Nuclear Medicine Communications最新文献

{"title":"The evolution and hotspots of radioactive iodine therapy in hyperthyroidism: a bibliometric analysis.","authors":"Shi-Qi Chen, Rui-Qin Gou, Qing Zhang","doi":"10.1097/MNM.0000000000001940","DOIUrl":"10.1097/MNM.0000000000001940","url":null,"abstract":"<p><strong>Objective: </strong>Hyperthyroidism, a prevalent endocrine disorder, disrupts metabolic balance and cardiovascular health, affecting millions globally. Radioactive iodine (RAI), a treatment for hyperthyroidism, employs high-energy beta particles to reduce thyroid tissue, lowering volume and hormone levels. This study utilizes bibliometric analysis to outline RAI's evolution and identify hotspots in hyperthyroidism treatment.</p><p><strong>Methods: </strong>A total of 2904 articles and reviews published between 1981 and 2023 were retrieved from the Web of Science Core Collection using the research strategy. Bibliometric analyses, employing VOSviewer and CiteSpace, were performed to visualize the cooperation network, evolution, and hot topics.</p><p><strong>Results: </strong>Annual publications rose in waves, 2904 papers from 2564 institutions, and 84 countries. The USA led, contributing the largest share, with the journal Thyroid dominating publication. The University of Pisa contributed the most articles. Co-occurrence analysis classified keywords into five clusters: treatment mechanism, safety, effectiveness assessment, individualized radioactive dosage, and management. The development of RAI therapy for hyperthyroidism can be divided into three stages: safety and efficacy assessment, personalized treatment plans, and treatment of drug-resistant and surgery-resistant hyperthyroidism.</p><p><strong>Conclusion: </strong>Attention to RAI in hyperthyroidism should be significantly increased. It is necessary to establish collaborations between authors, countries, and institutions to promote the development of this field. Recent research has focused on personalized radioactive dosage formulation and follow-up. Future studies are likely to concentrate on drug-resistant and surgery-resistant hyperthyroidism, which is also worthy of investigation. These findings provide a new perspective on the study of RAI in hyperthyroidism, potentially contributing to the improvement of the quality of life for patients with hyperthyroidism.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"204-217"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142786389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18 F-FDG metabolic abnormalities precede perfusion and atrophic changes in diagnosis of early frontotemporal dementia: study from a tertiary care university hospital.","authors":"Padma Subramanyam, Shanmuga Sundaram Palaniswamy","doi":"10.1097/MNM.0000000000001942","DOIUrl":"10.1097/MNM.0000000000001942","url":null,"abstract":"<p><strong>Objective: </strong>Diagnosis of early onset dementia is critical for initiating management. Although structural MRI is an established procedure for dementia evaluation, early cases may be missed. Neurodegenerative diseases lead to reductions in glucose consumption and grey matter volume loss. Our primary aim was to establish whether metabolic changes precede perfusion abnormalities in early cases of dementia especially, frontotemporal dementia (FTD). Secondly to study if cerebral atrophy using Pasquier visual rating scales can be used reliably to correlate with hypometabolism in this group of patients.</p><p><strong>Materials and methods: </strong>A total of 56 patients (M:F = 39:17) with memory loss as per the DSM-5 diagnostic criteria were clinically and neurologically examined and referred for 18 F-Fluorodeoxyglucose (FDG) PET brain imaging. A few patients who had a prior (recent, <1 week) MR brain underwent brain 18 F-FDG PET-CT, and all others were considered for simultaneous 18 F-FDG PETMR imaging of brain. T2-weighted images were used to report Pasquier rating scales in all our patients as per recommendation.</p><p><strong>Results: </strong>Cognitive assessments were analysed along with neuroimaging findings. Highest diagnostic performance was obtained with 18 F-FDG PET for identifying early FTD in our series of patients. Sensitivity, specificity and accuracy of FDG and arterial spin labeling (ASL) using simultaneous PETMR were found to be 96.34%/90.1%/89 : 53.57%/62.12%/78, respectively. Cerebral atrophy rated using Pasquier visual scales showed the lowest diagnostic performance. Our study showed that the earliest phase of cognitive decline was found to be associated with specific patterns of hypometabolism, even in the absence of atrophy, which are currently considered diagnostic biomarkers.