Pancreas最新文献_第3页

Preoperative chemotherapy with Gemcitabine for pancreatic cancer causes zinc deficiency. 使用吉西他滨进行胰腺癌术前化疗会导致锌缺乏。

IF 1.7 4区医学

Pancreas Pub Date : 2024-08-06 DOI: 10.1097/MPA.0000000000002396

Masahiro Iseki, Masamichi Mizuma, Mitsuhiro Shimura, Takashi Kokumai, Hideaki Sato, Akiko Kusaka, Shuichi Aoki, Koetsu Inoue, Shun Nakayama, Daisuke Douchi, Takayuki Miura, Shimpei Maeda, Masaharu Ishida, Kei Nakagawa, Takashi Kamei, Michiaki Unno

{"title":"Preoperative chemotherapy with Gemcitabine for pancreatic cancer causes zinc deficiency.","authors":"Masahiro Iseki, Masamichi Mizuma, Mitsuhiro Shimura, Takashi Kokumai, Hideaki Sato, Akiko Kusaka, Shuichi Aoki, Koetsu Inoue, Shun Nakayama, Daisuke Douchi, Takayuki Miura, Shimpei Maeda, Masaharu Ishida, Kei Nakagawa, Takashi Kamei, Michiaki Unno","doi":"10.1097/MPA.0000000000002396","DOIUrl":"https://doi.org/10.1097/MPA.0000000000002396","url":null,"abstract":"Objectives: The aim of this study was to investigate how preoperative chemotherapy affected the serum zinc concentrations in patients with pancreatic cancer (PC).Methods: Two hundreds and thirty-one patients with PC who underwent pancreatectomy at our department from 2013 to 2019 were enrolled in this study and measured for the serum zinc concentrations before pancreatectomy. Patient characteristics, course of treatment, and laboratory data were analyzed.Results: One hundred thirty-five patients underwent upfront pancreatectomy and 58 received preoperative Gemcitabine + S1 (GEM + S1) and 29 received Gemcitabine + nab-Paclitaxel (GEM + nab-PTX). Comparing the serum zinc concentrations before and after preoperative treatment, it was found to decrease after treatment with statistical difference (79.3 μg/dl vs. 68.7 μg/dl, p < 0.001). The result was consistent with the investigation for both the patients who received GEM + S1 and those who received GEM + nab-PTX (p = 0.019, p < 0.001, respectively).Conclusions: The preoperative chemotherapy consistently reduced the serum zinc concentrations in the PC patients, regardless of their regimen such as GEM + S1 and GEM + nab-PTX. Monitoring the serum zinc concentration and appropriate zinc supplementation may be essential for PC patients undergoing preoperative chemotherapy and pancreatectomy.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors of negative diagnosis of MRCP in acute biliary pancreatitis patients with choledocholithiasis. 急性胆源性胰腺炎合并胆总管结石患者 MRCP 阴性诊断的风险因素。

IF 1.7 4区医学

Pancreas Pub Date : 2024-08-06 DOI: 10.1097/MPA.0000000000002395

Si-Hai Chen, Wen-Qing Wang, Xiao Fei, Yin Zhu, Xu Shu, Chen Yu, Qian Liao, Hui-Fang Xiong

{"title":"Risk factors of negative diagnosis of MRCP in acute biliary pancreatitis patients with choledocholithiasis.","authors":"Si-Hai Chen, Wen-Qing Wang, Xiao Fei, Yin Zhu, Xu Shu, Chen Yu, Qian Liao, Hui-Fang Xiong","doi":"10.1097/MPA.0000000000002395","DOIUrl":"https://doi.org/10.1097/MPA.0000000000002395","url":null,"abstract":"Background: Assessment of the presence of choledocholithiasis is crucial among acute biliary pancreatitis (ABP). Magnetic resonance cholangiopancreatography (MRCP) and endoscopic ultrasonography (EUS) are widely used to identify the gallstones of common bile duct (CBD). EUS provides better diagnostic accuracy and sensitivity than MRCP but carries a certain risk due to sedation. We investigated the risk factors of negative diagnosis of MRCP in ABP patients with choledocholithiasis for better selection of MRCP or EUS.Methods: A total of 2321 ABP patients were retrospectively included in this study. Based on the exclusion criteria, 337 ABP patients with negative MRCP results were ultimately included. Among these patients, 75 patients had positive EUS findings. Univariate and multivariate logistic regression models were used to screen the risk factors of negative diagnosis of MRCP in ABP patients with choledocholithiasis.Results: Patients with positive EUS findings were older (62.0 vs. 55.0) and had higher rate of cholecystectomy history (18.7% vs. 7.3%) than those with negative EUS findings. The result of univariate logistic regression showed that the history of cholecystectomy, age and sex were potential risk factors (all p < 0.05). Then after adjusting the other potential risk factors (Direct bilirubin (DBIL), alanine transaminase (ALT), gamma-glutamyl transpeptidase (GGT) and alkaline phosphatase (ALP)), a history of cholecystectomy (OR = 2.859 [1.312,6.23]), older age (1.03 [1.009,1.052]) and male (2.016 [1.152,3.528]) were independent risk factors of negative diagnosis of MRCP in ABP patients with choledocholithiasis.Conclusions: The history of cholecystectomy, older age and male are independently associated with an increased risk of negative diagnosis of MRCP in ABP patients with choledocholithiasis. We suggest that patients with these risk factors should undergo EUS first, rather than MRCP.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Important Radiologic and Clinical Factors for Predicting Overall Survival in Pancreatic Adenocarcinoma Patients Who Underwent FOLFIRINOX. 预测接受 FOLFIRINOX 治疗的胰腺腺癌患者总生存期的重要放射学和临床因素

