Pancreas最新文献_第8页

Multidisciplinary Approach for the Management of Metastatic Poorly Differentiated Neuroendocrine Carcinoma of the Pancreas: A Case Report of an Exceptional Responder. 多学科方法治疗转移性分化不良胰腺神经内分泌癌：一位特殊患者的病例报告。

IF 1.7 4区医学

Pancreas Pub Date : 2024-07-01 Epub Date: 2024-03-06 DOI: 10.1097/MPA.0000000000002322

Elizabeth S Nakasone, Hannah C Bustillos, Xianyong Gui, Eric Q Konnick, Jonathan G Sham, Stacey A Cohen

{"title":"Multidisciplinary Approach for the Management of Metastatic Poorly Differentiated Neuroendocrine Carcinoma of the Pancreas: A Case Report of an Exceptional Responder.","authors":"Elizabeth S Nakasone, Hannah C Bustillos, Xianyong Gui, Eric Q Konnick, Jonathan G Sham, Stacey A Cohen","doi":"10.1097/MPA.0000000000002322","DOIUrl":"10.1097/MPA.0000000000002322","url":null,"abstract":"Abstract: Poorly differentiated pancreatic neuroendocrine carcinomas (pNECs) are rare, highly aggressive neoplasms. Frequently metastatic at diagnosis, prognosis is poor with median overall survival estimated to be less than 1 year. Although multidisciplinary management, including systemic medications and locoregional therapies aimed at reducing and preventing symptoms caused by mass effect, is the mainstay of treatment for patients with metastatic well-differentiated pancreatic neuroendocrine tumors, rapid progression, organ dysfunction, and poor performance status often preclude initiation of even single-modality palliative chemotherapy for patients with metastatic pNEC, limiting the use of and recommendation for multidisciplinary management.We describe the case of a 51-year-old male patient diagnosed with pNEC metastatic to liver and lymph nodes presenting with impending cholestatic liver failure for whom we were able to successfully initiate and dose-escalate cytotoxic chemotherapy with excellent radiographic response. After multidisciplinary review of his case, the patient underwent pancreaticoduodenectomy and hepatic wedge biopsies, with pathology demonstrating a pathologic complete response to chemotherapy in both the pancreas and liver. Surveillance scans at 2 years from initial diagnosis and 1 year from surgery remain without evidence of locoregional or distant recurrence, highlighting the importance and utility of multidisciplinary management in select cases.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e487-e491"},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140068652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on "The serum carbohydrate antigen 19-9 and metabolite hypotaurine are predictive markers for early recurrence of pancreatic ductal adenocarcinoma". 关于 "血清碳水化合物抗原 19-9 和代谢物低牛磺酸是胰腺导管腺癌早期复发的预测标志物 "的评论。

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-17 DOI: 10.1097/MPA.0000000000002369

Qiongying Xu, Junwu Zhang, Difeng Chen

引用次数: 0

Liquid Biopsy for Pancreatic Cancer by Serum Extracellular Vesicle-Encapsulated Long Noncoding RNA HEVEPA. 通过血清胞外囊泡包裹的长非编码 RNA HEVEPA 进行胰腺癌液体活检。

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-01 Epub Date: 2024-02-26 DOI: 10.1097/MPA.0000000000002315

Kenji Takahashi, Tatsutoshi Inuzuka, Yuta Shimizu, Kazuki Sawamoto, Kenzui Taniue, Yusuke Ono, Fumi Asai, Kazuya Koyama, Hiroki Sato, Hidemasa Kawabata, Hidetaka Iwamoto, Keisuke Yamakita, Yohei Kitano, Takashi Teramoto, Mikihiro Fujiya, Satoshi Fujii, Yusuke Mizukami, Toshikatsu Okumura

{"title":"Liquid Biopsy for Pancreatic Cancer by Serum Extracellular Vesicle-Encapsulated Long Noncoding RNA HEVEPA.","authors":"Kenji Takahashi, Tatsutoshi Inuzuka, Yuta Shimizu, Kazuki Sawamoto, Kenzui Taniue, Yusuke Ono, Fumi Asai, Kazuya Koyama, Hiroki Sato, Hidemasa Kawabata, Hidetaka Iwamoto, Keisuke Yamakita, Yohei Kitano, Takashi Teramoto, Mikihiro Fujiya, Satoshi Fujii, Yusuke Mizukami, Toshikatsu Okumura","doi":"10.1097/MPA.0000000000002315","DOIUrl":"10.1097/MPA.0000000000002315","url":null,"abstract":"Objectives: The role of long noncoding RNAs (lncRNAs) in pancreatic ductal adenocarcinoma (PDAC) remain unclear. Extracellular vesicle (EV)-encapsulated RNAs could be effective targets for liquid biopsy. We aimed to identify previously unknown EV-encapsulated lncRNAs in PDAC and establish highly accurate methods for isolating EVs.Materials and methods: Extracellular vesicles were isolated using existing and newly developed methods, namely, PEViA-UC and PEViA-IP, from serum samples of 20 patients with PDAC, 22 patients with intraductal papillary mucinous neoplasms, and 21 healthy individuals. Extracellular vesicle lncRNA expression was analyzed using digital PCR.Results: Gene expression analysis using cDNA microarray revealed a highly expressed lncRNA, HEVEPA , in serum EVs from patients with PDAC. We established PEViA-UC and PEViA-IP using PEViA reagent, ultracentrifugation, and immunoprecipitation. Although detection of EV-encapsulated HEVEPA using existing methods is challenging, PEViA-UC and PEViA-IP detected EV HEVEPA , which was highly expressed in patients with PDAC compared with non-PDAC patients. The detection sensitivity for discriminating PDAC from non-PDAC using the combination of HEVEPA and HULC , which are highly expressed lncRNAs in PDAC, and carbohydrate antigen 19-9 (CA19-9), was higher than that of HEVEPA , HULC , or CA19-9 alone.Conclusions: Extracellular vesicle lncRNAs isolated using PEViA-IP and CA19-9 together could be effective targets in liquid biopsy for PDAC diagnosis.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e395-e404"},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of gut microbiota and innate immune response in an autoimmune pancreatitis model. 肠道微生物群和先天性免疫反应在自身免疫性胰腺炎模型中的作用

