Pancreas最新文献_第8页

Somatic Genomic Profiling of Pancreatic Ductal Adenocarcinomas From a Diverse Cohort of Patients. 来自不同患者队列的胰腺导管腺癌的体细胞基因组分析。

IF 1.7 4区医学

Pancreas Pub Date : 2025-03-01 DOI: 10.1097/MPA.0000000000002408

Andrea N Riner, Enrique I Velazquez-Villarreal, Seeta Rajpara, Jing Qian, Yuxin Jin, Donna Loza, Ashwin Akki, Kelly M Herremans, Rohit Raj, Terence M Williams, Nipun Merchant, Thomas J George, Steven J Hughes, Mariana C Stern, Renee Reams, Ken Redda, Diana J Wilkie, Folakemi T Odedina, Srikar Chamala, Bo Han, Edward Agyare, David W Craig, John D Carpten, Jose G Trevino

{"title":"Somatic Genomic Profiling of Pancreatic Ductal Adenocarcinomas From a Diverse Cohort of Patients.","authors":"Andrea N Riner, Enrique I Velazquez-Villarreal, Seeta Rajpara, Jing Qian, Yuxin Jin, Donna Loza, Ashwin Akki, Kelly M Herremans, Rohit Raj, Terence M Williams, Nipun Merchant, Thomas J George, Steven J Hughes, Mariana C Stern, Renee Reams, Ken Redda, Diana J Wilkie, Folakemi T Odedina, Srikar Chamala, Bo Han, Edward Agyare, David W Craig, John D Carpten, Jose G Trevino","doi":"10.1097/MPA.0000000000002408","DOIUrl":"10.1097/MPA.0000000000002408","url":null,"abstract":"Objectives: Black/African American (B/AA) pancreatic ductal adenocarcinoma (PDAC) patients have worse clinical outcomes than White patients and are underrepresented in genomic databases. We aimed to expand our understanding of the PDAC somatic landscape from a diverse cohort.Materials and methods: Formalin-fixed paraffin-embedded specimens from 24 surgically resected PDAC cases were collected, with self-reported race/ethnicity. Whole exome sequencing was performed on malignant and benign tissue. Bioinformatics analysis included deduction of genetic ancestry and somatic mutational analysis, with comparisons to public datasets.Results: Out of 24 cases, 17 identified as B/AA race; genetic ancestry analysis confirmed proportions of Sub-Saharan African ancestry greater than 47%. The most commonly mutated genes included KRAS, TP53, SMAD4, and CDKN2A. Comparison of mutations in our cohort versus publicly available, predominantly White datasets showed higher mutation frequencies of ATM, RREB1, BRCA1/2, KDM6A, ARID1A, BRAF, and MYC (P < 0.04). When cohorts were combined and analyzed by race, no mutation frequencies differences were observed, including KRAS.Conclusions: Genomic analysis of PDAC tumors from B/AA and White patients demonstrate similarities in mutation frequencies. Larger studies are needed to further understand molecular characterizations across continental subpopulations. This study provides further rationale for equitable representation of diverse patients in genomic databases and clinical trials.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"54 3","pages":"e171-e178"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Significant Impact of Fibrinogen-C-Reactive Protein-Albumin Ratio on the Long-Term Outcomes After Pancreatic Resection for Pancreatic Cancer. 纤维蛋白原- c反应蛋白-白蛋白比值对胰腺癌切除术后长期预后的显著影响。

IF 1.7 4区医学

Pancreas Pub Date : 2025-03-01 Epub Date: 2024-11-18 DOI: 10.1097/MPA.0000000000002416

Yoshiaki Tanji, Koichiro Haruki, Yosuke Igarashi, Mitsuru Yanagaki, Yoshihiro Shirai, Tomohiko Taniai, Kenei Furukawa, Shinji Onda, Taro Sakamoto, Toru Ikegami

