Pancreas最新文献_第9页

Genetic Assessment of Intraductal Papillary Mucinous Neoplasm for Predicting Concomitant Pancreatic Ductal Adenocarcinoma. 对 IPMN 进行基因评估以预测并发胰腺导管腺癌。

IF 1.7 4区医学

Pancreas Pub Date : 2024-11-01 Epub Date: 2024-05-15 DOI: 10.1097/MPA.0000000000002373

Hideyuki Oi, Yuto Hozaka, Toshiaki Akahane, Kosuke Fukuda, Tetsuya Idichi, Kiyonori Tanoue, Yoichi Yamasaki, Yota Kawasaki, Yuko Mataki, Hiroshi Kurahara, Michiyo Higashi, Akihide Tanimoto, Takao Ohtsuka

{"title":"Genetic Assessment of Intraductal Papillary Mucinous Neoplasm for Predicting Concomitant Pancreatic Ductal Adenocarcinoma.","authors":"Hideyuki Oi, Yuto Hozaka, Toshiaki Akahane, Kosuke Fukuda, Tetsuya Idichi, Kiyonori Tanoue, Yoichi Yamasaki, Yota Kawasaki, Yuko Mataki, Hiroshi Kurahara, Michiyo Higashi, Akihide Tanimoto, Takao Ohtsuka","doi":"10.1097/MPA.0000000000002373","DOIUrl":"10.1097/MPA.0000000000002373","url":null,"abstract":"Objective: The role of Krüppel-like transcription factor 4 ( KLF4 ) mutations in IPMNs with concomitant pancreatic ductal adenocarcinoma (PDAC) remains unclear. This study clarified the rate and effect of KLF4 mutations in IPMN with concomitant PDAC.Materials and methods: DNA was extracted from 65 formalin-fixed and paraffin-embedded samples from 52 patients including 13 IPMNs with concomitant PDAC and 39 IPMNs alone. A comprehensive screening using next-generation sequencing and then targeted sequencing for KLF4 , GNAS , and KRAS mutations were performed.Results: In next-generation sequencing screening, KRAS mutations were observed in all samples except for one, GNAS mutation in 2 IPMNs with concomitant PDAC, and a KLF4 mutation in 1 IPMN with concomitant PDAC. Targeted sequence detected KLF4 mutations in 11 of the 52 IPMNs. Concomitant PDAC developed only in the nonintestinal, noninvasive, and branch-duct IPMNs, and KLF4 mutations were more frequent in this IPMN type than in the other type. For this IPMN type with KLF4 mutation, PDAC-prediction sensitivity, specificity, and accuracy were 63%, 82%, and 79%, respectively.Conclusion: For selected IPMNs with nonintestinal, noninvasive, and branch-duct, genetic assessment might be helpful for predicting the possible development of concomitant PDAC, although a prospective validation study using a larger study population is needed.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e790-e795"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140921178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real Risk Factors for Post-ERCP Pancreatitis Patients. ERCP术后胰腺炎患者的真实风险因素。

IF 1.7 4区医学

Pancreas Pub Date : 2024-11-01 Epub Date: 2024-05-17 DOI: 10.1097/MPA.0000000000002368

Wanjun Wu, Zheng Peng

引用次数: 0

Diagnostic Accuracy of Preoperative Imaging for Differentiation of Branch Duct Versus Mixed Duct Intraductal Papillary Mucinous Neoplasms: Erratum. 鉴别支管与混合管导管内乳头状粘液瘤的术前影像学诊断准确性：勘误。

IF 1.7 4区医学

Pancreas Pub Date : 2024-11-01 DOI: 10.1097/MPA.0000000000002380

引用次数: 0

Total Pancreatectomy With Percutaneous Islet Autotransplant After Remote Islet Processing: A Viable Paradigm? 全胰腺切除术与远程胰岛处理后的经皮胰岛自体移植：可行的范例？

IF 1.7 4区医学

Pancreas Pub Date : 2024-11-01 Epub Date: 2024-06-03 DOI: 10.1097/MPA.0000000000002376

Kyle A Lewellen, Thomas K Maatman, Michael G House, Kathleen McGreevy, Melissa K Cavaghan, Michael R Dorwart, Evan L Fogel, Paul M Haste, Anne Mary Montero, Alexandra M Roch, Nicholas J Zyromski