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-01 DOI: 10.1097/mpa.0000000000002339

Suguru Ito, Masaaki Higashiyama, Hiroyuki Nishimura, Akira Tomioka, Rina Tanemoto, Shin Nishii, Akinori Mizoguchi, Yoshihiro Akita, Yoshikiyo Okada, Chie Kurihara, Kazuyuki Narimatsu, Shunsuke Komoto, Kengo Tomita, Ryota Hokari

引用次数: 0

Handgrip Strength Predicts Survival in Patients With Pancreatic Cancer. 手握强度可预测胰腺癌患者的生存期

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-01 Epub Date: 2024-03-21 DOI: 10.1097/MPA.0000000000002319

Julia Freckelton, Ashray Rajagopalan, Gregory T Moore, Daniel Croagh

{"title":"Handgrip Strength Predicts Survival in Patients With Pancreatic Cancer.","authors":"Julia Freckelton, Ashray Rajagopalan, Gregory T Moore, Daniel Croagh","doi":"10.1097/MPA.0000000000002319","DOIUrl":"10.1097/MPA.0000000000002319","url":null,"abstract":"Objectives: Pancreatic ductal adenocarcinoma (PDAC) is a common cancer with a poor prognosis and is associated with a high prevalence of cachexia, a metabolic syndrome of muscle wasting due to complex mechanisms. In addition to loss of muscle mass, cancer patients also experience functional deterioration. The aim of this study is to determine whether there is an association between muscle mass and function and clinical outcomes, particularly survival.Methods: We performed a prospective cohort study including all patients with PDAC at Monash Health from March 2016 to December 2017. We conducted body composition analysis for myopenia and handgrip strength testing. We constructed Kaplan-Meier curves to estimate whether myopenia and low hand grip strength were associated with poorer survival.Results: Myopenia was not associated with a significant difference in PDAC-specific survival (log-rank P = 0.60). However, low handgrip strength was associated with significantly worse PDAC-specific survival compared with other patients (log-rank hazard ratio, 1.88; 95% confidence interval, 1.15-3.09; P = 0.004).Conclusions: The relationship between survival in PDAC and handgrip strength, but not anatomical muscle mass, suggests that functional testing of strength may be important in prognostication of patients with PDAC, alongside existing tools such as the Eastern Cooperative Oncology Group performance status.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e405-e409"},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differences in Plasma Fatty Acid Composition Related to Chronic Pancreatitis: A Pilot Study. 与慢性胰腺炎有关的血浆脂肪酸组成差异：一项试点研究

IF 1.7 4区医学

Pancreas Pub Date : 2024-05-01 Epub Date: 2024-03-13 DOI: 10.1097/MPA.0000000000002318

Kristyn Gumpper-Fedus, Olivia Crowe, Phil A Hart, Valentina Pita-Grisanti, Ericka Velez-Bonet, Martha A Belury, Mitchell L Ramsey, Rachel M Cole, Niharika Badi, Stacey Culp, Alice Hinton, Luis F Lara, Somashekar G Krishna, Darwin L Conwell, Zobeida Cruz-Monserrate