{"title":"The Significant Impact of Fibrinogen-C-Reactive Protein-Albumin Ratio on the Long-Term Outcomes After Pancreatic Resection for Pancreatic Cancer.","authors":"Yoshiaki Tanji, Koichiro Haruki, Yosuke Igarashi, Mitsuru Yanagaki, Yoshihiro Shirai, Tomohiko Taniai, Kenei Furukawa, Shinji Onda, Taro Sakamoto, Toru Ikegami","doi":"10.1097/MPA.0000000000002416","DOIUrl":"10.1097/MPA.0000000000002416","url":null,"abstract":"Objectives: This study aimed to assess the prognostic significance of a novel biomarker, the fibrinogen-C-reactive protein-albumin ratio (F-CAR), in pancreatic cancer patients undergoing pancreatectomy.Method: We retrospectively analyzed 163 patients undergoing pancreatectomy for pancreatic cancer. The relationship between F-CAR, calculated from preoperative serum fibrinogen, albumin, and C-reactive protein levels, and long-term outcomes following pancreatectomy was examined.Results: Multivariate analysis revealed that several factors, including age (P < 0.01), high serum carbohydrate antigen 19-9 (CA19-9) level (P < 0.01), high serum carcinoembryonic antigen level (P = 0.049), pT3 or pT4 (UICC) (P < 0.01), pN1 or pN2 (P < 0.01), and high F-CAR (hazards ratio, 1.51; 95% confidence interval, 1.03-2.22; P = 0.04), were independent and significant predictors of disease-free survival. Moreover, factors such as age (P = 0.02), high serum carcinoembryonic antigen level (P < 0.01), preoperative biliary drainage (P = 0.02), preoperative chemotherapy (P = 0.04), lymph node metastasis (P < 0.01), adjuvant chemotherapy (P = 0.046), and high F-CAR (hazards ratio, 1.55; 95% confidence interval, 1.03-2.35; P = 0.04) were found to be independent and significant predictors of overall survival.Conclusions: F-CAR is a useful prognostic factor for disease-free survival and overall survival after pancreatectomy in pancreatic cancer patients.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"54 3","pages":"e194-e200"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperplasia of Fat-Containing Cells With Mature Adipocyte Marker Is Associated With Pancreatic Fat Enlargement. 具有成熟脂肪细胞标记的含脂细胞增生与胰腺脂肪增大有关。

IF 1.7 4区医学

Pancreas Pub Date : 2025-03-01 Epub Date: 2024-11-18 DOI: 10.1097/MPA.0000000000002422

Yukari Fujita, Junji Kozawa, Tomomi Horii, Satoshi Kawata, Chisaki Ishibashi, Megu Y Baden, Hidetoshi Eguchi, Iichiro Shimomura

{"title":"Hyperplasia of Fat-Containing Cells With Mature Adipocyte Marker Is Associated With Pancreatic Fat Enlargement.","authors":"Yukari Fujita, Junji Kozawa, Tomomi Horii, Satoshi Kawata, Chisaki Ishibashi, Megu Y Baden, Hidetoshi Eguchi, Iichiro Shimomura","doi":"10.1097/MPA.0000000000002422","DOIUrl":"10.1097/MPA.0000000000002422","url":null,"abstract":"Objectives: To elucidate the specific characteristics of fat-containing cells in the pancreas and the mechanism of intrapancreatic fat deposition in humans.Materials and methods: Fifteen Japanese patients who had undergone pancreatic resection were enrolled, and the normal region from each samples was examined. Immunostaining for adiponectin and perilipin 1 was performed, and the relationships between the pancreatic fat-cell area or clinical parameters and the density or the diameter of the fat cells were analyzed.Results: The expression of adiponectin in the cytoplasm and perilipin 1 along the plasma membrane was observed in fat-containing cells in the pancreas. The fat-containing cell area had a significant positive correlation with cell density. In addition, fat-containing cell density was significantly positively correlated with homeostasis model assessment insulin resistance. The diameter of fat-containing cells had significant positive correlations with BMI, fasting immunoreactive insulin, and homeostasis model assessment insulin resistance. Of all fat-containing cells, 10.4% were intralobular cells, and the diameter of intralobular cells showed a tendency for positive correlation with age.Conclusions: The characteristics of fat-containing cells in the pancreas indicate that some of them may be mature adipocytes, and fat volume may be increased by hyperplasia of fat-containing cells associated with insulin resistance.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"54 3","pages":"e221-e226"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Radiotherapy in Neoadjuvant Treatment of Borderline Resectable and Locally Advanced Pancreatic Cancer: A Systematic Review and Meta-analysis. 放射治疗在边缘可切除和局部晚期胰腺癌新辅助治疗中的作用：系统回顾和荟萃分析。

IF 1.7 4区医学

Pancreas Pub Date : 2025-03-01 Epub Date: 2024-08-12 DOI: 10.1097/MPA.0000000000002400

