Nuclear Medicine Communications最新文献

{"title":"The application of mass defect percentage in the evaluation of acute coronary syndrome.","authors":"Man Zhang, Yinuo Sun, Limeng Zhang, Yu Xu, Yifan Liu, Kun Li","doi":"10.1097/MNM.0000000000001907","DOIUrl":"10.1097/MNM.0000000000001907","url":null,"abstract":"<p><strong>Objectives: </strong>White blood cells, neutrophils, lymphocytes, and neutrophil-to-lymphocyte ratio (NLR) distribution patterns in patients with anatomic coronary disease have previously been associated with cardiac events such as myocardial infarct size, complications, and prognosis. However, it remains unknown whether myocardial perfusion mass defect percentage (MDP) obtained from gated myocardial perfusion imaging (G-MPI) correlates with these hematological parameters. Therefore, our research aimed to investigate the application of MDP in the evaluation of acute coronary syndrome (ACS).</p><p><strong>Methods: </strong>Thirty-six patients with ACS underwent single-photon emission computed tomography/computed tomography using retrospective electrocardiography gating during the resting state. The primary outcome was the percentage of left ventricular mass with abnormal myocardial perfusion (i.e. MDP) in G-MPI. Furthermore, the correlation between myocardial perfusion MDP and lymphocyte count, neutrophil count, white blood cell count, and NLR was calculated. In addition, we explored the relationship of myocardial perfusion MDP with other cardiac function parameters obtained from G-MPI, such as summed rest score, left ventricular ejection fraction, end-systolic volume, and end-diastolic volume.</p><p><strong>Results: </strong>Myocardial perfusion MDP significantly correlated with white blood cell count, neutrophil count, and NLR ( P  < 0.01). Furthermore, these hematological parameters were significantly different between low and high MDP groups. Additionally, myocardial perfusion MDP negatively correlated with end-systolic volume ( r  = -0.615) and left ventricular ejection fraction ( r  = -0.657).</p><p><strong>Conclusion: </strong>Myocardial perfusion MDP has a high correlation with inflammatory cell counts and cardiac function parameters obtained from G-MPI in ACS; this may be of help in the evaluation and treatment of these patients.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"1-6"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UK national survey on nuclear medicine in-house clinical software: the calm before the storm.","authors":"Anthony W Murray, James W Scuffham, John C Dickson, Matthew Memmott","doi":"10.1097/MNM.0000000000001917","DOIUrl":"10.1097/MNM.0000000000001917","url":null,"abstract":"<p><strong>Introduction: </strong>The use of in-house developed software as a medical device (IHD-SaMD) is core to many nuclear medicine (NM) services in the UK, including applications in nonimaging studies and image processing. Expected regulatory changes in 2025 could have significant implications due to a lack of resources and expertise in the implementation and maintenance of software Quality Management Systems (QMS) and associated standards. This survey investigated the national use of IHD-SaMD and the readiness of services to adapt to the upcoming regulatory changes.</p><p><strong>Method: </strong>An online survey was used to investigate the current national usage of IHD-SaMD. Representatives of 64 UK NM physics services were invited to participate, with 43 responding.</p><p><strong>Results: </strong>It was found that 98% of respondents use IHD-SaMD clinically. About 65% use IHD-SaMD that respondents felt was under-supported (e.g. legacy software). Approximately 60% of respondents use or support two or more pieces of IHD-SaMD. Around 66% of respondents use a QMS in their department, with about 48% using a software-specific QMS. Most respondents indicate understaffing, particularly with regard to IT/software skillsets. Almost all respondents indicate without an increase in the preparedness and understanding of the requirements, all dependent clinical services would be severely impacted or indeed stopped.</p><p><strong>Conclusion: </strong>This national survey shows that pending regulatory changes could significantly impact NM services, up to and including stopping clinical services. Additional resources would be required to support in-house software management under an appropriate QMS or move to European conformity marking (CE)-marked software where available. This must be urgently considered and addressed by all NM stakeholders.