{"title":"Total Pancreatectomy With Percutaneous Islet Autotransplant After Remote Islet Processing: A Viable Paradigm?","authors":"Kyle A Lewellen, Thomas K Maatman, Michael G House, Kathleen McGreevy, Melissa K Cavaghan, Michael R Dorwart, Evan L Fogel, Paul M Haste, Anne Mary Montero, Alexandra M Roch, Nicholas J Zyromski","doi":"10.1097/MPA.0000000000002376","DOIUrl":"10.1097/MPA.0000000000002376","url":null,"abstract":"Objectives: Total pancreatectomy with islet autotransplant (TPIAT) is important therapy for select chronic pancreatitis (CP) patients. The specialized technique of islet isolation limits widespread TPIAT use. We hypothesized that remote islet isolation provides satisfactory islet yield and perioperative outcomes.Methods: A retrospective review of TPIAT patients between 2020 and 2022 was conducted. Islet isolation was performed off-site, with percutaneous intraportal islet autotransplant (IAT) completed the morning following pancreatectomy. Demographics and perioperative outcomes were analyzed.Results: Fourteen patients underwent TPIAT; median age was 43 (interquartile range, 12.5) years. Operation occurred 7.5 (14.8) years after pancreatitis diagnosis. The most common pancreatitis etiology was genetic (50%). All patients underwent preoperative endoscopic therapy; three underwent prior pancreatectomy. Operative time was 236 (51) minutes; subsequent percutaneous IAT time was 87 (35) minutes. The islet equivalent (IEQ)/kilogram (kg) yield was 3456 (3815) IEQ/kg. Nine patients had positive islet cultures. Two thromboembolic events and one bacteremia occurred. One perihepatic hematoma occurred after percutaneous portal venous access. The median postoperative length of stay was 14.5 days, and five patients (36%) were readmitted within 90 days. All patients were discharged home on insulin. No mortality occurred.Conclusions: Total pancreatectomy with remote islet isolation provides excellent islet yield for autotransplant and satisfactory perioperative outcomes.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e796-e801"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant Cyst of Intrapancreatic Accessory Spleen Mimicking a Malignant Cystic Neoplasm of the Pancreas: A Case Report. 模仿胰腺恶性囊性肿瘤的胰腺内附属脾脏巨型囊肿：病例报告。

IF 1.7 4区医学

Pancreas Pub Date : 2024-11-01 Epub Date: 2024-06-24 DOI: 10.1097/MPA.0000000000002383

Yang Sun, Jieli Luo, Fengbo Huang, Pintong Huang, Risheng Yu

引用次数: 0

Increased Gremlin1 Expression in Pancreatic Ductal Adenocarcinoma Promotes a Fibrogenic Stromal Microenvironment. 胰腺导管腺癌中 Gremlin1 表达的增加促进了纤维基质微环境的形成。

IF 1.7 4区医学

Pancreas Pub Date : 2024-11-01 Epub Date: 2024-06-04 DOI: 10.1097/MPA.0000000000002378

Rachel R Tindall, Erika Y Faraoni, Jiajing Li, Yinjie Zhang, Shun-Ming Ting, Beanna Okeugo, Xiurong Zhao, Yuying Liu, Mamoun Younes, Qiang Shen, Jennifer M Bailey-Lundberg, Yanna Cao, Tien C Ko

{"title":"Increased Gremlin1 Expression in Pancreatic Ductal Adenocarcinoma Promotes a Fibrogenic Stromal Microenvironment.","authors":"Rachel R Tindall, Erika Y Faraoni, Jiajing Li, Yinjie Zhang, Shun-Ming Ting, Beanna Okeugo, Xiurong Zhao, Yuying Liu, Mamoun Younes, Qiang Shen, Jennifer M Bailey-Lundberg, Yanna Cao, Tien C Ko","doi":"10.1097/MPA.0000000000002378","DOIUrl":"10.1097/MPA.0000000000002378","url":null,"abstract":"Objective: Pancreatic ductal adenocarcinoma (PDAC) microenvironment is primarily composed of cancer-associated fibroblasts and immune cells. Gremlin1 (Grem1) is a profibrogenic factor that promotes tumorigenesis in several cancers. However, the role of Grem1 in the PDAC microenvironment is not defined.Materials and methods: We correlated Grem1 levels with activated stroma and immune cells in human PDAC using The Cancer Genome Atlas RNA-sequencing data and characterized expression of Grem1 transcripts and isoforms in pancreatic cell lines and PDAC tissues. We assessed the role of Grem1 in the microenvironment by in vitro studies.Results: Grem1 expression is associated with an activated stroma and increased M1 and M2 macrophages. Only full length Grem1 variant 1 and isoform 1 were detectable in human pancreatic cells, and remarkably high levels of Grem1 were observed in pancreatic fibroblasts. Immunohistochemistry detected Grem1 protein in PDAC tumor and stromal cells, which correlated with infiltrating macrophages in PDAC tumors. Grem1 knockdown in cancer-associated fibroblasts suppressed transforming growth factor β-induced extracellular matrix proteins. Grem1 recombinant protein treatment in vitro increased M1 and M2 macrophages.Conclusions: Grem1 acts as a profibrogenic factor in the PDAC microenvironment via modulation of fibroblasts and macrophages. Grem1 may have the potential to be developed as a therapeutic target for PDAC.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e808-e817"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141200432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regarding the Risk of Hypertriglyceridemic Acute Pancreatitis. 关于高甘油三酯急性胰腺炎的风险。