Peng Tang, Junfeng Zhang, Qiang Zhou, Wenmin Yi, Huaizhi Wang

{"title":"Effect of Radiotherapy in Neoadjuvant Treatment of Borderline Resectable and Locally Advanced Pancreatic Cancer: A Systematic Review and Meta-analysis.","authors":"Peng Tang, Junfeng Zhang, Qiang Zhou, Wenmin Yi, Huaizhi Wang","doi":"10.1097/MPA.0000000000002400","DOIUrl":"10.1097/MPA.0000000000002400","url":null,"abstract":"Background: Pancreatic cancer is a malignant tumor with poor prognosis and bad curative effect. Previous studies did not confirm the role of radiotherapy in neoadjuvant treatment of borderline resectable pancreatic cancer (BRPC) and locally advanced pancreatic cancer (LAPC). By reviewing new findings reported in recent years, we conducted this study to evaluate the survival impact by comparing chemoradiotherapy (CRT) with chemotherapy alone.Materials and methods: PubMed, Embase, MEDLINE, Web of Science, Scopus, and Cochrane Library were searched for studies reporting median overall survival (OS) in patients with BRPC or LAPC treated with neoadjuvant treatment. Secondary outcomes included progression-free survival (PFS) or disease-free survival (DFS) or recurrence-free survival (RFS) and R0 resection rate.Results: A total of 18 studies were included in the meta-analysis. OS (hazard ratio [HR] = 0.76, 95% confidence interval [CI]: 0.64-0.91, I2 = 61.7%) and PFS/DFS/RFS (HR = 0.72, 95% CI: 0.58-0.91, I2 = 52.3%) are both favored CRT. Although R0 resection rate was increased in CRT group, significant survival benefit of radiotherapy was found in LAPC and low resection rate subgroup in stratification analysis. Regression analysis showed that only tumor resectability was associated with OS.Conclusions: For patients with LAPC and who are unlikely to receive resection, neoadjuvant radiotherapy seems to improve OS and PFS/DFS/RFS.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"54 3","pages":"e246-e254"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Understanding of Therapeutic and Diagnostic Applications of Exosomes in Pancreatic Cancer. 外泌体在胰腺癌治疗和诊断中的应用现状。

IF 1.7 4区医学

Pancreas Pub Date : 2025-03-01 Epub Date: 2024-12-11 DOI: 10.1097/MPA.0000000000002414

Neda Shakerian, Aida Tafazoli, Amir Razavinia, Zahra Sadrzadeh Aghajani, Nikoo Bana, Maysam Mard-Soltani, Bahman Khalesi, Zahra Sadat Hashemi, Saeed Khalili

{"title":"Current Understanding of Therapeutic and Diagnostic Applications of Exosomes in Pancreatic Cancer.","authors":"Neda Shakerian, Aida Tafazoli, Amir Razavinia, Zahra Sadrzadeh Aghajani, Nikoo Bana, Maysam Mard-Soltani, Bahman Khalesi, Zahra Sadat Hashemi, Saeed Khalili","doi":"10.1097/MPA.0000000000002414","DOIUrl":"10.1097/MPA.0000000000002414","url":null,"abstract":"Abstract: Unusual symptoms, rapid progression, lack of reliable early diagnostic biomarkers, and lack of efficient treatment choices are the ongoing challenges of pancreatic cancer. Numerous research studies have demonstrated the correlation between exosomes and various aspects of pancreatic cancer. In light of these facts, exosomes possess the potential to play functional roles in the treatment, prognosis, and diagnosis of the pancreatic cancer. In the present study, we reviewed the most recent developments in approaches for exosome separation, modification, monitoring, and communication. Moreover, we discussed the clinical uses of exosomes as less invasive liquid biopsies and drug carriers and their contribution to the control of angiogenic activity of pancreatic cancer. Better investigation of exosome biology would help to effectively engineer therapeutic exosomes with certain nucleic acids, proteins, and even exogenous drugs as their cargo. Circulating exosomes have shown promise as reliable candidates for pancreatic cancer early diagnosis and monitoring in high-risk people without clinical cancer manifestation. Although we have tried to reflect the status of exosome applications in the treatment and detection of pancreatic cancer, it is evident that further studies and clinical trials are required before exosomes may be employed as a routine therapeutic and diagnostic tools for pancreatic cancer.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e255-e267"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oncogenic KRAS Promotes Ferroptosis in Pancreatic Cancer Through Regulation of the Fosl1-Tfrc Axis. 致癌KRAS通过调节FOSL1-TFRC轴促进胰腺癌铁下垂。