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"106-108"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of PSMA PET/CT on clinical decision-making of radical prostatectomy and pelvic lymph node dissection.","authors":"Oktay Özman, Hans Veerman, Marinus J Hagens, Pim J van Leeuwen, André N Vis, Henk G van der Poel","doi":"10.1097/MNM.0000000000001916","DOIUrl":"10.1097/MNM.0000000000001916","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of prostate-specific membrane antigen (PSMA) PET/computed tomography (CT) on clinical decision-making of radical prostatectomy (RP) and pelvic lymph node dissection (PLND) after its utilization in daily clinical practice at an European high-volume cancer center.</p><p><strong>Materials and methods: </strong>Patients who had unfavorable intermediate- and high-risk prostate cancer between 2017 and 2021 were included retrospectively and divided into two groups; those who staged using PSMA PET/CT (group 1) and those who staged using conventional modalities (group 2). Clinical decision-making of RP over nonsurgical treatments and f PLND were primary endpoints and evaluated using regression models.</p><p><strong>Results: </strong>PSMA PET/CT claimed significantly more N1 (24.2% vs. 11.3%; P = 0.01; OR, 1.97; 95% CI, 1.18-3.28) but insignificantly more M1 disease (9.9% vs. 5.7%; P = 0.42; OR, 1.91; 95% CI, 0.39-9.23), compared with the conventional imaging modalities. miN0 stage was related to more RP decisions compared with cN0 stage ( P  < 0.001; OR, 1.91; 95% CI, 1.48-2.46). PLND decision-making was significantly driven by positive cmiN stage findings, which were more reliable when it was reported after a PSMA PET/CT examination ( P  < 0.001; OR, 35.55; 95% CI, 6.74-187.45 for conventional imaging modalities vs. P  < 0.001; OR, 91.72; 95% CI, 11.25-747.56 for PSMA PET/CT).</p><p><strong>Conclusions: </strong>Patients with no suspicion of lymph node invasion on molecular imaging (PSMA PET/CT) tended to be referred to RP more compared to radiological imaging. Also, the PLND decision was strongly driven by staging findings. Compared with conventional imaging, PSMA PET/CT findings were more reliable during PLND decision-making.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"83-88"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solid versus liquid pulmonary micro-aspiration of reflux disease. Does it make a difference in determining the need for intervention?","authors":"Leticia Burton, Oleksandr Khoma, Susannah Gooley, Gregory L Falk, Daminda Weerasinghe, Hans Van der Wall","doi":"10.1097/MNM.0000000000001914","DOIUrl":"10.1097/MNM.0000000000001914","url":null,"abstract":"<p><strong>Background: </strong>Pulmonary micro-aspiration (PMA) is a feared complication of gastroesophageal reflux disease (GORD). A novel scintigraphic test for GORD has been developed and validated. It can demonstrate contamination of the upper and lower airways by refluxate. Current observations have led to the hypothesis that prolongation in solid gastric emptying (SGE) is critical in pulmonary micro-aspiration.</p><p><strong>Methods: </strong>Standard LGE and SGE studies and the novel reflux test were evaluated in paired studies in patients with severe GORD to measure rates of PMA after each meal. Either water labeled with 99m Technetium Phyton for the LGE or a labeled egg sandwich for the solid meal was utilized. Major symptoms were noted and the cough and reflux severity index (CSI & RSI) was obtained in all patients.</p><p><strong>Results: </strong>A total of 131 patients were enrolled (59M/72F) with age range of 21-83 years (mean: 52 years). Patients were in the overweight range for BMI (mean: 26.8). Major symptoms were bloating, nausea, belching, and dyspepsia (< 20% had heartburn). SGE was abnormal in 92% (mean 766 min) and LGE abnormal in 53% (mean 82 min). PMA was shown in 35% after the SGE and in 71% after the LGE. PMA+ patients were older. A significant correlation was found between SGE and PMA ( P  < 0.00) but not LGE. The only significant symptom in the PMA group was bloating. RSI was abnormal in 64% and CSI in 46%.</p><p><strong>Conclusion: </strong>The majority of patients with PMA do not complain of heartburn. Bloating in patients with severe GORD should raise the possibility of gastroparesis and PMA.