IF 1.7 4区医学

Pancreas Pub Date : 2024-08-01 Epub Date: 2024-03-13 DOI: 10.1097/MPA.0000000000002330

Sae-Jin Park, Jung Hoon Kim, Seo-Youn Choi, Ijin Joo

{"title":"Important Radiologic and Clinical Factors for Predicting Overall Survival in Pancreatic Adenocarcinoma Patients Who Underwent FOLFIRINOX.","authors":"Sae-Jin Park, Jung Hoon Kim, Seo-Youn Choi, Ijin Joo","doi":"10.1097/MPA.0000000000002330","DOIUrl":"10.1097/MPA.0000000000002330","url":null,"abstract":"Background: To predict poor overall survival (OS) in pancreatic adenocarcinoma (PAC) who underwent FOLFIRINOX (5-fluorouracil/leucovorin/irinotecan/oxaliplatin) using clinical and computed tomography (CT) findings.Methods: A total of 189 patients with PAC who received FOLFIRINOX were retrospectively included. Two reviewers assessed CT findings and resectability based on National Comprehensive Cancer Network guidelines. They determined tumor size changes according to Response Evaluation Criteria in Solid Tumors (RECIST 1.1). Delta measurements were performed. Clinical results, such as whether to perform surgery, were also investigated. A Cox proportional hazard model was used to identify significant predictors for OS. A CT-based nomogram was constructed to predict OS.Results: Seventy-four patients (39.2%) underwent surgery. For OS, rim enhancement of PAC on baseline CT (hazard ratio [HR], 1.75; 95% confidence interval [CI], 1.10-2.77; P = 0.018), high delta tumor on baseline CT (HR, 2.46; 95% CI, 1.55-3.91; P < 0.001), progressive disease at follow-up CT (HR, 8.89; 95% CI, 2.94-26.87; P < 0.001), and without surgery (HR, 2.81; 95% CI, 1.49-5.30; P = 0.001) were important features related to poor prognosis. The nomogram showed good predictive ability for the survival.Conclusion: Both clinical and CT findings were useful for predicting OS after FOLFIRINOX in PAC.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140294172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Potential Clinical Benefits of Direct Surgical Transgastric Pancreatic Necrosectomy for Patients With Infected Necrotizing Pancreatitis. 直接经胃胰腺坏死切除术对感染性坏死性胰腺炎患者的潜在临床益处

IF 1.7 4区医学

Pancreas Pub Date : 2024-08-01 DOI: 10.1097/MPA.0000000000002334

Hester C Timmerhuis, Rejoice F Ngongoni, Amy Li, Sean P McGuire, Kyle A Lewellen, Monica M Dua, Komal Chughtai, Nicholas J Zyromski, Brendan C Visser