{"title":"Differences in Plasma Fatty Acid Composition Related to Chronic Pancreatitis: A Pilot Study.","authors":"Kristyn Gumpper-Fedus, Olivia Crowe, Phil A Hart, Valentina Pita-Grisanti, Ericka Velez-Bonet, Martha A Belury, Mitchell L Ramsey, Rachel M Cole, Niharika Badi, Stacey Culp, Alice Hinton, Luis F Lara, Somashekar G Krishna, Darwin L Conwell, Zobeida Cruz-Monserrate","doi":"10.1097/MPA.0000000000002318","DOIUrl":"10.1097/MPA.0000000000002318","url":null,"abstract":"Objectives: Chronic pancreatitis (CP) is an inflammatory disease affecting the absorption of fat-soluble nutrients. Signaling in pancreatic cells that lead to inflammation may be influenced by fatty acids (FAs) through diet and de novo lipogenesis. Here, we investigated the relationship between plasma FA composition in CP with heterogeneity of etiology and complications of CP.Materials and methods: Blood and clinical parameters were collected from subjects with CP (n = 47) and controls (n = 22). Plasma was analyzed for FA composition using gas chromatography and compared between controls and CP and within CP.Results: Palmitic acid increased, and linoleic acid decreased in CP compared with controls. Correlations between age or body mass index and FAs are altered in CP compared with controls. Diabetes, pancreatic calcifications, and substance usage, but not exocrine pancreatic dysfunction, were associated with differences in oleic acid and linoleic acid relative abundance in CP. De novo lipogenesis index was increased in the plasma of subjects with CP compared with controls and in calcific CP compared with noncalcific CP.Conclusions: Fatty acids that are markers of de novo lipogenesis and linoleic acid are dysregulated in CP depending on the etiology or complication. These results enhance our understanding of CP and highlight potential pathways targeting FAs for treating CP.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e416-e423"},"PeriodicalIF":1.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11087201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140294219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Global Burden of Early-Onset Pancreatic Cancer and Its Risk Factors: A Perspective From Global Burden of Disease Study 2019. 早发胰腺癌的全球负担及其风险因素：2019年全球疾病负担研究透视》。

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-01 Epub Date: 2024-03-13 DOI: 10.1097/MPA.0000000000002331

Pojsakorn Danpanichkul, Kanokphong Suparan, Aunchalee Jaroenlapnopparat, Natchaya Polpichai, Panisara Fangsaard, Areeya Detboon, Pinyada Moolkaew, Adivitch Sripusanapan, Karan Srisurapanont, Yatawee Kanjanakot, Kwanjit Duangsonk, Michael B Wallace, Karn Wijarnpreecha

{"title":"The Global Burden of Early-Onset Pancreatic Cancer and Its Risk Factors: A Perspective From Global Burden of Disease Study 2019.","authors":"Pojsakorn Danpanichkul, Kanokphong Suparan, Aunchalee Jaroenlapnopparat, Natchaya Polpichai, Panisara Fangsaard, Areeya Detboon, Pinyada Moolkaew, Adivitch Sripusanapan, Karan Srisurapanont, Yatawee Kanjanakot, Kwanjit Duangsonk, Michael B Wallace, Karn Wijarnpreecha","doi":"10.1097/MPA.0000000000002331","DOIUrl":"10.1097/MPA.0000000000002331","url":null,"abstract":"Objectives: Despite evidence of increased incidence of early-onset pancreatic cancer (EOPC), defined as pancreatic cancer diagnosed in patients below 50 years old, and its risk factors in the Western region, global epidemiological data addressing this issue is still lacking.Materials and methods: Utilizing data from the Global Burden of Disease Study 2019, we aimed to conduct a comprehensive analysis of the incidence, deaths, and disability-adjusted life years (DALYs) associated with EOPC and its risk factors, including smoking, obesity, and diabetes. The analysis examined the annual percentage change (APC) over the period.Results: In 2019, the incidence of EOPC surpassed 35,000 cases worldwide. This burden of EOPC tends to be more prevalent in males, as well as in Europe and high SDI countries. However, there is a noticeable upward trend in the burden of EOPC in the Eastern Mediterranean. While there is a global decline in EOPC mortality attributed to smoking (APC -0.33%), there is a concerning increase in mortality associated with diabetes (APC +2.84%) and obesity (APC +2.12%).Conclusions: The burden of EOPC has been increasing. The mortality is rising mainly from metabolic factors. There is an urgent need for national policy development for reducing the burden of this disease.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e434-e444"},"PeriodicalIF":2.9,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140294176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreas 2.0: Many Promises to Keep and Many More to Deliver. A Message From the Editor-In-Chief, Ashok K. Saluja, PhD. 胰腺 2.0：胰腺 2.0：许多承诺要遵守，更多承诺要兑现。主编 Ashok K. Saluja 博士的致辞。

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-01 DOI: 10.1097/MPA.0000000000002367

引用次数: 0

Essential Fatty Acid Deficiency is Common after Total Pancreatectomy and Islet AutoTransplantation. 全胰腺切除术和胰岛自体移植后常见必需脂肪酸缺乏症。

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-01 DOI: 10.1097/mpa.0000000000002365

Elissa M Downs, James S Hodges, Guru Trikudanathan, Martin L Freeman, Srinath Chinnakotla, Varvara Kirchner, Timothy L Pruett, Gregory Beilman, Sarah Jane Schwarzenberg, Melena D Bellin

引用次数: 0

Endotherapy for the proximal migration of pancreatic stents: A systematic review. 胰腺支架近端移位的内治疗法：系统综述。

IF 2.9 4区医学

Pancreas Pub Date : 2024-05-01 DOI: 10.1097/mpa.0000000000002354

Yi-Li Cai, Fan Wang, Zhao-Shen Li, Liang-Hao Hu

引用次数: 0