Nuclear Medicine Communications最新文献

{"title":"The progress of fibroblast activation protein inhibitors PET/computed tomography in the diagnosis and treatment of lymphoma: a narrative review.","authors":"Jie Liu, Dehui Liu","doi":"10.1097/MNM.0000000000002162","DOIUrl":"10.1097/MNM.0000000000002162","url":null,"abstract":"<p><p>Lymphoma is a highly heterogeneous hematologic malignancy, for which precise diagnosis and staging are crucial for treatment planning. Although fluorine-18 fluorodeoxyglucose PET/computed tomography ( 18 F-FDG PET/CT) is the current 'gold standard' for imaging evaluation, it has limitations such as lack of cancer specificity and insufficient sensitivity in indolent lymphomas. Isotope-labeled fibroblast activation protein inhibitors (FAPI), such as gallium-68 FAPI ( 68 Ga-FAPI), represent a novel class of radiopharmaceuticals targeting the tumor microenvironment and have shown unique potential in PET/CT imaging for various tumors, including lymphoma. This narrative review compares the imaging characteristics, diagnostic and staging accuracy, and therapeutic value of FAPI PET/CT and 18 F-FDG PET/CT in lymphoma by synthesizing existing literature. The results indicate that for most lymphoma subtypes, the overall performance of FAPI PET/CT remains inferior to that of 18 F-FDG PET/CT. However, in specific scenarios (e.g. indolent lymphoma, gastrointestinal involvement), it can serve as an important complementary imaging modality and further reveal the molecular characteristics of the tumor. FAPI-based targeted therapy also shows preliminary promise. Overall, current evidence supports FAPI PET/CT as a valuable supplement to 18 F-FDG PET/CT in specific clinical contexts. Its definitive clinical role awaits further clarification through more prospective studies.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":"917-927"},"PeriodicalIF":1.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147646014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Gustave Roussy immune score as a superior gatekeeper for predicting myocardial perfusion abnormalities and high-risk phenotypes: a comparative study with the systemic immune-inflammation index and Naples prognostic score.","authors":"Mustafa Genc","doi":"10.1097/MNM.0000000000002214","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002214","url":null,"abstract":"<p><strong>Objective: </strong>Ischemic heart disease is driven by systemic immunonutritional disruptions rather than isolated epicardial stenoses. We investigated the diagnostic utility of the Gustave Roussy immune score (GRIS) and Naples prognostic score (NPS) in predicting ischemia, scar burden, and high-risk markers on myocardial perfusion imaging (MPI) in suspected stable coronary artery disease.</p><p><strong>Methods: </strong>This retrospective cohort included 325 patients (193 men; mean age, 60 years) undergoing ECG-gated single-photon emission computed tomography MPI. Patients were stratified into normal, ischemia, scar, and mixed groups. Routine blood parameters yielded the neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), NPS, and GRIS.</p><p><strong>Results: </strong>Inflammatory indices (NLR, SII) and complex scores (NPS, GRIS) were significantly elevated in the ischemia and scar groups versus the normal perfusion group (P < 0.001). In multivariable analysis, GRIS - integrating cellular destruction and nutritional depletion with inflammation - was the strongest independent predictor of myocardial perfusion abnormalities (odds ratio: 10.57; 95% confidence interval: 5.11-21.89; P < 0.001), outperforming all other indices (area under the curve: 0.770; 86.3% specificity at >1 cutoff). Furthermore, elevated GRIS and NPS independently predicted poor prognosis (scar or reduced left ventricular ejection fraction) and transient ischemic dilation (>1.22) (P < 0.05).</p><p><strong>Conclusion: </strong>GRIS and NPS significantly outperform traditional inflammatory indices in detecting myocardial ischemia and cellular reserve depletion. Derived from routine blood tests, GRIS serves as a powerful clinical 'gatekeeper' before invasive procedures, effectively identifying patients with high biological frailty.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148664145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18F-fluorodeoxyglucose PET/computed tomography-derived radiomics and 2.5D deep learning for noninvasive prediction of lymph node metastasis in pancreatic ductal adenocarcinoma.","authors":"Jiyuan Jin, Dongxue Wang, Furui Duan, Yunfei Cai, Yu Zhao, Yong Wan, Wei Yuan, Huazhen Liu, Hongquan Li, Ping Li","doi":"10.1097/MNM.0000000000002212","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002212","url":null,"abstract":"<p><strong>Background: </strong>Accurate preoperative prediction of lymph node metastasis (LNM) guides treatment and prognostic stratification for pancreatic ductal adenocarcinoma (PDAC). This study established an interpretable PET/computed tomography (CT)-based artificial intelligence model combining clinical indicators, radiomic and 2.5D deep learning features to predict preoperative LNM.