{"title":"The Potential Clinical Benefits of Direct Surgical Transgastric Pancreatic Necrosectomy for Patients With Infected Necrotizing Pancreatitis.","authors":"Hester C Timmerhuis, Rejoice F Ngongoni, Amy Li, Sean P McGuire, Kyle A Lewellen, Monica M Dua, Komal Chughtai, Nicholas J Zyromski, Brendan C Visser","doi":"10.1097/MPA.0000000000002334","DOIUrl":"10.1097/MPA.0000000000002334","url":null,"abstract":"Objective: Surgical transgastric pancreatic necrosectomy (STGN) has the potential to overcome the shortcomings (ie, repeat interventions, prolonged hospitalization) of the step-up approach for infected necrotizing pancreatitis. We aimed to determine the outcomes of STGN for infected necrotizing pancreatitis.Materials and methods: This observational cohort study included adult patients who underwent STGN for infected necrosis at two centers from 2008 to 2022. Patients with a procedure for pancreatic necrosis before STGN were excluded. Primary outcomes included mortality, length of hospital and intensive care unit (ICU) stay, new-onset organ failure, repeat interventions, pancreatic fistulas, readmissions, and time to episode closure.Results: Forty-three patients underwent STGN at a median of 48 days (interquartile range [IQR] 32-70) after disease onset. Mortality rate was 7% (n = 3). After STGN, the median length of hospital was 8 days (IQR 6-17), 23 patients (53.5%) required ICU admission (2 days [IQR 1-7]), and new-onset organ failure occurred in 8 patients (18.6%). Three patients (7%) required a reintervention, 1 (2.3%) developed a pancreatic fistula, and 11 (25.6%) were readmitted. The median time to episode closure was 11 days (IQR 6-22).Conclusions: STGN allows for treatment of retrogastric infected necrosis in one procedure and with rapid episode resolution. With these advantages and few pancreatic fistulas, direct STGN challenges the step-up approach.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141580500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type 2 Autoimmune Pancreatitis Masquerading as Epstein-Barr Virus Infection: A Case Report. 伪装成 Epstein-Barr 病毒感染的 2 型自身免疫性胰腺炎：病例报告。

IF 1.7 4区医学

Pancreas Pub Date : 2024-08-01 Epub Date: 2024-05-01 DOI: 10.1097/MPA.0000000000002338

Ziwei Wang, Xin Hu

引用次数: 0

Primary Angiomyolipoma of the Distal Pancreas. 胰腺远端原发性血管肌脂肪瘤

IF 1.7 4区医学

Pancreas Pub Date : 2024-08-01 Epub Date: 2024-05-13 DOI: 10.1097/MPA.0000000000002341

Juliana C Levy, Abby Wong, Huaibin M Ko, John Chabot

引用次数: 0

Ex-vivo 3D cellular models of pancreatic ductal adenocarcinoma: from embryonic development to precision oncology. 胰腺导管腺癌的体外三维细胞模型：从胚胎发育到精准肿瘤学。

IF 1.7 4区医学

Pancreas Pub Date : 2024-07-30 DOI: 10.1097/MPA.0000000000002393

Ivana Acimovic, Viktorie Gabrielová, Stanislava Martínková, Michal Eid, Jakub Vlažný, Petr Moravčík, Jan Hlavsa, Lukáš Moráň, Riza Can Cakmakci, Peter Staňo, Vladimír Procházka, Zdeněk Kala, Jan Trnka, Petr Vaňhara

{"title":"Ex-vivo 3D cellular models of pancreatic ductal adenocarcinoma: from embryonic development to precision oncology.","authors":"Ivana Acimovic, Viktorie Gabrielová, Stanislava Martínková, Michal Eid, Jakub Vlažný, Petr Moravčík, Jan Hlavsa, Lukáš Moráň, Riza Can Cakmakci, Peter Staňo, Vladimír Procházka, Zdeněk Kala, Jan Trnka, Petr Vaňhara","doi":"10.1097/MPA.0000000000002393","DOIUrl":"https://doi.org/10.1097/MPA.0000000000002393","url":null,"abstract":"Abstract: Pancreas is a vital gland of gastro-intestinal system with exocrine and endocrine secretory functions, interweaved into essential metabolic circuitries of the human body. Pancreatic ductal adenocarcinoma (PDAC) represents one of the most lethal malignancies, with a five-year survival rate of 11%. This poor prognosis is primarily attributed to the absence of early symptoms, rapid metastatic dissemination, and the limited efficacy of current therapeutic interventions. Despite recent advancements in understanding the etiopathogenesis and treatment of PDAC, there remains a pressing need for improved individualized models, the identification of novel molecular targets, and the development of unbiased predictors of disease progression. Here we aim to explore the concept of precision medicine utilizing three-dimensional, patient-specific cellular models of pancreatic tumors and discuss their potential applications in uncovering novel druggable molecular targets and predicting clinical parameters for individual patients.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk factors of acute pancreatitis in young adults: a Nationwide population-based cohort study in South Korea. 年轻人患急性胰腺炎的风险因素：韩国全国人口队列研究。