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"7-14"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of additional lateral pinhole and SPECT/CT imaging in dual-phase Tc-99m MIBI parathyroid scintigraphy for localising parathyroid pathologies in patients with primary hyperparathyroidism: a single-institution experience.","authors":"Selin Kesim, Halil Turgut Turoglu, Tuncay Kotan, Zeynep Ceren Balaban Genc, Khanim Niftaliyeva, Hasan Toper, Dilek Gogas Yavuz, Salih Ozguven, Handan Kaya, Fuat Dede, Mustafa Umit Ugurlu, Kevser Oksuzoglu, Feyza Cagliyan, Bahadir Mahmut Gulluoglu, Tunc Ones, Tanju Yusuf Erdil","doi":"10.1097/MNM.0000000000001924","DOIUrl":"10.1097/MNM.0000000000001924","url":null,"abstract":"<p><strong>Purpose: </strong>Parathyroid imaging with dual-phase technetium-99m methoxyisobutrylizonitrile (Tc-99m MIBI) scintigraphy serves as an important prerequisite for the identification of hyperfunctioning parathyroid gland(s) in patients with primary hyperparathyroidism (PHPT) for a successful targeted parathyroidectomy. This study aimed to evaluate the clinical value of additional lateral imaging and single-photon emission computed tomography/computed tomography (SPECT/CT) versus conventional planar imaging for locating parathyroid pathologies in patients with PHPT.</p><p><strong>Materials and methods: </strong>A retrospective review was performed on 105 patients who underwent dual-phase Tc-99m MIBI scintigraphy and were surgically treated by parathyroidectomy. Dual-phase Tc-99m-MIBI planar scintigraphy with additional lateral pinhole views and SPECT/CT imaging was performed on a routine basis, as per departmental protocol. Comparison study between imaging modalities was done by patient-based analysis and scintigraphy results were compared with the clinical findings, biochemical markers, and histopathological findings.</p><p><strong>Results: </strong>Sensitivity and specificity for anterior planar dual-phase Tc-99m MIBI scintigraphy were 78.8 and 80%, respectively. In comparison, lateral pinhole scan and SPECT/CT alone were found to have sensitivities of 85.9 and 90.9%, respectively, with the same specificity. Sensitivity decreased in patients with normocalcaemia and multiglandular disease. The mean adenoma weight and size for true-positive studies were significantly higher than those for false-negative or false-positive studies.</p><p><strong>Conclusion: </strong>SPECT/CT provided the highest diagnostic accuracy for preoperative identification of parathyroid lesions in PHPT patients. Lateral pinhole imaging offers comparable sensitivity and aids in adenoma localisation when SPECT/CT is unavailable.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"47-54"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142605297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic role of whole-body volumetric positron emission tomography/computed tomography parameters in treatment naive colorectal cancer patients with liver metastases.","authors":"Hüseyin Karaoğlan, Ferat Kepenek, Halil Kömek, İhsan Kaplan, Ömer Yeprem, Ridvan Kaya, Yunus Güzel, Veysi Şenses, Fulya Kaya İpek, Canan Can","doi":"10.1097/MNM.0000000000001915","DOIUrl":"10.1097/MNM.0000000000001915","url":null,"abstract":"<p><strong>Purpose: </strong>The present study aimed to predict the prognostic role of quantitative 18 F-fluorodeoxyglucose PET/computed tomography parameters such as maximum standardized uptake value (SUV max ), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) obtained from primary tumor, lymph node metastases, and liver metastasis (LM) in patients with colorectal LM (CLM).</p><p><strong>Material and method: </strong>The research was designed as a retrospective study and 66 patients with CLM were enrolled between January 2017 and December 2018. Primary tumor SUV max (PSUV max ), liver SUV max (LSUV max ), and lymph node SUV max (LnSUV max ) values obtained from the primary tumor, liver, and lymph nodes were recorded. In addition, total MTV (TMTV) and total TLG (TTLG) values were obtained by summing the values obtained from the primary tumor (PMTV and PTLG), lymph nodes (LnMTV and LnTLG), and liver (LMTV and LTLG). Univariate and multivariate Cox regression analysis was used to measure the effects of prognostic variables on mortality and survival.</p><p><strong>Result: </strong>In univariate Cox regression analysis, PMTV ( P  = 0.001), LnMTV ( P  = 0.008), LnTLG ( P  = 0.008), LnSUV max ( P  = 0.047), and TTLG ( P  = 0.038) were identified as prognostic factors for overall survival. No statistically significant relationship was found between MTV and TLG values of LM and overall survival. In multivariate analysis, PMTV ( P  = 0.022) was identified as an independent prognostic factor.</p><p><strong>Conclusion: </strong>In conclusion, our study demonstrated that the PMTV value used in evaluating treatment-naive patients diagnosed with CLM is an independent prognostic factor for survival. Our results need to be confirmed with more studies involving more patients.