IF 1.7 4区医学

Pancreas Pub Date : 2025-03-01 Epub Date: 2024-11-29 DOI: 10.1097/MPA.0000000000002426

Huijia Zhao, Qi Huang, Ying-Ao Liu, Wenming Wu

引用次数: 0

Enhancing Pancreatic Cancer Therapy With Targeted CD133-Exosome Delivery of PD-L1 siRNA: A Preclinical Investigation. 通过CD133-外泌体靶向递送PD-L1 siRNA加强胰腺癌治疗：临床前研究。

IF 1.7 4区医学

Pancreas Pub Date : 2025-03-01 Epub Date: 2024-11-26 DOI: 10.1097/MPA.0000000000002419

Young Chul Yoon, Dosang Lee, Jung Hyun Park, Ok-Hee Kim, Ho Joong Choi, Say-June Kim

{"title":"Enhancing Pancreatic Cancer Therapy With Targeted CD133-Exosome Delivery of PD-L1 siRNA: A Preclinical Investigation.","authors":"Young Chul Yoon, Dosang Lee, Jung Hyun Park, Ok-Hee Kim, Ho Joong Choi, Say-June Kim","doi":"10.1097/MPA.0000000000002419","DOIUrl":"10.1097/MPA.0000000000002419","url":null,"abstract":"Objectives: This study assessed the anticancer potential of genetically modified exosomes engineered to express CD133-binding peptides on their surface and carry PD-L1 siRNA for the treatment of murine model of metastatic pancreatic cancer.Materials and methods: CD133-targeting exosomes (tEx) were generated by harvesting conditioned media from adipose-derived stem cells (ASCs) that had undergone transformation using pDisplay vectors encoding CD133-binding peptide sequences. Subsequently, siPD-L1-loaded CD133-targeting Exosomes, referred to as tEx(s), were created by incorporating PD-L1 siRNA into the tEx using Exofect kit.Results: tEx(s) demonstrated superior targetability compared to other materials, including Ex, Ex(p), and tEx. This was substantiated by higher total radiant efficiency (TRE) observed in metastatic liver and pancreatic tissues following intravenous administration of tEx(s) ( P < 0.05). Furthermore, the intravenous delivery of tEx(s) resulted in the most pronounced upregulation of proapoptotic markers (BIM and c-caspase 3) and the least downregulation of the antiapoptotic markers (Mcl-1 and Bcl-xL), which has been demonstrated in various methods, including real-time polymerase chain reaction, western blot analysis, and immunohistochemistry in the metastatic lesions in the livers ( P < 0.05).Conclusions: PD-L1 siRNA-loaded CD133-tEx demonstrated remarkable anticancer efficacy, characterized by specific binding to CD133-positive pancreatic cancer cells and suppression of PD-L1 expression within these cells.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":"e210-e220"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142731258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term Outcomes of Surgical Treatment for Pancreatic Neuroendocrine Neoplasm With Synchronous Hepatic Metastasis: A Multicenter Retrospective Cohort Study. 伴有同步肝转移的胰腺神经内分泌肿瘤手术治疗的远期疗效：一项多中心回顾性队列研究。

IF 1.7 4区医学

Pancreas Pub Date : 2025-03-01 Epub Date: 2024-11-18 DOI: 10.1097/MPA.0000000000002417

Qiang Xu, Bohui Yin, Xu Han, Siqian Ren, Jialin Jiang, Fang Li, Karn Wijarnpreecha, Jingqiao Wang, Quan Liao, Menghua Dai, Taiping Zhang, Abuduhaibaier Sadula, Wenhui Lou, Chunhui Yuan, Wenming Wu, Yupei Zhao

