Rachel M Cole, Niharika Badi, Stacey Culp, Alice Hinton, Luis F Lara, Somashekar G Krishna, Darwin L Conwell, Zobeida Cruz-Monserrate

{"title":"Differences in Plasma Fatty Acid Composition Related to Chronic Pancreatitis: A Pilot Study.","authors":"Kristyn Gumpper-Fedus, Olivia Crowe, Phil A Hart, Valentina Pita-Grisanti, Ericka Velez-Bonet, Martha A Belury, Mitchell L Ramsey, Rachel M Cole, Niharika Badi, Stacey Culp, Alice Hinton, Luis F Lara, Somashekar G Krishna, Darwin L Conwell, Zobeida Cruz-Monserrate","doi":"10.1097/MPA.0000000000002318","DOIUrl":"10.1097/MPA.0000000000002318","url":null,"abstract":"Objectives: Chronic pancreatitis (CP) is an inflammatory disease affecting the absorption of fat-soluble nutrients. Signaling in pancreatic cells that lead to inflammation may be influenced by fatty acids (FAs) through diet and de novo lipogenesis. Here, we investigated the relationship between plasma FA composition in CP with heterogeneity of etiology and complications of CP.Materials and methods: Blood and clinical parameters were collected from subjects with CP (n = 47) and controls (n = 22). Plasma was analyzed for FA composition using gas chromatography and compared between controls and CP and within CP.Results: Palmitic acid increased, and linoleic acid decreased in CP compared with controls. Correlations between age or body mass index and FAs are altered in CP compared with controls. Diabetes, pancreatic calcifications, and substance usage, but not exocrine pancreatic dysfunction, were associated with differences in oleic acid and linoleic acid relative abundance in CP. De novo lipogenesis index was increased in the plasma of subjects with CP compared with controls and in calcific CP compared with noncalcific CP.Conclusions: Fatty acids that are markers of de novo lipogenesis and linoleic acid are dysregulated in CP depending on the etiology or complication. These results enhance our understanding of CP and highlight potential pathways targeting FAs for treating CP.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e416-e423"},"PeriodicalIF":1.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11087201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140294219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Global Burden of Early-Onset Pancreatic Cancer and Its Risk Factors: A Perspective From Global Burden of Disease Study 2019. 早发胰腺癌的全球负担及其风险因素：2019年全球疾病负担研究透视》。

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-01 Epub Date: 2024-03-13 DOI: 10.1097/MPA.0000000000002331

Pojsakorn Danpanichkul, Kanokphong Suparan, Aunchalee Jaroenlapnopparat, Natchaya Polpichai, Panisara Fangsaard, Areeya Detboon, Pinyada Moolkaew, Adivitch Sripusanapan, Karan Srisurapanont, Yatawee Kanjanakot, Kwanjit Duangsonk, Michael B Wallace, Karn Wijarnpreecha

{"title":"The Global Burden of Early-Onset Pancreatic Cancer and Its Risk Factors: A Perspective From Global Burden of Disease Study 2019.","authors":"Pojsakorn Danpanichkul, Kanokphong Suparan, Aunchalee Jaroenlapnopparat, Natchaya Polpichai, Panisara Fangsaard, Areeya Detboon, Pinyada Moolkaew, Adivitch Sripusanapan, Karan Srisurapanont, Yatawee Kanjanakot, Kwanjit Duangsonk, Michael B Wallace, Karn Wijarnpreecha","doi":"10.1097/MPA.0000000000002331","DOIUrl":"10.1097/MPA.0000000000002331","url":null,"abstract":"Objectives: Despite evidence of increased incidence of early-onset pancreatic cancer (EOPC), defined as pancreatic cancer diagnosed in patients below 50 years old, and its risk factors in the Western region, global epidemiological data addressing this issue is still lacking.Materials and methods: Utilizing data from the Global Burden of Disease Study 2019, we aimed to conduct a comprehensive analysis of the incidence, deaths, and disability-adjusted life years (DALYs) associated with EOPC and its risk factors, including smoking, obesity, and diabetes. The analysis examined the annual percentage change (APC) over the period.Results: In 2019, the incidence of EOPC surpassed 35,000 cases worldwide. This burden of EOPC tends to be more prevalent in males, as well as in Europe and high SDI countries. However, there is a noticeable upward trend in the burden of EOPC in the Eastern Mediterranean. While there is a global decline in EOPC mortality attributed to smoking (APC -0.33%), there is a concerning increase in mortality associated with diabetes (APC +2.84%) and obesity (APC +2.12%).Conclusions: The burden of EOPC has been increasing. The mortality is rising mainly from metabolic factors. There is an urgent need for national policy development for reducing the burden of this disease.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e434-e444"},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140294176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreas 2.0: Many Promises to Keep and Many More to Deliver. A Message From the Editor-In-Chief, Ashok K. Saluja, PhD. 胰腺 2.0：胰腺 2.0：许多承诺要遵守，更多承诺要兑现。主编 Ashok K. Saluja 博士的致辞。