</p><p><strong>Conclusion: </strong>Metabolic derangements indeed precede perfusion changes and cerebral atrophy in the setting of early dementia. Simultaneous FDG PETMR is being recommended as the investigation of choice for the evaluation of early FTD. This pilot study shows that FDG PET outperforms cognitive assessments and anatomical imaging modalities in early dementia evaluation. Although ASL can detect perfusion deficits in dementia, compared with FDG PET, its sensitivity and specificity for discerning early onset dementia from controls remain inferior to FDG PET. Pasquier scales, although easy to implement, cannot replace FDG PET metabolic findings, which start very early in the neuronal disease process.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"248-259"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142838617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of fluorine-18-fluorodeoxyglucose PET/MRI for detection of disease recurrence in differentiated thyroid cancer: a compartment-based analysis.","authors":"Elgin Özkan, Sena Ünal, Pinar Akkuş, Elif Peker, Mine Araz, Ecenur Dursun, Cigdem Soydal, Nil Sezer Yilmazer Zorlu, Mustafa Kursat Gökcan, Murat Faik Erdoğan, Yasemin Yavuz, Nuriye Ozlem Küçük","doi":"10.1097/MNM.0000000000001937","DOIUrl":"10.1097/MNM.0000000000001937","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this study is to evaluate the diagnostic performance of neck fluorodeoxyglucose (FDG) PET/MRI in addition to whole-body PET/computed tomography (CT) and to compare it with MRI in the detection of suspicion of disease relapse in patients with differentiated thyroid cancer (DTC) who underwent total thyroidectomy and radioactive iodine therapy.</p><p><strong>Methods: </strong>Twenty-nine patients with DTC who underwent whole-body 18 F-FDG PET/CT followed by neck PET/MRI because of increased serum thyroglobulin (Tg) or anti-Tg antibody levels and negative 131 I whole-body scan were included. At least 6 months of clinical and radiological (neck ultrasound) follow-up or histopathological examination results were accepted as the gold standard. Lesion and compartment-based analyses were performed to evaluate the diagnostic performances of PET/CT, MRI, and PET/MRI. In addition, changes of clinical management were evaluated.</p><p><strong>Results: </strong>On lesion-based analysis, for PET/CT, MRI, and PET/MRI: sensitivity: 33.3, 33.3, and 37%; specificity: 90.1, 87.9, and 95.9%; accuracy: 87.5, 85.4, and 93.2 were calculated, respectively. Specificity of PET/MRI was significantly superior to PET/CT and MRI ( P  of0.001); however, sensitivity of PET/MRI was not significant to PET/CT and MRI ( P  of0.05). On compartment-based analysis, specificity of PET/MRI and MRI were comparable but significantly superior to PET/CT at levels 1 and 2; however, specificity of PET/CT and PET/MRI were comparable but significantly superior than MRI, especially at levels 3, 4, and 5.</p><p><strong>Conclusion: </strong>PET/MRI especially helps in the accurate exclusion of findings that are suspicious on PET/CT and MRI, and has the potential to change the clinical management by identifying uncertain neck findings.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"230-238"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Semiquantitative muscle parameters derived from FAPI and FDG PET/CT in evaluating sarcopenia among patients with malignant tumors.","authors":"Yang Chen, Qing Zhang, Yinting Hu, Entao Liu, Xiaoyue Tan, Hui Yuan, Lei Jiang","doi":"10.1097/MNM.0000000000001945","DOIUrl":"10.1097/MNM.0000000000001945","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study is to explore and compare the potential utility of fibroblast activation protein inhibitor (FAPI) and fluorodeoxyglucose PET/computed tomography (CT) in assessing sarcopenia among patients with malignant tumors.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 127 patients with histologically confirmed malignant tumors who underwent both 18 F/ 68 Ga-FAPI and fluorine-18-fluorodeoxyglucose ( 18 F-FDG) PET/CT scans. Clinical characteristics and PET/CT parameters of maximum and mean standard uptake value (SUV max and SUV mean ) of muscle at the 3 rd lumbar (L3) level were reviewed. Skeletal muscle area at the L3 level was measured, and skeletal muscle index was calculated to determine sarcopenia. The association between sarcopenia and PET/CT parameters was analyzed.