IF 1.7 4区医学

Pancreas Pub Date : 2024-10-01 Epub Date: 2024-04-30 DOI: 10.1097/MPA.0000000000002361

Beibei Wang, Zheng Peng

引用次数: 0

Financial Toxicity in Patients With Chronic Pancreatitis. 慢性胰腺炎患者的经济毒性。

IF 1.7 4区医学

Pancreas Pub Date : 2024-10-01 Epub Date: 2024-06-21 DOI: 10.1097/MPA.0000000000002384

Radmila Choate, Carrigan Wasilchenko, Kshitij Thakur, Rachel Hill, Elizabeth Wright, Darwin L Conwell

{"title":"Financial Toxicity in Patients With Chronic Pancreatitis.","authors":"Radmila Choate, Carrigan Wasilchenko, Kshitij Thakur, Rachel Hill, Elizabeth Wright, Darwin L Conwell","doi":"10.1097/MPA.0000000000002384","DOIUrl":"10.1097/MPA.0000000000002384","url":null,"abstract":"Objectives: Patients with chronic illnesses are susceptible to the financial burden of disease-related treatment costs. Financial toxicity is well researched in cancer and several chronic diseases. This review explores the financial challenges faced by patients with chronic pancreatitis and the impact of financial hardship on their well-being.Materials and methods: We performed a review of the published literature to summarize the body of existing research and to identify knowledge gaps related to the financial burden experienced by patients with chronic pancreatitis.Results: Research on financial burden, cost-coping behaviors, cost-related nonadherence to prescribed medications, and social vulnerabilities in people with chronic pancreatitis is sparse. No studies have assessed the suitability and validity of instruments measuring subjective financial toxicity in a patient population with chronic pancreatitis.Conclusions: There is a critical need for further studies of financial toxicity in the patient population with chronic pancreatitis, considering that if the sources of financial burden can be identified, opportunities emerge to dampen or mitigate their impact on patients with chronic pancreatitis.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e774-e779"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on "The Serum Carbohydrate Antigen 19-9 and Metabolite Hypotaurine Are Predictive Markers for Early Recurrence of Pancreatic Ductal Adenocarcinoma". 关于 "血清碳水化合物抗原 19-9 和代谢物低牛磺酸是胰腺导管腺癌早期复发的预测标志物 "的评论。

IF 1.7 4区医学

Pancreas Pub Date : 2024-10-01 Epub Date: 2024-05-16 DOI: 10.1097/MPA.0000000000002369

Qiongying Xu, Junwu Zhang, Difeng Chen

引用次数: 0

The Prognostic Significance of Collagen VI in Pancreatic Ductal Adenocarcinoma. 胰腺导管腺癌中胶原蛋白 VI 的预后意义。

IF 1.7 4区医学

Pancreas Pub Date : 2024-10-01 Epub Date: 2024-06-24 DOI: 10.1097/MPA.0000000000002360

Ella Kesti, Emmy Borgmästars, Jaana Hagström, Harri Mustonen, Hanna Seppänen, Caj Haglund, Malin Sund

{"title":"The Prognostic Significance of Collagen VI in Pancreatic Ductal Adenocarcinoma.","authors":"Ella Kesti, Emmy Borgmästars, Jaana Hagström, Harri Mustonen, Hanna Seppänen, Caj Haglund, Malin Sund","doi":"10.1097/MPA.0000000000002360","DOIUrl":"10.1097/MPA.0000000000002360","url":null,"abstract":"Objectives: Pancreatic ductal adenocarcinoma (PDAC) is characterized by poor prognosis and lack of biomarkers. A rich desmoplastic tumor stroma is considered a hallmark of PDAC and previous studies have indicated upregulated expression of collagen VI (COL6) in PDAC. COL6 is shown to associate with prognosis in many cancers but has been less extensively studied in PDAC.Materials and methods: The expression of COL6 was analyzed by immunohistochemistry in tissue microarrays containing resected tumor tissue samples from PDAC patients (n = 164). Significance of COL6 was estimated with Kaplan-Meier survival estimates and multivariable Cox regression analysis. COL6 protein and mRNA expression patterns were further investigated in publicly available datasets.Results: There were no statistically significant ( P < 0.05) differences in survival when comparing high and low protein expression of any of the analyzed COL6 α-chains (α1(VI): hazard ratio [HR] 0.90, 95% confidence interval [CI] 0.64-1.28; α2(VI): HR 1.28, 95% CI 0.86-1.89; α3(VI): HR 0.91, 95% CI 0.64-1.29). Similar results were obtained when assessing public data from the Cancer Proteome Atlas, Clinical Proteomic Tumor Analysis Consortium, and The Cancer Genome Atlas.Conclusions: In contrast with previous studies and some other cancers, we did not find any association of COL6 tissue expression and PDAC survival.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e729-e738"},"PeriodicalIF":1.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0