腹主动脉钙化对胰肾联合移植患者胰腺移植存活的影响。

IF 1.7 4区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY
Shohei Takaichi, Yoshito Tomimaru, Shogo Kobayashi, Toshinori Ito, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Takehiro Noda, Hidenori Takahashi, Yuichiro Doki, Hidetoshi Eguchi
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引用次数: 0

摘要

背景:胰腺移植(PTx)是1型糖尿病和晚期慢性肾脏疾病患者的最终治疗方法。腹主动脉钙化(AAC)常见于等待PTx的患者,并根据等待时间进展,但AAC对长期预后的影响尚不清楚。在本研究中,我们旨在阐明AAC对长期预后的影响。方法:我们回顾了2000年4月至2022年11月在我院连续发生的65例PTx病例,并纳入了50例同步胰肾移植(SPK)患者。AAC采用多检测器计算机断层扫描Agatston法评定为AAC评分。结果:采用受试者工作特征曲线确定死亡-未审查胰腺移植存活的AAC评分临界值;曲线下面积为0.711 (P=0.029)。根据AAC分界点将患者分为两组,AAC评分高组透析时间明显长于AAC评分低组(P=0.001)。高AAC评分组的死亡-未审查胰腺移植生存率和SPK后患者生存率显著低于低AAC评分组(P分别=0.001和0.001)。在Cox比例风险回归模型中,高AAC评分与死亡-未审查胰腺移植损失独立相关(P=0.002)。结论:AAC与SPK患者的死亡-未审查胰腺移植生存相关。评估AAC可用于预测ptx后的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of Abdominal Aortic Calcification on Pancreas Graft Survival in Patients Undergoing Simultaneous Pancreas-kidney Transplantation.

Background: Pancreas transplantation (PTx) is a definitive therapy for patients with type 1 diabetes and advanced chronic kidney disease. Abdominal aortic calcification (AAC) is often observed in patients waiting for PTx and progresses according to the waiting period, but the impact of AAC on long-term outcomes remains unclear. In this study, we aimed to elucidate the impact of AAC on long-term outcomes.

Methods: We reviewed 65 consecutive PTx cases at our institution between April 2000 and November 2022 and enrolled 50 patients with simultaneous pancreas-kidney transplantation (SPK). AAC was assessed as AAC score by the Agatston method using multidetector computed tomography.

Results: Receiver operating characteristic curves were used to determine the cutoff value of the AAC score for death-uncensored pancreas graft survival; the area under the curve was 0.711 ( P =0.029). After dividing the patients into 2 groups according to the AAC cutoff, the dialysis period was significantly longer in the high AAC score group than in the low AAC score group ( P =0.001). Death-uncensored pancreas graft survival and patient survival after SPK were significantly lower in the high AAC score group than in the low AAC score group ( P =0.001, 0.001, respectively). In a Cox proportional hazards regression model, a high AAC score was independently associated with death-uncensored pancreas graft loss ( P =0.002).

Conclusions: AAC is associated with death-uncensored pancreas graft survival in patients undergoing SPK. Evaluation of AAC could be useful for predicting post-PTx prognosis.

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来源期刊
Pancreas
Pancreas 医学-胃肠肝病学
CiteScore
4.70
自引率
3.40%
发文量
289
审稿时长
1 months
期刊介绍: Pancreas provides a central forum for communication of original works involving both basic and clinical research on the exocrine and endocrine pancreas and their interrelationships and consequences in disease states. This multidisciplinary, international journal covers the whole spectrum of basic sciences, etiology, prevention, pathophysiology, diagnosis, and surgical and medical management of pancreatic diseases, including cancer.
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