</p><p><strong>Results: </strong>The incidence of sarcopenia was 41.7% among these 127 patients. Higher age, male, lower BMI, lower SUV max and SUV mean of muscle from 18 F/ 68 Ga-FAPI PET/CT, and lower SUV max of muscle from 18 F-FDG PET/CT were correlated with a higher prevalence of sarcopenia ( P  < 0.05). Besides, no significant differences in SUV max and SUV mean of muscle were noted between 18 F-FAPI and 68 Ga-FAPI groups. The best cutoff value of SUV max of muscle from 18 F/ 68 Ga-FAPI PET/CT was 1.17, yielding the area under the curve (AUC) of 0.764 and sensitivity and specificity of 74.3% and 71.7%, while the optimal cutoff value of SUV max of muscle from 18 F-FDG PET/CT was 0.76, with an AUC of 0.642 and sensitivity and specificity of 36.5% and 86.8%, respectively.</p><p><strong>Conclusion: </strong>Patients with sarcopenia exhibit decreased muscle uptake of FAPI and fluorodeoxyglucose. FAPI PET/CT emerges as a more valuable tool for sarcopenia assessment in patients with malignant tumors compared to fluorodeoxyglucose PET/CT.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"260-267"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of surface contamination of low-dose radioactive iodine ( 131 I) treatment container.","authors":"Chan-Ju Ryu","doi":"10.1097/MNM.0000000000001939","DOIUrl":"10.1097/MNM.0000000000001939","url":null,"abstract":"<p><p>With the advancement of radiotherapy technology in the medical field, the amount of radioactive waste has rapidly increased, and the International Atomic Energy Agency (IAEA) has proposed waste deregulation standards based on individual dose, collective dose, and nuclide concentration. The purpose of this study is to define the standard period (1 day) required to measure collected radioactive waste using direct and indirect methods with a radioactivity meter, ensure that the radiation dose remains below the allowable level, and transport the waste safely. In this study, 131 I low-dose (30 mCi) radioactive waste discarded after radioiodine treatment at a medical institution was collected, and a measuring container was prepared to measure radioactivity concentration according to IAEA standards. The experiments showed that the minimum number of days required for the contamination levels of the inner and outer parts of containers and therapeutic plastics to fall below the tolerance limit were 6, 1, and 5 days, respectively. Conversely, the contamination levels measured immediately after 131 I treatments in the cases of Styrofoam and paper boxes were below the tolerance limit. The study emphasizes the need for a safe disposal process and active radioactive waste management operations by radioactive waste transporters by specifying the scope for safe transportation beyond the permissible limit.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"187-192"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic markers derived from 18 F-FDG PET/CT in suspected recurrent ovarian carcinoma: predictive value for disease burden and prognosis.","authors":"Bela Jain, Yogita Khandelwal, Manish Ora, Prabhakar Mishra, Punita Lal, Sanjay Gambhir","doi":"10.1097/MNM.0000000000001944","DOIUrl":"10.1097/MNM.0000000000001944","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to assess the role of 18 F-fluorodeoxyglucose (FDG) PET/computed tomography (CT) in suspected recurrent ovarian carcinoma. Several clinical and PET parameters were assessed to evaluate disease burden and prognosis.</p><p><strong>Methods: </strong>We did a single-center, retrospective study in patients with suspected recurrent ovarian carcinoma who underwent 18 F-FDG PET/CT. The disease burden on the scan was evaluated. We calculated several semiquantitative markers, including standard uptake values (SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG). Survival analysis was done with clinical parameters, CA-125 levels, disease distribution, and metabolic markers.</p><p><strong>Results: </strong>Fifty-two patients were included in the study. Half of the patients had suspected recurrence within 12 months of primary diagnosis. PET/CT scan suggested disease in 35 (67.3%) patients. Multiple metastatic sites were noted in 21 (40.4%) patients. Extra-abdominal metastases were seen in 15 (28.8%) patients. Eight patients had 18 F-FDG avid disease despite a low CA-125 level (<35 IU). Young patients (<50 years), extra-abdominal disease, multiple metastases, and higher restaging were associated with poor outcomes. Meanwhile, treatment history, CA-125 level, and post-PET/CT treatment had no significant effect on survival. MTV@40% SUV (>17.21) and TLG@40% SUV (>68.7) had the sensitivity of 87.5% and 75% for predicting disease outcome.</p><p><strong>Conclusion: </strong>Recurrent ovarian carcinoma commonly presents with multiple metastasis and extra-abdominal metastases. 