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-01 DOI: 10.1097/MPA.0000000000002367

引用次数: 0

Essential Fatty Acid Deficiency is Common after Total Pancreatectomy and Islet AutoTransplantation. 全胰腺切除术和胰岛自体移植后常见必需脂肪酸缺乏症。

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-01 DOI: 10.1097/mpa.0000000000002365

Elissa M Downs, James S Hodges, Guru Trikudanathan, Martin L Freeman, Srinath Chinnakotla, Varvara Kirchner, Timothy L Pruett, Gregory Beilman, Sarah Jane Schwarzenberg, Melena D Bellin

引用次数: 0

Endotherapy for the proximal migration of pancreatic stents: A systematic review. 胰腺支架近端移位的内治疗法：系统综述。

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-01 DOI: 10.1097/mpa.0000000000002354

Yi-Li Cai, Fan Wang, Zhao-Shen Li, Liang-Hao Hu

引用次数: 0

Prediction of Admission to Intensive Care Unit and 1-Year Mortality After Acute Pancreatitis With Walled-Off Pancreatic Necrosis: A Retrospective, Single-Center Cohort Study. 预测急性胰腺炎并发胰腺壁脱落坏死后入住重症监护病房和 1 年死亡率：一项回顾性单中心队列研究。

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-01 Epub Date: 2024-02-26 DOI: 10.1097/MPA.0000000000002314

Mohamed Ebrahim, Mikkel Parsberg Werge, Srdan Novovic, Nadia Emad Lotfi Amin, John Gásdal Karstensen, Henrik Løvendahl Jørgensen

{"title":"Prediction of Admission to Intensive Care Unit and 1-Year Mortality After Acute Pancreatitis With Walled-Off Pancreatic Necrosis: A Retrospective, Single-Center Cohort Study.","authors":"Mohamed Ebrahim, Mikkel Parsberg Werge, Srdan Novovic, Nadia Emad Lotfi Amin, John Gásdal Karstensen, Henrik Løvendahl Jørgensen","doi":"10.1097/MPA.0000000000002314","DOIUrl":"10.1097/MPA.0000000000002314","url":null,"abstract":"Background and aims: Pancreatic walled-off necrosis (WON) carries significant mortality and morbidity risks, often necessitating intensive care unit (ICU) admission. This retrospective study aimed to evaluate whether routine biochemical parameters at the time of the index endoscopic procedure could predict ICU admission and 1-year mortality following endoscopic treatment of WON.Materials and methods: We retrospectively identified 201 consecutive patients who underwent endoscopic drainage for WON between January 1, 2010, and December 31, 2020. Associations between routine biochemical blood tests and outcomes were assessed using logistic regression models.Results: Within 1 year of the index endoscopy, 31 patients (15.4%) died, and 40 (19.9%) were admitted to the ICU due to sepsis. Preoperative electrolyte disturbances were more prevalent among ICU-admitted patients and nonsurvivors. Hyperkalemia, hypoalbuminemia, and elevated urea were significant predictors of 1-year mortality, while hypernatremia, elevated serum creatinine, and hypoalbuminemia predicted ICU admission. Predictive models exhibited good discriminative ability, with an AUC of 0.84 (95% CI,0,75-0.93) for 1-year mortality and 0.86 (95%CI, 0.79-0.92) for ICU admission.Conclusions: Preoperative imbalances in routine blood tests effectively predict adverse outcomes in endoscopically treated WON patients.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e386-e394"},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Intratumor Heterogeneity in Pancreatic Ductal Adenocarcinoma Progression and Treatment. 肿瘤内异质性对胰腺导管腺癌进展和治疗的影响