</p><p><strong>Methods: </strong>A total of 173 pathologically confirmed PDAC patients with preoperative 18F-fluorodeoxyglucose PET/CT scans were retrospectively enrolled and randomly split into training and test sets at a 7 : 3 ratio. Clinical indicators, PET/CT radiomic features and ResNet50-based 2.5D deep learning features were extracted. Feature selection was implemented via, Spearman correlation analysis and logistic regression. Seven machine learning algorithms were built and compared: support vector machine, logistic regression, random forest, extra trees, gradient boosting machine (GBM), k-nearest neighbors and linear discriminant analysis (LDA). Model performance was assessed by receiver operating characteristics curve, DeLong test, calibration curve, Hosmer-Lemeshow test and decision curve analysis, and Shapley Additive Explanations (SHAP) were used for model interpretability.</p><p><strong>Results: </strong>Among 173 patients, 105 were LNM-positive and 68 were LNM-negative. The GBM model achieved the highest area under the curve (AUC) of 0.970 in the training set with suspected overfitting. On the independent test set, LDA yielded optimal performance (AUC = 0.871, accuracy = 0.792, sensitivity = 0.719, specificity = 0.905, F1 = 0.807). Decision curve analysis verified favorable clinical applicability. SHAP analysis indicated PET/CT-derived deep learning and radiomic features exerted stronger predictive effects than conventional clinical variables.</p><p><strong>Conclusion: </strong>This interpretable PET/CT-based model provides a noninvasive tool for individualized preoperative LNM risk assessment in PDAC.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148664184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rigorous standardized uptake value-based framework for monitoring tafamidis response in transthyretin cardiac amyloidosis with bone-avid single-photon emission computed tomography/computed tomography.","authors":"Alessandro Spimpolo, Roberto Cemin, Alessandro Fracchetti, Mauro Monastero, Leda Lorenzon, Viktorija Sokolova, Mohsen Farsad","doi":"10.1097/MNM.0000000000002211","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002211","url":null,"abstract":"<p><strong>Background: </strong>Bone scintigraphy with technetium-labeled tracers has become a cornerstone in diagnosing transthyretin cardiac amyloidosis (ATTR-CM). While visual grading systems like the Perugini Score are widely used, they lack sensitivity for monitoring therapeutic response. Quantitative single-photon emission computed tomography (SPECT)/computed tomography (CT) offers potential for objective assessment of myocardial tracer uptake and disease activity.</p><p><strong>Methods: </strong>We retrospectively analyzed 25 wild-type ATTR-CM patients who underwent sequential 99mTc-HMDP whole-body scintigraphy and thoracic SPECT/CT before and after tafamidis therapy. SPECT images were reconstructed quantitatively, and myocardial volumes were manually segmented on fused SPECT/CT images. Standardized uptake values (SUVmean, SUVmax, SUVpeak) were extracted and normalized to a reference vertebral volume. Nonparametric tests were used for paired comparisons and correlations with the Perugini Score.</p><p><strong>Results: </strong>All myocardial SUV parameters (SUVmean, SUVmax, SUVpeak) decreased significantly after tafamidis (Wilcoxon signed-rank, two-sided P < 0.0001 for all), while vertebral SUVmean remained stable (P = 0.5539). Myocardial-to-bone SUV ratios also decreased significantly. At baseline, SUVpeak showed a moderate positive association with the Perugini Score (Kendall's τ = 0.476, P = 0.0045); a monotonic increasing trend across categories was confirmed (Jonckheere-Terpstra z = 2.93, two-sided P = 0.0034; Kruskal-Wallis H = 7.75, P = 0.0207). Effect sizes for paired changes (Hodges-Lehmann and rank-biserial r) indicated large and concordant within-patient reductions for SUVmax and SUVpeak.</p><p><strong>Conclusion: </strong>Quantitative SPECT/CT using SUV-based metrics provides a reproducible and sensitive method for assessing tafamidis response in ATTR-CM. Compared with existing approaches, our method - based on SUVpeak and bone normalization - offers robustness and clinical relevance, supporting its integration into routine practice.