18 F-FDG PET/CT-guided patterns of disease distribution were significant markers for poor prognosis. Disease burden on PET/CT-derived semiquantitative parameters was associated with poor outcomes.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"268-275"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142838620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of cerebral technetium-99m-ethyl cysteinate dimer perfusion in patients with dementia with Lewy bodies and Parkinson's disease dementia.","authors":"Aili Toyli, Guang-Uei Hung, Chen Zhao, Qiuying Sha, Pai-Yi Chiu, Weihua Zhou","doi":"10.1097/MNM.0000000000001946","DOIUrl":"10.1097/MNM.0000000000001946","url":null,"abstract":"<p><strong>Objective: </strong>Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are closely related neurodegenerative conditions within the Lewy body spectrum. The relationship between DLB and PDD remains debated, with ongoing discussion about whether they are distinct diseases or different manifestations of the same disorder. This study aimed to identify differences in cerebral perfusion patterns between DLB and PDD patients.</p><p><strong>Methods: </strong>Single-photon emission computed tomography (SPECT) ethyl cysteinate dimer (ECD) imaging was performed on patients diagnosed with DLB ( n  = 46) and PDD ( n  = 30). The data were acquired by two SPECT/computed tomography systems from two affiliated centers and were retrospectively recruited under the local ethics approval. Relative tracer uptake levels were calculated across 47 automatically determined regions of interest and 240 subregions. A two-sided Welch's t -test was employed to evaluate mean perfusion differences, with results further confirmed through a voxel-wise t -test mapping. The Benjamini-Hochberg procedure was used to adjust P -values for multiple comparisons.</p><p><strong>Results: </strong>The greatest difference in perfusion was in the left associative visual cortex in planes 34 and 36 and the right primary visual cortex in plane 34, with lower mean perfusion observed in PDD patients than those with DLB ( P  = 0.005).</p><p><strong>Conclusion: </strong>No statistically significant differences in ECD perfusion were found between DLB and PDD patients. The greatest difference was in the visual cortices, where PDD patients suffered a greater loss of perfusion.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"218-222"},"PeriodicalIF":1.3,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11798712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of the association between baseline [18F] fluorodeoxyglucose uptake and axillary pathological complete response in node-positive breast cancer patients: focus on clinical subtypes.","authors":"Melissa Lenaerts, Florien J G van Amstel, Felix M Mottaghy, Sandra M E Geurts, Vivianne C G Tjan-Heijnen, Marjolein L Smidt, Thiemo J A van Nijnatten","doi":"10.1097/MNM.0000000000001964","DOIUrl":"10.1097/MNM.0000000000001964","url":null,"abstract":"<p><p>The objective is to assess whether the degree of metabolic uptake of the primary tumor and axillary lymph nodes (ALNs) on baseline [18F] fluorodeoxyglucose ([18F]FDG) PET/CT is associated with the probability to achieve axillary pathologic complete response (pCR) in clinically node-positive (cN+) breast cancer patients treated with neoadjuvant systemic therapy (NST), overall and per clinical subtype. Studies that assessed the maximum standardized uptake value (SUVmax) in the primary tumor and ALNs on baseline [18F]FDG PET/CT and reported axillary pCR rates in patients diagnosed with cN+ invasive breast cancer treated with NST, followed by surgery, were searched. Area under the curve (AUC) values were obtained. A total of seven studies (561 patients) were included. The mean baseline SUVmax of the primary tumor ranged from 8.1 (±4.3) to 9.8 (±7.2). Mean baseline axillary SUVmax ranged from 6.0 (±5.6) to 7.3 (±6.2). The axillary pCR rate ranged from 38.0% to 48.1%. Considering the primary tumor, no study reported on the association between baseline SUVmax and the axillary pCR rate. Considering the ALNs, the AUC value for baseline axillary SUVmax to predict axillary pCR ranged from 0.52 [95% confidence interval (CI): 0.39-0.65; all subtypes included] to 0.74 (95% CI: 0.53-0.95; only human epidermal growth factor receptor 2+ and triple negative). In conclusion, no association between the primary tumor SUVmax on baseline [18F]FDG PET/CT and axillary pCR was found. Concerning the axilla, based on limited scientific evidence, the axillary SUVmax on baseline [18F]FDG PET/CT may be associated with axillary pCR after NST in cN+ breast cancer patients, however, potential differences between clinical subtypes should be considered.