IF 1.7 4区医学

Pancreas Pub Date : 2024-05-01 DOI: 10.1097/MPA.0000000000002342

Othman Saleh, Hani Shihadeh, Ahmad Yousef, Hana Erekat, Fatima Abdallh, Ahmad Al-Leimon, Rawan Elsalhy, Abdalrahman Altiti, Majd Dajani, Majd M AlBarakat

{"title":"The Effect of Intratumor Heterogeneity in Pancreatic Ductal Adenocarcinoma Progression and Treatment.","authors":"Othman Saleh, Hani Shihadeh, Ahmad Yousef, Hana Erekat, Fatima Abdallh, Ahmad Al-Leimon, Rawan Elsalhy, Abdalrahman Altiti, Majd Dajani, Majd M AlBarakat","doi":"10.1097/MPA.0000000000002342","DOIUrl":"10.1097/MPA.0000000000002342","url":null,"abstract":"Background and objectives: Pancreatic cancer is one of the most lethal malignancies. Even though many substantial improvements in the survival rates for other major cancer forms were made, pancreatic cancer survival rates have remained relatively unchanged since the 1960s. Even more, no standard classification system for pancreatic cancer is based on cellular biomarkers. This review will discuss and provide updates about the role of stem cells in the progression of PC, the genetic changes associated with it, and the promising biomarkers for diagnosis.Materials and methods: The search process used PubMed, Cochrane Library, and Scopus databases to identify the relevant and related articles. Articles had to be published in English to be considered.Results: The increasing number of studies in recent years has revealed that the diversity of cancer-associated fibroblasts is far greater than previously acknowledged, which highlights the need for further research to better understand the various cancer-associated fibroblast subpopulations. Despite the huge diversity in pancreatic cancer, some common features can be noted to be shared among patients. Mutations involving CDKN2, P53, and K-RAS can be seen in a big number of patients, for example. Similarly, some patterns of genes and biomarkers expression and the level of their expression can help in predicting cancer behavior such as metastasis and drug resistance. The current trend in cancer research, especially with the advancement in technology, is to sequence everything in hopes of finding disease-related mutations.Conclusion: Optimizing pancreatic cancer treatment requires clear classification, understanding CAF roles, and exploring stroma reshaping approaches.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"53 5","pages":"e450-e465"},"PeriodicalIF":1.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140904879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aryl hydrocarbon receptor knockout accelerates PanIN formation and fibro-inflammation in a mutant Kras-driven pancreatic cancer model. 在突变 Kras 驱动的胰腺癌模型中，敲除芳基烃受体可加速 PanIN 的形成和纤维炎症。

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-01 DOI: 10.1097/mpa.0000000000002357

Morgan T Walcheck, Patrick B Schwartz, Noah D Carrillo, Kristina A Matkowsky, Manabu Nukaya, Christopher A Bradfield, Sean M Ronnekleiv-Kelly

引用次数: 0

Severity of gallstone, sludge or microlithiasis induced pancreatitis - all of the same? 胆结石、淤血或微结石诱发胰腺炎的严重程度--都一样吗？

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-01 DOI: 10.1097/mpa.0000000000002349

Simon Sirtl, Katharina Bretthauer, Mahmood Ahmad, Eric Hohmann, Vanessa F Schmidt, Prince Allawadhi, Marlies Vornhülz, Sarah Klauss, Elisabetta Goni, Jakob Vielhauer, Elisabeth Orgler, Didem Saka, Mathilda Knoblauch, Felix O Hofmann, Jörg Schirra, Christian Schulz, Georg Beyer, Ujjwal M Mahajan, Julia Mayerle, Michal Zorniak

引用次数: 0