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"55-59"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of exclusive rib lesions detected by [ 68 Ga]Ga-PSMA-11 PET/CT.","authors":"Marine Stoffels, François Cousin, Maréva Lamande, Chloé Denis, David Waltregny, Roland Hustinx, Brieuc Sautois, Nadia Withofs","doi":"10.1097/MNM.0000000000001919","DOIUrl":"10.1097/MNM.0000000000001919","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to characterize exclusive costal lesions detected by 68 Gallium-labelled prostate-specific membrane antigen ([ 68 Ga]Ga-PSMA-11) PET/computed tomography (CT) at initial staging or biochemical recurrence (BCR) in prostate cancer (PCa) patients, and to identify clinical and/or PET/CT criteria associated with benign and malignant lesions.</p><p><strong>Methods: </strong>We retrospectively identified 54 patients with PCa who underwent [ 68 Ga]Ga-PSMA-11 PET/CT for initial staging ( N  = 39) or BCR ( N  = 15) and whose reports described rib lesions, at the exclusion of any other lesions, whether doubtful, suspicious, or established. Posttherapy prostate-specific antigen (PSA) levels were used to determine whether those lesions were benign or malignant. Each patient's prostate-specific membrane antigen PET/CT report was classified as true positive, true negative, false positive, or false negative based on the posttherapy PSA level. We then assessed whether any clinical and/or PET/CT criteria could help differentiate benign from malignant lesions, and if any criteria were misleading.</p><p><strong>Results: </strong>Among the 54 patients, 46 (85.2%) had 64 benign costal lesions, and eight (14.8%) had 10 malignant lesions. PET/CT reports indicated rib lesions as benign/equivocal in 38/54 (55.6%) patients and malignant in 16/54 (29.6%). Benign features on CT were the only parameter significantly associated with the final diagnosis. Factors such as patient age, maximum standardized uptake value of lesions, lesion dispersion, and malignant features described on CT were found to be misleading when deciding the malignant or benign status.</p><p><strong>Conclusion: </strong>Most exclusive costal lesions detected by [ 68 Ga]Ga-PSMA-11 PET/CT are benign. Apart from specific benign CT features, no clinical or PET/CT criteria reliably differentiate benign from malignant costal lesions.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"95-105"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of baseline 18 F-FDG PET/CT and peripheral blood inflammatory markers for aggressive lymphoma in non-Hodgkin's lymphoma.","authors":"Qichen Jia, Aihui Wang, Yuang Liu, Yishuo Fan, Xiaohong Zhou, Yupeng Liu, Liying Wu, Xiaohui Ouyang, Jiagui Su, Baolong Shi, Xiaofei Liu","doi":"10.1097/MNM.0000000000001912","DOIUrl":"10.1097/MNM.0000000000001912","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to investigate the diagnostic value of baseline F18 fluorodeoxyglucose (FDG) PET/computed tomography (CT) parameters and peripheral blood inflammatory markers in aggressive lymphoma of non-Hodgkin lymphoma (NHL) and the correlation between peripheral blood inflammatory markers and maximum standardized uptake value (SUV max ).</p><p><strong>Patients and methods: </strong>We conducted a retrospective analysis including 121 patients with NHL. Patients were divided into aggressive lymphoma group and indolent lymphoma group. Mann-Whitney U test, chi-square test and multivariate stepwise logistic regression were used to analyse. Subsequently, receiver operating characteristic (ROC) curve analysis was conducted to evaluate the diagnostic performance. Additionally, Spearman correlation analysis was utilized to explore the correlation between peripheral blood inflammatory markers and SUV max .</p><p><strong>Results: </strong>Leptin mass criterion uptake value (SUL) max , SUV max , SUV avg , SUV peak , focal SUV max /liver SUV max , focal SUV max / mediastinal SUV max , SUL avg , SUL peak , systemic immune-inflammation (SII), neutrophil ratio, total lesion glycolysis (TLG), neutrophils versus lymphocyte ratio (NLR), plateletto-lymphocyte ratio (PLR), lactate dehydrogenase (LDH) and lymphocyle ratio between two groups were statistically significant ( P  < 0.05). SUV max was an independent influencing factor, and the area under the ROC curve was 0.862. There was a positive correlation between the PLR and SUV max ( r  = 0.239; P  = 0.008).</p><p><strong>Conclusion: </strong>PET/CT parameters and peripheral blood inflammatory markers have certain value in the diagnosis of aggressive lymphoma in NHL, among which SUV max is an independent influencing marker and is positively correlated with PLR.