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148621059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the prognostic value of 18F-fluorodeoxyglucose PET/MRI and PET/computed tomography in recurrent ovarian cancer.","authors":"Muhammet Halil Baltacioglu, Cigdem Soydal, Mine Araz, Digdem Kuru Oz, Salih Taskin, Nuriye Ozlem Kucuk, Atilla Halil Elhan","doi":"10.1097/MNM.0000000000002217","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002217","url":null,"abstract":"<p><strong>Purpose: </strong>Peritoneal metastases significantly affect prognosis in ovarian cancer. We aimed to compare the prognostic value of 18F-fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) and 18F-FDG PET/MRI performed for restaging in patients with suspected recurrence and elevated CA-125.</p><p><strong>Materials and methods: </strong>Forty-five recurrent ovarian cancer patients who underwent same-session 18F-FDG PET/CT followed by whole-abdomen 18F-FDG PET/MRI for restaging were included from a previously published prospective cohort; patients were followed for overall survival (OS; median follow-up: 61.9 months). Kaplan-Meier and Cox regression analyses were performed.</p><p><strong>Results: </strong>18F-FDG PET/MRI detected peritoneal involvement more frequently than 18F-FDG PET/CT (78% vs. 58%, P = 0.012) and yielded higher peritoneal cancer index (PCI) scores (P < 0.001). During follow-up, 35 patients (77.8%) died, and the median OS was 27.7 months. On 18F-FDG PET/CT, the number of peritoneal lesions (P = 0.002), PCI score (P = 0.004), and distant organ metastases (P = 0.017) were significantly associated with OS. Peritoneal involvement showed clearer survival separation on 18F-FDG PET/CT than on 18F-FDG PET/MRI (P = 0.046 vs. P = 0.222). For 18F-FDG PET/MRI, the number of peritoneal lesions (P = 0.038) and PCI score (P = 0.005) were significantly associated with OS, whereas peritoneal involvement on 18F-FDG PET/MRI was not associated with OS. Thus, binary PET/MRI positivity and quantitative PET/MRI-derived disease burden showed different prognostic associations. In addition, among 18F-FDG PET/MRI-positive patients, OS did not differ significantly between those positive only on 18F-FDG PET/MRI and those positive on both 18F-FDG PET/MRI and 18F-FDG PET/CT (P = 0.246). In the multivariable Cox model including age and both imaging modalities simultaneously, only 18F-FDG PET/CT-defined peritoneal lesion burden (>5 vs. ≤5 lesions) remained independently associated with OS [hazard ratio = 3.80, 95% confidence interval (CI) = 1.35-10.68, P = 0.012], whereas 18F-FDG PET/MRI-defined lesion burden (>5 vs. ≤5 lesions) did not retain statistical significance (hazard ratio = 1.31, 95% CI = 0.53-3.25, P = 0.555).</p><p><strong>Conclusion: </strong>Although 18F-FDG PET/MRI detected peritoneal metastases more frequently and yielded higher PCI scores, 18F-FDG PET/CT-derived peritoneal lesion burden demonstrated stronger independent prognostic value. 18F-FDG PET/CT appears sufficient for baseline prognostic stratification, whereas 18F-FDG PET/MRI may still provide complementary value for anatomical localization, detection of small-volume disease, and treatment planning.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline metabolic tumor architecture in diffuse large B-cell lymphoma defined by total metabolic tumor volume and lesion count: a two-center 18 F-fluorodeoxyglucose PET/computed tomography study.","authors":"Lin Lin, Ming Li, Tao He, Hongyue Zhao, Yexin Su, Peng Fu","doi":"10.1097/MNM.0000000000002213","DOIUrl":"10.1097/MNM.0000000000002213","url":null,"abstract":"<p><strong>Objective: </strong>Baseline total metabolic tumor volume (TMTV) is an established 18 F-fluorodeoxyglucose PET/computed tomography ( 18 F-FDG PET/CT) marker of tumor burden in diffuse large B-cell lymphoma (DLBCL), but it does not show whether disease is concentrated in a few bulky lesions or fragmented across many foci. We evaluated whether combining TMTV with lesion count could define a simple baseline metabolic architecture framework.</p><p><strong>Methods: </strong>We retrospectively analyzed 198 treatment-naive patients with DLBCL from two clinical centers who underwent baseline 18 F-FDG PET/CT. Semi-automatic lesion segmentation was followed by reader-driven consensus review. Patients were classified using cohort-median cutoffs for TMTV (59.1 mL) and lesion count (16) into low-burden/low-count ( n  = 74), high-burden/low-count ( n  = 23), multifocal low-burden ( n  = 25), and high-burden disseminated ( n  = 76) patterns.</p><p><strong>Results: </strong>Log-transformed TMTV and lesion count were moderately correlated ( r  = 0.686, R2  = 0.471), indicating related but noninterchangeable dimensions. The four patterns differed in maximum standardized uptake value, total lesion glycolysis, and Dmax (all P  < 0.001). Pattern distribution was associated with advanced-stage disease ( P  = 0.004) and trans-diaphragmatic spread ( P  = 0.005), but not with stage IV disease ( P  = 0.273) or extranodal organ involvement ( P  = 0.683). In advanced-stage patients ( n  = 149), the patterns remained metabolically distinct, whereas conventional staging variables no longer differed across groups.