{"title":"Adjacent object distorts the organ-of-interest in filtered back-projection tomographic image reconstruction: 'ramp filter' or 'reconstruction' artifact revisited.","authors":"Mohsen Qutbi","doi":"10.1097/MNM.0000000000001830","DOIUrl":"10.1097/MNM.0000000000001830","url":null,"abstract":"<p><strong>Objective: </strong>To simulate the artifact caused by an adjacent object on organ-of-interest during filtered back-projection (FBP) tomographic reconstruction (the so-called \"ramp filter\" artifact) and to demonstrate the extent to which an organ-of-interest is influenced by such adjacent hot spot or attenuating object.</p><p><strong>Methods and materials: </strong>Two simulations are conducted with two simplified phantoms: \"hot spot\" and \"cardiac.\" First one is used to visualize effect of hot spot on its periphery. Second one is used to evaluate effect of nearby object (liver) on left ventricle (LV) as organ-of-interest. To generate sinograms, forward projection process is done with and without modeling radiation attenuation. FBP using windowed ramp filter is done. All slices are analyzed by plotting intensity profiles.</p><p><strong>Results: </strong>In tomographic slices, there is a hypo-intense halo around presumed edge of object when compared to background intensity, more noticeable in phantoms with less blurring. Even with ramp filter applied, no halo is visible in FBP without attenuation for cardiac phantom. In contrast, in slices with considering attenuation, zones with different levels of count suppression on both sides of object are visualized instead. The most prominent one is between liver and LV in simulation with higher-attenuating object and higher activity.</p><p><strong>Conclusion: </strong>A single hot spot with sufficient amount of blurring does not distort its surroundings. Hot spots and attenuating objects near organ-of-interest, however, distort myocardial perfusion imaging. Artifactual defects are thus only created when attenuation is modeled during FBP, producing zones of count suppression between organ-of-interest and nearby object or hot spot.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140094406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Can 18F FDG PET/CT metabolic parameters be used to noninvasively differentiate between different histopathological subtypes and Fuhrman grades of renal cell cancer?","authors":"Yash Jain, Archi Agrawal, Amit Joshi, Santosh Menon, Gagan Prakash, Vedang Murthy, Nilendu Purandare, Sneha Shah, Ameya Puranik, Sayak Choudhury, Varun Shukla, Indraja Dev, Kumar Prabhash, Vanita Noronha, Venkatesh Rangarajan","doi":"10.1097/mnm.0000000000001844","DOIUrl":"https://doi.org/10.1097/mnm.0000000000001844","url":null,"abstract":"To evaluate relationship between metabolic PET metabolic parameters and size of the primary tumor, various histopathological subtypes of renal cell carcinoma (RCC) and Fuhrman grade of the tumors.","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140828652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of 68Ga-FAPI-04 PET/CT with 18F-FDG PET/CT for diagnosis and staging of gastric and colorectal cancer.","authors":"Bin Wang, Xinming Zhao, Yunuan Liu, Zhaoqi Zhang, Xiaoshan Chen, Fenglian Jing, Xiaolin Chen, Yu Hua, Jianqiang Zhao","doi":"10.1097/mnm.0000000000001845","DOIUrl":"https://doi.org/10.1097/mnm.0000000000001845","url":null,"abstract":"The objective of this study is to evaluate the effectiveness of 68Ga-FAPI-04 PET/computed tomography (CT) for the diagnosis of primary and metastatic gastric cancer and colorectal cancer lesions as compared with 18F-FDG PET/CT.","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140829162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akram Al-Ibraheem, Sudqi Allouzi, A. Abdlkadir, Miriam Mikhail-Lette, K. Al-rabi, M. Ma'koseh, Peter Knoll, Zaid Abdelrhman, Omar Shahin, Malik E. Juweid, Diana Paez, E. Lopci
{"title":"PET/CT in leukemia: utility and future directions.","authors":"Akram Al-Ibraheem, Sudqi Allouzi, A. Abdlkadir, Miriam Mikhail-Lette, K. Al-rabi, M. Ma'koseh, Peter Knoll, Zaid Abdelrhman, Omar Shahin, Malik E. Juweid, Diana Paez, E. Lopci","doi":"10.1097/MNM.0000000000001846","DOIUrl":"https://doi.org/10.1097/MNM.0000000000001846","url":null,"abstract":"2-Deoxy-2-[18F]fluoro-d-glucose PET/computed tomography ([18F]FDG PET/CT) has proven to be a sensitive method for the detection and evaluation of hematologic malignancies, especially lymphoma. The increasing incidence and mortality rates of leukemia have raised significant concerns. Through the utilization of whole-body imaging, [18F]FDG PET/CT provides a thorough assessment of the entire bone marrow, complementing the limited insights provided by biopsy samples. In this regard, [18F]FDG PET/CT has the ability to assess diverse types of leukemia The utilization of [18F]FDG PET/CT has been found to be effective in evaluating leukemia spread beyond the bone marrow, tracking disease relapse, identifying Richter's transformation, and assessing the inflammatory activity associated with acute graft versus host disease. However, its role in various clinical scenarios in leukemia remains unacknowledged. Despite their less common use, some novel PET/CT radiotracers are being researched for potential use in specific scenarios in leukemia patients. Therefore, the objectives of this review are to provide a thorough assessment of the current applications of [18F]FDG PET/CT in the staging and monitoring of leukemia patients, as well as the potential for an expanding role of PET/CT in leukemia patients.","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140675492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alberto Bestetti, Barbara Zangheri, Sara Vincenzina Gabanelli, Vincenzo Parini, Carla Fornara