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"60-66"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-center analysis of cardiac amyloidosis using 99m Tc-HMDP imaging for diagnosis and evaluation after tafamidis treatment.","authors":"Ryuta Egi, Yohji Matsusaka, Kaho Watanabe, Akira Seto, Ichiro Matsunari, Takahide Arai, Shintaro Nakano, Ichiei Kuji","doi":"10.1097/MNM.0000000000001922","DOIUrl":"10.1097/MNM.0000000000001922","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the diagnostic performance of 99m Tc-hydroxymethylene diphosphonate ( 99m Tc-HMDP) imaging for cardiac amyloidosis and to demonstrate changes in cardiac uptake of 99m Tc-HMDP after tafamidis treatment.</p><p><strong>Methods: </strong>Seventy-five patients with suspected cardiac amyloidosis who underwent 99m Tc-HMDP imaging were included. We compared visual Perugini grades and semiquantitative heart-to-contralateral (H/CL) area ratios, myocardial maximum standardized uptake value (SUVmax), and peak of SUV (SUVpeak) between cardiac transthyretin amyloidosis (ATTR) and amyloid light-chain amyloidosis (AL). Comparison of interobserver reproducibility between H/CL ratios and myocardial SUVmax/SUVpeak was performed. H/CL ratio of 99m Tc-HMDP and myocardial SUVmax/SUVpeak were compared before and after tafamidis administration for cardiac wild-type ATTR.</p><p><strong>Results: </strong>Among 75 patients, 20 patients (26.7%) were visually positive based on Perugini grade. Fifteen and three patients were pathologically identified as cardiac ATTR and AL, respectively. ATTR group ( n  = 15) had significantly higher H/CL ratios of 99m Tc-HMDP than AL group ( n  = 3) ( P  = 0.003). ATTR group ( n  = 15) had significantly higher myocardial SUVmax/SUVpeak of 99m Tc-HMDP than AL group ( n  = 2) ( P  = 0.015). Myocardial SUVmax/SUVpeak had better interobserver reproducibility than H/CL ratios. After tafamidis treatment for cardiac wild-type ATTR, the decrease in myocardial SUVpeak was significant but not in H/CL ratios and myocardial SUVmax.</p><p><strong>Conclusion: </strong>H/CL ratio and SUVmax/SUVpeak in 99m Tc-HMDP imaging were useful for diagnosing cardiac ATTR. Myocardial SUVpeak may be useful for monitoring changes in cardiac uptake after tafamidis treatment for cardiac ATTR.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"38-46"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low false-positive lymph nodes for 18 F-fibroblast activation protein inhibitors PET/computed tomography in preoperative staging of patients with nonsmall cell lung cancer.","authors":"Xingyu Mu, Ludeng Lu, Jingze Li, Lei Zhang, Yanyun Deng, Wei Fu","doi":"10.1097/MNM.0000000000001913","DOIUrl":"10.1097/MNM.0000000000001913","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the diagnostic accuracy of 18 F-fibroblast activation protein inhibitor (FAPI) PET/computed tomography (CT) in identifying primary tumors and mediastinal lymph node metastases in nonsmall cell lung cancer (NSCLC), with histopathological findings serving as the reference standard.</p><p><strong>Methods: </strong>Nineteen patients underwent preoperative 18 F-FAPI PET/CT and subsequent surgery; of these, 13 also underwent 18 F-fluorodeoxyglucose (FDG) PET/CT within 1 week. The diagnostic accuracy of primary tumors and lymph node metastases was evaluated for both modalities. Semiquantitative parameters, including maximum standardized uptake values (SUV max ) and target-to-background ratios (TBRs), for both primary tumors and lymph node metastases were assessed for both modalities.</p><p><strong>Results: </strong>For primary tumors, 18 of 19 (94.7%) showed positive results on 18 F-FAPI PET/CT scans. In 13 patients who also underwent 18 F-FDG PET/CT, 18 F-FAPI PET/CT demonstrated a higher detection rate compared with 18 F-FDG PET/CT (100% vs. 69.1%). The overall accuracy of lymph node assessment with 18 F-FAPI PET/CT (95.9-97.1%) was significantly higher compared to 18 F-FDG PET/CT (51.0%). Malignant lymph nodes exhibited significantly higher SUV max and TBR on 18 F-FAPI scans (SUV max : 7.0 vs. 0.9, P  < 0.001; TBR muscle : 5.0 vs. 0.8, P  < 0.001) than on 18 F-FDG scans (SUV max : 3.9 vs. 1.8, P  = 0.01), except for the liver TBR on 18 F-FDG scans (TBR liver : 1.8 vs. 1.0, P  = 0.055).</p><p><strong>Conclusion: </strong>18 F-FAPI could be utilized in the preoperative staging of NSCLC to mitigate the incidence of false positives associated with 18 F-FDG, due to its higher accuracy in identifying mediastinal lymph node metastasis.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"67-75"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}