IF 1.7 4区医学

Pancreas Pub Date : 2024-07-30 DOI: 10.1097/MPA.0000000000002394

Namyoung Park, Jae Min Lee, Jin Myung Park, Sang Hyub Lee, Kyung-Do Han, Kwang Ro Joo, Ji Kon Ryu, Yong-Tae Kim

{"title":"Risk factors of acute pancreatitis in young adults: a Nationwide population-based cohort study in South Korea.","authors":"Namyoung Park, Jae Min Lee, Jin Myung Park, Sang Hyub Lee, Kyung-Do Han, Kwang Ro Joo, Ji Kon Ryu, Yong-Tae Kim","doi":"10.1097/MPA.0000000000002394","DOIUrl":"https://doi.org/10.1097/MPA.0000000000002394","url":null,"abstract":"Objectives: This study aimed to identify the risk factors for acute pancreatitis (AP) in young adults in their 20s based on data from the nationwide cohort in South Korea.Methods: From the 2009 national health examination database of South Korea, total 471,098 individuals between the ages of 20 and 29 were analyzed. To identify the newly developed AP, the linked claims database was used.Results: The incidence rates of AP were 18.8 and 9.8 per 100,000 person-years in male and female participants, respectively. Alcohol consumption and smoking were associated with the heightened risk of AP. The risk of AP development was increased as daily alcohol consumption increased. Also, ex-smokers and current smokers showed higher AP risk than never smokers. Hypertriglyceridemia and obesity were associated with the increased AP risk as well. Compared to female participants, male participants showed a higher risk of AP in univariate analysis, but showed a lower risk of AP in multivariate analysis.Conclusions: In the young adult population, alcohol consumption, smoking, hypertriglyceridemia, and obesity were associated with an elevated risk of developing AP. It is important to identify and manage the modifiable AP risk factors in young adults to minimize the socioeconomic burden of AP.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple Carcinomas In Situ Scattered Throughout the Pancreas Diagnosed by Assessing Focal Pancreatic Parenchymal Atrophy. 通过评估局灶性胰腺实质萎缩诊断出散布于整个胰腺的多发性原位癌

IF 1.7 4区医学

Pancreas Pub Date : 2024-07-01 DOI: 10.1097/MPA.0000000000002332

Takato Inoue, Koichiro Mandai, Koji Uno

引用次数: 0

Evaluation of the Treatment Duration of Japanese Patients With Pancreatic Cancer in a Real-World Setting Using a Large Hospital Claims Database: The SUISEI Study. 利用大型医院报销数据库评估日本胰腺癌患者的实际治疗时间：SUISEI 研究》。

IF 2.9 4区医学

Pancreas Pub Date : 2024-07-01 Epub Date: 2024-05-16 DOI: 10.1097/MPA.0000000000002321

Hideki Ueno, Kyoko Shimizu, Ayako Fukui, Masahiro Nii, Ryo Koto, Michiaki Unno

{"title":"Evaluation of the Treatment Duration of Japanese Patients With Pancreatic Cancer in a Real-World Setting Using a Large Hospital Claims Database: The SUISEI Study.","authors":"Hideki Ueno, Kyoko Shimizu, Ayako Fukui, Masahiro Nii, Ryo Koto, Michiaki Unno","doi":"10.1097/MPA.0000000000002321","DOIUrl":"10.1097/MPA.0000000000002321","url":null,"abstract":"Objectives: To clarify the treatment reality of pancreatic cancer in Japan, focusing on treatment duration and time to death.Materials and methods: We retrospectively analyzed Japanese hospital claims data for patients diagnosed with pancreatic cancer between April 2009 and October 2018 to investigate treatment patterns, duration of first-line chemotherapy, and time to death.Results: Of 81,185 eligible patients, 54.2% were male, the mean age was 71.7 years, and 23.3% (n = 18,884) received chemotherapy as primary treatment. The median treatment duration was 14.1 weeks for the 6.7% of patients who received oxaliplatin, irinotecan, fluorouracil, and leucovorin (FOLFIRINOX; recommended first-line regimen) and 16.9 weeks for the 30.2% of patients who received gemcitabine plus nab-paclitaxel (GEM + nab-PTX). Time to death for patients who received FOLFIRINOX or GEM + nab-PTX was similar (15.4 and 14.8 months, respectively). The duration of first-line chemotherapy regimens tended to increase annually for both regimens. The time to death for all first-line chemotherapy regimens also increased annually.Conclusions: This study revealed the treatment reality of pancreatic cancer in the real-world Japanese setting. Treatment duration and time to death tended to increase over time and did not differ numerically between FOLFIRINOX and GEM + nab-PTX.","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141070660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0