{"title":"Long-term Outcomes of Surgical Treatment for Pancreatic Neuroendocrine Neoplasm With Synchronous Hepatic Metastasis: A Multicenter Retrospective Cohort Study.","authors":"Qiang Xu, Bohui Yin, Xu Han, Siqian Ren, Jialin Jiang, Fang Li, Karn Wijarnpreecha, Jingqiao Wang, Quan Liao, Menghua Dai, Taiping Zhang, Abuduhaibaier Sadula, Wenhui Lou, Chunhui Yuan, Wenming Wu, Yupei Zhao","doi":"10.1097/MPA.0000000000002417","DOIUrl":"10.1097/MPA.0000000000002417","url":null,"abstract":"Objective: To evaluate surgical impact on the overall survival (OS) of pancreatic neuroendocrine neoplasm (pNEN) with synchronous hepatic metastases (sHMs).Methods: A total of 163 pNEN-sHM patients were recruited from 3 institutions in China, who were categorized into 3 groups: no resection, resection of the primary lesion, and resection of both primary and hepatic lesions (PHR). Cox regression was employed to evaluate surgical impact on the OS.Results: In the overall cohort analysis, PHR demonstrated a significant protective effect on OS (hazard ratio, 0.302; 95% confidence interval, 0.127-0.721; P = 0.007). Nevertheless, subgroup analysis revealed PHR conferred a survival advantage in patients with pancreatic neuroendocrine tumor (pNET) located on the pancreatic body/tail (bt-pNET-sHM) (hazard ratio, 0.287; 95% CI, 0.087-0.946; P = 0.040), whereas surgical treatment did not significantly impact survival in the subgroups of pancreatic neuroendocrine carcinoma-sHM or pancreatic head/neck pNET-sHM (hn-pNET-sHM).Conclusions: In this study, the survival benefit of surgery was observed only in the bt-pNET-sHM subgroup. Considering the multifactorial nature of decision-making, surgical intervention for pNEN-sHM management should be approached with a careful and comprehensive assessment, to prevent excessive surgery strategies.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"54 3","pages":"e179-e187"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intratumoral Injection of Cytotoxic Drugs Plus Hapten Elicits Significant Immune Responses in Sentinel Lymph Nodes: Implications for Cancer Immunotherapy. 肿瘤内注射细胞毒性药物加半抗原在前哨淋巴结引起显著的免疫反应：癌症免疫治疗的意义。

IF 1.7 4区医学

Pancreas Pub Date : 2025-03-01 DOI: 10.1097/MPA.0000000000002439

Baofa Yu, Jian Zhang, Yan Han, Feng Gao, Peng Jing, Peicheng Zhang, Guoqin Jing, Shengjun Zhou, Huan-You Wang

{"title":"Intratumoral Injection of Cytotoxic Drugs Plus Hapten Elicits Significant Immune Responses in Sentinel Lymph Nodes: Implications for Cancer Immunotherapy.","authors":"Baofa Yu, Jian Zhang, Yan Han, Feng Gao, Peng Jing, Peicheng Zhang, Guoqin Jing, Shengjun Zhou, Huan-You Wang","doi":"10.1097/MPA.0000000000002439","DOIUrl":"10.1097/MPA.0000000000002439","url":null,"abstract":"Objectives: Studying the sentinel lymph nodes (SLNs) to define the metastasis and the mechanisms of abscopal effect.Method: Using scRNA-seq to investigate the cellular and genomic changes of SLNs before or after treatment of the primar pancreatic carcinoma site by intratumoral injection of cytotoxic chemotherapy drugs plus hapten.Result: A very significant decrease of SLN carcinoma cells, but increased macrophages, monocytes, CD8 T-effector cells, and fibroblasts. At the genomic and functional levels, the above treatment increased the ability of angiogenesis, epithelial mesenchymal transition (EMT), and cancer-associated fibroblast (CAF) signaling. In addition, matricellular proteins were upregulated.Alternative conclusion: Our study demonstrated a marked reduction in carcinoma cells within SLNs following treatment, alongside a notable increase in inflammatory and stromal cells, which suggested a dynamic reorganization of the lymph node microenvironment rather than straightforward tumor growth. The absence of significant enlargement of SLNs, despite the increase in cellular density, may be attributed to the remodeling effects induced by the treatment. The observed upregulation of angiogenic factors, EMT pathways, and CAF signaling highlighted a complex interaction between tumor and immune responses. These findings provided new insights into the abscopal effect, revealing how targeted therapies can modulate lymph node microenvironments to enhance local immune responses and potentially improve systemic antitumor efficacy.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":"54 3","pages":"e227-e234"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancrelipase Delayed-Release Capsules Improve Stool Frequency and Consistency in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis or Pancreatic Surgery: Posthoc Analysis of Patient-Reported Daily Symptoms in a Double-Blind Randomized Trial. 胰酶缓释胶囊改善慢性胰腺炎或胰腺手术引起的外分泌胰功能不全患者的大便频率和一致性：一项双盲随机试验中患者报告的每日症状的事后分析

IF 1.7 4区医学

Pancreas Pub Date : 2025-03-01 Epub Date: 2024-12-03 DOI: 10.1097/MPA.0000000000002423

Jodie A Barkin, Jens J Kort, Jamie S Barkin

引用次数: 0