</p><p><strong>Conclusion: </strong>The TMTV-lesion count framework captures a visually auditable architectural layer of baseline DLBCL that complements cumulative tumor burden and Ann Arbor staging.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148605928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Threshold behavior of droplet release in automated fluorine-18 fluorodeoxyglucose quality control.","authors":"Hiroshi Yamaguchi","doi":"10.1097/MNM.0000000000002216","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002216","url":null,"abstract":"<p><p>This study aimed to investigate the variability in optimal dispensing volume required for reliable droplet release in automated fluorine-18 fluorodeoxyglucose ([18F]FDG) quality control and to identify factors affecting reproducibility. Dispensing behavior was evaluated using an automated quality control system across multiple sessions. Droplet formation and release were assessed at different dispensing volumes under routine operating conditions. Particular attention was given to small-volume dispensing used for semi-quantitative pH paper testing, thin-layer chromatography-based residual Kryptofix testing, and aluminum ion testing. Droplet release reliability was found to be highly sensitive to small differences in dispensing volume. At volumes around 0.011 ml, droplets frequently adhered to the needle tip and failed to reach the target surface. Increasing the volume to approximately 0.013 ml resulted in consistent droplet release. Borderline behavior was observed at intermediate volumes (0.012 ml), with variability depending on syringe and needle characteristics. The optimal dispensing volume exhibited time-dependent shifts, likely associated with changes in syringe condition and surface properties. Reliable droplet release in automated [18F]FDG quality control is strongly influenced by small variations in dispensing volume and system-dependent factors. Careful adjustment and periodic verification of dispensing parameters are essential to ensure reproducibility in routine clinical operations.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148605947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of ordered physiological myocardial 18F-fluorodeoxyglucose uptake patterns on non-cardiac PET/computed tomography: an ordinal regression analysis.","authors":"Chen Chen, Lina Zhao, Dan Huang, Bei Zhang","doi":"10.1097/MNM.0000000000002210","DOIUrl":"https://doi.org/10.1097/MNM.0000000000002210","url":null,"abstract":"<p><strong>Objective: </strong>On routine non-cardiac PET/computed tomography (CT), myocardial 18F-fluorodeoxyglucose (18F-FDG) uptake demonstrates substantial interindividual variability and may complicate image interpretation. However, the systemic metabolic and clinical determinants associated with different myocardial FDG uptake patterns remain incompletely understood.</p><p><strong>Methods: </strong>This retrospective single-center study included 292 patients who underwent whole-body 18F-FDG PET/CT following a minimum 6-h fast, without dedicated cardiac preparation. Myocardial FDG uptake was visually categorized into three ordered patterns: no/low, focal, and diffuse uptake. Clinical, laboratory, hemodynamic, and treatment-related variables were analyzed using proportional odds ordinal logistic regression to identify factors associated with increasing uptake categories. Exploratory prediction models for higher myocardial uptake patterns and diffuse uptake were additionally constructed to support clinical interpretability. Model performance was evaluated using receiver operating characteristic curves and calibration analysis.</p><p><strong>Results: </strong>Among the 292 patients, 122 (41.8%) demonstrated no/low uptake, 60 (20.5%) focal uptake, and 110 (37.7%) diffuse uptake. In multivariable ordinal logistic regression, blood pressure control remained strongly associated with myocardial uptake patterns. Compared with poor blood pressure control, no hypertension [odds ratio (OR) 0.155, 95% confidence interval (CI) 0.072-0.334, P < 0.001] and good blood pressure control (OR 0.054, 95% CI 0.019-0.151, P < 0.001) were associated with lower odds of higher uptake categories. Absence of hormone therapy was also independently associated with lower odds of higher uptake patterns (OR 0.216, 95% CI 0.098-0.476, P < 0.001). Fasting glucose, diabetes, blood-pool maximum standardized uptake value, and chemotherapy were not independently significant after adjustment. The higher uptake model achieved an area under the curve of 0.898, while the diffuse uptake model achieved an area under the curve of 0.839, with satisfactory calibration performance.</p><p><strong>Conclusions: </strong>Myocardial FDG uptake patterns observed on routine non-cardiac PET/CT were associated with a graded spectrum of systemic metabolic and hemodynamic characteristics. These findings may provide a framework for more structured interpretation of myocardial FDG uptake in routine PET/CT imaging. These findings should be interpreted as observational associations rather than evidence of causal relationships.