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11964195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of thyroglobulin after radioiodine therapy for excellent response to treatment in postoperative thyroid cancer.","authors":"Yuan Zhu, Xiaoying Yang, Zhao Liu, Qinghua Zhang, Zhiyong Li, Xiancun Hou, Hui Zhu","doi":"10.1097/MNM.0000000000001933","DOIUrl":"10.1097/MNM.0000000000001933","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the usefulness of thyroglobulin (Tg) after radioiodine (RAI) therapy in predicting excellent response (ER) to therapy in postoperative differentiated thyroid cancer (DTC).</p><p><strong>Methods: </strong>A retrospective observational study was conducted on postoperative DTC patients who underwent RAI from August 2018 to December 2022. Various factors were analyzed to predict ER to treatment. This involved Tg under stimulation (sTg) before RAI, Tg immediately (imTg) 112 h post-RAI and imTg/sTg(rTg). Based on the efficacy of RAI, patients were categorized into two groups: ER and non-ER (NER). Univariate logistic analysis was utilized to compare parameters between the two groups, followed by binary logistic regression analysis on factors associated with ER. Receiver operating characteristic (ROC) curves were employed to evaluate the sensitivity, specificity, and optimal diagnostic cutoff points for parameters affecting ER.</p><p><strong>Results: </strong>The analysis included 45 ER patients and 56 NER patients. Statistical significance was found in the binary logistic regression analysis for the number of lymph nodes in the lateral cervical region ( P  = 0.016), sTg ( P  = 0.021), and rTg ( P  ≤ 0.001) concerning ER. ROC curve analysis revealed that the rTg area under the curve was 0.845, with an optimal cutoff value of 11.78, sensitivity of 82.6%, and specificity of 74.5%.</p><p><strong>Conclusion: </strong>Post-RAI therapy, significant value is demonstrated by rTg with high sensitivity and specificity. This provides a foundation for the evaluation and decisions about DTC treatment in advance.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"146-151"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of preoperative 18F-flurodeoxyglucose PET/CT scanning in preoperative evaluation and surgical planning for pulmonary tuberculosis.","authors":"Lei-Lei Li, Lin Wang, Hong-Wei Li, Hui Chen, Lei Shi, Lai-Yi Wan, Yan-Zheng Song","doi":"10.1097/MNM.0000000000001930","DOIUrl":"https://doi.org/10.1097/MNM.0000000000001930","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to investigate the utility of preoperative 18F-FDG PET/CT scanning in preoperative evaluation and surgical planning for pulmonary tuberculosis.</p><p><strong>Methods: </strong>The study involved a retrospective analysis of clinical data and preoperative chest 18F-FDG PET/CT data of 24 patients with pulmonary tuberculosis who underwent pneumonectomy at the Shanghai Public Health Clinical Center between December 2017 and January 2022.</p><p><strong>Results: </strong>All 24 patients successfully underwent chest 18F-FDG PET/CT imaging, and complete data pertaining to the maximum standardized uptake value, mean standardized uptake value, minimum standardized uptake value, total lesion glycolysis, and metabolic tumor volume were obtained. Surgical excision plans were finalized using the chest 18F-FDG PET/CT findings along with the conventional chest CT scans. Pneumonectomy was successfully completed in all 24 patients, and these included 13 cases of pulmonary lobectomy, two cases of total pneumonectomy, one case of combined pulmonary lobectomy, one case of segmentectomy, and seven cases of pulmonary wedge resection. The actual surgical procedures had a conformity rate of 100% to the preoperative surgical plans that were made. The intraoperative bronchial stump embedding rate was 69% (11/18 cases), the incidence rate of postoperative air leakage was 3.8% (1/24 cases), and there were no reported cases of postoperative bronchopleural fistula or death.</p><p><strong>Conclusion: </strong>Preoperative 18F-FDG PET/CT scans had significant utility in surgical planning, the selection of surgical methods, and the formulation of postoperative antituberculosis treatment courses for patients with pulmonary tuberculosis. The use of 18F-FDG PET/CT shows considerable promise in being promoted clinically for the surgical management of patients with pulmonary tuberculosis.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":"46 2","pages":"180-186"},"PeriodicalIF":1.3,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}