{"title":"Union is strength: the combination of radiomics features and 3D-deep learning in a sole model increases diagnostic accuracy in demented patients: a whole brain 18FDG PET-CT analysis.","authors":"Alberto Bestetti, Barbara Zangheri, Sara Vincenzina Gabanelli, Vincenzo Parini, Carla Fornara","doi":"10.1097/mnm.0000000000001853","DOIUrl":"https://doi.org/10.1097/mnm.0000000000001853","url":null,"abstract":"FDG PET imaging plays a crucial role in the evaluation of demented patients by assessing regional cerebral glucose metabolism. In recent years, both radiomics and deep learning techniques have emerged as powerful tools for extracting valuable information from medical images. This article aims to provide a comparative analysis of radiomics features, 3D-deep learning convolutional neural network (CNN) and the fusion of them, in the evaluation of 18F-FDG PET whole brain images in patients with dementia and normal controls.","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140629224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relationship between transient ischemic dilatation and changes in heart rate during gated SPECT acquisition in a low-risk population without perfusion defects.","authors":"Fernando Mut, María P Gaudiano, Miguel Kapitán","doi":"10.1097/mnm.0000000000001852","DOIUrl":"https://doi.org/10.1097/mnm.0000000000001852","url":null,"abstract":"Transient ischemic dilatation (TID) in myocardial perfusion single photon emission computed tomography (SPECT) is considered a marker of poor prognosis. However, it has been suggested that some cases are due to apparent volumetric changes secondary to differences in heart rate (HR) at the time of acquisition. We assessed the correlation between transient dilatation and HR in low risk patients with no perfusion defects.","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140563326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sarah Wicks, Danielle Levart, Lauren Conway, Neil Heraghty, A Michael Peters
{"title":"Noninvasive measurement of tracer extraction efficiency in tissue, illustrated with Tc-99m-MAG3.","authors":"Sarah Wicks, Danielle Levart, Lauren Conway, Neil Heraghty, A Michael Peters","doi":"10.1097/mnm.0000000000001837","DOIUrl":"https://doi.org/10.1097/mnm.0000000000001837","url":null,"abstract":"The aim of this study is to develop a noninvasive technique for measuring tissue tracer extraction efficiency (E) and illustrate it for Tc-99m-mercaptoacetyltriglycine (MAG3) and kidney. E was measured in 10 patients with normal MAG3 renography. E is the ratio of tissue clearance-to-blood flow (Ki/F). For single-photon tracers, attenuation constants are unknown, so Ki and F cannot be separately measured. However, by deriving attenuation-uncorrected Ki' and F' from the same regions of interests (ROIs), these constants cancel out, giving E. Using a lung ROI for blood activity, F was measured from first-pass and Ki' from Gjedde-Patlak-Rutland (GPR) analysis up to 130 s. Because of interference from right ventricle, a left ventricular ROI (LV) is unsuitable for F' but was used in GPR analysis, making an adjustment for the ratio of respective blood pool signals arising from lung and LV ROIs in early frames (60-90 s). A lung ROI underestimates F' by 4% at normal LV function. Chest wall interstitial activity (I), which does not affect F', amounted to 53 and 30% of the lung and LV signals at 20 min, and 12 and 6% at 130 s, resulting in underestimations of Ki of 4 and 2%, respectively. Ignoring these opposing errors, E based on lung ROI for left and right kidneys was 43.5 (SD 8)% and 47.3 (9)%, and based on LV ROI for GPR analysis was 44.5 (10.9)% and 48.3 (10.6)%. E can be measured by combining blood flow from first-pass with clearance from GPR analysis, and has potential value both clinically and in clinical research.","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140611565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of iodine contrast media on gamma camera-based GFR and factors affecting the difference between serum creatinine-based estimated GFR and Gate's GFR.","authors":"Shiro Ishii, Shigeyasu Sugawara, Yumi Tanaka, Natsumi Kawamoto, Junko Hara, Ryo Yamakuni, Hiroki Suenaga, Kenji Fukushima, Hiroshi Ito","doi":"10.1097/mnm.0000000000001848","DOIUrl":"https://doi.org/10.1097/mnm.0000000000001848","url":null,"abstract":"We aimed to elucidate the factors underlying the difference between estimated glomerular filtration rate (eGFR) calculated from serum creatinine and Gate's GFR (gGFR) measured using technetium-99m diethylene triamine pentaacetic acid (99mTc-DTPA) scintigraphy.","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140563846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"18F-FDG PET imaging for treatment response assessment and management guidance in patients with skull base osteomyelitis.","authors":"Awiral Saxena, Padma Subramanyam, Manjit Sarma, Bhagirath Bhad, Renjitha Bhaskaran, Shanmuga Sundaram Palaniswamy","doi":"10.1097/mnm.0000000000001847","DOIUrl":"https://doi.org/10.1097/mnm.0000000000001847","url":null,"abstract":"The objective of this study is to evaluate the role of hybrid 18F-FDG PET for treatment response assessment and management guidance in patients with skull base osteomyelitis.","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140563414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of skull bone viability and effect of early surgical intervention in electrical contact burns using 18F-Sodium Fluoride PET-CT imaging.","authors":"Parmod Kumar, Pulkit Arora, Rajender Kumar, Harmandeep Singh, Atul Parashar, Bhagwant R Mittal, Anish Bhattacharya","doi":"10.1097/mnm.0000000000001842","DOIUrl":"https://doi.org/10.1097/mnm.0000000000001842","url":null,"abstract":"Electrical contact burns of the scalp cause serious morbidity and mortality. Early necrotic bone debridement and flap cover are crucial for successful wound closure. 18F Sodium Fluoride (NaF), with high bone-to-soft tissue activity ratio, is useful for bone viability assessment. This study evaluated the role of 18F NaF PET-computed tomography (CT) in objectively defining the extent and depth of nonviable calvarial bone, to guide adequate bone debridement.","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140563421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}