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148605937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibroblast activation protein inhibitor PET/computed tomography versus 18 F-fluorodeoxyglucose PET/computed tomography in inflammatory bowel disease: a systematic review and exploratory meta-analysis with focus on ulcerative colitis.","authors":"Nitin Gupta, Priyavrat Purohit, Shipra Sood, Amit Rana","doi":"10.1097/MNM.0000000000002209","DOIUrl":"10.1097/MNM.0000000000002209","url":null,"abstract":"<p><p>Fibroblast activation protein inhibitor (FAPI) PET/computed tomography (CT) is an emerging molecular-imaging approach for inflammatory bowel disease (IBD), particularly where fibroblast activation, stromal remodeling, and fibrosis are clinically relevant. Fluorodeoxyglucose (FDG) PET reflects inflammatory glucose metabolism but may be limited by physiologic bowel uptake and poor fibrosis specificity. To review original human studies evaluating FAPI-PET and FDG-PET in IBD, perform exploratory comparative synthesis where extractable data permitted, and appraise the ulcerative colitis-specific evidence base. Original human studies of FAPI-PET and FDG-PET in Crohn disease, ulcerative colitis, or mixed IBD cohorts were identified and categorized as direct comparative, supportive FAPI, or supportive FDG studies. Extractable 2 × 2 diagnostic data were summarized descriptively. Sensitivity analyses were performed by reference standard type and by excluding surgical or stricturing-enriched cohorts where feasible. Eleven original studies were included, of which four formed the direct comparative core. Three studies contributed segment-level 2 × 2 data to the primary lesion detection dataset, including Crohn disease and ulcerative colitis cohorts and different FAPI radiopharmaceuticals. In this exploratory segment-level aggregate, FAPI-PET showed descriptively higher sensitivity, specificity, accuracy, and diagnostic odds-ratio than FDG-PET. Restriction to endoscopy-referenced cohorts preserved the direction of effect. Patient-level 2 × 2 tables were not uniformly reported, so patient-level pooled estimates could not be generated. FAPI-PET is a promising imaging modality in IBD, with the strongest evidence in Crohn disease and fibrostenotic characterization. In ulcerative colitis, direct comparative evidence remains sparse.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-grade glial tumors imaging by means of gallium-68 fibroblast activation protein inhibitor-04 PET-computed tomography in correlation with histopathology fibroblast activation protein analysis.","authors":"Zehra Pinar Koç, Pinar Pelin Özcan, Vehbi Erçolak, Emel Avci, Ayşe Türkmen Dedeoğlu, Hasan Basir, Hamide Sayar, Gülhan Örekici, Adil Gümüş","doi":"10.1097/MNM.0000000000002207","DOIUrl":"10.1097/MNM.0000000000002207","url":null,"abstract":"<p><strong>Aim: </strong>Gallium-68 fibroblast activation protein inhibitor-04 PET-computed tomography ( 68 Ga-FAPi-04 PET-CT) imaging is a promising modality with higher tumor affinity and lower background activity than 18 F-fluorodeoxyglucose, especially for brain imaging, which has no significant physiological uptake. This study aimed to determine the uptake of high-grade glioma lesions in correlation with histopathological FAP expression and to assess the contribution of imaging accordingly.</p><p><strong>Materials and methods: </strong>Fifteen patients with high-grade gliomas (WHO grade 3 and 4) were the subjects of this study. The patients presented with suspicion of recurrent tumors, which were determined by MRI imaging. 68 Ga-FAPi-04 PET-CT was performed on all subjects. The images were analyzed by visual and quantitative evaluation, which was compared with FAP expression determined from the pathology specimens, and all results were compared with the follow-up results (progression) at 12.2 ± 14.6 months.</p><p><strong>Results: </strong>PET-CT imaging revealed an area under the curve of 0.97 for the tumor-to-background ratio of 14.3, with 100% sensitivity and 88.9% specificity for predicting progression in this small patient cohort ( Fig. 1 ). In addition, whole-body imaging revealed suspicion of bone metastasis in three patients and liver metastasis in one patient, but validation was not possible because of short survival after imaging.</p><p><strong>Conclusion: </strong>Although the sample size is limited, Ga-FAPi-04 PET-CT imaging showed high diagnostic value for recurrent tumors, as tumor-to-background ratio values correlate with prognosis. In addition, a theranostic approach using these radiopharmaceuticals might yield favorable results in further studies.</p>","PeriodicalId":19708,"journal":{"name":"Nuclear Medicine Communications","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}